| RA CAPITAL MANAGEMENT, L.P. | 10.3M | $2.19B | — | Held |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 5.19M | $1.11B | — | Held |
| Avoro Capital Advisors LLC | 5.11M | $1.09B | — | Held |
| Fidelity | 4.15M | $885.7M | — | Held |
| JANUS HENDERSON GROUP PLC | 4.06M | $866.1M | — | Held |
| Artisan Partners Limited Partnership | 3.23M | $687.9M | — | Held |
| Capital International Investors | 3.06M | $653.4M | — | Held |
| FRANKLIN RESOURCES INC | 49.2M | $474.5M | — | Held |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 1.89M | $402.3M | — | Held |
| WELLINGTON MANAGEMENT GROUP LLP | 3.76M | $378.7M | — | Held |
| AMERICAN CENTURY COMPANIES INC | 1.44M | $307.7M | — | Held |
| PERCEPTIVE ADVISORS LLC | 1.08M | $230.6M | — | Held |
| PRINCIPAL FINANCIAL GROUP INC | 1.03M | $218.9M | — | Held |
| Linden Advisors LP | 137.4M | $195.1M | — | Held |
| BlackRock, Inc. | 7.9M | $144.3M | — | Held |
| MORGAN STANLEY | 2.81M | $134.9M | $79.3M | Added$48.6M |
| Invesco Ltd. | 3.59M | $129.2M | — | Held |
| GOLDMAN SACHS GROUP INC | 596.7K | $127.2M | — | Held |
| AMERIPRISE FINANCIAL INC | 7.05M | $126.6M | — | Held |
| WOLVERINE ASSET MANAGEMENT LLC | 79.2M | $112.4M | — | Held |
| JPMORGAN CHASE & CO | 2.72M | $111.3M | — | Held |
| Citadel | 519.5K | $110.8M | — | Held |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 496.8K | $105.9M | — | Held |
| FIL Ltd | 478.6K | $102.1M | — | Held |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 471K | $100.4M | — | Held |
| Spyglass Capital Management LLC | 415.5K | $88.6M | — | Held |
| Polar Capital Holdings Plc | 5.37M | $86.1M | — | Held |
| FRED ALGER MANAGEMENT, LLC | 352.1K | $75.1M | — | Held |
| BNP PARIBAS FINANCIAL MARKETS | 2.09M | $68M | — | Held |
| UBS Group AG | 308.2K | $65.7M | — | Held |
| DEUTSCHE BANK AG\ | 671.8K | $63.8M | — | Held |
| ALLIANCEBERNSTEIN L.P. | 288.6K | $61.5M | — | Held |
| SEI INVESTMENTS CO | 281.5K | $60M | — | Held |
| Tri Locum Partners LP | 265K | $56.5M | — | Held |
| MILLENNIUM MANAGEMENT LLC | 262.3K | $55.9M | — | Held |
| PFM Health Sciences, LP | 10.8M | $53M | — | Held |
| TWO SIGMA INVESTMENTS, LP | 247.9K | $52.9M | — | Held |
| Siren, L.L.C. | 235.9K | $50.3M | — | Held |
| TD Asset Management Inc | 234K | $49.9M | — | Held |
| DeepCurrents Investment Group LLC | 33.4M | $47.4M | — | Held |
| Aberdeen Group plc | 221.7K | $47.3M | — | Held |
| Jain Global LLC | 216.5K | $46.2M | — | Held |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 216.2K | $46.1M | — | Held |
| Rock Springs Capital Management LP | 203.5K | $43.4M | — | Held |
| Bank of New York Mellon Corp | 394.6K | $41.8M | — | Held |
| Qube Research & Technologies Ltd | 193.5K | $41.3M | — | Held |
| Allspring Global Investments Holdings, LLC | 187.6K | $40M | — | Held |
| Candriam S.C.A. | 186.9K | $39.9M | — | Held |
| NEW YORK STATE COMMON RETIREMENT FUND | 182.2K | $38.9M | — | Held |
| Vestal Point Capital, LP | 175K | $37.3M | — | Held |
| ARS Investment Partners, LLC | 174.6K | $37.2M | — | Held |
| ORBIMED ADVISORS LLC | 172K | $36.7M | — | Held |
| CAPSTONE INVESTMENT ADVISORS, LLC | 25.8M | $36.6M | — | Held |
| BANK OF AMERICA CORP /DE/ | 1.1M | $36M | −$7.88M | Added$5.83M |
| Driehaus Capital Management LLC | 156.3K | $33.3M | — | Held |
| State Street | 12.5M | $32.2M | — | Held |
| RICE HALL JAMES & ASSOCIATES, LLC | 145K | $30.9M | — | Held |
| TENOR CAPITAL MANAGEMENT Co., L.P. | 21M | $29.9M | — | Held |
| Frazier Life Sciences Management, L.P. | 133.3K | $28.4M | — | Held |
| Point72 Asset Management, L.P. | 20M | $28.3M | — | Held |
| First Turn Management, LLC | 131.8K | $28.1M | — | Held |
| ODDO BHF ASSET MANAGEMENT SAS | 130.1K | $27.9M | — | Held |
| LOOMIS SAYLES & CO L P | 130K | $27.7M | — | Held |
| D. E. Shaw & Co., Inc. | 125.8K | $26.8M | — | Held |
| MOORE CAPITAL MANAGEMENT, LP | 125K | $26.7M | — | Held |
| Catalio Capital Management, LP | 119.3K | $25.4M | — | Held |
| BRAUN STACEY ASSOCIATES INC | 119.1K | $25.4M | — | Held |
| IMC-Chicago, LLC | 113.7K | $24.2M | — | Held |
| 1832 Asset Management L.P. | 110K | $23.5M | — | Held |
| Woodline Partners LP | 102.5K | $21.8M | — | Held |
| Cormorant Asset Management, LP | 100K | $21.3M | — | Held |
| Integral Health Asset Management, LLC | 90K | $19.2M | — | Held |
| Resolute Capital Asset Partners LLC | 88.6K | $18.9M | — | Held |
| Defilade Capital Management, L.P. | 85.7K | $18.3M | — | Held |
| ExodusPoint Capital Management, LP | 82.9K | $17.7M | — | Held |
| Beck Bode, LLC | 81.1K | $17.3M | — | Held |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 73.3K | $15.6M | — | Held |
| Pictet Asset Management Holding SA | 73.4K | $15.5M | — | Held |
| SSI INVESTMENT MANAGEMENT LLC | 10.9M | $15.4M | — | Held |
| CANADA PENSION PLAN INVESTMENT BOARD | 71.5K | $15.3M | — | Held |
| Ensign Peak Advisors, Inc | 69.6K | $14.8M | — | Held |
| Voleon Capital Management LP | 69.4K | $14.8M | — | Held |
| GEODE CAPITAL MANAGEMENT, LLC | 68.9K | $14.7M | — | Held |
| VOYA INVESTMENT MANAGEMENT LLC | 1.76M | $14.6M | — | Held |
| Davidson Kempner Capital Management LP | 10M | $14.2M | — | New |
| CASTLEARK MANAGEMENT LLC | 66.3K | $14.1M | — | Held |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 60.9K | $12.7M | — | Held |
| Trexquant Investment LP | 59K | $12.6M | — | Held |
| Chevy Chase Trust Holdings, LLC | 56.7K | $12.1M | — | Held |
| Boussard & Gavaudan Investment Management LLP | 8.5K | $12M | — | Held |
| DAFNA Capital Management LLC | 4.03M | $11.5M | — | Held |
| BAROMETER CAPITAL MANAGEMENT INC. | 91.4K | $10.8M | — | Held |
| SILVERARC CAPITAL MANAGEMENT, LLC | 49.2K | $10.5M | — | Held |
| Eversept Partners, LP | 48.2K | $10.3M | — | Held |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | 48.1K | $10.3M | $296.3K | Added$9.56M |
| Brevan Howard Capital Management LP | 48.3K | $10.2M | — | Held |
| TWO SIGMA ADVISERS, LP | 47.4K | $10.1M | — | Held |
| Nicholas Investment Partners, LP | 6.04M | $9.89M | — | Held |
| CITIGROUP INC | 2.25M | $9.72M | — | Held |
| NOMURA ASSET MANAGEMENT CO LTD | 43.7K | $9.32M | — | Held |
| VICTORY CAPITAL MANAGEMENT INC | 43.2K | $9.21M | — | Held |
| DIVERSIFIED TRUST CO | 42.3K | $9.01M | — | Held |
| LAZARD ASSET MANAGEMENT LLC | 35.3M | $8.85M | — | Held |
| Skandinaviska Enskilda Banken AB (publ) | 39K | $8.31M | — | Held |
| Empowered Funds, LLC | 36.7K | $7.83M | — | Held |
| Russell Investments Group, Ltd. | 214.9K | $7.7M | — | Held |
| WELLS FARGO & COMPANY/MN | 383.8K | $7.69M | — | Held |
| NORTHERN TRUST CORP | 32.9K | $7.01M | — | Held |
| MARSHALL WACE, LLP | 30.1K | $6.41M | — | Held |
| Affinity Asset Advisors, LLC | 30K | $6.4M | — | Held |
| Lombard Odier Asset Management (Europe) Ltd | 4.17M | $5.91M | — | Held |
| Jump Financial, LLC | 27.6K | $5.89M | — | Held |
| Matisse Capital | 27.3K | $5.82M | — | Held |
| ADAR1 Capital Management, LLC | 25.3K | $5.4M | — | Held |
| CAPITAL INTERNATIONAL SARL | 24.9K | $5.32M | — | Held |
| Sterling Capital Management LLC | 24.8K | $5.29M | — | Held |
| BROWN ADVISORY INC | 24.5K | $5.23M | — | Held |
| Bellevue Group AG | 24.3K | $5.19M | — | Held |
| Balyasny Asset Management L.P. | 24.1K | $5.13M | — | Held |
| JANE STREET GROUP, LLC | 21.2K | $4.53M | — | Held |
| Atika Capital Management LLC | 20.6K | $4.4M | — | Held |
| BARCLAYS PLC | 1.37M | $4.31M | −$2.11M | Added$2.17M |
| STIFEL FINANCIAL CORP | 20.2K | $4.31M | — | Held |
| Erste Asset Management GmbH | 20.3K | $4.28M | — | Held |
| STATE OF WISCONSIN INVESTMENT BOARD | 3M | $4.25M | — | Held |
| KENNEDY CAPITAL MANAGEMENT LLC | 19.9K | $4.24M | — | Held |
| Artia Global Partners LP | 17.7K | $3.78M | — | Held |
| CAPITAL INTERNATIONAL LTD /CA/ | 16.9K | $3.6M | — | Held |
| CAPITAL FUND MANAGEMENT S.A. | 16.4K | $3.49M | — | Held |
| ENVESTNET ASSET MANAGEMENT INC | 16.3K | $3.48M | — | Held |
| SECTOR GAMMA AS | 16.3K | $3.48M | — | Held |
| Calamos Advisors LLC | 16.3K | $3.48M | — | Held |
| Zweig-DiMenna Associates LLC | 15.5K | $3.31M | — | Held |
| Atom Investors LP | 15.5K | $3.3M | — | Held |
| Rhenman & Partners Asset Management AB | 15K | $3.2M | — | Held |
| STEMPOINT CAPITAL LP | 14.8K | $3.16M | — | Held |
| Legal & General Group Plc | 14.8K | $3.15M | — | Held |
| LPL Financial LLC | 14.1K | $3.01M | — | Held |
| Nan Fung Group Holdings Ltd | 13.6K | $2.9M | — | Held |
| Henry James International Management Inc. | 13.5K | $2.87M | — | Held |
| Lighthouse Investment Partners, LLC | 12.7K | $2.71M | — | Held |
| Advisors Asset Management, Inc. | 12.4K | $2.64M | — | Held |
| Evolutionary Tree Capital Management, LLC | 12.3K | $2.62M | — | Held |
| FIRST TRUST ADVISORS LP | 12.2K | $2.61M | — | Held |
| Headlands Technologies LLC | 11.6K | $2.47M | — | Held |
| SPHERA FUNDS MANAGEMENT LTD. | 11K | $2.35M | — | Held |
| FIDEURAM - INTESA SANPAOLO PRIVATE BANKING S.P.A. | 10.9K | $2.32M | — | Held |
| Jefferies Financial Group Inc. | 1.57M | $2.24M | — | Held |
| China Universal Asset Management Co., Ltd. | 10K | $2.13M | — | Held |
| FIRST NATIONAL BANK OF OMAHA | 9.94K | $2.08M | — | New |
| CIBC Private Wealth Group LLC | 9.38K | $2M | — | Held |
| Quantedge Capital Pte Ltd | 9.2K | $1.96M | — | Held |
| Nuveen, LLC | 9.1K | $1.94M | — | Held |
| Capital International, Inc./CA/ | 9.06K | $1.93M | — | Held |
| PNC Financial Services Group, Inc. | 8.7K | $1.85M | — | Held |
| Gilbert & Cook, Inc. | 8.64K | $1.84M | — | Held |
| ASSETMARK, INC | 8.58K | $1.83M | — | Held |
| Dorsey Wright & Associates | 8.5K | $1.81M | — | Held |
| DIVERSIFY WEALTH MANAGEMENT, LLC | 7.75K | $1.67M | — | Held |
| Man Group plc | 1.16M | $1.64M | — | Held |
| Engineers Gate Manager LP | 7.48K | $1.59M | — | Held |
| Verition Fund Management LLC | 7.42K | $1.58M | — | Held |
| Crossmark Global Holdings, Inc. | 7.39K | $1.58M | — | Held |
| ZAZOVE ASSOCIATES LLC | 1.05M | $1.49M | — | Held |
| Mirae Asset Global Investments Co., Ltd. | 6.94K | $1.48M | — | Held |
| DIADEMA PARTNERS LP | 6.84K | $1.46M | — | Held |
| Creative Planning | 6.79K | $1.45M | — | Held |
| GUGGENHEIM CAPITAL LLC | 6.73K | $1.44M | — | Held |
| RAYMOND JAMES FINANCIAL INC | 6.66K | $1.42M | — | Held |
| Avior Wealth Management, LLC | 6.5K | $1.39M | — | Held |
| Morse Asset Management, Inc | 6.49K | $1.38M | — | Held |
| Squarepoint Ops LLC | 6.47K | $1.38M | — | Held |
| RWC Asset Management LLP | 970K | $1.37M | — | Held |
| ROYAL BANK OF CANADA | 578.5K | $1.36M | — | Held |
| CIBC WORLD MARKET INC. | 6.36K | $1.36M | — | Held |
| Y-Intercept (Hong Kong) Ltd | 6.03K | $1.29M | — | Held |
| Shay Capital LLC | 6K | $1.28M | — | Held |
| DNB Asset Management AS | 5.98K | $1.27M | — | Held |
| Allianz Asset Management GmbH | 5.95K | $1.27M | — | Held |
| Vestmark Advisory Solutions, Inc. | 5.81K | $1.24M | — | Held |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 5.78K | $1.23M | — | Held |
| AdvisorShares Investments LLC | 5.72K | $1.22M | — | Held |
| OPPENHEIMER ASSET MANAGEMENT INC. | 5.69K | $1.21M | — | Held |
| Seven Fleet Capital Management LP | 5.67K | $1.21M | — | Held |
| BAMCO INC /NY/ | 5.6K | $1.19M | — | Held |
| Progeny 3, Inc. | 5.23K | $1.12M | — | Held |
| Ishara Investments LP | 5K | $1.07M | — | Held |
| Sigma Planning Corp | 4.78K | $1.02M | — | Held |
| OAKTREE CAPITAL MANAGEMENT LP | 700K | $994.3K | — | Held |
| TOTH FINANCIAL ADVISORY CORP | 4.64K | $989.4K | — | Held |
| GROUPAMA ASSET MANAGMENT | 700K | $986.7K | $29.1K | Added$451.9K |
| Cetera Investment Advisers | 4.55K | $969.8K | — | Held |
| FOX RUN MANAGEMENT, L.L.C. | 4.5K | $958.7K | — | Held |
| XTX Topco Ltd | 4.46K | $950.8K | — | Held |
| TORONTO DOMINION BANK | 635K | $885.8K | — | Held |
| Chicago Partners Investment Group LLC | 3.5K | $823.4K | — | Held |
| Atria Investments, Inc | 3.74K | $796.9K | — | Held |
| HighVista Strategies LLC | 3.66K | $780.5K | — | Held |
| Corient Private Wealth LLC | 3.39K | $723.5K | — | Held |
| SECTORAL ASSET MANAGEMENT INC | 3.25K | $693.9K | — | Held |
| AlphaCentric Advisors LLC | 3.24K | $690.5K | — | Held |
| Virtus Investment Advisers, LLC | 3.1K | $661K | — | Held |
| MIdWestOne Financial Group, Inc. | 3.07K | $654K | — | Held |
| Central Pacific Bank - Trust Division | 458K | $648.8K | — | Held |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | 3K | $639.1K | — | Held |
| Csenge Advisory Group | 2.95K | $628.2K | — | Held |
| SHENKMAN CAPITAL MANAGEMENT INC | 439K | $626K | — | Held |
| Union Bancaire Privee, UBP SA | 520K | $622.6K | — | Held |
| CAPITAL GROUP INVESTMENT MANAGEMENT PTE. LTD. | 2.91K | $619.7K | — | Held |
| Diversify Advisory Services, LLC | 2.88K | $593K | — | Held |
| ALTFEST L J & CO INC | 2.76K | $587.7K | — | Held |
| ProShare Advisors LLC | 2.71K | $578.3K | — | Held |
| Clearstead Advisors, LLC | 2.68K | $570.8K | — | Held |
| Schonfeld Strategic Advisors LLC | 2.58K | $550.4K | — | Held |
| PSP Research LLC | 2.58K | $549.9K | — | Held |
| Mariner, LLC | 2.57K | $547.5K | — | Held |
| NEW WAVE WEALTH ADVISORS LLC | 2.52K | $536.9K | — | Held |
| Campbell & CO Investment Adviser LLC | 2.29K | $489.2K | — | Held |
| Severin Investments, LLC | 2.25K | $479K | — | New |
| Brooklyn Investment Group | 2.22K | $467.8K | — | Held |
| Ninepoint Partners LP | 2.12K | $451K | — | Held |
| Legato Capital Management LLC | 2.02K | $431.4K | — | Held |
| Scientech Research LLC | 2.02K | $430.1K | — | Held |
| Vident Advisory, LLC | 1.93K | $410.7K | — | Held |
| Persistent Asset Partners Ltd | 1.83K | $390.7K | $26.4K | Cut−$867.8K |
| NEOS Investment Management LLC | 1.8K | $383.6K | — | Held |
| TRUIST FINANCIAL CORP | 1.79K | $381.5K | — | Held |
| RHUMBLINE ADVISERS | 1.74K | $370.8K | — | Held |
| T. Rowe Price Investment Management, Inc. | 1.67M | $355.6K | — | Held |
| US BANCORP \DE\ | 1.6K | $340.3K | — | Held |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1.57M | $334.8K | — | Held |
| Vanguard Personalized Indexing Management, LLC | 1.46K | $310.9K | — | Held |
| PERSONAL CFO SOLUTIONS, LLC | 1.46K | $310.3K | — | Held |
| PURSUE WEALTH PARTNERS LLC | 1.45K | $309K | — | Held |
| Burns Matteson Capital Management, LLC | 1.43K | $304.7K | — | Held |
| FARALLON CAPITAL MANAGEMENT LLC | 1.4K | $298.5K | $20.2K | Added$20.2K |
| CHOREO, LLC | 1.42K | $296.9K | — | Held |
| Havemeyer Place LP | 1.35K | $288.3K | — | Held |
| DEARBORN PARTNERS LLC | 1.3K | $277.2K | — | Held |
| Moody Aldrich Partners LLC | 1.28K | $272.1K | — | Held |
| POLEN CAPITAL MANAGEMENT LLC | 1.21K | $258.2K | — | Held |
| GF FUND MANAGEMENT CO. LTD. | 1.21K | $257.2K | — | Held |
| Aigen Investment Management, LP | 1.18K | $252.5K | — | Held |
| CERTUITY, LLC | 1.17K | $249.5K | — | Held |
| COMMONWEALTH EQUITY SERVICES, LLC | 1.17K | $248.8K | — | Held |
| LVW Advisors, LLC | 1.17K | $248.4K | — | Held |
| OSAIC HOLDINGS, INC. | 1.14K | $243.1K | — | Held |
| PharVision Advisers, LLC | 1.12K | $239.3K | — | Held |
| Graham Capital Management, L.P. | 1.07K | $228.4K | — | Held |
| MERCER GLOBAL ADVISORS INC /ADV | 1.06K | $225.6K | — | Held |