| Fidelity | 7.09M | $99.6M | −$9.51M | Cut−$6.83M |
| Fairmount Funds Management LLC | 4.55M | $64M | −$6.28M | Cut−$6.28M |
| RA CAPITAL MANAGEMENT, L.P. | 3.67M | $51.6M | −$5.07M | Cut−$5.07M |
| Bellevue Group AG | 3.5M | $49.2M | −$4.61M | Cut−$2.36M |
| VR ADVISER, LLC | 3.22M | $45.2M | −$4.44M | Cut−$4.44M |
| JANUS HENDERSON GROUP PLC | 3.11M | $43.6M | — | New |
| BlackRock, Inc. | 2.31M | $32.5M | −$3.19M | Cut−$11.8M |
| VANGUARD CAPITAL MANAGEMENT LLC | 1.8M | $25.2M | — | Held |
| BAKER BROS. ADVISORS LP | 1.64M | $23.1M | −$2.26M | Cut−$2.26M |
| Remedium Capital Partners, LLC | 1.58M | $22.2M | $22.1M | Added$22.1M |
| Versant Venture Management, LLC | 1.53M | $21.4M | −$2.11M | Cut−$2.11M |
| Avidity Partners Management LP | 1.4M | $19.7M | −$1.93M | Cut−$1.93M |
| SAMSARA BIOCAPITAL, LLC | 968.8K | $13.6M | −$1.34M | Cut−$1.34M |
| GREAT POINT PARTNERS LLC | 964.5K | $13.6M | −$1.11M | Added$1.11M |
| MARSHALL WACE, LLP | 944.8K | $13.3M | −$1.21M | Cut−$231.4K |
| Aberdeen Group plc | 867.3K | $12.2M | −$1.2M | Cut−$1.2M |
| GEODE CAPITAL MANAGEMENT, LLC | 822.5K | $11.6M | −$1.13M | Cut−$1.43M |
| Soleus Capital Management, L.P. | 796.7K | $11.2M | −$1.1M | Cut−$1.1M |
| ACORN CAPITAL ADVISORS, LLC | 786.8K | $11.1M | — | New |
| State Street | 655.7K | $9.21M | −$887.2K | Cut−$707.8K |
| Affinity Asset Advisors, LLC | 640K | $8.99M | −$883.1K | Cut−$2.04M |
| Driehaus Capital Management LLC | 635.5K | $8.93M | −$877K | Cut−$4.76M |
| RTW INVESTMENTS, LP | 573.2K | $8.05M | −$791K | Cut−$14.3M |
| Ikarian Capital, LLC | 512.3K | $7.2M | −$414K | Added$2.57M |
| Opaleye Management Inc. | 427.6K | $6.01M | −$590.1K | Cut−$590.1K |
| Balyasny Asset Management L.P. | 402.5K | $5.65M | — | New |
| Logos Global Management LP | 400K | $5.62M | −$545.1K | Cut−$474.9K |
| Foresite Capital Management VI LLC | 320K | $4.5M | — | New |
| Point72 Asset Management, L.P. | 264.3K | $3.71M | −$364.8K | Cut−$4.9M |
| NORTHERN TRUST CORP | 241.9K | $3.4M | −$333.8K | Cut−$830.6K |
| VANGUARD FIDUCIARY TRUST CO | 219.5K | $3.08M | — | Held |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 211.3K | $2.97M | — | Held |
| ORBIMED ADVISORS LLC | 185K | $2.6M | −$255.3K | Cut−$5.6M |
| Connor, Clark & Lunn Investment Management Ltd. | 169.1K | $2.38M | −$92.8K | Added$1.34M |
| MILLENNIUM MANAGEMENT LLC | 160.1K | $2.25M | −$86.7K | Added$1.28M |
| STEMPOINT CAPITAL LP | 154K | $2.16M | — | New |
| GOLDMAN SACHS GROUP INC | 153K | $2.15M | −$90.2K | Added$1.14M |
| BOOTHBAY FUND MANAGEMENT, LLC | 140K | $1.97M | −$112K | Added$714.4K |
| Citadel | 137.2K | $1.93M | −$49.8K | Added$1.37M |
| Renaissance Technologies | 135K | $1.9M | −$96K | Added$823.4K |
| WELLINGTON MANAGEMENT GROUP LLP | 129.2K | $1.81M | −$141.6K | Added$231.4K |
| Russell Investments Group, Ltd. | 107.6K | $1.51M | −$8.19K | Added$1.42M |
| Sofinnova Investments, Inc. | 107.4K | $1.51M | −$148.2K | Cut−$148.2K |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 91.6K | $1.29M | −$126.5K | Cut−$653K |
| Bank of New York Mellon Corp | 90K | $1.26M | −$124.2K | Cut−$509K |
| XTX Topco Ltd | 78.1K | $1.1M | −$39.8K | Added$652.7K |
| UBS Group AG | 65K | $913.6K | −$89.7K | Cut−$579.8K |
| MORGAN STANLEY | 50.6K | $710.9K | −$69.8K | Cut−$519.9K |
| ALLIANCEBERNSTEIN L.P. | 45.3K | $699.5K | $0 | Held |
| Nuveen, LLC | 46.2K | $649.6K | −$63.8K | Cut−$1.27M |
| Squarepoint Ops LLC | 44.6K | $627.3K | — | New |
| RHUMBLINE ADVISERS | 40.6K | $569.7K | −$56K | Cut−$202.6K |
| DEUTSCHE BANK AG\ | 39.2K | $550.7K | −$47.5K | Added$19.1K |
| BANK OF AMERICA CORP /DE/ | 38.6K | $542.3K | −$51.8K | Cut−$36.5K |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 39.3K | $520.8K | −$90.1K | Cut−$90.1K |
| AMERICAN CENTURY COMPANIES INC | 33.4K | $468.8K | — | New |
| Quantinno Capital Management LP | 30.6K | $429.2K | −$40.7K | Cut−$25.8K |
| Invesco Ltd. | 29.6K | $415.3K | −$40.8K | Cut−$2.67M |
| BNP PARIBAS FINANCIAL MARKETS | 28.6K | $402.2K | −$13.6K | Added$249.9K |
| Trexquant Investment LP | 28.1K | $394.9K | — | New |
| Y-Intercept (Hong Kong) Ltd | 25.1K | $353.1K | — | New |
| Qube Research & Technologies Ltd | 24.8K | $348.3K | — | New |
| BARCLAYS PLC | 24.7K | $346.5K | −$34K | Cut−$767.5K |
| Vanguard Global Advisers, LLC | 23.7K | $333K | — | Held |
| ADAR1 Capital Management, LLC | 20K | $281K | −$27.6K | Cut−$43K |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 18.3K | $257.2K | — | New |
| TWO SIGMA INVESTMENTS, LP | 18.3K | $256.4K | −$22.8K | Added$1.89K |
| Virtus Investment Advisers, LLC | 18.2K | $255.8K | −$24.5K | Cut−$18.3K |
| MetLife Investment Management, LLC | 17.9K | $252K | −$24.8K | Cut−$150.3K |
| DELTEC ASSET MANAGEMENT LLC | 15.8K | $221.4K | −$21.7K | Cut−$21.7K |
| STATE OF WISCONSIN INVESTMENT BOARD | 15K | $211K | — | New |
| JPMORGAN CHASE & CO | 15.9K | $210.3K | −$34.4K | Cut−$107.5K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 15K | $210.2K | −$20.6K | Cut−$121.9K |
| ExodusPoint Capital Management, LP | 14.1K | $198.5K | −$19.5K | Cut−$4.24M |
| WELLS FARGO & COMPANY/MN | 12K | $169.2K | −$16.6K | Cut−$631.4K |
| Jump Financial, LLC | 11.8K | $165.8K | — | New |
| Police & Firemen's Retirement System of New Jersey | 9.22K | $129.5K | −$12.7K | Cut−$57.1K |
| CITIGROUP INC | 7.62K | $107K | −$1.84K | Added$86.4K |
| NEW YORK STATE COMMON RETIREMENT FUND | 7.42K | $104.3K | −$10.2K | Cut−$121.3K |
| Tower Research Capital LLC (TRC) | 4.95K | $69.6K | −$1.73K | Added$50.3K |
| Legal & General Group Plc | 2.81K | $39.4K | −$3.87K | Cut−$24.3K |
| Ameritas Investment Partners, Inc. | 2.61K | $36.6K | −$3.6K | Cut−$14.5K |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1.73K | $24.4K | −$2.39K | Cut−$19.6K |
| NISA INVESTMENT ADVISORS, LLC | 1.37K | $19.3K | −$650 | Added$12K |
| SUMMIT SECURITIES GROUP LLC | 1.14K | $15.9K | — | New |
| Sterling Capital Management LLC | 1.06K | $14.8K | −$1.46K | Cut−$26.3K |
| Versant Capital Management, Inc | 905 | $12.7K | −$542 | Added$6.65K |
| SIGNATUREFD, LLC | 732 | $10.3K | −$177 | Added$8.31K |
| GAMMA Investing LLC | 662 | $9.3K | −$493 | Added$3.79K |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 493 | $6.93K | −$289 | Added$3.69K |
| Advisory Services Network, LLC | 275 | $3.86K | — | New |
| Larson Financial Group LLC | 104 | $1.46K | −$32 | Added$1.11K |
| Arax Advisory Partners | 104 | $1.46K | −$5 | Added$1.41K |
| Allworth Financial LP | 100 | $1.41K | −$34 | Added$1.03K |
| PNC Financial Services Group, Inc. | 95 | $1.33K | −$128 | Cut−$100 |
| Farther Finance Advisors, LLC | 78 | $1.25K | $46 | Added$62 |
| SIMPLEX TRADING, LLC | 83 | $1.17K | −$81 | Added$256 |
| CWM, LLC | 75 | $1.05K | $547 | Added$1.05K |
| ROYAL BANK OF CANADA | 71 | $1K | −$95 | Cut−$22K |
| OSAIC HOLDINGS, INC. | 48 | $674 | −$1 | Added$659 |
| HRT FINANCIAL LP | 24.4K | $343 | — | New |
| PRICE T ROWE ASSOCIATES INC /MD/ | 22.6K | $318 | −$31 | Cut−$71 |
| GSA CAPITAL PARTNERS LLP | 19.6K | $275 | — | New |
| SBI Securities Co., Ltd. | 18 | $253 | −$19 | Added$37 |
| US BANCORP \DE\ | 15 | $211 | — | New |
| Stone House Investment Management, LLC | 8 | $112 | — | New |
| Owl Creek Wealth Partners LLC | 7 | $99 | — | Held |
| ROTHSCHILD INVESTMENT LLC | 7 | $98 | −$10 | Cut−$41 |
| MAI Capital Management | 6 | $85 | — | New |
| GROUP ONE TRADING LLC | 4 | $56 | −$6 | Cut−$64.7K |
| TFC Financial Management, Inc. | 3 | $43 | −$4 | Cut−$4 |
| JONES FINANCIAL COMPANIES LLLP | 2 | $27 | −$4 | Cut−$4 |
| ASSETMARK, INC | 1 | $14 | −$1 | Cut−$1 |
| Hughes Financial Services, LLC | 1 | $14 | — | New |
| Caitong International Asset Management Co., Ltd | 1 | $14 | — | New |
| EverSource Wealth Advisors, LLC | 1 | $14 | −$1 | Cut−$1.36K |
| Keating Financial Advisory Services, Inc. | 1 | $14 | — | New |
| Root Financial Partners, LLC | 1 | $14 | — | New |
| Avion Wealth | 7 | $0 | $0 | Held |
| Capital Advisors, Ltd. LLC | 6 | $0 | $0 | Held |