| Frazier Life Sciences Management, L.P. | 22.7M | $84.6M | — | Held |
| VR ADVISER, LLC | 17.9M | $66.4M | — | Held |
| BlackRock, Inc. | 15.6M | $58M | — | Held |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 14.5M | $53.9M | — | Held |
| Paradigm Biocapital Advisors LP | 14.2M | $52.7M | — | Held |
| Logos Global Management LP | 13M | $48.4M | — | Held |
| Vanguard | 12.8M | $47.7M | — | Held |
| ARCH Venture Management, LLC | 11.1M | $41.1M | — | Held |
| Vivo Capital, LLC | 9.27M | $34.5M | — | Held |
| Siren, L.L.C. | 8.76M | $32.6M | — | Held |
| State Street | 6.17M | $23M | — | Held |
| 5AM Venture Management, LLC | 5.41M | $20.1M | — | Held |
| GEODE CAPITAL MANAGEMENT, LLC | 4.93M | $18.3M | — | Held |
| Affinity Asset Advisors, LLC | 3.9M | $14.5M | — | Held |
| Spruce Street Capital LP | 3.89M | $14.5M | — | Held |
| GOLDMAN SACHS GROUP INC | 3.33M | $12.4M | — | Held |
| a16z Capital Management, L.L.C. | 2.86M | $10.6M | — | Held |
| MILLENNIUM MANAGEMENT LLC | 2.24M | $8.33M | — | Held |
| Soleus Capital Management, L.P. | 2.16M | $8.04M | — | Held |
| Woodline Partners LP | 1.93M | $7.18M | — | Held |
| DIMENSIONAL FUND ADVISORS LP | 1.78M | $6.6M | — | Held |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1.67M | $6.23M | — | Held |
| BANK OF AMERICA CORP /DE/ | 1.61M | $6M | $2.36M | Added$2.65M |
| ExodusPoint Capital Management, LP | 1.49M | $5.55M | — | Held |
| NORTHERN TRUST CORP | 1.33M | $4.95M | — | Held |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1.32M | $4.9M | — | Held |
| JPMORGAN CHASE & CO | 1.15M | $4.29M | — | Held |
| Citadel | 1.03M | $3.83M | — | Held |
| Rock Springs Capital Management LP | 951.7K | $3.54M | — | Held |
| JANE STREET GROUP, LLC | 912.5K | $3.39M | — | Held |
| TANG CAPITAL MANAGEMENT LLC | 900K | $3.35M | — | Held |
| Renaissance Technologies | 850.1K | $3.16M | — | Held |
| MORGAN STANLEY | 810.4K | $3.01M | $413.8K | Added$2.43M |
| Ikarian Capital, LLC | 735.4K | $2.74M | — | Held |
| Icahn Capital | 669.9K | $2.49M | — | Held |
| Bank of New York Mellon Corp | 546.8K | $2.03M | — | Held |
| WELLINGTON MANAGEMENT GROUP LLP | 543.2K | $2.02M | — | Held |
| Fidelity | 521.5K | $1.94M | — | Held |
| Nuveen, LLC | 424.7K | $1.58M | — | Held |
| BARCLAYS PLC | 402.8K | $1.5M | $413.1K | Added$913.6K |
| Creative Planning | 381.7K | $1.42M | — | Held |
| SIMPLEX TRADING, LLC | 346.1K | $1.29M | — | Held |
| Invesco Ltd. | 329.8K | $1.23M | — | Held |
| Squarepoint Ops LLC | 258.3K | $960.8K | — | Held |
| DAFNA Capital Management LLC | 254.4K | $946.5K | — | Held |
| TD Asset Management Inc | 229.8K | $855K | — | Held |
| WELLS FARGO & COMPANY/MN | 220.1K | $818.9K | — | Held |
| ALLIANCEBERNSTEIN L.P. | 208.8K | $776.8K | — | Held |
| D. E. Shaw & Co., Inc. | 201.9K | $751.2K | — | Held |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 199.8K | $743.2K | — | Held |
| RHUMBLINE ADVISERS | 189K | $703.1K | — | Held |
| BOOTHBAY FUND MANAGEMENT, LLC | 188.5K | $701.1K | — | Held |
| UBS Group AG | 170.5K | $634.4K | — | Held |
| AMERICAN CENTURY COMPANIES INC | 165.4K | $615.1K | — | Held |
| Hudson Bay Capital Management LP | 158K | $587.8K | — | New |
| RTW INVESTMENTS, LP | 146.7K | $545.5K | — | Held |
| Palumbo Wealth Management LLC | 139.4K | $518.5K | — | Held |
| Rafferty Asset Management, LLC | 131K | $487.4K | — | Held |
| DEUTSCHE BANK AG\ | 122K | $453.8K | — | Held |
| PANAGORA ASSET MANAGEMENT INC | 118.2K | $439.8K | — | Held |
| Balyasny Asset Management L.P. | 98.1K | $364.8K | — | Held |
| CITIGROUP INC | 95.8K | $356.3K | — | Held |
| INTECH INVESTMENT MANAGEMENT LLC | 90.7K | $337.5K | — | Held |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 88.2K | $326.8K | — | Held |
| MetLife Investment Management, LLC | 80.4K | $299K | — | Held |
| Cresset Asset Management, LLC | 79.9K | $297.3K | $123.1K | Added$123.1K |
| Virtus Investment Advisers, LLC | 73.9K | $274.9K | — | Held |
| Scientech Research LLC | 72.2K | $268.6K | — | Held |
| MARSHALL WACE, LLP | 62K | $230.5K | — | Held |
| Cerity Partners LLC | 61.5K | $228.9K | — | Held |
| IEQ CAPITAL, LLC | 60.3K | $224.5K | — | Held |
| Susquehanna Portfolio Strategies, LLC | 59.1K | $219.8K | — | Held |
| NEW YORK STATE COMMON RETIREMENT FUND | 55.6K | $206.7K | — | Held |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 54.8K | $203.7K | — | Held |
| TUDOR INVESTMENT CORP ET AL | 53.4K | $198.8K | — | New |
| Brevan Howard Capital Management LP | 52.7K | $196.2K | — | Held |
| PROFUND ADVISORS LLC | 50.6K | $188.3K | — | Held |
| China Universal Asset Management Co., Ltd. | 46.2K | $172K | — | Held |
| ProShare Advisors LLC | 44.2K | $164.5K | — | Held |
| Police & Firemen's Retirement System of New Jersey | 44K | $163.8K | — | Held |
| Jain Global LLC | 42.3K | $157.5K | — | Held |
| TWO SIGMA INVESTMENTS, LP | 38K | $141.4K | — | Held |
| BAILARD, INC. | 35.2K | $131.1K | — | Held |
| Vanguard Personalized Indexing Management, LLC | 34.7K | $128.9K | — | Held |
| VOYA INVESTMENT MANAGEMENT LLC | 33.2K | $123.5K | — | Held |
| BNP PARIBAS FINANCIAL MARKETS | 32.5K | $120.8K | — | Held |
| EP Wealth Advisors, LLC | 30K | $111.6K | — | Held |
| Y-Intercept (Hong Kong) Ltd | 24.3K | $90.4K | — | Held |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 22.5K | $81.7K | — | Held |
| AXQ CAPITAL, LP | 20.5K | $76.1K | — | Held |
| VICTORY CAPITAL MANAGEMENT INC | 18.4K | $68.4K | — | Held |
| CAPTRUST FINANCIAL ADVISORS | 17.6K | $65.5K | — | Held |
| QUADRANT CAPITAL GROUP LLC | 17.5K | $65.3K | — | Held |
| SEI INVESTMENTS CO | 16.7K | $62.1K | — | Held |
| T. Rowe Price Investment Management, Inc. | 16.1M | $59.9K | — | Held |
| Abel Hall, LLC | 15.7K | $58.3K | — | Held |
| Legal & General Group Plc | 15.4K | $57.5K | — | Held |
| SHERBROOKE PARK ADVISERS LLC | 15.3K | $56.9K | — | Held |
| Wealthcare Advisory Partners LLC | 15.2K | $56.4K | — | Held |
| Ameritas Investment Partners, Inc. | 14.6K | $54.5K | — | Held |
| Russell Investments Group, Ltd. | 14.4K | $53.5K | — | Held |
| Ballentine Partners, LLC | 14K | $52.1K | — | Held |
| Pallas Capital Advisors LLC | 13.9K | $51.8K | — | Held |
| Mirae Asset Global Investments Co., Ltd. | 13.8K | $51.3K | — | Held |
| XPONANCE LLC | 13.5K | $50.2K | — | Held |
| Quadrature Capital Ltd | 13.2K | $49K | — | Held |
| PRUDENTIAL FINANCIAL INC | 12.8K | $47.4K | — | Held |
| NEUBERGER BERMAN GROUP LLC | 12.4K | $46K | — | Held |
| CIBC WORLD MARKETS CORP | 11.5K | $42.7K | — | Held |
| TWO SIGMA ADVISERS, LP | 11.3K | $42K | — | Held |
| Mariner, LLC | 10.8K | $40.3K | — | Held |
| XTX Topco Ltd | 10.8K | $40.2K | — | Held |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 10.7K | $39.8K | — | Held |
| MACKENZIE FINANCIAL CORP | 11.1K | $39.4K | — | Held |
| STIFEL FINANCIAL CORP | 10.3K | $38.3K | — | Held |
| EntryPoint Capital, LLC | 10.3K | $38.3K | — | Held |
| Sterling Capital Management LLC | 10.1K | $37.6K | — | Held |
| AlphaCore Capital LLC | 10K | $37.2K | — | Held |
| CANADA PENSION PLAN INVESTMENT BOARD | 8K | $29.8K | — | Held |
| SIGNATUREFD, LLC | 7.1K | $26.4K | — | Held |
| Tower Research Capital LLC (TRC) | 6.88K | $25.6K | — | Held |
| GF FUND MANAGEMENT CO. LTD. | 5.57K | $20.7K | — | Held |
| ROYAL BANK OF CANADA | 5.01K | $18K | — | Held |
| NISA INVESTMENT ADVISORS, LLC | 4.41K | $16.4K | — | Held |
| Parallel Advisors, LLC | 4.23K | $15.7K | — | Held |
| EverSource Wealth Advisors, LLC | 2.39K | $8.89K | — | Held |
| Farther Finance Advisors, LLC | 2.33K | $8.66K | — | Held |
| Allworth Financial LP | 1.95K | $7.25K | $2.8K | Added$3.28K |
| SUMMIT SECURITIES GROUP LLC | 1.76K | $6.55K | — | Held |
| GAMMA Investing LLC | 1.61K | $6K | — | Held |
| Physician Wealth Advisors, Inc. | 1.19K | $4.43K | — | Held |
| True Wealth Design, LLC | 1.12K | $4.15K | — | Held |
| FEDERATED HERMES, INC. | 1K | $3.74K | — | Held |
| Optiver Holding B.V. | 920 | $3.42K | — | Held |
| Rockefeller Capital Management L.P. | 656 | $2.44K | — | Held |
| HRT FINANCIAL LP | 536.9K | $2K | — | Held |
| Essential Partners LLC | 459 | $1.71K | $694 | Added$724 |
| SBI Securities Co., Ltd. | 427 | $1.59K | — | Held |
| Rialto Wealth Management, LLC | 413 | $1.54K | — | Held |
| ROTHSCHILD INVESTMENT LLC | 394 | $1.47K | — | Held |
| Cornerstone Financial Management LLC | 338 | $1.26K | — | Held |
| Hughes Financial Services, LLC | 213 | $792 | — | Held |
| Steward Partners Investment Advisory, LLC | 200 | $744 | — | Held |
| Sunbelt Securities, Inc. | 162 | $603 | — | Held |
| PRICE T ROWE ASSOCIATES INC /MD/ | 103.5K | $386 | — | Held |
| IFP Advisors, Inc | 94 | $350 | $145 | Added$145 |
| SG Americas Securities, LLC | 48.7K | $181 | — | Held |
| CWM, LLC | 33.6K | $125 | — | Held |
| Arax Advisory Partners | 24 | $89 | — | Held |
| PNC Financial Services Group, Inc. | 8 | $30 | — | Held |
| AMALGAMATED BANK | 5.45K | $20 | — | Held |
| BESSEMER GROUP INC | 1.59K | $6 | — | Held |
| Daiwa Securities Group Inc. | 1.07K | $4 | — | Held |
| Covestor Ltd | 40 | $0 | — | Held |