| RA CAPITAL MANAGEMENT, L.P. | 7M | $168.1M | −$26.9M | Cut−$26.9M |
| TRV GP V, LLC | 6.22M | $149.4M | −$23.9M | Cut−$23.9M |
| Driehaus Capital Management LLC | 4.4M | $105.6M | −$16.9M | Cut−$28.5M |
| TRV GP VI, LLC | 4.21M | $101.2M | −$16.2M | Cut−$16.2M |
| SAMSARA BIOCAPITAL, LLC | 3.15M | $75.7M | −$12.1M | Cut−$12.1M |
| GOLDMAN SACHS GROUP INC | 2.91M | $69.8M | −$10.5M | Cut−$5.86M |
| Siren, L.L.C. | 2M | $48.1M | −$7.7M | Cut−$7.7M |
| BlackRock, Inc. | 1.82M | $43.8M | −$6.94M | Cut−$6.43M |
| BVF INC/IL | 1.35M | $32.5M | −$5.21M | Cut−$15.5M |
| Avoro Capital Advisors LLC | 1.34M | $32.1M | −$5.15M | Cut−$5.15M |
| VANGUARD CAPITAL MANAGEMENT LLC | 1.2M | $28.8M | — | Held |
| ADAR1 Capital Management, LLC | 1.09M | $26.2M | −$4.2M | Cut−$6.09M |
| PRIMECAP MANAGEMENT CO/CA/ | 1.05M | $25.2M | −$2.1M | Added$9.98M |
| JANUS HENDERSON GROUP PLC | 890.8K | $21.3M | — | New |
| First Light Asset Management, LLC | 732.9K | $17.6M | −$2.39M | Added$302.4K |
| GEODE CAPITAL MANAGEMENT, LLC | 645.1K | $15.5M | −$2.21M | Cut−$465.3K |
| State Street | 631.4K | $15.2M | −$2.08M | Added$117.7K |
| Casdin Capital, LLC | 553.3K | $13.3M | −$2.13M | Cut−$2.13M |
| VR ADVISER, LLC | 506.1K | $12.2M | −$1.95M | Cut−$4.87M |
| Catalio Capital Management, LP | 294.4K | $7.07M | −$1.13M | Cut−$1.13M |
| Soleus Capital Management, L.P. | 275K | $6.61M | −$1.06M | Cut−$4.08M |
| Balyasny Asset Management L.P. | 236.7K | $5.69M | −$13.7K | Added$5.59M |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 224K | $5.38M | −$857.4K | Cut−$826.3K |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 195K | $4.69M | — | Held |
| Kalehua Capital Management LLC | 194.5K | $4.67M | −$749K | Cut−$749K |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 181.6K | $4.36M | −$699.1K | Cut−$856.9K |
| NORTHERN TRUST CORP | 164.5K | $3.95M | −$593.7K | Cut−$345.3K |
| VANGUARD FIDUCIARY TRUST CO | 154.5K | $3.71M | — | Held |
| MILLENNIUM MANAGEMENT LLC | 124.1K | $2.98M | −$413.7K | Cut−$13.9K |
| UBS Group AG | 117K | $2.81M | −$264.9K | Added$892.4K |
| MORGAN STANLEY | 110.5K | $2.66M | −$400.3K | Cut−$243.1K |
| HUSSMAN STRATEGIC ADVISORS, INC. | 105K | $2.52M | — | New |
| Checkpoint Capital L.P. | 100.3K | $2.41M | — | New |
| FEDERATED HERMES, INC. | 89.3K | $2.15M | −$303.8K | Cut−$54K |
| Invesco Ltd. | 82.9K | $1.99M | −$319K | Cut−$2.53M |
| JPMORGAN CHASE & CO | 84.7K | $1.97M | −$313K | Added$67.6K |
| TWO SIGMA INVESTMENTS, LP | 75.4K | $1.81M | −$290.2K | Cut−$776.4K |
| Longaeva Partners L.P. | 74.6K | $1.79M | −$192.1K | Added$400.6K |
| AMERICAN CENTURY COMPANIES INC | 61.3K | $1.47M | −$195.2K | Added$59.6K |
| Bank of New York Mellon Corp | 58.7K | $1.41M | −$213K | Cut−$131.9K |
| Jump Financial, LLC | 53K | $1.27M | −$32.3K | Added$1.04M |
| Sofinnova Investments, Inc. | 47.5K | $1.14M | — | New |
| MARSHALL WACE, LLP | 39.8K | $957.4K | −$153.4K | Cut−$5.37M |
| Rangeley Capital, LLC | 39.8K | $956.4K | −$153.2K | Cut−$878.1K |
| Renaissance Technologies | 37.7K | $905.9K | — | New |
| XTX Topco Ltd | 36.7K | $882.5K | −$89.8K | Added$232.4K |
| Trexquant Investment LP | 35.3K | $848.3K | −$135.9K | Cut−$378.6K |
| Alyeska Investment Group, L.P. | 35K | $841K | −$134.7K | Cut−$134.8K |
| Nuveen, LLC | 29.2K | $701.1K | −$99.3K | Cut−$18.1K |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 28.4K | $683.3K | −$109.5K | Cut−$1.03M |
| RHUMBLINE ADVISERS | 26.6K | $639.3K | −$101.7K | Cut−$97.3K |
| BANK OF AMERICA CORP /DE/ | 26K | $624.1K | −$100K | Cut−$424K |
| Y-Intercept (Hong Kong) Ltd | 25.8K | $619.3K | — | New |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 24K | $576.7K | — | New |
| Logos Global Management LP | 23.5K | $565.9K | −$90.7K | Cut−$90.7K |
| Fidelity | 23.4K | $563.4K | −$12.7K | Added$471.2K |
| ALLIANCEBERNSTEIN L.P. | 19.6K | $546.4K | $0 | Held |
| BARCLAYS PLC | 22.7K | $545.8K | −$87.4K | Cut−$517.7K |
| Swiss National Bank | 22.1K | $531.1K | — | New |
| Squarepoint Ops LLC | 18.1K | $434.5K | −$57.2K | Added$20.6K |
| STRS OHIO | 17.2K | $413.3K | −$56.2K | Added$6.27K |
| DEUTSCHE BANK AG\ | 16.8K | $404.7K | −$57.3K | Cut−$10.1K |
| VARCOV Co. | 16.8K | $402.6K | −$64.5K | Cut−$228.5K |
| Engineers Gate Manager LP | 16.5K | $397.2K | — | New |
| Vanguard Global Advisers, LLC | 16.2K | $390.4K | — | Held |
| Icahn Capital | 15.4K | $369.5K | −$30.1K | Added$151.3K |
| Numerai GP LLC | 15.1K | $362.4K | −$58.1K | Cut−$916.3K |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 14.2K | $341.6K | $36.1K | Cut−$57.1K |
| MetLife Investment Management, LLC | 13.7K | $328.9K | −$52.7K | Cut−$52.7K |
| EntryPoint Capital, LLC | 12.8K | $307K | — | New |
| OSAIC HOLDINGS, INC. | 12.7K | $305.1K | −$48.9K | Cut−$48.7K |
| Verition Fund Management LLC | 12.3K | $296.6K | — | New |
| China Universal Asset Management Co., Ltd. | 11.9K | $287.1K | −$39.6K | Added$10 |
| Man Group plc | 11.9K | $284.9K | — | New |
| Russell Investments Group, Ltd. | 11.5K | $276.7K | −$44.3K | Cut−$150.1K |
| Seven Fleet Capital Management LP | 11.4K | $275K | −$44.1K | Cut−$44.1K |
| Virtus Investment Advisers, LLC | 10.7K | $257.6K | −$40.3K | Cut−$34K |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 10.4K | $249.5K | — | New |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 10K | $240.8K | −$38.2K | Cut−$36.2K |
| WELLS FARGO & COMPANY/MN | 9.87K | $237.2K | −$38K | Cut−$502.5K |
| CITIGROUP INC | 9.2K | $221K | −$35.4K | Cut−$45.6K |
| WINTON GROUP Ltd | 8.84K | $212.5K | — | New |
| VANGUARD ASSET MANAGEMENT, Ltd | 7.42K | $178.3K | — | Held |
| Legal & General Group Plc | 5.74K | $137.8K | −$7.43K | Added$83.6K |
| NEW YORK STATE COMMON RETIREMENT FUND | 5.6K | $134.6K | −$21.6K | Cut−$21.6K |
| BNP PARIBAS FINANCIAL MARKETS | 5.36K | $128.8K | −$20.6K | Cut−$23.1K |
| Police & Firemen's Retirement System of New Jersey | 5.17K | $124.4K | −$19.9K | Cut−$19.9K |
| Vanguard Investments Australia, Ltd. | 3.9K | $93.6K | — | Held |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 3.37K | $81.1K | −$13K | Cut−$214.3K |
| KLP KAPITALFORVALTNING AS | 2.5K | $60.1K | — | New |
| Mirae Asset Global Investments Co., Ltd. | 2.33K | $56.1K | −$8.38K | Cut−$4.56K |
| Ameritas Investment Partners, Inc. | 1.94K | $46.7K | −$7.49K | Cut−$7.49K |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1.16K | $27.8K | −$4.45K | Cut−$8.89K |
| GAMMA Investing LLC | 1.11K | $26.7K | −$3.53K | Added$1.14K |
| GF FUND MANAGEMENT CO. LTD. | 1.01K | $24.2K | −$3.38K | Cut−$305 |
| SIGNATUREFD, LLC | 966 | $23.2K | −$3.72K | Cut−$4.36K |
| CWM, LLC | 894 | $21.5K | $21.3K | Added$21.5K |
| NISA INVESTMENT ADVISORS, LLC | 841 | $20.2K | −$1.31K | Added$10.7K |
| Tower Research Capital LLC (TRC) | 717 | $17.2K | −$2.76K | Cut−$42.9K |
| Sterling Capital Management LLC | 712 | $17.1K | −$2.74K | Cut−$17.2K |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 508 | $12.2K | — | New |
| Pinnacle Wealth Planning Services, Inc. | 322 | $7.74K | −$1.24K | Cut−$1.24K |
| Versant Capital Management, Inc | 261 | $6.27K | −$1K | Cut−$1K |
| Larson Financial Group LLC | 204 | $4.9K | — | New |
| DIADEMA PARTNERS LP | 202 | $4.85K | — | New |
| US BANCORP \DE\ | 197 | $4.73K | −$731 | Cut−$563 |
| N.E.W. Advisory Services LLC | 180 | $4.33K | −$693 | Cut−$693 |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 155 | $3.73K | — | New |
| MassMutual Private Wealth & Trust, FSB | 135 | $3.24K | −$242 | Added$1.49K |
| EverSource Wealth Advisors, LLC | 68 | $1.63K | −$242 | Cut−$122 |
| SBI Securities Co., Ltd. | 55 | $1.32K | −$211 | Cut−$211 |
| Cornerstone Financial Management LLC | 52 | $1.25K | −$200 | Cut−$200 |
| PNC Financial Services Group, Inc. | 43 | $1.03K | −$166 | Cut−$4.49K |
| Caitong International Asset Management Co., Ltd | 38 | $913 | −$146 | Cut−$87.5K |
| ACADIAN ASSET MANAGEMENT LLC | 31K | $741 | −$119 | Cut−$117 |
| ROTHSCHILD INVESTMENT LLC | 30 | $721 | −$115 | Cut−$115 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 28.1K | $675 | −$98 | Cut−$35 |
| ALGERT GLOBAL LLC | 21K | $505 | −$81 | Cut−$469 |
| Fortitude Family Office, LLC | 20 | $481 | −$76 | Cut−$1.5K |
| Allworth Financial LP | 17 | $409 | — | New |
| Farther Finance Advisors, LLC | 7 | $171 | −$4 | Added$143 |
| QUADRANT CAPITAL GROUP LLC | 7 | $169 | — | New |
| MAI Capital Management | 6 | $145 | — | New |
| Covestor Ltd | 2.26K | $54 | −$8 | Held |