| NOVO HOLDINGS A/S | 3.69M | $64.8M | — | Held |
| FCPM III SERVICES B.V. | 3.23M | $56.7M | — | Held |
| GOLDMAN SACHS GROUP INC | 1.94M | $34M | — | Held |
| BlackRock, Inc. | 1.1M | $19.2M | — | Held |
| Nan Fung Group Holdings Ltd | 971.3K | $17.1M | — | Held |
| 5AM Venture Management, LLC | 950K | $16.7M | — | Held |
| Sanofi | 912K | $16M | — | Held |
| Vanguard | 869.7K | $15.3M | — | Held |
| Pivotal bioVenture Partners Investment Advisor LLC | 611.4K | $10.7M | — | Held |
| PERCEPTIVE ADVISORS LLC | 550K | $9.66M | — | Held |
| Velan Capital Investment Management LP | 522.3K | $9.17M | — | Held |
| Siren, L.L.C. | 450K | $7.9M | — | Held |
| GEODE CAPITAL MANAGEMENT, LLC | 389K | $6.83M | — | Held |
| Vestal Point Capital, LP | 385K | $6.76M | — | Held |
| BAKER BROS. ADVISORS LP | 364.7K | $6.41M | — | Held |
| Jain Global LLC | 327.7K | $5.76M | — | Held |
| Blue Owl Capital Holdings LP | 327.1K | $5.74M | — | Held |
| State Street | 229.5K | $4.03M | — | Held |
| LAZARD ASSET MANAGEMENT LLC | 207.5K | $3.64M | — | Held |
| Board of Trustees of The Leland Stanford Junior University | 199.2K | $3.5M | — | Held |
| Citadel | 190.1K | $3.34M | — | Held |
| Freestone Grove Partners LP | 183.8K | $3.23M | — | Held |
| Tetragon Partners GP Ltd | 164.5K | $2.89M | — | Held |
| DAFNA Capital Management LLC | 143.8K | $2.53M | — | Held |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 138.4K | $2.43M | — | Held |
| NORTHERN TRUST CORP | 119.6K | $2.1M | — | Held |
| SEVEN GRAND MANAGERS, LLC | 100K | $1.76M | — | Held |
| STEMPOINT CAPITAL LP | 100K | $1.76M | — | Held |
| BURKEHILL GLOBAL MANAGEMENT, LP | 75K | $1.32M | — | Held |
| AMERIPRISE FINANCIAL INC | 66.9K | $1.17M | — | Held |
| DIADEMA PARTNERS LP | 63.8K | $1.12M | — | Held |
| ORBIMED ADVISORS LLC | 56K | $952K | — | Held |
| TUDOR INVESTMENT CORP ET AL | 47.8K | $840.3K | — | New |
| MARSHALL WACE, LLP | 39.7K | $696.8K | — | Held |
| BANK OF AMERICA CORP /DE/ | 37.8K | $664.3K | — | New |
| TD Asset Management Inc | 37K | $649.2K | — | Held |
| Bank of New York Mellon Corp | 35.9K | $629.8K | — | Held |
| BARCLAYS PLC | 26.4K | $464K | — | New |
| MORGAN STANLEY | 23.2K | $407.9K | — | New |
| Persistent Asset Partners Ltd | 21.8K | $382.3K | — | New |
| Nuveen, LLC | 20.2K | $354.8K | — | Held |
| Ghisallo Capital Management LLC | 20K | $351.3K | — | Held |
| WELLS FARGO & COMPANY/MN | 18.7K | $328.2K | — | Held |
| UBS Group AG | 18.3K | $321.3K | — | Held |
| OXFORD ASSET MANAGEMENT LLP | 17.8K | $312K | — | New |
| MILLENNIUM MANAGEMENT LLC | 13.9K | $244.9K | — | Held |
| RHUMBLINE ADVISERS | 13.6K | $239.6K | — | Held |
| Lynx1 Capital Management LP | 13.5K | $236.7K | — | Held |
| Invesco Ltd. | 13K | $227.8K | — | Held |
| DEUTSCHE BANK AG\ | 11.9K | $209.6K | — | Held |
| Walleye Capital LLC | 11.7K | $205.3K | — | Held |
| LMR Partners LLP | 10K | $175.7K | — | Held |
| MetLife Investment Management, LLC | 9.8K | $172.1K | — | Held |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 7.82K | $137.3K | — | Held |
| JPMORGAN CHASE & CO | 6.74K | $118.4K | — | Held |
| NEW YORK STATE COMMON RETIREMENT FUND | 5.3K | $93.1K | — | Held |
| Police & Firemen's Retirement System of New Jersey | 3.99K | $70K | — | Held |
| BNP PARIBAS FINANCIAL MARKETS | 3.46K | $60.7K | — | Held |
| STRS OHIO | 3K | $52.7K | — | Held |
| Tower Research Capital LLC (TRC) | 2.87K | $50.4K | — | Held |
| T. Rowe Price Investment Management, Inc. | 2.8M | $49.2K | — | Held |
| Legal & General Group Plc | 1.65K | $29K | — | Held |
| Ameritas Investment Partners, Inc. | 1.37K | $24.1K | — | Held |
| Russell Investments Group, Ltd. | 1.34K | $23.5K | — | Held |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1.04K | $18.3K | — | Held |
| Fidelity | 904 | $15.9K | — | Held |
| SBI Securities Co., Ltd. | 607 | $10.7K | — | Held |
| ROYAL BANK OF CANADA | 582 | $10K | — | Held |
| Sterling Capital Management LLC | 519 | $9.12K | — | Held |
| Federation des caisses Desjardins du Quebec | 500 | $8.78K | — | Held |
| CITIGROUP INC | 383 | $6.73K | — | Held |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 147.9K | $2.6K | — | Held |
| Farther Finance Advisors, LLC | 120 | $2.11K | — | Held |
| AMALGAMATED BANK | 530 | $9 | — | Held |