| RA CAPITAL MANAGEMENT, L.P. | 6.67M | $713.6M | — | Held |
| BlackRock, Inc. | 6.3M | $674.1M | — | Held |
| Vanguard | 6.21M | $664.8M | — | Held |
| BAKER BROS. ADVISORS LP | 5.6M | $599.9M | — | Held |
| PRIMECAP MANAGEMENT CO/CA/ | 3.48M | $372.4M | — | Held |
| NEA Management Company, LLC | 2.91M | $311.5M | — | Held |
| PERCEPTIVE ADVISORS LLC | 2.55M | $272.6M | — | Held |
| State Street | 2.2M | $235.3M | — | Held |
| GOLDMAN SACHS GROUP INC | 1.83M | $196M | — | Held |
| Fidelity | 1.71M | $182.6M | — | Held |
| FEDERATED HERMES, INC. | 1.62M | $173.8M | — | Held |
| JPMORGAN CHASE & CO | 1.42M | $152.4M | — | Held |
| GEODE CAPITAL MANAGEMENT, LLC | 1.38M | $147.3M | — | Held |
| Driehaus Capital Management LLC | 1.29M | $137.6M | — | Held |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 1.27M | $135.6M | — | Held |
| Polar Capital Holdings Plc | 1.19M | $126.9M | — | Held |
| JANUS HENDERSON GROUP PLC | 1.13M | $120.6M | — | Held |
| Checkpoint Capital L.P. | 992.2K | $106.2M | — | Held |
| Capital Research Global Investors | 985.1K | $105.4M | — | Held |
| ALLIANCEBERNSTEIN L.P. | 930.2K | $99.6M | — | Held |
| JENNISON ASSOCIATES LLC | 918.6K | $98.3M | — | Held |
| FRANKLIN RESOURCES INC | 695.7K | $74.5M | — | Held |
| Rock Springs Capital Management LP | 695K | $74.4M | — | Held |
| Woodline Partners LP | 688.8K | $73.7M | — | Held |
| MORGAN STANLEY | 651.4K | $69.7M | $2.81M | Added$22.7M |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 621.6K | $66.5M | — | Held |
| Pictet Asset Management Holding SA | 614.7K | $66.2M | — | Held |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 549K | $58.8M | — | Held |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 532.4K | $57M | — | Held |
| Clearbridge Investments, LLC | 506.1K | $54.2M | — | Held |
| LOOMIS SAYLES & CO L P | 503.9K | $53.9M | — | Held |
| Siren, L.L.C. | 500K | $53.5M | — | Held |
| NORTHERN TRUST CORP | 488.2K | $52.3M | — | Held |
| Integral Health Asset Management, LLC | 475K | $50.8M | — | Held |
| Point72 Asset Management, L.P. | 429.4K | $46M | — | Held |
| UBS Group AG | 427.2K | $45.7M | — | Held |
| Renaissance Technologies | 341.2K | $36.5M | — | Held |
| Opaleye Management Inc. | 330K | $35.3M | — | Held |
| Qube Research & Technologies Ltd | 310.9K | $33.3M | — | Held |
| Bank of New York Mellon Corp | 301.1K | $32.2M | — | Held |
| First Light Asset Management, LLC | 295.8K | $31.7M | — | Held |
| Invesco Ltd. | 291.1K | $31.2M | — | Held |
| Candriam S.C.A. | 287.9K | $30.8M | — | Held |
| Sofinnova Investments, Inc. | 271.4K | $29.1M | — | Held |
| Artisan Partners Limited Partnership | 263.6K | $28.2M | — | Held |
| AMERIPRISE FINANCIAL INC | 261.2K | $28M | — | Held |
| WELLINGTON MANAGEMENT GROUP LLP | 250.2K | $26.8M | — | Held |
| VOYA INVESTMENT MANAGEMENT LLC | 249.9K | $26.7M | — | Held |
| ORBIMED ADVISORS LLC | 239.8K | $25.7M | — | Held |
| Hood River Capital Management LLC | 237K | $25.4M | — | Held |
| BANK OF AMERICA CORP /DE/ | 224.5K | $24M | $1.36M | Added$482.9K |
| Logos Global Management LP | 190K | $20.3M | — | Held |
| MILLENNIUM MANAGEMENT LLC | 186.7K | $20M | — | Held |
| BNP PARIBAS FINANCIAL MARKETS | 164.6K | $17.6M | — | Held |
| Citadel | 153.3K | $16.4M | — | Held |
| Connor, Clark & Lunn Investment Management Ltd. | 149.4K | $16M | — | Held |
| First Turn Management, LLC | 146.3K | $15.7M | — | Held |
| M&G PLC | 137.1K | $14.7M | — | Held |
| SILVERARC CAPITAL MANAGEMENT, LLC | 135.9K | $14.6M | — | Held |
| Russell Investments Group, Ltd. | 134.2K | $14.4M | — | Held |
| BARCLAYS PLC | 131.4K | $14.1M | $795.2K | Cut−$310.6K |
| DEUTSCHE BANK AG\ | 129.1K | $13.8M | — | Held |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 123.5K | $13.2M | — | Held |
| Nuveen, LLC | 115.9K | $12.4M | — | Held |
| Capital World Investors | 115.7K | $12.4M | — | Held |
| Swiss National Bank | 111.3K | $11.9M | — | Held |
| NEW YORK STATE COMMON RETIREMENT FUND | 93.7K | $10M | — | Held |
| FIRST TRUST ADVISORS LP | 88.5K | $9.47M | — | Held |
| AXIOM INVESTORS LLC /DE | 83.6K | $8.94M | — | Held |
| Zweig-DiMenna Associates LLC | 81.6K | $8.73M | — | Held |
| SummitTX Capital, L.P. | 80.7K | $8.64M | — | Held |
| ExodusPoint Capital Management, LP | 75.1K | $8.04M | — | Held |
| NEUBERGER BERMAN GROUP LLC | 73.6K | $7.88M | — | Held |
| WELLS FARGO & COMPANY/MN | 72.6K | $7.77M | — | Held |
| Balyasny Asset Management L.P. | 72.3K | $7.74M | — | Held |
| RHUMBLINE ADVISERS | 71.2K | $7.62M | — | Held |
| Icahn Capital | 70K | $7.5M | — | Held |
| NEXTBio Capital Management LP | 67.6K | $7.23M | — | Held |
| NORGES BANK | 66.2K | $7.09M | $3.58M | Cut−$4.75M |
| CASTLEARK MANAGEMENT LLC | 64.5K | $6.9M | — | Held |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 60.6K | $6.48M | — | Held |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 59.6K | $6.37M | — | Held |
| PDT Partners, LLC | 59.4K | $6.36M | — | Held |
| STEMPOINT CAPITAL LP | 58.9K | $6.31M | — | Held |
| Informed Momentum Co LLC | 57.3K | $6.14M | — | Held |
| Rafferty Asset Management, LLC | 55.5K | $5.94M | — | Held |
| Legal & General Group Plc | 55.1K | $5.9M | — | Held |
| TD Asset Management Inc | 55K | $5.89M | — | Held |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 53.5K | $5.73M | — | Held |
| Granahan Investment Management, LLC | 53.5K | $5.72M | — | Held |
| PRUDENTIAL FINANCIAL INC | 53.1K | $5.69M | — | Held |
| ADAR1 Capital Management, LLC | 51.3K | $5.5M | — | Held |
| Nan Fung Group Holdings Ltd | 49.1K | $5.26M | — | Held |
| VICTORY CAPITAL MANAGEMENT INC | 45.4K | $4.86M | — | Held |
| WCM INVESTMENT MANAGEMENT, LLC | 44.8K | $4.78M | — | Held |
| Harvest Investment Services, LLC | 44K | $4.7M | — | Held |
| HighVista Strategies LLC | 42.9K | $4.59M | — | Held |
| Hillsdale Investment Management Inc. | 42.3K | $4.53M | — | Held |
| RAYMOND JAMES FINANCIAL INC | 41.1K | $4.4M | — | Held |
| PFM Health Sciences, LP | 40.2K | $4.3M | — | Held |
| KENNEDY CAPITAL MANAGEMENT LLC | 39.9K | $4.27M | — | Held |
| SEI INVESTMENTS CO | 37.4K | $4.01M | — | Held |
| STATE OF WISCONSIN INVESTMENT BOARD | 36.1K | $3.86M | — | Held |
| Rhenman & Partners Asset Management AB | 35K | $3.75M | — | Held |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 34.9K | $3.73M | — | Held |
| Nicholas Investment Partners, LP | 34.7K | $3.72M | — | Held |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 34.1K | $3.65M | — | Held |
| Squarepoint Ops LLC | 32.8K | $3.51M | — | Held |
| DIMENSIONAL FUND ADVISORS LP | 32K | $3.43M | — | Held |
| D. E. Shaw & Co., Inc. | 31.4K | $3.36M | — | Held |
| Magnetar Financial LLC | 29.6K | $3.17M | — | Held |
| EFG International AG | 29.3K | $3.14M | — | Held |
| MetLife Investment Management, LLC | 29.2K | $3.12M | — | Held |
| LAZARD ASSET MANAGEMENT LLC | 25.6K | $2.74M | — | Held |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 24.3K | $2.72M | — | Held |
| Creative Planning | 25.2K | $2.7M | — | Held |
| Atom Investors LP | 22.9K | $2.45M | — | Held |
| INTECH INVESTMENT MANAGEMENT LLC | 21.4K | $2.29M | — | Held |
| PROFUND ADVISORS LLC | 21K | $2.25M | — | Held |
| State of New Jersey Common Pension Fund D | 19.3K | $2.06M | — | Held |
| WEDGE CAPITAL MANAGEMENT L L P/NC | 19.2K | $2.06M | — | Held |
| Advisors Asset Management, Inc. | 18.5K | $1.98M | — | Held |
| CAPTRUST FINANCIAL ADVISORS | 18.3K | $1.96M | — | Held |
| ARIZONA STATE RETIREMENT SYSTEM | 15.8K | $1.69M | — | Held |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 14.7K | $1.57M | — | Held |
| Police & Firemen's Retirement System of New Jersey | 14.2K | $1.52M | — | Held |
| STIFEL FINANCIAL CORP | 13.2K | $1.42M | — | Held |
| NISA INVESTMENT ADVISORS, LLC | 13.1K | $1.41M | — | Held |
| CITIGROUP INC | 12.7K | $1.36M | — | Held |
| ProShare Advisors LLC | 12.6K | $1.35M | — | Held |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 12.4K | $1.33M | — | Held |
| GUGGENHEIM CAPITAL LLC | 12.4K | $1.33M | — | Held |
| KLP KAPITALFORVALTNING AS | 12K | $1.28M | — | Held |
| STRS OHIO | 12K | $1.28M | — | Held |
| Rockefeller Capital Management L.P. | 11.8K | $1.26M | — | Held |
| DNB Asset Management AS | 11.2K | $1.19M | — | Held |
| Hennion & Walsh Asset Management, Inc. | 10.9K | $1.17M | — | Held |
| China Universal Asset Management Co., Ltd. | 10.9K | $1.16M | — | Held |
| XTX Topco Ltd | 10.4K | $1.12M | — | Held |
| Knights of Columbus Asset Advisors LLC | 10.3K | $1.1M | — | Held |
| Cannon Financial Strategists, Inc. | 10K | $1.07M | — | Held |
| TOTH FINANCIAL ADVISORY CORP | 10K | $1.07M | — | Held |
| Man Group plc | 9.56K | $1.02M | — | Held |
| FRED ALGER MANAGEMENT, LLC | 9.3K | $995.6K | — | Held |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 9.2K | $984.8K | — | Held |
| Headlands Technologies LLC | 8.63K | $924K | — | Held |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 8.36K | $894.7K | — | Held |
| Allianz Asset Management GmbH | 8K | $856.3K | — | Held |
| Bellevue Group AG | 7.5K | $803.2K | — | Held |
| Leo Wealth, LLC | 6.95K | $744.1K | — | Held |
| Jump Financial, LLC | 6.76K | $723.5K | — | Held |
| E. Ohman J:or Asset Management AB | 6.59K | $705.3K | — | Held |
| PRINCIPAL FINANCIAL GROUP INC | 6.2K | $663.4K | — | Held |
| EXCHANGE TRADED CONCEPTS, LLC | 6.08K | $650.8K | — | Held |
| Virtus Investment Advisers, LLC | 6.02K | $644.1K | — | Held |
| Legato Capital Management LLC | 5.72K | $612.6K | — | Held |
| Jasper Ridge Partners, L.P. | 5.64K | $603.6K | — | Held |
| Quantedge Capital Pte Ltd | 5.6K | $599.4K | — | Held |
| LPL Financial LLC | 5.43K | $580.9K | — | Held |
| AlphaCentric Advisors LLC | 5.05K | $540.8K | — | Held |
| Voleon Capital Management LP | 5.03K | $537.9K | — | Held |
| TWO SIGMA SECURITIES, LLC | 4.94K | $529.1K | — | Held |
| Gotham Asset Management, LLC | 4.85K | $519.3K | — | Held |
| PSP Research LLC | 4.74K | $507.2K | — | Held |
| PNC Financial Services Group, Inc. | 4.66K | $498.7K | — | Held |
| Caption Management, LLC | 4.61K | $493.9K | — | Held |
| Vestmark Advisory Solutions, Inc. | 4.56K | $488.1K | — | Held |
| Verition Fund Management LLC | 4.5K | $482.1K | — | Held |
| MACKENZIE FINANCIAL CORP | 4.4K | $468.6K | — | Held |
| Ameritas Investment Partners, Inc. | 4.37K | $467.2K | — | Held |
| XPONANCE LLC | 4.27K | $457K | — | Held |
| Empowered Funds, LLC | 4.16K | $445.7K | — | Held |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 4.1K | $438.5K | — | Held |
| COMERICA BANK | 4.01K | $429.6K | — | Held |
| Ensign Peak Advisors, Inc | 3.86K | $413.1K | — | Held |
| Quantinno Capital Management LP | 3.83K | $410.1K | — | Held |
| Freestone Capital Holdings, LLC | 3.7K | $396K | — | Held |
| Cerity Partners LLC | 3.66K | $392.2K | — | Held |
| O'SHAUGHNESSY ASSET MANAGEMENT, LLC | 3.58K | $383.2K | — | Held |
| Avior Wealth Management, LLC | 3.57K | $382.3K | — | Held |
| CIBC WORLD MARKETS CORP | 3.5K | $374.9K | — | Held |
| Tidal Investments LLC | 3.34K | $357.1K | — | Held |
| KEYBANK NATIONAL ASSOCIATION/OH | 3.27K | $350.1K | — | Held |
| Mirae Asset Global Investments Co., Ltd. | 3.24K | $347.1K | — | Held |
| Cinctive Capital Management LP | 3.23K | $345.2K | — | Held |
| Yorktown Management & Research Co Inc | 3.05K | $326.5K | — | Held |
| CIM INVESTMENT MANAGEMENT INC | 2.99K | $320.4K | — | Held |
| Tower Research Capital LLC (TRC) | 2.96K | $317.1K | — | Held |
| TWO SIGMA ADVISERS, LP | 2.9K | $310.4K | — | Held |
| Blueshift Asset Management, LLC | 2.88K | $308.4K | — | Held |
| JGP Global Gestao de Recursos Ltda. | 2.87K | $306.8K | — | Held |
| CIBC Asset Management Inc | 2.85K | $304.9K | — | Held |
| Swiss Life Asset Management Ltd | 2.65K | $284K | $14.9K | Added$35.4K |
| Chicago Partners Investment Group LLC | 2.74K | $281.8K | — | Held |
| Entropy Technologies, LP | 2.49K | $266.7K | — | Held |
| State of Wyoming | 2.44K | $261.3K | — | Held |
| Vanguard Personalized Indexing Management, LLC | 2.38K | $254.6K | — | Held |
| Abel Hall, LLC | 2.14K | $229.1K | — | Held |
| M&T Bank Corp | 2.1K | $224.9K | — | Held |
| Cambria Investment Management, L.P. | 2K | $213.8K | — | New |
| ELEVATION WEALTH PARTNERS, LLC | 1.97K | $211K | — | Held |
| JANE STREET GROUP, LLC | 1.96K | $209.8K | — | Held |
| WHITTIER TRUST CO | 1.81K | $180.1K | — | Held |
| ROYAL BANK OF CANADA | 1.68K | $180K | — | Held |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1.56M | $167.1K | — | Held |
| AlphaQuest LLC | 1.51K | $161.4K | — | Held |
| Persistent Asset Partners Ltd | 1.45K | $154.8K | — | New |
| GF FUND MANAGEMENT CO. LTD. | 1.31K | $140.2K | — | Held |
| Clearstead Advisors, LLC | 1.25K | $133.4K | — | Held |
| DANSKE BANK A/S | 1.1K | $117.7K | — | New |
| OSAIC HOLDINGS, INC. | 1.04K | $111.2K | — | Held |
| US BANCORP \DE\ | 953 | $102K | — | Held |
| Global Retirement Partners, LLC | 857 | $91.7K | — | Held |
| CFG Wealth Management Services, Inc. | 800 | $85.6K | — | Held |
| Farther Finance Advisors, LLC | 642 | $68.7K | — | Held |
| LORD, ABBETT & CO. LLC | 619.5K | $66.3K | — | Held |
| Smartleaf Asset Management LLC | 399 | $42.6K | — | Held |
| Arax Advisory Partners | 381 | $40.8K | — | Held |
| GAMMA Investing LLC | 361 | $38.6K | — | Held |
| Sterling Capital Management LLC | 344 | $36.8K | — | Held |
| SBI Securities Co., Ltd. | 343 | $36.7K | — | Held |
| EverSource Wealth Advisors, LLC | 266 | $28.5K | — | Held |
| SIGNATUREFD, LLC | 232 | $24.8K | — | Held |
| JONES FINANCIAL COMPANIES LLLP | 231 | $24.7K | — | Held |
| Essential Partners LLC | 223 | $23.9K | $1.2K | Added$3.87K |
| Kemnay Advisory Services Inc. | 207 | $22.2K | — | Held |
| True Wealth Design, LLC | 147 | $15.7K | — | Held |
| Truvestments Capital LLC | 138 | $14.8K | — | Held |
| AdvisorNet Financial, Inc | 137 | $14.7K | — | Held |
| Bayforest Capital Ltd | 134 | $14.3K | — | Held |
| Allworth Financial LP | 109 | $11.7K | $660 | Cut−$1.56K |
| Optiver Holding B.V. | 92 | $9.85K | — | Held |
| ROTHSCHILD INVESTMENT LLC | 91 | $9.74K | — | Held |
| ALGERT GLOBAL LLC | 88.3K | $9.45K | — | Held |
| Quarry LP | 77 | $8.24K | — | Held |
| Larson Financial Group LLC | 77 | $8.24K | — | Held |
| HARBOUR INVESTMENTS, INC. | 60 | $6.42K | — | Held |
| WPG Advisers, LLC | 60 | $6.42K | — | Held |
| EASTERN BANK | 59 | $6.32K | — | Held |
| Root Financial Partners, LLC | 43 | $4.6K | — | Held |
| HARBOR CAPITAL ADVISORS, INC. | 40.9K | $4.38K | — | Held |
| ORG Partners LLC | 37 | $3.96K | — | Held |
| IFP Advisors, Inc | 36 | $3.85K | $115 | Added$1.93K |
| Versant Capital Management, Inc | 36 | $3.85K | — | Held |
| Parkside Financial Bank & Trust | 33 | $3.53K | — | Held |
| SageView Advisory Group, LLC | 30 | $3.21K | — | Held |
| FIRST HORIZON CORP | 30 | $3.21K | — | Held |
| Parallel Advisors, LLC | 25 | $2.68K | — | Held |
| Bare Financial Services, Inc | 22 | $2.35K | — | Held |
| Penserra Capital Management LLC | 21.5K | $2.3K | — | Held |