| NOVO HOLDINGS A/S | 3.69M | $74.9M | $10.2M | Added$10.2M |
| FCPM III SERVICES B.V. | 3.23M | $65.6M | $8.92M | Added$8.92M |
| GOLDMAN SACHS GROUP INC | 1.99M | $40.6M | $5.36M | Added$6.53M |
| BlackRock, Inc. | 1.34M | $27.2M | $3.03M | Added$7.99M |
| Blue Owl Capital Holdings LP | 1.01M | $20.5M | $904.3K | Added$14.7M |
| Nan Fung Group Holdings Ltd | 971.3K | $19.7M | $2.69M | Added$2.69M |
| 5AM Venture Management, LLC | 950K | $19.3M | $2.63M | Added$2.63M |
| Sanofi | 912K | $18.5M | $2.52M | Added$2.52M |
| VANGUARD CAPITAL MANAGEMENT LLC | 719.8K | $14.6M | — | Held |
| Pivotal bioVenture Partners Investment Advisor LLC | 611.4K | $12.4M | $1.69M | Added$1.69M |
| Velan Capital Investment Management LP | 492.9K | $10M | $1.36M | Added$846.2K |
| GEODE CAPITAL MANAGEMENT, LLC | 481.2K | $9.79M | $1.08M | Added$2.95M |
| Siren, L.L.C. | 450K | $9.15M | $1.24M | Added$1.24M |
| Vestal Point Capital, LP | 420K | $8.54M | $1.06M | Added$1.78M |
| ADAR1 Capital Management, LLC | 374.9K | $7.62M | — | New |
| BAKER BROS. ADVISORS LP | 364.7K | $7.41M | $1.01M | Added$1.01M |
| State Street | 339.1K | $6.89M | $634.5K | Added$2.86M |
| Freestone Grove Partners LP | 314K | $6.38M | $508.1K | Added$3.15M |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 267.7K | $5.44M | $3M | Added$5.44M |
| RA CAPITAL MANAGEMENT, L.P. | 248.3K | $5.05M | — | New |
| UBS Group AG | 236.5K | $4.81M | $50.6K | Added$4.49M |
| Fidelity | 204.5K | $4.16M | $2.5K | Added$4.14M |
| Board of Trustees of The Leland Stanford Junior University | 199.2K | $4.05M | $550.9K | Added$550.8K |
| SUPERSTRING CAPITAL MANAGEMENT LP | 192.1K | $3.91M | — | New |
| DAFNA Capital Management LLC | 171K | $3.48M | $397.5K | Added$951.3K |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 161.1K | $3.28M | $382.8K | Added$844.6K |
| NORTHERN TRUST CORP | 146.2K | $2.97M | $330.6K | Added$871.7K |
| LAZARD ASSET MANAGEMENT LLC | 142K | $2.89M | $392.7K | Cut−$757.4K |
| VANGUARD FIDUCIARY TRUST CO | 131.2K | $2.67M | — | Held |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 112.6K | $2.29M | — | Held |
| Tetragon Partners GP Ltd | 112.1K | $2.28M | $310K | Cut−$610.6K |
| SEVEN GRAND MANAGERS, LLC | 100K | $2.03M | $276.5K | Added$276.5K |
| STEMPOINT CAPITAL LP | 100K | $2.03M | $276.5K | Added$276.5K |
| BURKEHILL GLOBAL MANAGEMENT, LP | 75K | $1.52M | $207.4K | Added$207.4K |
| JANUS HENDERSON GROUP PLC | 54.8K | $1.11M | — | New |
| TD Asset Management Inc | 47.8K | $971.1K | $102.2K | Added$321.9K |
| WELLINGTON MANAGEMENT GROUP LLP | 46.2K | $939.4K | — | New |
| Bank of New York Mellon Corp | 39.5K | $802.3K | $99.1K | Added$172.5K |
| BNP PARIBAS FINANCIAL MARKETS | 37.3K | $758.3K | $9.55K | Added$697.6K |
| TUDOR INVESTMENT CORP ET AL | 36.7K | $746.9K | $101.6K | Cut−$93.4K |
| MORGAN STANLEY | 30.5K | $620.2K | $64.2K | Added$212.3K |
| Nuveen, LLC | 23.1K | $469.4K | $55.8K | Added$114.6K |
| RHUMBLINE ADVISERS | 20.4K | $414.1K | $37.7K | Added$174.5K |
| Ghisallo Capital Management LLC | 20K | $406.6K | $55.3K | Added$55.3K |
| BANK OF AMERICA CORP /DE/ | 18.9K | $383.6K | $52.2K | Cut−$280.7K |
| MARKET STREET WEALTH MANAGEMENT ADVISORS LLC | 14.1K | $287.1K | — | New |
| TWO SIGMA INVESTMENTS, LP | 14.1K | $286.6K | — | New |
| DEUTSCHE BANK AG\ | 13.7K | $278.1K | $32.9K | Added$68.5K |
| Invesco Ltd. | 12.3K | $249.1K | $33.9K | Added$21.3K |
| Walleye Capital LLC | 11.6K | $235.3K | $32K | Added$30K |
| XTX Topco Ltd | 10.3K | $208.6K | — | New |
| LMR Partners LLP | 10K | $203.3K | $27.6K | Added$27.6K |
| MetLife Investment Management, LLC | 9.8K | $199.2K | $27.1K | Added$27.1K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 9.06K | $184.2K | $21.6K | Added$46.9K |
| Vanguard Global Advisers, LLC | 8.43K | $171.3K | — | Held |
| JPMORGAN CHASE & CO | 7.87K | $147.2K | $7.72K | Added$28.8K |
| WELLS FARGO & COMPANY/MN | 7.16K | $145.6K | $19.8K | Cut−$182.6K |
| BARCLAYS PLC | 5.79K | $117.7K | $16K | Cut−$346.3K |
| NEW YORK STATE COMMON RETIREMENT FUND | 5.3K | $107.7K | $14.7K | Added$14.7K |
| Police & Firemen's Retirement System of New Jersey | 3.99K | $81K | $11K | Added$11K |
| STRS OHIO | 3K | $61K | $8.29K | Added$8.29K |
| T. Rowe Price Investment Management, Inc. | 2.8M | $57K | $7.74K | Added$7.8K |
| Tower Research Capital LLC (TRC) | 1.93K | $39.2K | $5.33K | Cut−$11.2K |
| Legal & General Group Plc | 1.8K | $36.7K | $4.56K | Added$7.73K |
| Ameritas Investment Partners, Inc. | 1.37K | $27.9K | $3.79K | Added$3.79K |
| Russell Investments Group, Ltd. | 1.34K | $27.2K | $3.7K | Added$3.7K |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1.06K | $21.6K | $2.87K | Added$3.32K |
| CITIGROUP INC | 960 | $19.5K | $1.06K | Added$12.8K |
| SBI Securities Co., Ltd. | 557 | $11.3K | $1.54K | Added$662 |
| Sterling Capital Management LLC | 370 | $7.52K | $1.02K | Cut−$1.59K |
| Farther Finance Advisors, LLC | 120 | $2.5K | $392 | Added$392 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 112.7K | $2.29K | — | New |
| GAMMA Investing LLC | 94 | $1.91K | — | New |
| CWM, LLC | 57 | $1.16K | — | New |
| Versant Capital Management, Inc | 50 | $1.02K | — | New |
| Root Financial Partners, LLC | 28 | $569 | — | New |
| MAI Capital Management | 12 | $244 | — | New |
| EverSource Wealth Advisors, LLC | 6 | $122 | — | New |
| Allworth Financial LP | 6 | $122 | — | New |
| True Wealth Design, LLC | 3 | $61 | — | New |
| Arax Advisory Partners | 5 | $20 | — | New |