| SUVRETTA CAPITAL MANAGEMENT, LLC | 6.56M | $74.2M | — | Held |
| RA CAPITAL MANAGEMENT, L.P. | 6.05M | $68.5M | — | Held |
| TCG Crossover Management, LLC | 5.25M | $59.4M | — | Held |
| Nantahala Capital Management, LLC | 4.29M | $48.6M | — | Held |
| BlackRock, Inc. | 4.26M | $48.2M | — | Held |
| Vanguard | 3.56M | $40.3M | — | Held |
| BRAIDWELL LP | 3.06M | $34.6M | — | Held |
| Point72 Asset Management, L.P. | 2.4M | $27.1M | — | Held |
| Siren, L.L.C. | 1.95M | $22.1M | — | Held |
| D. E. Shaw & Co., Inc. | 1.91M | $21.6M | — | Held |
| First Turn Management, LLC | 1.89M | $21.4M | — | Held |
| GSK plc | 1.79M | $20.2M | — | Held |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1.7M | $19.2M | — | Held |
| Ikarian Capital, LLC | 1.38M | $15.6M | — | Held |
| Aberdeen Group plc | 1.25M | $14.2M | — | Held |
| ADAR1 Capital Management, LLC | 1.25M | $14.2M | — | Held |
| Citadel | 1.21M | $13.7M | — | Held |
| GEODE CAPITAL MANAGEMENT, LLC | 1.11M | $12.5M | — | Held |
| DIMENSIONAL FUND ADVISORS LP | 1.05M | $11.9M | — | Held |
| State Street | 1.01M | $11.4M | — | Held |
| Balyasny Asset Management L.P. | 970.4K | $11M | — | Held |
| Vestal Point Capital, LP | 950K | $10.7M | — | Held |
| GREAT POINT PARTNERS LLC | 800K | $9.05M | — | Held |
| Connor, Clark & Lunn Investment Management Ltd. | 582.4K | $6.59M | — | Held |
| NORTHERN TRUST CORP | 552.2K | $6.25M | — | Held |
| BOOTHBAY FUND MANAGEMENT, LLC | 517.5K | $5.85M | — | Held |
| JANE STREET GROUP, LLC | 493.8K | $5.58M | — | Held |
| Invesco Ltd. | 417.2K | $4.72M | — | Held |
| SILVERARC CAPITAL MANAGEMENT, LLC | 394.6K | $4.46M | — | Held |
| Qube Research & Technologies Ltd | 392.5K | $4.44M | — | Held |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 388.9K | $4.4M | — | Held |
| Sio Capital Management, LLC | 382K | $4.32M | — | Held |
| Trexquant Investment LP | 355.5K | $4.02M | — | Held |
| GOLDMAN SACHS GROUP INC | 323.9K | $3.66M | — | Held |
| DEUTSCHE BANK AG\ | 287.1K | $3.25M | — | Held |
| Driehaus Capital Management LLC | 243.4K | $2.75M | — | Held |
| BANK OF AMERICA CORP /DE/ | 231.2K | $2.61M | $310.6K | Added$1.26M |
| Catalio Capital Management, LP | 201.3K | $2.28M | — | Held |
| Nicholas Investment Partners, LP | 183K | $2.07M | — | Held |
| WELLS FARGO & COMPANY/MN | 166.4K | $1.88M | — | Held |
| MORGAN STANLEY | 165.6K | $1.87M | $349.5K | Cut−$370.1K |
| Simplify Asset Management Inc. | 159.7K | $1.81M | — | Held |
| AMERICAN CENTURY COMPANIES INC | 157.7K | $1.78M | — | Held |
| WELLINGTON MANAGEMENT GROUP LLP | 146.4K | $1.66M | — | Held |
| SummitTX Capital, L.P. | 138.1K | $1.56M | — | Held |
| Fiduciary Trust Co | 136.6K | $1.54M | — | Held |
| BARCLAYS PLC | 132.5K | $1.5M | $189.1K | Added$674.6K |
| Bank of New York Mellon Corp | 116.9K | $1.32M | — | Held |
| Nuveen, LLC | 112.2K | $1.27M | — | Held |
| Walleye Capital LLC | 108.4K | $1.23M | — | Held |
| UBS Group AG | 103K | $1.16M | — | Held |
| MARSHALL WACE, LLP | 102.9K | $1.16M | — | Held |
| AMERIPRISE FINANCIAL INC | 100.7K | $1.14M | — | Held |
| Maven Securities LTD | 100K | $1.13M | — | Held |
| PRINCIPAL FINANCIAL GROUP INC | 97.7K | $1.1M | — | Held |
| Jump Financial, LLC | 92.2K | $1.04M | — | Held |
| Exome Asset Management LLC | 92.1K | $1.04M | — | Held |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 87.9K | $994.5K | — | Held |
| STATE OF WISCONSIN INVESTMENT BOARD | 86.5K | $978.3K | — | Held |
| RBF Capital, LLC | 80.5K | $910.5K | — | Held |
| Verition Fund Management LLC | 74.7K | $844.8K | — | Held |
| SUPERSTRING CAPITAL MANAGEMENT LP | 72.1K | $815K | — | Held |
| CITIGROUP INC | 67.1K | $758.9K | — | Held |
| Y-Intercept (Hong Kong) Ltd | 66.7K | $754.6K | — | Held |
| Legato Capital Management LLC | 66.3K | $750.4K | — | Held |
| Squarepoint Ops LLC | 65.9K | $744.8K | — | Held |
| Integrated Quantitative Investments LLC | 62.5K | $707.1K | — | Held |
| Informed Momentum Co LLC | 61.6K | $696.9K | — | Held |
| Atom Investors LP | 60.6K | $685.3K | — | Held |
| NEW YORK STATE COMMON RETIREMENT FUND | 57.7K | $652.9K | — | Held |
| RHUMBLINE ADVISERS | 55.7K | $630.1K | — | Held |
| MILLENNIUM MANAGEMENT LLC | 54.4K | $615.6K | — | Held |
| XTX Topco Ltd | 51.8K | $585.9K | — | Held |
| KVP Capital Advisors, LP | 50K | $565.5K | — | Held |
| BURKEHILL GLOBAL MANAGEMENT, LP | 50K | $565.5K | — | Held |
| SEVEN GRAND MANAGERS, LLC | 50K | $565.5K | — | Held |
| Brevan Howard Capital Management LP | 48.9K | $559.4K | — | Held |
| STRS OHIO | 49.3K | $557.6K | — | Held |
| Graham Capital Management, L.P. | 48.5K | $548.1K | — | Held |
| FRANKLIN RESOURCES INC | 44.2K | $500.5K | — | Held |
| HSBC HOLDINGS PLC | 43.3K | $497.9K | — | Held |
| Jain Global LLC | 41.3K | $466.7K | — | Held |
| COMMONWEALTH EQUITY SERVICES, LLC | 40K | $452.4K | — | Held |
| SEI INVESTMENTS CO | 37.5K | $424.2K | — | Held |
| Campbell & CO Investment Adviser LLC | 35.6K | $402.6K | — | Held |
| GROUP ONE TRADING LLC | 34.8K | $393K | — | Held |
| AXQ CAPITAL, LP | 31.5K | $356.8K | — | Held |
| Woodline Partners LP | 30.8K | $348.3K | — | Held |
| TWO SIGMA ADVISERS, LP | 30.5K | $345K | — | Held |
| COUNTRY TRUST BANK | 30K | $339.8K | — | Held |
| LMR Partners LLP | 30K | $339.3K | — | Held |
| Quantinno Capital Management LP | 29.3K | $331K | — | Held |
| PRELUDE CAPITAL MANAGEMENT, LLC | 28.8K | $326.1K | — | Held |
| FOX RUN MANAGEMENT, L.L.C. | 25.6K | $289.2K | — | Held |
| MetLife Investment Management, LLC | 22.7K | $256.9K | — | Held |
| Creative Planning | 22.1K | $250K | — | Held |
| JPMORGAN CHASE & CO | 20.8K | $235.1K | — | Held |
| Virtus Investment Advisers, LLC | 20.5K | $231.4K | — | Held |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 20K | $226.4K | — | Held |
| INTECH INVESTMENT MANAGEMENT LLC | 19.7K | $223.3K | — | Held |
| Renaissance Technologies | 17.4K | $196.8K | — | Held |
| Quarry LP | 17.2K | $194.1K | — | Held |
| Schonfeld Strategic Advisors LLC | 16.8K | $189.9K | — | Held |
| Legal & General Group Plc | 16.4K | $185.2K | — | Held |
| Icahn Capital | 15.5K | $175.3K | — | Held |
| ALLIANCEBERNSTEIN L.P. | 15.3K | $172.7K | — | Held |
| Man Group plc | 15.3K | $172.5K | — | Held |
| EntryPoint Capital, LLC | 15.1K | $170.5K | — | Held |
| WINTON GROUP Ltd | 14.3K | $161.7K | — | Held |
| Alphabet Inc. | 14.3K | $161.3K | — | Held |
| Matisse Capital | 13.5K | $152.2K | — | Held |
| Vanguard Personalized Indexing Management, LLC | 13.2K | $148.8K | — | Held |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 12.9K | $145.7K | — | Held |
| Police & Firemen's Retirement System of New Jersey | 12.8K | $145.3K | — | Held |
| Entropy Technologies, LP | 12K | $135.7K | — | Held |
| BAILARD, INC. | 11.8K | $133.2K | — | Held |
| BNP PARIBAS FINANCIAL MARKETS | 10.5K | $119K | — | Held |
| ProShare Advisors LLC | 10.3K | $116K | — | Held |
| AlphaQuest LLC | 9.66K | $109.2K | — | Held |
| China Universal Asset Management Co., Ltd. | 8.82K | $99.7K | — | Held |
| ASSETMARK, INC | 8.18K | $92.6K | — | Held |
| SIMPLEX TRADING, LLC | 8.01K | $90.6K | — | Held |
| Fidelity | 7.69K | $87K | — | Held |
| Persistent Asset Partners Ltd | 6.62K | $74.8K | — | New |
| ROYAL BANK OF CANADA | 4.11K | $47K | — | Held |
| NISA INVESTMENT ADVISORS, LLC | 3.6K | $40.7K | — | Held |
| Ameritas Investment Partners, Inc. | 3.6K | $40.7K | — | Held |
| Russell Investments Group, Ltd. | 3.57K | $40.4K | — | Held |
| MEEDER ASSET MANAGEMENT INC | 3.48K | $39.3K | — | Held |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 2.65K | $30K | — | Held |
| Mirae Asset Global Investments Co., Ltd. | 2.63K | $29.7K | — | Held |
| Sterling Capital Management LLC | 2.33K | $26.4K | — | Held |
| Farther Finance Advisors, LLC | 2.19K | $24.8K | — | Held |
| Versant Capital Management, Inc | 1.8K | $20.4K | — | Held |
| Tower Research Capital LLC (TRC) | 1.62K | $18.4K | — | Held |
| PNC Financial Services Group, Inc. | 1.44K | $16.3K | — | Held |
| GF FUND MANAGEMENT CO. LTD. | 1.06K | $12K | — | Held |
| IFP Advisors, Inc | 988 | $11.2K | $2.08K | Cut−$7K |
| ACADIAN ASSET MANAGEMENT LLC | 736.7K | $8.33K | — | Held |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 709 | $8.02K | — | Held |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 915 | $7.87K | — | Held |
| Aster Capital Management (DIFC) Ltd | 623 | $7.05K | — | Held |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 472 | $5.34K | — | Held |
| NATIONAL BANK OF CANADA /FI/ | 443 | $5K | — | Held |
| FEDERATED HERMES, INC. | 328 | $3.71K | — | Held |
| Optiver Holding B.V. | 322 | $3.64K | — | Held |
| COMERICA BANK | 287 | $3.25K | — | Held |
| BESSEMER GROUP INC | 287K | $3.25K | — | Held |
| Physician Wealth Advisors, Inc. | 283 | $3.2K | — | Held |
| Rockefeller Capital Management L.P. | 224 | $2.53K | — | Held |
| EverSource Wealth Advisors, LLC | 207 | $2.34K | — | Held |
| Arax Advisory Partners | 181 | $2.05K | — | Held |
| Rialto Wealth Management, LLC | 159 | $1.8K | — | Held |
| Altshuler Shaham Ltd | 100 | $1.13K | — | Held |
| GSA CAPITAL PARTNERS LLP | 99.7K | $1.13K | — | Held |
| OSAIC HOLDINGS, INC. | 90 | $1.02K | — | Held |
| SIGNATUREFD, LLC | 68 | $769 | — | Held |
| PRICE T ROWE ASSOCIATES INC /MD/ | 63.8K | $722 | — | Held |
| DekaBank Deutsche Girozentrale | 60K | $617 | — | Held |
| Caitong International Asset Management Co., Ltd | 41 | $464 | — | Held |
| GAMMA Investing LLC | 25 | $283 | — | Held |
| Keating Financial Advisory Services, Inc. | 24 | $271 | — | Held |
| True Wealth Design, LLC | 16 | $181 | — | Held |
| SG Americas Securities, LLC | 11.8K | $133 | — | Held |
| MAI Capital Management | 10 | $114 | — | Held |
| ROTHSCHILD INVESTMENT LLC | 8 | $90 | — | Held |
| SBI Securities Co., Ltd. | 4 | $45 | — | Held |
| SJS Investment Consulting Inc. | 3 | $34 | — | Held |
| AMALGAMATED BANK | 1.35K | $15 | — | Held |
| Essential Partners LLC | 1 | $11 | $2 | Added$2 |
| CWM, LLC | 372 | $4 | — | Held |
| Daiwa Securities Group Inc. | 180 | $2 | — | Held |