| Fidelity | 6.89M | $106.4M | — | Held |
| Fairmount Funds Management LLC | 4.55M | $70.3M | — | Held |
| RA CAPITAL MANAGEMENT, L.P. | 3.67M | $56.6M | — | Held |
| Bellevue Group AG | 3.34M | $51.6M | — | Held |
| VR ADVISER, LLC | 3.22M | $49.7M | — | Held |
| BlackRock, Inc. | 2.87M | $44.3M | — | Held |
| Vanguard | 2.1M | $32.3M | — | Held |
| BAKER BROS. ADVISORS LP | 1.64M | $25.3M | — | Held |
| Versant Venture Management, LLC | 1.53M | $23.5M | — | Held |
| RTW INVESTMENTS, LP | 1.45M | $22.4M | — | Held |
| Avidity Partners Management LP | 1.4M | $21.6M | — | Held |
| SAMSARA BIOCAPITAL, LLC | 968.8K | $14.9M | — | Held |
| Driehaus Capital Management LLC | 887.2K | $13.7M | — | Held |
| MARSHALL WACE, LLP | 875.3K | $13.5M | — | Held |
| Aberdeen Group plc | 867.3K | $13.4M | — | Held |
| GEODE CAPITAL MANAGEMENT, LLC | 841.8K | $13M | — | Held |
| GREAT POINT PARTNERS LLC | 806.3K | $12.4M | — | Held |
| Soleus Capital Management, L.P. | 796.7K | $12.3M | — | Held |
| Affinity Asset Advisors, LLC | 715K | $11M | — | Held |
| State Street | 642.9K | $9.92M | — | Held |
| Point72 Asset Management, L.P. | 558.5K | $8.62M | — | Held |
| ORBIMED ADVISORS LLC | 531.2K | $8.2M | — | Held |
| Opaleye Management Inc. | 427.6K | $6.6M | — | Held |
| Logos Global Management LP | 395K | $6.09M | — | Held |
| Ikarian Capital, LLC | 300K | $4.63M | — | Held |
| Caption Management, LLC | 297.1K | $4.58M | — | Held |
| ExodusPoint Capital Management, LP | 287.6K | $4.44M | — | Held |
| NORTHERN TRUST CORP | 274.1K | $4.23M | — | Held |
| Invesco Ltd. | 199.7K | $3.08M | — | Held |
| AMERIPRISE FINANCIAL INC | 187.3K | $2.89M | — | Held |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 125.8K | $1.94M | — | Held |
| Nuveen, LLC | 124.5K | $1.92M | — | Held |
| Bank of New York Mellon Corp | 114.9K | $1.77M | — | Held |
| Sofinnova Investments, Inc. | 107.4K | $1.66M | — | Held |
| WELLINGTON MANAGEMENT GROUP LLP | 102.6K | $1.58M | — | Held |
| UBS Group AG | 96.8K | $1.49M | — | Held |
| Woodline Partners LP | 82.1K | $1.27M | — | Held |
| BOOTHBAY FUND MANAGEMENT, LLC | 81.1K | $1.25M | — | Held |
| MORGAN STANLEY | 79.8K | $1.23M | $368.8K | Added$762.7K |
| BARCLAYS PLC | 72.2K | $1.11M | $311.2K | Added$719K |
| Renaissance Technologies | 69.6K | $1.07M | — | Held |
| Connor, Clark & Lunn Investment Management Ltd. | 67.2K | $1.04M | — | Held |
| GOLDMAN SACHS GROUP INC | 65.3K | $1.01M | — | Held |
| MILLENNIUM MANAGEMENT LLC | 62.8K | $969.1K | — | Held |
| 9823 Capital, L.P. | 53.2K | $820.7K | — | Held |
| WELLS FARGO & COMPANY/MN | 51.9K | $800.7K | — | Held |
| RHUMBLINE ADVISERS | 50.1K | $772.3K | — | Held |
| ALLIANCEBERNSTEIN L.P. | 45.3K | $699.5K | — | Held |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 39.3K | $611K | — | Held |
| BANK OF AMERICA CORP /DE/ | 37.5K | $578.8K | $99.1K | Added$453K |
| Citadel | 36.1K | $556.3K | — | Held |
| DEUTSCHE BANK AG\ | 34.5K | $531.6K | — | Held |
| Quantinno Capital Management LP | 29.5K | $455.1K | — | Held |
| XTX Topco Ltd | 28.8K | $444.7K | — | Held |
| MetLife Investment Management, LLC | 26.1K | $402.2K | — | Held |
| TUDOR INVESTMENT CORP ET AL | 24.2K | $373.4K | — | New |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 21.5K | $332.1K | — | Held |
| ADAR1 Capital Management, LLC | 21K | $324K | — | Held |
| JPMORGAN CHASE & CO | 20.6K | $317.8K | — | Held |
| Virtus Investment Advisers, LLC | 17.8K | $274K | — | Held |
| TWO SIGMA INVESTMENTS, LP | 16.5K | $254.5K | — | Held |
| DELTEC ASSET MANAGEMENT LLC | 15.8K | $243.1K | — | Held |
| NEW YORK STATE COMMON RETIREMENT FUND | 14.6K | $225.6K | — | Held |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 14K | $216.2K | — | Held |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 21.6K | $212.5K | — | Held |
| Persistent Asset Partners Ltd | 12.5K | $192.4K | — | New |
| Police & Firemen's Retirement System of New Jersey | 12.1K | $186.7K | — | Held |
| INTECH INVESTMENT MANAGEMENT LLC | 11.8K | $182.1K | — | Held |
| BNP PARIBAS FINANCIAL MARKETS | 9.87K | $152.3K | — | Held |
| Russell Investments Group, Ltd. | 5.93K | $91.5K | — | Held |
| GROUP ONE TRADING LLC | 4.2K | $64.7K | — | Held |
| Legal & General Group Plc | 4.13K | $63.7K | — | Held |
| Ameritas Investment Partners, Inc. | 3.31K | $51.1K | — | Held |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 2.85K | $44K | — | Held |
| Sterling Capital Management LLC | 2.67K | $41.2K | — | Held |
| Remedium Capital Partners, LLC | 1.58M | $24.3K | — | Held |
| ROYAL BANK OF CANADA | 1.49K | $23K | — | Held |
| CITIGROUP INC | 1.33K | $20.6K | — | Held |
| Tower Research Capital LLC (TRC) | 1.25K | $19.3K | — | Held |
| STRS OHIO | 900 | $13.9K | — | Held |
| NISA INVESTMENT ADVISORS, LLC | 471 | $7.27K | — | Held |
| Versant Capital Management, Inc | 393 | $6.06K | — | Held |
| GAMMA Investing LLC | 357 | $5.51K | — | Held |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 210 | $3.24K | — | Held |
| SIGNATUREFD, LLC | 128 | $1.98K | — | Held |
| Aster Capital Management (DIFC) Ltd | 95 | $1.47K | — | Held |
| PNC Financial Services Group, Inc. | 93 | $1.44K | — | Held |
| EverSource Wealth Advisors, LLC | 89 | $1.37K | — | Held |
| Farther Finance Advisors, LLC | 77 | $1.19K | — | Held |
| SIMPLEX TRADING, LLC | 59 | $910 | — | Held |
| PRICE T ROWE ASSOCIATES INC /MD/ | 25.2K | $389 | — | Held |
| Allworth Financial LP | 24 | $371 | — | New |
| Larson Financial Group LLC | 23 | $355 | — | Held |
| SBI Securities Co., Ltd. | 14 | $216 | — | Held |
| ROTHSCHILD INVESTMENT LLC | 9 | $139 | — | Held |
| Torren Management, LLC | 5 | $77 | — | Held |
| TFC Financial Management, Inc. | 3 | $47 | — | Held |
| Arax Advisory Partners | 3 | $47 | — | Held |
| JONES FINANCIAL COMPANIES LLLP | 2 | $31 | — | Held |
| AMALGAMATED BANK | 1.45K | $22 | — | Held |
| ASSETMARK, INC | 1 | $15 | — | Held |
| OSAIC HOLDINGS, INC. | 1 | $15 | — | Held |
| CWM, LLC | 39 | $1 | — | Held |
| Capital Advisors, Ltd. LLC | 6 | $0 | — | Held |
| Avion Wealth | 7 | $0 | — | Held |