| Vanguard | 6.54M | $271.5M | — | Held |
| Decheng Capital LLC | 6.37M | $264.6M | — | Held |
| WELLINGTON MANAGEMENT GROUP LLP | 6M | $249.1M | — | Held |
| BlackRock, Inc. | 4.84M | $201.1M | — | Held |
| Fidelity | 4.3M | $178.5M | — | Held |
| TCG Crossover Management, LLC | 3.67M | $152.4M | — | Held |
| State Street | 3M | $124.4M | — | Held |
| Foresite Capital Management VI LLC | 2.22M | $92.2M | — | Held |
| RTW INVESTMENTS, LP | 2.01M | $83.5M | — | Held |
| UBS Group AG | 1.92M | $79.9M | — | Held |
| BRAIDWELL LP | 1.87M | $77.7M | — | Held |
| ALLIANCEBERNSTEIN L.P. | 1.61M | $67M | — | Held |
| FRANKLIN RESOURCES INC | 1.56M | $64.8M | — | Held |
| ORBIMED ADVISORS LLC | 1.52M | $63M | — | Held |
| Seven Fleet Capital Management LP | 1.52M | $62.9M | — | Held |
| GEODE CAPITAL MANAGEMENT, LLC | 1.51M | $62.8M | — | Held |
| Avidity Partners Management LP | 1.47M | $61.1M | — | Held |
| DV Trading LLC | 1.44M | $59.8M | — | Held |
| Pictet Asset Management Holding SA | 1.35M | $56M | — | Held |
| GOLDMAN SACHS GROUP INC | 1.32M | $55M | — | Held |
| BANK OF AMERICA CORP /DE/ | 1.19M | $49.4M | $927.9K | Added$19.3M |
| ACORN CAPITAL ADVISORS, LLC | 1.13M | $47M | — | Held |
| Polar Capital Holdings Plc | 1.1M | $45.6M | — | Held |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1.09M | $45.3M | — | Held |
| Foresite Capital Management V, LLC | 1M | $41.7M | — | Held |
| Kynam Capital Management, LP | 945.8K | $39.3M | — | Held |
| Candriam S.C.A. | 797.6K | $33.1M | — | Held |
| EcoR1 Capital, LLC | 772K | $32.1M | — | Held |
| Clearbridge Investments, LLC | 705K | $29.3M | — | Held |
| Citadel | 681.2K | $28.3M | — | Held |
| JPMORGAN CHASE & CO | 586.8K | $24.4M | — | Held |
| MORGAN STANLEY | 545K | $22.6M | $675.8K | Cut−$3.25M |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 542.7K | $22.5M | — | Held |
| Ensign Peak Advisors, Inc | 530.8K | $22M | — | Held |
| Woodline Partners LP | 492.5K | $20.4M | — | Held |
| Elmind Capital, LP | 492.5K | $20.4M | — | Held |
| NORTHERN TRUST CORP | 481.9K | $20M | — | Held |
| DIMENSIONAL FUND ADVISORS LP | 461.1K | $19.1M | — | Held |
| TimesSquare Capital Management, LLC | 426K | $17.7M | — | Held |
| Opaleye Management Inc. | 410K | $17M | — | Held |
| SILVERARC CAPITAL MANAGEMENT, LLC | 361.2K | $15M | — | Held |
| EVENTIDE ASSET MANAGEMENT, LLC | 312.4K | $13M | — | Held |
| Eversept Partners, LP | 308.5K | $12.8M | — | Held |
| Caption Management, LLC | 306.8K | $12.7M | — | Held |
| Rosalind Advisors, Inc. | 300K | $12.5M | — | Held |
| JENNISON ASSOCIATES LLC | 282.5K | $11.7M | — | Held |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 281.1K | $11.3M | — | Held |
| MARSHALL WACE, LLP | 261.1K | $10.8M | — | Held |
| ADAR1 Capital Management, LLC | 258.1K | $10.7M | — | Held |
| ArrowMark Colorado Holdings LLC | 245.8K | $10.2M | — | Held |
| AMERIPRISE FINANCIAL INC | 240.5K | $9.98M | — | Held |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 201.9K | $8.38M | — | Held |
| Logos Global Management LP | 200K | $8.3M | — | Held |
| Ikarian Capital, LLC | 199.5K | $8.28M | — | Held |
| BARCLAYS PLC | 187.5K | $7.79M | $190.9K | Added$1.58M |
| TD Asset Management Inc | 186.4K | $7.74M | — | Held |
| FIRST TRUST ADVISORS LP | 181.8K | $7.55M | — | Held |
| Soleus Capital Management, L.P. | 170K | $7.06M | — | Held |
| PFM Health Sciences, LP | 164K | $6.81M | — | Held |
| Davern Capital Partners, LP | 162K | $6.73M | — | Held |
| Bank of New York Mellon Corp | 155.2K | $6.44M | — | Held |
| Point72 Asset Management, L.P. | 151.4K | $6.28M | — | Held |
| DEUTSCHE BANK AG\ | 150.2K | $6.24M | — | Held |
| Russell Investments Group, Ltd. | 143.3K | $5.95M | — | Held |
| Nuveen, LLC | 134.7K | $5.59M | — | Held |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 128.5K | $5.2M | — | Held |
| AMERICAN CENTURY COMPANIES INC | 124.5K | $5.17M | — | Held |
| Icahn Capital | 112.3K | $4.66M | — | Held |
| Nantahala Capital Management, LLC | 109.4K | $4.54M | — | Held |
| Rafferty Asset Management, LLC | 106.1K | $4.4M | — | Held |
| BNP PARIBAS FINANCIAL MARKETS | 96.1K | $3.99M | — | Held |
| MILLENNIUM MANAGEMENT LLC | 91.5K | $3.8M | — | Held |
| Swiss National Bank | 84.4K | $3.5M | — | Held |
| RHUMBLINE ADVISERS | 70.6K | $2.93M | — | Held |
| CenterBook Partners LP | 69.2K | $2.87M | — | Held |
| ALPS ADVISORS INC | 66K | $2.74M | — | Held |
| WELLS FARGO & COMPANY/MN | 62.6K | $2.6M | — | Held |
| BOOTHBAY FUND MANAGEMENT, LLC | 59.4K | $2.47M | — | Held |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | 55.2K | $2.29M | — | New |
| SECTOR GAMMA AS | 52K | $2.16M | — | Held |
| SummitTX Capital, L.P. | 49.9K | $2.07M | — | Held |
| Legal & General Group Plc | 45.1K | $1.87M | — | Held |
| VOYA INVESTMENT MANAGEMENT LLC | 43.7K | $1.82M | — | Held |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 43.1K | $1.78M | — | Held |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 41.7K | $1.73M | — | Held |
| AMI ASSET MANAGEMENT CORP | 41.2K | $1.71M | — | Held |
| PDT Partners, LLC | 40K | $1.66M | — | Held |
| PROFUND ADVISORS LLC | 39.3K | $1.63M | — | Held |
| AlphaQuest LLC | 38.9K | $1.61M | — | Held |
| Invesco Ltd. | 38.1K | $1.58M | — | Held |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 37.8K | $1.57M | — | Held |
| Cinctive Capital Management LP | 37.2K | $1.54M | — | Held |
| NEOS Investment Management LLC | 36.6K | $1.52M | — | Held |
| TEMA ETFS LLC | 36.1K | $1.5M | — | Held |
| XTX Topco Ltd | 33.7K | $1.4M | — | Held |
| MetLife Investment Management, LLC | 32.3K | $1.34M | — | Held |
| Lynx1 Capital Management LP | 31.6K | $1.31M | — | Held |
| HighVista Strategies LLC | 29.3K | $1.22M | — | Held |
| STATE OF WISCONSIN INVESTMENT BOARD | 27.3K | $1.13M | — | Held |
| WESBANCO BANK INC | 27K | $1.12M | — | Held |
| Sicart Associates LLC | 25K | $1.04M | — | Held |
| Verition Fund Management LLC | 23.9K | $992.3K | — | Held |
| D. E. Shaw & Co., Inc. | 23K | $956.1K | — | Held |
| INTECH INVESTMENT MANAGEMENT LLC | 23K | $955.7K | — | Held |
| JANUS HENDERSON GROUP PLC | 18.5K | $768.6K | — | Held |
| Knights of Columbus Asset Advisors LLC | 17.8K | $739.1K | — | Held |
| NEW YORK STATE COMMON RETIREMENT FUND | 17.8K | $738.9K | — | Held |
| CITIGROUP INC | 17.7K | $734.4K | — | Held |
| Police & Firemen's Retirement System of New Jersey | 15.6K | $648.1K | — | Held |
| State of New Jersey Common Pension Fund D | 14.6K | $606.1K | — | Held |
| ProShare Advisors LLC | 13.8K | $572.3K | — | Held |
| PSP Research LLC | 13.3K | $551.9K | — | Held |
| China Universal Asset Management Co., Ltd. | 13.1K | $545.8K | — | Held |
| Persistent Asset Partners Ltd | 12.3K | $512.5K | — | New |
| ARIZONA STATE RETIREMENT SYSTEM | 11.9K | $493.4K | — | Held |
| TWINBEECH CAPITAL LP | 11.1K | $460.9K | — | Held |
| Voleon Capital Management LP | 9.7K | $402.7K | — | Held |
| ROYAL BANK OF CANADA | 9.65K | $400K | — | Held |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 9.19K | $381.4K | — | Held |
| KLP KAPITALFORVALTNING AS | 9.1K | $377.8K | — | Held |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 9K | $373.6K | — | Held |
| DARK FOREST CAPITAL MANAGEMENT LP | 8.89K | $369.3K | — | Held |
| SBI Okasan Asset Management Co.Ltd. | 9K | $358.7K | — | Held |
| SEI INVESTMENTS CO | 8.55K | $354.9K | — | Held |
| RAYMOND JAMES FINANCIAL INC | 8.3K | $344.7K | — | Held |
| Creative Planning | 8.16K | $339K | — | Held |
| FARALLON CAPITAL MANAGEMENT LLC | 8K | $332.2K | $9.92K | Added$9.92K |
| LMR Partners LLP | 7.63K | $316.8K | — | Held |
| Allianz Asset Management GmbH | 7.6K | $315.6K | — | Held |
| Virtus Investment Advisers, LLC | 6.5K | $269.8K | — | Held |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 6.32K | $262.6K | — | Held |
| LPL Financial LLC | 6.2K | $257.5K | — | Held |
| VICTORY CAPITAL MANAGEMENT INC | 5.83K | $242.2K | — | Held |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 5.51K | $222.3K | — | Held |
| Ameritas Investment Partners, Inc. | 4.67K | $193.8K | — | Held |
| Mirae Asset Global Investments Co., Ltd. | 3.92K | $162.8K | — | Held |
| FEDERATED HERMES, INC. | 3.5K | $145.3K | — | Held |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3.44M | $143K | — | Held |
| Bellevue Group AG | 3.1K | $128.5K | — | Held |
| PNC Financial Services Group, Inc. | 3.07K | $127.5K | — | Held |
| PICTON MAHONEY ASSET MANAGEMENT | 2.85K | $118.3K | — | Held |
| GF FUND MANAGEMENT CO. LTD. | 1.58K | $65.8K | — | Held |
| COMERICA BANK | 1.03K | $42.7K | — | Held |
| NISA INVESTMENT ADVISORS, LLC | 729 | $30.3K | — | Held |
| WHITTIER TRUST CO OF NEVADA INC | 666 | $26.9K | — | Held |
| US BANCORP \DE\ | 607 | $25.2K | — | Held |
| GAMMA Investing LLC | 511 | $21.2K | — | Held |
| CIBC Private Wealth Group LLC | 500 | $20.8K | — | Held |
| T. Rowe Price Investment Management, Inc. | 422.6K | $17.5K | — | Held |
| Tower Research Capital LLC (TRC) | 383 | $15.9K | — | Held |
| Sterling Capital Management LLC | 365 | $15.2K | — | Held |
| EverSource Wealth Advisors, LLC | 273 | $11.3K | — | Held |
| Rockefeller Capital Management L.P. | 192 | $7.97K | — | Held |
| OSAIC HOLDINGS, INC. | 186 | $7.72K | — | Held |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 169 | $7.18K | — | Held |
| Essential Partners LLC | 156 | $6.48K | $193 | Added$193 |
| Kemnay Advisory Services Inc. | 145 | $6.02K | — | Held |
| LORD, ABBETT & CO. LLC | 125.6K | $5.22K | — | Held |
| EASTERN BANK | 102 | $4.24K | — | Held |
| Optiver Holding B.V. | 94 | $3.9K | — | Held |
| ROTHSCHILD INVESTMENT LLC | 90 | $3.74K | — | Held |
| J.Safra Asset Management Corp | 72 | $2.99K | — | Held |
| PRIVATE TRUST CO NA | 71 | $2.95K | — | Held |
| Smartleaf Asset Management LLC | 67 | $2.69K | — | Held |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 58.1K | $2.41K | — | Held |
| Allworth Financial LP | 56 | $2.33K | $70 | Added$30 |
| SBI Securities Co., Ltd. | 51 | $2.12K | — | Held |
| Private Wealth Management Group, LLC | 46 | $1.91K | — | Held |
| Arax Advisory Partners | 41 | $1.7K | — | Held |
| Versant Capital Management, Inc | 39 | $1.62K | — | Held |
| Sivik Global Healthcare LLC | 35K | $1.45K | — | Held |
| Larson Financial Group LLC | 34 | $1.41K | — | Held |
| Global Retirement Partners, LLC | 33 | $1.37K | — | Held |
| True Wealth Design, LLC | 30 | $1.25K | — | Held |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 27.8K | $1.15K | — | Held |
| Manchester Capital Management LLC | 22 | $914 | — | Held |
| MAI Capital Management | 21 | $872 | — | Held |
| SG Americas Securities, LLC | 20.9K | $870 | — | Held |
| Parkside Financial Bank & Trust | 20 | $831 | — | Held |
| Handelsbanken Fonder AB | 19.1K | $793 | — | Held |
| Bare Financial Services, Inc | 13 | $540 | — | Held |
| Farther Finance Advisors, LLC | 10 | $415 | — | Held |
| IFP Advisors, Inc | 7 | $291 | $9 | Added$9 |
| CWM, LLC | 6.24K | $259 | — | Held |
| GSA CAPITAL PARTNERS LLP | 4.98K | $207 | — | Held |
| Root Financial Partners, LLC | 2 | $83 | — | Held |
| AMALGAMATED BANK | 1.76K | $73 | — | Held |
| Winthrop Capital Management, LLC | 1.47K | $61 | — | Held |
| Dunhill Financial, LLC | 1 | $59 | — | Held |
| Hughes Financial Services, LLC | 1 | $42 | — | Held |
| WPG Advisers, LLC | 1 | $42 | — | Held |
| Covestor Ltd | 349 | $14 | — | Held |
| Daiwa Securities Group Inc. | 239 | $10 | — | Held |
| Cygnus Capital Advisors, LLC | 221 | $9 | — | Held |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | $0 | — | Held |