| RTW INVESTMENTS, LP | 6.98M | $472.7M | $52.6M | Added$389.2M |
| Decheng Capital LLC | 6.37M | $431.2M | $166.7M | Added$166.7M |
| WELLINGTON MANAGEMENT GROUP LLP | 5.37M | $363.5M | $140.5M | Added$114.4M |
| BlackRock, Inc. | 5.06M | $342.7M | $126.7M | Added$141.7M |
| Fidelity | 3.76M | $254.8M | $98.5M | Added$76.3M |
| TCG Crossover Management, LLC | 3.67M | $248.4M | $96M | Added$96M |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 3.1M | $209.5M | — | Held |
| VANGUARD CAPITAL MANAGEMENT LLC | 3.03M | $205.3M | — | Held |
| State Street | 2.65M | $179.2M | $69.2M | Added$54.7M |
| Foresite Capital Management VI LLC | 2.22M | $150.3M | $58.1M | Added$58.1M |
| GEODE CAPITAL MANAGEMENT, LLC | 1.6M | $108.1M | $39.6M | Added$45.3M |
| Seven Fleet Capital Management LP | 1.52M | $102.5M | $39.6M | Added$39.6M |
| FRANKLIN RESOURCES INC | 1.51M | $102M | $39.4M | Added$37.2M |
| BANK OF AMERICA CORP /DE/ | 1.45M | $98.1M | $31.1M | Added$48.7M |
| DV Trading LLC | 1.44M | $97.4M | $37.7M | Added$37.7M |
| UBS Group AG | 1.31M | $88.8M | $34.3M | Added$8.92M |
| Avidity Partners Management LP | 1.29M | $87.2M | $33.7M | Added$26.1M |
| GOLDMAN SACHS GROUP INC | 1.16M | $78.5M | $30.3M | Added$23.5M |
| ACORN CAPITAL ADVISORS, LLC | 1.13M | $76.6M | $29.6M | Added$29.6M |
| EcoR1 Capital, LLC | 1.1M | $74.6M | $20.2M | Added$42.5M |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1.06M | $72.1M | $27.9M | Added$26.8M |
| Foresite Capital Management V, LLC | 1M | $68M | $26.3M | Added$26.3M |
| Driehaus Capital Management LLC | 999.6K | $67.7M | — | New |
| BRAIDWELL LP | 984.8K | $66.7M | $25.8M | Cut−$11M |
| ORBIMED ADVISORS LLC | 948.3K | $64.2M | $24.8M | Added$1.21M |
| ALLIANCEBERNSTEIN L.P. | 1.29M | $53.6M | −$0 | Cut−$13.4M |
| Clearbridge Investments, LLC | 730.3K | $49.4M | $18.4M | Added$20.2M |
| Polar Capital Holdings Plc | 704.5K | $47.7M | $18.4M | Added$2.06M |
| FARALLON CAPITAL MANAGEMENT LLC | 674K | $45.6M | $209.3K | Added$45.3M |
| Logos Global Management LP | 575K | $38.9M | $5.23M | Added$30.6M |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 542.4K | $36.7M | $14.2M | Added$14.2M |
| Candriam S.C.A. | 542K | $36.7M | $14.2M | Added$3.57M |
| JPMORGAN CHASE & CO | 559.6K | $35.8M | $12.6M | Added$11.4M |
| MORGAN STANLEY | 520.2K | $35.2M | $13.6M | Added$12.6M |
| NORTHERN TRUST CORP | 519.7K | $35.2M | $12.6M | Added$15.2M |
| Woodline Partners LP | 492.9K | $33.4M | $12.9M | Added$12.9M |
| JENNISON ASSOCIATES LLC | 476.1K | $32.2M | $7.39M | Added$20.5M |
| VANGUARD FIDUCIARY TRUST CO | 470.3K | $31.8M | — | Held |
| Fisher Asset Management, LLC | 465K | $31.5M | — | New |
| Ensign Peak Advisors, Inc | 456K | $30.9M | $11.9M | Added$8.83M |
| DIMENSIONAL FUND ADVISORS LP | 438.7K | $29.7M | $11.5M | Added$10.5M |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 399.9K | $27.1M | — | New |
| Point72 Asset Management, L.P. | 399.4K | $27M | $3.96M | Added$20.7M |
| Pictet Asset Management Holding SA | 398K | $26.9M | $10.4M | Cut−$29.1M |
| Caption Management, LLC | 378.5K | $25.6M | $8.03M | Added$12.9M |
| EVENTIDE ASSET MANAGEMENT, LLC | 370K | $25M | $8.16M | Added$12.1M |
| FIRST TRUST ADVISORS LP | 333.2K | $22.6M | $4.76M | Added$15M |
| AMERIPRISE FINANCIAL INC | 311.5K | $21.1M | $6.29M | Added$11.1M |
| Elmind Capital, LP | 291.8K | $19.7M | $7.63M | Cut−$699.6K |
| TD Asset Management Inc | 288.8K | $19.5M | $4.88M | Added$11.8M |
| TimesSquare Capital Management, LLC | 253.7K | $17.2M | $6.64M | Cut−$517.4K |
| STEMPOINT CAPITAL LP | 205.6K | $13.9M | — | New |
| HSBC HOLDINGS PLC | 187.8K | $12.7M | — | New |
| ArrowMark Colorado Holdings LLC | 186.3K | $12.6M | $4.87M | Added$2.4M |
| ADAR1 Capital Management, LLC | 185.7K | $12.6M | $4.86M | Added$1.85M |
| Citadel | 172.8K | $11.7M | $4.52M | Cut−$16.6M |
| Bank of New York Mellon Corp | 167K | $11.3M | $4.06M | Added$4.86M |
| SILVERARC CAPITAL MANAGEMENT, LLC | 166.3K | $11.3M | $4.35M | Cut−$3.74M |
| PFM Health Sciences, LP | 165.9K | $11.2M | $4.29M | Added$4.42M |
| Russell Investments Group, Ltd. | 163.2K | $11M | $3.75M | Added$5.09M |
| DEUTSCHE BANK AG\ | 156.5K | $10.6M | $3.93M | Added$4.35M |
| FEDERATED HERMES, INC. | 148.8K | $10.1M | $91.6K | Added$9.92M |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 156.3K | $10M | $3.72M | Cut−$1.29M |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 144.1K | $9.75M | $989.7K | Added$8.18M |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 136.8K | $9.26M | $3.58M | Added$877.8K |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 136.5K | $9.24M | $3.49M | Added$4.04M |
| Nuveen, LLC | 128.4K | $8.69M | $3.36M | Added$3.1M |
| Icahn Capital | 114.3K | $7.74M | $2.94M | Added$3.07M |
| BNP PARIBAS FINANCIAL MARKETS | 108K | $7.31M | $2.51M | Added$3.32M |
| Rosalind Advisors, Inc. | 100K | $6.77M | $2.62M | Cut−$5.69M |
| Opaleye Management Inc. | 94.8K | $6.42M | $2.48M | Cut−$10.6M |
| Invesco Ltd. | 92K | $6.23M | $997.7K | Added$4.64M |
| Swiss National Bank | 84.4K | $5.71M | $2.21M | Added$2.21M |
| RHUMBLINE ADVISERS | 71.1K | $4.81M | $1.85M | Added$1.88M |
| ALPS ADVISORS INC | 68.7K | $4.65M | $1.73M | Added$1.91M |
| Rafferty Asset Management, LLC | 68K | $4.6M | $1.78M | Added$197.5K |
| PICTON MAHONEY ASSET MANAGEMENT | 67.4K | $4.56M | $74.6K | Added$4.44M |
| Blackstone Inc. | 64.1K | $4.34M | — | New |
| Tidal Investments LLC | 63.2K | $4.27M | — | New |
| TEMA ETFS LLC | 63.2K | $4.27M | $943.3K | Added$2.78M |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 57.7K | $3.91M | $3.9M | Added$3.9M |
| VOYA INVESTMENT MANAGEMENT LLC | 57.3K | $3.88M | $1.14M | Added$2.06M |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 51.5K | $3.49M | $1.09M | Added$1.76M |
| Aquatic Capital Management LLC | 49.6K | $3.36M | — | New |
| Nantahala Capital Management, LLC | 49.4K | $3.35M | $1.29M | Cut−$1.2M |
| D. E. Shaw & Co., Inc. | 46.6K | $3.15M | $602.4K | Added$2.2M |
| Informed Momentum Co LLC | 46.1K | $3.12M | — | New |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 45.6K | $3.07M | $1.12M | Added$1.29M |
| SummitTX Capital, L.P. | 40.6K | $2.75M | $1.06M | Added$672.8K |
| Legal & General Group Plc | 38K | $2.57M | $994.3K | Added$697.9K |
| MetLife Investment Management, LLC | 32.6K | $2.21M | $846.2K | Added$863.5K |
| Lynx1 Capital Management LP | 31.6K | $2.14M | $826.4K | Added$826.4K |
| PROFUND ADVISORS LLC | 30.7K | $2.08M | $802.8K | Added$444.4K |
| Vanguard Global Advisers, LLC | 30.3K | $2.05M | — | Held |
| VANGUARD ASSET MANAGEMENT, Ltd | 28.9K | $1.96M | — | Held |
| STATE OF WISCONSIN INVESTMENT BOARD | 26.8K | $1.82M | $702.1K | Added$682K |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 25.8K | $1.75M | — | New |
| Cinctive Capital Management LP | 25K | $1.69M | $654.4K | Added$149.8K |
| Sicart Associates LLC | 25K | $1.69M | $654K | Added$654K |
| WELLS FARGO & COMPANY/MN | 24.6K | $1.66M | $643.5K | Cut−$932.2K |
| Knights of Columbus Asset Advisors LLC | 23.2K | $1.57M | $465.6K | Added$831.1K |
| WESBANCO BANK INC | 22.3K | $1.51M | $583.4K | Added$388.2K |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | 21.8K | $1.47M | $569.7K | Cut−$816.1K |
| AMI ASSET MANAGEMENT CORP | 20.1K | $1.36M | $526.6K | Cut−$348.7K |
| Soleus Capital Management, L.P. | 20K | $1.35M | $523.2K | Cut−$5.7M |
| HighVista Strategies LLC | 19.9K | $1.35M | $520.9K | Added$130.2K |
| JANUS HENDERSON GROUP PLC | 18.5K | $1.25M | $484.3K | Added$484.3K |
| SEI INVESTMENTS CO | 18.1K | $1.22M | $223.8K | Added$869.7K |
| NEW YORK STATE COMMON RETIREMENT FUND | 17.8K | $1.2M | $465.5K | Added$465.5K |
| Creative Planning | 16.8K | $1.14M | $213.6K | Added$800.3K |
| INTECH INVESTMENT MANAGEMENT LLC | 16.5K | $1.12M | $431.2K | Added$160K |
| Police & Firemen's Retirement System of New Jersey | 16.2K | $1.1M | $408.3K | Added$448.9K |
| China Universal Asset Management Co., Ltd. | 15K | $1.01M | $343.9K | Added$468.3K |
| State of New Jersey Common Pension Fund D | 14.6K | $989.3K | $381.9K | Added$383.2K |
| Bridgefront Capital, LLC | 14.4K | $974.7K | — | New |
| CITIGROUP INC | 14.2K | $960.8K | $371.4K | Added$226.3K |
| Balyasny Asset Management L.P. | 14.2K | $959.1K | — | New |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 12.9K | $871.9K | $240.3K | Added$490.5K |
| Voleon Capital Management LP | 12.9K | $871.3K | $253.7K | Added$468.6K |
| ProShare Advisors LLC | 12.3K | $835.8K | $323K | Added$263.5K |
| Allianz Asset Management GmbH | 12.3K | $832.5K | $198.8K | Added$516.9K |
| ARIZONA STATE RETIREMENT SYSTEM | 11.7K | $795K | $307.3K | Added$301.6K |
| Persistent Asset Partners Ltd | 11.6K | $787.7K | $304.5K | Added$275.2K |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 11.6K | $785.7K | $235.4K | Added$412.1K |
| Brevan Howard Capital Management LP | 11.6K | $785K | — | New |
| BARCLAYS PLC | 11.5K | $778.3K | $300.8K | Cut−$7.01M |
| ROYAL BANK OF CANADA | 11.4K | $774K | $252.7K | Added$374K |
| SBI Okasan Asset Management Co.Ltd. | 12.1K | $773.9K | $216.9K | Added$415.2K |
| PDT Partners, LLC | 11.2K | $756.8K | $292.5K | Cut−$902.6K |
| RAYMOND JAMES FINANCIAL INC | 11.1K | $750.6K | $217.2K | Added$405.8K |
| Vanguard Investments Australia, Ltd. | 11K | $744.1K | — | Held |
| PRUDENTIAL FINANCIAL INC | 9.7K | $656.5K | — | New |
| KLP KAPITALFORVALTNING AS | 9.5K | $643K | $238.1K | Added$265.1K |
| E Fund Management Co., Ltd. | 8.78K | $594.2K | — | Held |
| Eleva Capital SAS | 8.29K | $561K | — | Held |
| Tower Research Capital LLC (TRC) | 8.29K | $560.9K | $10K | Added$545K |
| Hudson Bay Capital Management LP | 7.48K | $506.2K | — | New |
| Blueshift Asset Management, LLC | 7.19K | $486.8K | — | New |
| T. Rowe Price Investment Management, Inc. | 6.72M | $454.8K | $11.1K | Added$437.3K |
| Virtus Investment Advisers, LLC | 6.66K | $450.7K | $170K | Added$181K |
| STRS OHIO | 6.6K | $446.7K | — | New |
| LPL Financial LLC | 6.48K | $438.8K | $162.2K | Added$181.3K |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 6.37K | $430.1K | $149.3K | Added$207.7K |
| CWM, LLC | 6.34K | $429.1K | $422.3K | Added$428.8K |
| Sanctuary Advisors, LLC | 6.24K | $422.1K | — | New |
| VICTORY CAPITAL MANAGEMENT INC | 6.1K | $412.6K | $152.6K | Added$170.3K |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 5.52K | $373.7K | $144.4K | Added$111.1K |
| XPONANCE LLC | 5.47K | $370.1K | — | New |
| XTX Topco Ltd | 5.36K | $362.7K | $140.2K | Cut−$1.04M |
| Vanguard Personalized Indexing Management, LLC | 5.18K | $350.9K | — | New |
| Quantinno Capital Management LP | 5K | $338.5K | — | New |
| AMERICAN CENTURY COMPANIES INC | 4.91K | $332.1K | $128.4K | Cut−$4.84M |
| Ameritas Investment Partners, Inc. | 4.84K | $327.6K | $122.1K | Added$133.8K |
| Caitong International Asset Management Co., Ltd | 4.69K | $317.6K | — | New |
| Total Clarity Wealth Management, Inc. | 4.6K | $311.3K | — | New |
| Mirae Asset Global Investments Co., Ltd. | 4.4K | $298.1K | $102.5K | Added$135.3K |
| PRINCIPAL FINANCIAL GROUP INC | 4.27K | $288.8K | — | New |
| M&T Bank Corp | 4.09K | $276.5K | — | New |
| ENVESTNET ASSET MANAGEMENT INC | 3.9K | $264.2K | — | New |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3.65M | $247.2K | $90.1K | Added$104.3K |
| TWO SIGMA SECURITIES, LLC | 3.56K | $241.2K | — | New |
| CIBC Bancorp USA Inc. | 3.47K | $235.1K | — | Held |
| JONES FINANCIAL COMPANIES LLLP | 3.58K | $231.3K | — | New |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | 3.37K | $228.1K | — | New |
| Abel Hall, LLC | 3.36K | $227.2K | — | New |
| KEYBANK NATIONAL ASSOCIATION/OH | 3.3K | $223.4K | — | New |
| RWC Asset Management LLP | 3.29K | $223K | — | New |
| Northwest & Ethical Investments L.P. | 3.14K | $212.1K | — | New |
| FOX RUN MANAGEMENT, L.L.C. | 3.3K | $210.8K | — | New |
| Bayforest Capital Ltd | 3.1K | $210.1K | — | New |
| JANE STREET GROUP, LLC | 3.1K | $209.6K | — | New |
| Magnetar Financial LLC | 3.08K | $208.2K | — | New |
| ELLERSON GROUP INC /ADV | 3.05K | $206.5K | — | New |
| Quantbot Technologies LP | 2.88K | $195.1K | — | New |
| PNC Financial Services Group, Inc. | 2.73K | $184.6K | $71.4K | Added$57.2K |
| ABS Direct Equity Fund LLC | 2.6K | $176K | — | New |
| OSAIC HOLDINGS, INC. | 2.48K | $168.2K | $4.86K | Added$160.5K |
| GF FUND MANAGEMENT CO. LTD. | 1.81K | $122.6K | $41.5K | Added$56.8K |
| GROUP ONE TRADING LLC | 1.44K | $97.1K | — | New |
| NISA INVESTMENT ADVISORS, LLC | 1.29K | $87.2K | $19.1K | Added$56.9K |
| FIFTH THIRD BANCORP | 1.09K | $73.8K | — | New |
| Strengthening Families & Communities, LLC | 1K | $67.7K | — | New |
| Rockefeller Capital Management L.P. | 964 | $65.2K | $5.02K | Added$57.3K |
| WHITTIER TRUST CO OF NEVADA INC | 666 | $45K | $18.1K | Added$18.1K |
| GAMMA Investing LLC | 661 | $44.7K | $13.4K | Added$23.5K |
| US BANCORP \DE\ | 643 | $43.5K | $15.9K | Added$18.3K |
| Kemnay Advisory Services Inc. | 584 | $39.5K | $3.79K | Added$33.5K |
| Newbridge Financial Services Group, Inc. | 500 | $33.8K | — | New |
| Sterling Capital Management LLC | 383 | $25.9K | $9.55K | Added$10.8K |
| LORD, ABBETT & CO. LLC | 340.2K | $23K | $3.29K | Added$17.8K |
| EverSource Wealth Advisors, LLC | 287 | $19.4K | $7.14K | Added$8.09K |
| J.Safra Asset Management Corp | 276 | $18.7K | $1.88K | Added$15.7K |
| E Fund Management (Hong Kong) Co., Ltd. | 233 | $15.8K | — | New |
| Smartleaf Asset Management LLC | 181 | $11.6K | $1.59K | Added$8.89K |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 159 | $10.8K | $4.01K | Added$3.58K |
| Essential Partners LLC | 156 | $10.6K | $4.08K | Added$4.08K |
| FIL Ltd | 126 | $8.53K | — | New |
| ROTHSCHILD INVESTMENT LLC | 102 | $6.9K | $2.35K | Added$3.17K |
| EASTERN BANK | 102 | $6.9K | $2.67K | Added$2.67K |
| SBI Securities Co., Ltd. | 100 | $6.77K | $1.33K | Added$4.65K |
| Optiver Holding B.V. | 76 | $5.14K | $1.99K | Added$1.24K |
| Allworth Financial LP | 72 | $4.87K | $1.46K | Added$2.55K |
| PRIVATE TRUST CO NA | 71 | $4.8K | $1.86K | Added$1.86K |
| Larson Financial Group LLC | 62 | $4.2K | $889 | Added$2.78K |
| Private Wealth Management Group, LLC | 46 | $3.11K | $1.2K | Added$1.2K |
| Versant Capital Management, Inc | 39 | $2.64K | $1.02K | Added$1.02K |
| Rossby Financial, LCC | 39 | $2.6K | — | New |
| Arax Advisory Partners | 38 | $2.57K | $994 | Added$869 |
| Bare Financial Services, Inc | 32 | $2.17K | $340 | Added$1.63K |
| True Wealth Design, LLC | 30 | $2.03K | $785 | Added$785 |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 27.8K | $1.88K | $726 | Added$726 |
| MAI Capital Management | 27 | $1.83K | $550 | Added$956 |
| SG Americas Securities, LLC | 24.6K | $1.67K | $548 | Added$797 |
| MassMutual Private Wealth & Trust, FSB | 24 | $1.62K | — | New |
| Farther Finance Advisors, LLC | 24 | $1.6K | $253 | Added$1.19K |
| Manchester Capital Management LLC | 22 | $1.49K | $575 | Added$575 |
| Handelsbanken Fonder AB | 20.7K | $1.4K | $500 | Added$608 |
| Parkside Financial Bank & Trust | 20 | $1.35K | $523 | Added$523 |
| ALGERT GLOBAL LLC | 19.4K | $1.31K | — | New |
| Parallel Advisors, LLC | 11 | $744 | — | New |
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO | 10.5K | $713 | — | New |
| Jackson Creek Investment Advisors LLC | 7.82K | $529 | — | New |
| IFP Advisors, Inc | 7 | $474 | $183 | Added$183 |
| Advisory Services Network, LLC | 5 | $338 | — | New |
| PRAXIS INVESTMENT MANAGEMENT INC | 3.74K | $253 | — | New |
| TWIN PEAKS WEALTH ADVISORS, LLC | 2 | $135 | — | New |
| Root Financial Partners, LLC | 2 | $135 | $52 | Added$52 |
| Winthrop Capital Management, LLC | 1.47K | $99 | $38 | Added$38 |
| Dunhill Financial, LLC | 1 | $96 | $37 | Added$37 |
| KBC Group NV | 1.15K | $78 | — | New |
| WPG Advisers, LLC | 1 | $68 | $26 | Added$26 |
| Hughes Financial Services, LLC | 1 | $68 | $26 | Added$26 |
| Covestor Ltd | 314 | $21 | $8 | Added$7 |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | $0 | — | Held |