| Ikarian Capital, LLC | 967.6K | $11.8M | — | Held |
| MORGAN STANLEY | 596.4K | $7.27M | $816.7K | Added$5.91M |
| PERCEPTIVE ADVISORS LLC | 439.1K | $5.35M | — | Held |
| Siren, L.L.C. | 427.1K | $5.21M | — | Held |
| Point72 Asset Management, L.P. | 423.4K | $5.16M | — | Held |
| RTW INVESTMENTS, LP | 378.3K | $4.61M | — | Held |
| BOOTHBAY FUND MANAGEMENT, LLC | 352.2K | $4.29M | — | Held |
| BVF INC/IL | 339.5K | $4.14M | — | Held |
| MILLENNIUM MANAGEMENT LLC | 302.5K | $3.69M | — | Held |
| MARSHALL WACE, LLP | 298.2K | $3.63M | — | Held |
| Vanguard | 255.7K | $3.12M | — | Held |
| DIADEMA PARTNERS LP | 243.2K | $2.96M | — | Held |
| Vivo Capital, LLC | 208.3K | $2.54M | — | Held |
| SPHERA FUNDS MANAGEMENT LTD. | 190.1K | $2.32M | — | Held |
| Integral Health Asset Management, LLC | 167K | $2.04M | — | Held |
| JANUS HENDERSON GROUP PLC | 166.7K | $2.02M | — | Held |
| Woodline Partners LP | 143.5K | $1.75M | — | Held |
| Fidelity | 141.1K | $1.72M | — | Held |
| Citadel | 129.5K | $1.58M | — | Held |
| Renaissance Technologies | 125.6K | $1.53M | — | Held |
| Velan Capital Investment Management LP | 83.3K | $1.02M | — | Held |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 83.3K | $1.02M | — | Held |
| Persistent Asset Partners Ltd | 65.3K | $795.7K | — | New |
| ADAR1 Capital Management, LLC | 63.7K | $776.2K | — | Held |
| GEODE CAPITAL MANAGEMENT, LLC | 55.7K | $679K | — | Held |
| Vestal Point Capital, LP | 53.4K | $651.4K | — | Held |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 44.9K | $547.3K | — | Held |
| Artia Global Partners LP | 42.1K | $513K | — | Held |
| TWO SIGMA INVESTMENTS, LP | 33.5K | $408K | — | Held |
| GOLDMAN SACHS GROUP INC | 22.4K | $273.2K | — | Held |
| Quadrature Capital Ltd | 20.6K | $251.7K | — | Held |
| BlackRock, Inc. | 16.7K | $203.7K | — | Held |
| BNP PARIBAS FINANCIAL MARKETS | 15.3K | $186.5K | — | Held |
| TWO SIGMA ADVISERS, LP | 13.2K | $160.6K | — | Held |
| Corient Private Wealth LLC | 12.4K | $151K | — | Held |
| Stonepine Capital Management, LLC | 11.9K | $144.9K | — | Held |
| LETKO, BROSSEAU & ASSOCIATES INC | 10.7K | $129.8K | — | Held |
| BANK OF AMERICA CORP /DE/ | 3.78K | $46.1K | $1.16K | Added$44.1K |
| JPMORGAN CHASE & CO | 902 | $11K | — | Held |
| UBS Group AG | 676 | $8.24K | — | Held |
| Tower Research Capital LLC (TRC) | 199 | $2.43K | — | Held |
| Physician Wealth Advisors, Inc. | 1 | $13 | — | Held |
| Allworth Financial LP | 1 | $13 | $5 | Added$5 |
| Titiun Yejiel | 1 | $12 | — | Held |
| CITIGROUP INC | 1 | $12 | — | Held |
| JONES FINANCIAL COMPANIES LLLP | 1 | $12 | — | Held |
| Rockefeller Capital Management L.P. | 1 | $12 | — | Held |
| Union Bancaire Privee, UBP SA | 1 | $9 | — | Held |