| RA CAPITAL MANAGEMENT, L.P. | 7M | $195M | — | Held |
| TRV GP V, LLC | 6.22M | $173.3M | — | Held |
| Driehaus Capital Management LLC | 4.81M | $134.1M | — | Held |
| TRV GP VI, LLC | 4.21M | $117.4M | — | Held |
| SAMSARA BIOCAPITAL, LLC | 3.15M | $87.8M | — | Held |
| GOLDMAN SACHS GROUP INC | 2.72M | $75.7M | — | Held |
| Siren, L.L.C. | 2M | $55.8M | — | Held |
| BlackRock, Inc. | 1.8M | $50.2M | — | Held |
| BVF INC/IL | 1.72M | $48M | — | Held |
| Vanguard | 1.51M | $42M | — | Held |
| Avoro Capital Advisors LLC | 1.34M | $37.3M | — | Held |
| ADAR1 Capital Management, LLC | 1.16M | $32.3M | — | Held |
| First Light Asset Management, LLC | 620.8K | $17.3M | — | Held |
| VR ADVISER, LLC | 610.8K | $17M | — | Held |
| GEODE CAPITAL MANAGEMENT, LLC | 572.7K | $16M | — | Held |
| Casdin Capital, LLC | 553.3K | $15.4M | — | Held |
| PRIMECAP MANAGEMENT CO/CA/ | 546.1K | $15.2M | — | Held |
| State Street | 540K | $15.1M | — | Held |
| PERCEPTIVE ADVISORS LLC | 433.2K | $12.1M | — | Held |
| Woodline Partners LP | 385.3K | $10.7M | — | Held |
| Soleus Capital Management, L.P. | 383.4K | $10.7M | — | Held |
| Catalio Capital Management, LP | 294.4K | $8.21M | — | Held |
| MARSHALL WACE, LLP | 226.9K | $6.33M | — | Held |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 222.7K | $6.21M | — | Held |
| Kalehua Capital Management LLC | 194.5K | $5.42M | — | Held |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 187.2K | $5.22M | — | Held |
| Invesco Ltd. | 162K | $4.52M | — | Held |
| NORTHERN TRUST CORP | 154.2K | $4.3M | — | Held |
| MILLENNIUM MANAGEMENT LLC | 107.5K | $3M | — | Held |
| MORGAN STANLEY | 104K | $2.9M | $493.9K | Added$1.87M |
| TWO SIGMA INVESTMENTS, LP | 92.8K | $2.59M | — | Held |
| FEDERATED HERMES, INC. | 78.9K | $2.2M | — | Held |
| HighVista Strategies LLC | 78.7K | $2.19M | — | Held |
| Citadel | 75.9K | $2.12M | — | Held |
| UBS Group AG | 68.8K | $1.92M | — | Held |
| JPMORGAN CHASE & CO | 68.3K | $1.91M | — | Held |
| Rangeley Capital, LLC | 65.8K | $1.83M | — | Held |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 61.4K | $1.71M | — | Held |
| Bank of New York Mellon Corp | 55.3K | $1.54M | — | Held |
| AMERICAN CENTURY COMPANIES INC | 50.7K | $1.41M | — | Held |
| Longaeva Partners L.P. | 49.9K | $1.39M | — | Held |
| Numerai GP LLC | 45.9K | $1.28M | — | Held |
| JANE STREET GROUP, LLC | 44.1K | $1.23M | — | Held |
| Trexquant Investment LP | 44K | $1.23M | — | Held |
| BARCLAYS PLC | 38.1K | $1.06M | $273K | Added$497.3K |
| ExodusPoint Capital Management, LP | 37.9K | $1.06M | — | Held |
| BANK OF AMERICA CORP /DE/ | 37.6K | $1.05M | $341K | Added$79.5K |
| Alyeska Investment Group, L.P. | 35K | $975.8K | — | Held |
| WELLS FARGO & COMPANY/MN | 26.5K | $739.6K | — | Held |
| RHUMBLINE ADVISERS | 26.4K | $736.6K | — | Held |
| Nuveen, LLC | 25.8K | $719.2K | — | Held |
| TWO SIGMA ADVISERS, LP | 25.7K | $716.5K | — | Held |
| Logos Global Management LP | 23.5K | $656.5K | — | Held |
| XTX Topco Ltd | 23.3K | $650K | — | Held |
| VARCOV Co. | 22.6K | $631K | — | Held |
| ALLIANCEBERNSTEIN L.P. | 19.6K | $546.4K | — | Held |
| TUDOR INVESTMENT CORP ET AL | 18.1K | $503.3K | — | New |
| FRANKLIN RESOURCES INC | 16.9K | $469.8K | — | Held |
| Russell Investments Group, Ltd. | 15.3K | $426.8K | — | Held |
| DEUTSCHE BANK AG\ | 14.9K | $414.8K | — | Held |
| Squarepoint Ops LLC | 14.8K | $413.9K | — | Held |
| STRS OHIO | 14.6K | $407K | — | Held |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 18.6K | $398.6K | — | Held |
| AMERIPRISE FINANCIAL INC | 14.1K | $392.8K | — | Held |
| MetLife Investment Management, LLC | 13.7K | $381.5K | — | Held |
| INTECH INVESTMENT MANAGEMENT LLC | 13.3K | $370.3K | — | Held |
| OSAIC HOLDINGS, INC. | 12.7K | $353.9K | — | Held |
| Seven Fleet Capital Management LP | 11.4K | $319.1K | — | Held |
| Dynamic Technology Lab Private Ltd | 10.8K | $301K | — | Held |
| PharVision Advisers, LLC | 10.7K | $299.4K | — | Held |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 10.6K | $295.4K | — | Held |
| Virtus Investment Advisers, LLC | 10.5K | $291.5K | — | Held |
| China Universal Asset Management Co., Ltd. | 10.3K | $287.1K | — | Held |
| Baader Bank Aktiengesellschaft | 10K | $278.8K | — | Held |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 9.93K | $277K | — | Held |
| Atom Investors LP | 9.79K | $273K | — | Held |
| CITIGROUP INC | 9.56K | $266.6K | — | Held |
| Graham Capital Management, L.P. | 8.97K | $250.1K | — | Held |
| Jump Financial, LLC | 8.4K | $234.2K | — | Held |
| BANK OF NOVA SCOTIA | 8.3K | $231.4K | — | Held |
| Icahn Capital | 7.83K | $218.2K | — | Held |
| NEW YORK STATE COMMON RETIREMENT FUND | 5.6K | $156.1K | — | Held |
| BNP PARIBAS FINANCIAL MARKETS | 5.45K | $151.9K | — | Held |
| Police & Firemen's Retirement System of New Jersey | 5.17K | $144.3K | — | Held |
| Balyasny Asset Management L.P. | 3.57K | $99.6K | — | Held |
| Fidelity | 3.31K | $92.2K | — | Held |
| Caitong International Asset Management Co., Ltd | 3.17K | $88.4K | — | Held |
| Mirae Asset Global Investments Co., Ltd. | 2.18K | $60.7K | — | Held |
| Tower Research Capital LLC (TRC) | 2.16K | $60.1K | — | Held |
| Ameritas Investment Partners, Inc. | 1.94K | $54.2K | — | Held |
| Legal & General Group Plc | 1.95K | $54.2K | — | Held |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1.32K | $36.7K | — | Held |
| Global Retirement Partners, LLC | 1.26K | $35K | — | Held |
| Sterling Capital Management LLC | 1.23K | $34.3K | — | Held |
| SIGNATUREFD, LLC | 989 | $27.6K | — | Held |
| GROUP ONE TRADING LLC | 944 | $26.3K | — | Held |
| GAMMA Investing LLC | 916 | $25.5K | — | Held |
| GF FUND MANAGEMENT CO. LTD. | 878 | $24.5K | — | Held |
| Quarry LP | 724 | $20.2K | — | Held |
| ROYAL BANK OF CANADA | 628 | $18K | — | Held |
| NISA INVESTMENT ADVISORS, LLC | 341 | $9.51K | — | Held |
| Pinnacle Wealth Planning Services, Inc. | 322 | $8.98K | — | Held |
| Versant Capital Management, Inc | 261 | $7.28K | — | Held |
| PNC Financial Services Group, Inc. | 198 | $5.52K | — | Held |
| US BANCORP \DE\ | 190 | $5.3K | — | Held |
| N.E.W. Advisory Services LLC | 180 | $5.02K | — | Held |
| Fortitude Family Office, LLC | 71 | $1.98K | — | Held |
| MassMutual Private Wealth & Trust, FSB | 63 | $1.76K | — | Held |
| EverSource Wealth Advisors, LLC | 63 | $1.76K | — | Held |
| SBI Securities Co., Ltd. | 55 | $1.53K | — | Held |
| Cornerstone Financial Management LLC | 52 | $1.45K | — | Held |
| ALGERT GLOBAL LLC | 34.9K | $974 | — | Held |
| ACADIAN ASSET MANAGEMENT LLC | 30.9K | $858 | — | Held |
| ROTHSCHILD INVESTMENT LLC | 30 | $836 | — | Held |
| PRICE T ROWE ASSOCIATES INC /MD/ | 25.4K | $710 | — | Held |
| Aster Capital Management (DIFC) Ltd | 20 | $558 | — | Held |
| Arax Advisory Partners | 3 | $84 | — | Held |
| Covestor Ltd | 1.94K | $54 | — | Held |
| Farther Finance Advisors, LLC | 1 | $28 | — | Held |
| CWM, LLC | 888 | $25 | — | Held |
| AMALGAMATED BANK | 672 | $19 | — | Held |
| Daiwa Securities Group Inc. | 149 | $4 | — | Held |