| ORBIMED ADVISORS LLC | 15.5M | $385.1M | — | Held |
| RA CAPITAL MANAGEMENT, L.P. | 10.4M | $258.8M | — | Held |
| BlackRock, Inc. | 6.63M | $164.5M | — | Held |
| BAKER BROS. ADVISORS LP | 6.58M | $163.2M | — | Held |
| Paradigm Biocapital Advisors LP | 6.54M | $162.3M | — | Held |
| NOVO HOLDINGS A/S | 5.35M | $132.8M | — | Held |
| BRAIDWELL LP | 5.21M | $129.3M | — | Held |
| Vanguard | 4.87M | $120.9M | — | Held |
| JANUS HENDERSON GROUP PLC | 4.57M | $113.3M | — | Held |
| Siren, L.L.C. | 4.53M | $112.4M | — | Held |
| PERCEPTIVE ADVISORS LLC | 4.46M | $110.6M | — | Held |
| Driehaus Capital Management LLC | 4.19M | $104M | — | Held |
| Cormorant Asset Management, LP | 3.29M | $81.5M | — | Held |
| MORGAN STANLEY | 2.91M | $72.2M | $7.47M | Added$58.1M |
| UBS Group AG | 2.12M | $52.5M | — | Held |
| GEODE CAPITAL MANAGEMENT, LLC | 1.75M | $43.3M | — | Held |
| State Street | 1.72M | $42.6M | — | Held |
| MPM BIOIMPACT LLC | 1.66M | $41.1M | — | Held |
| First Light Asset Management, LLC | 1.57M | $39.1M | — | Held |
| Bellevue Group AG | 1.53M | $37.9M | — | Held |
| Integral Health Asset Management, LLC | 1.5M | $37.2M | — | Held |
| BANK OF AMERICA CORP /DE/ | 1.47M | $36.6M | $2.76M | Added$31.4M |
| DIMENSIONAL FUND ADVISORS LP | 1.21M | $30.1M | — | Held |
| AMERICAN CENTURY COMPANIES INC | 1.19M | $29.4M | — | Held |
| ALLIANCEBERNSTEIN L.P. | 1.04M | $25.7M | — | Held |
| Soleus Capital Management, L.P. | 910K | $22.6M | — | Held |
| Aberdeen Group plc | 821.9K | $20.4M | — | Held |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 765.7K | $19M | — | Held |
| NORGES BANK | 751.4K | $18.6M | $134.4K | Added$17.6M |
| VICTORY CAPITAL MANAGEMENT INC | 746.6K | $18.5M | — | Held |
| GOLDMAN SACHS GROUP INC | 718.4K | $17.8M | — | Held |
| Artisan Partners Limited Partnership | 704.1K | $17.5M | — | Held |
| Fidelity | 693K | $17.2M | — | Held |
| MARSHALL WACE, LLP | 681.9K | $16.9M | — | Held |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 640.4K | $15.9M | — | Held |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 611.4K | $15.2M | — | Held |
| EVENTIDE ASSET MANAGEMENT, LLC | 568.3K | $14.1M | — | Held |
| NORTHERN TRUST CORP | 559.6K | $13.9M | — | Held |
| Candriam S.C.A. | 501.2K | $12.4M | — | Held |
| Opaleye Management Inc. | 500K | $12.4M | — | Held |
| Sofinnova Investments, Inc. | 437.8K | $10.9M | — | Held |
| Parkman Healthcare Partners LLC | 427.7K | $10.6M | — | Held |
| D. E. Shaw & Co., Inc. | 394.7K | $9.79M | — | Held |
| BARCLAYS PLC | 372.7K | $9.25M | $2.02M | Added$5.44M |
| STEMPOINT CAPITAL LP | 360.9K | $8.96M | — | Held |
| Squadron Capital Management LLC | 350K | $8.69M | — | Held |
| Eversept Partners, LP | 337.3K | $8.37M | — | Held |
| Qube Research & Technologies Ltd | 296.2K | $7.35M | — | Held |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 271.4K | $6.73M | — | Held |
| KENNEDY CAPITAL MANAGEMENT LLC | 241.5K | $5.99M | — | Held |
| Sio Capital Management, LLC | 237.5K | $5.89M | — | Held |
| Granahan Investment Management, LLC | 232.3K | $5.76M | — | Held |
| Woodline Partners LP | 224.2K | $5.56M | — | Held |
| CITIGROUP INC | 223.3K | $5.54M | — | Held |
| DEUTSCHE BANK AG\ | 214.8K | $5.33M | — | Held |
| AMERIPRISE FINANCIAL INC | 202.3K | $5.02M | — | Held |
| Bank of New York Mellon Corp | 198.6K | $4.93M | — | Held |
| Ally Bridge Group (NY) LLC | 195K | $4.84M | — | Held |
| HighVista Strategies LLC | 171.1K | $4.25M | — | Held |
| Nuveen, LLC | 169.5K | $4.21M | — | Held |
| DAFNA Capital Management LLC | 159.7K | $3.96M | — | Held |
| Balyasny Asset Management L.P. | 151.9K | $3.77M | — | Held |
| JPMORGAN CHASE & CO | 146K | $3.62M | — | Held |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 145.3K | $3.57M | — | Held |
| KVP Capital Advisors, LP | 133K | $3.3M | — | Held |
| NEUBERGER BERMAN GROUP LLC | 127.1K | $3.15M | — | Held |
| MILLENNIUM MANAGEMENT LLC | 126.4K | $3.14M | — | Held |
| Citadel | 123.1K | $3.05M | — | Held |
| Jain Global LLC | 113.9K | $2.83M | — | Held |
| WELLINGTON MANAGEMENT GROUP LLP | 111.4K | $2.76M | — | Held |
| Quantum Private Wealth, LLC | 106K | $2.63M | — | Held |
| Swiss National Bank | 103.9K | $2.58M | — | Held |
| Exome Asset Management LLC | 100K | $2.48M | — | Held |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 98.1K | $2.43M | — | Held |
| ADAR1 Capital Management, LLC | 91K | $2.26M | — | Held |
| NEW YORK STATE COMMON RETIREMENT FUND | 88.9K | $2.21M | — | Held |
| ALPS ADVISORS INC | 86.9K | $2.16M | — | Held |
| RHUMBLINE ADVISERS | 85.1K | $2.11M | — | Held |
| FEDERATED HERMES, INC. | 82.1K | $2.04M | — | Held |
| Jump Financial, LLC | 79.9K | $1.98M | — | Held |
| WELLS FARGO & COMPANY/MN | 75.4K | $1.87M | — | Held |
| Invesco Ltd. | 75.4K | $1.87M | — | Held |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 70.2K | $1.74M | — | Held |
| Schonfeld Strategic Advisors LLC | 59.3K | $1.47M | — | Held |
| Ishara Investments LP | 58K | $1.44M | — | Held |
| XTX Topco Ltd | 55.6K | $1.38M | — | Held |
| HighMark Wealth Management LLC | 53.2K | $1.32M | — | Held |
| Legal & General Group Plc | 52.7K | $1.31M | — | Held |
| TWO SIGMA INVESTMENTS, LP | 50.8K | $1.26M | — | Held |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 50.4K | $1.25M | — | Held |
| FRANKLIN RESOURCES INC | 43.1K | $1.07M | — | Held |
| Moody Aldrich Partners LLC | 43.1K | $1.07M | — | Held |
| SILVERARC CAPITAL MANAGEMENT, LLC | 42.1K | $1.04M | — | Held |
| PRELUDE CAPITAL MANAGEMENT, LLC | 41.6K | $1.03M | — | Held |
| STATE OF WISCONSIN INVESTMENT BOARD | 40K | $992.5K | — | Held |
| VOYA INVESTMENT MANAGEMENT LLC | 39.6K | $983.9K | — | Held |
| Knights of Columbus Asset Advisors LLC | 38.7K | $959.7K | — | Held |
| ORACLE INVESTMENT MANAGEMENT INC | 38.3K | $951.5K | — | Held |
| MetLife Investment Management, LLC | 38.3K | $950.2K | — | Held |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 36.8K | $912.2K | — | Held |
| Verition Fund Management LLC | 33.6K | $833.6K | — | Held |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 31.4K | $778.4K | — | Held |
| SEI INVESTMENTS CO | 31.3K | $775.5K | — | Held |
| INTECH INVESTMENT MANAGEMENT LLC | 30.4K | $754.1K | — | Held |
| Elmind Capital, LP | 30K | $744.5K | — | Held |
| DIADEMA PARTNERS LP | 30K | $744.5K | — | Held |
| Optimize Financial Inc | 27.7K | $686.9K | — | Held |
| Creative Planning | 24.5K | $607.2K | — | Held |
| RAYMOND JAMES FINANCIAL INC | 21.6K | $536.2K | — | Held |
| Persistent Asset Partners Ltd | 21.2K | $526.2K | — | New |
| LMR Partners LLP | 20K | $496.3K | — | Held |
| Police & Firemen's Retirement System of New Jersey | 18.9K | $468.1K | — | Held |
| Y-Intercept (Hong Kong) Ltd | 18.7K | $463.3K | — | Held |
| State of New Jersey Common Pension Fund D | 18K | $446.1K | — | Held |
| China Universal Asset Management Co., Ltd. | 17.3K | $428.1K | — | Held |
| BNP PARIBAS FINANCIAL MARKETS | 17.1K | $423.4K | — | Held |
| ProShare Advisors LLC | 17K | $421.3K | — | Held |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 16.9K | $418.6K | — | Held |
| ARIZONA STATE RETIREMENT SYSTEM | 14.9K | $370.7K | — | Held |
| AlphaCentric Advisors LLC | 14.7K | $364.9K | — | Held |
| WINTON GROUP Ltd | 14.2K | $352K | — | Held |
| Icahn Capital | 13.7K | $341.1K | — | Held |
| Centiva Capital, LP | 12.5K | $310.2K | — | Held |
| FOX RUN MANAGEMENT, L.L.C. | 12.4K | $306.7K | — | Held |
| PROFUND ADVISORS LLC | 11.8K | $293.4K | — | Held |
| Odyssean, LLC | 11.8K | $291.7K | — | Held |
| KLP KAPITALFORVALTNING AS | 11.3K | $280.4K | — | Held |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 11.3K | $279.5K | — | Held |
| Virtus Investment Advisers, LLC | 11.3K | $279.5K | — | Held |
| GUGGENHEIM CAPITAL LLC | 10.6K | $262.4K | — | Held |
| ROYAL BANK OF CANADA | 10.2K | $253K | — | Held |
| VARCOV Co. | 10K | $249K | — | Held |
| SFMG, LLC | 10K | $248.2K | — | Held |
| NOMURA HOLDINGS INC | 10K | $248.2K | — | Held |
| Rafferty Asset Management, LLC | 9.85K | $244.4K | — | Held |
| Connecticut Capital Management Group, LLC | 9.84K | $244.2K | — | Held |
| Graham Capital Management, L.P. | 9.47K | $234.9K | — | Held |
| Lion Point Capital, LP | 9.1K | $225.8K | — | Held |
| SIMPLEX TRADING, LLC | 9.07K | $225K | — | Held |
| AlphaQuest LLC | 7.14K | $177.3K | — | Held |
| Russell Investments Group, Ltd. | 6.49K | $161.2K | — | Held |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 8.18K | $152.7K | — | Held |
| Quarry LP | 5.8K | $143.9K | — | Held |
| Ameritas Investment Partners, Inc. | 5.64K | $139.9K | — | Held |
| Mirae Asset Global Investments Co., Ltd. | 5.14K | $127.7K | — | Held |
| CANADA PENSION PLAN INVESTMENT BOARD | 3.9K | $96.8K | — | Held |
| Steward Partners Investment Advisory, LLC | 2.85K | $70.8K | — | Held |
| GF FUND MANAGEMENT CO. LTD. | 2.08K | $51.6K | — | Held |
| Seven Fleet Capital Management LP | 2K | $49.6K | — | Held |
| Tower Research Capital LLC (TRC) | 1.61K | $40K | — | Held |
| US BANCORP \DE\ | 1.56K | $38.8K | — | Held |
| GAMMA Investing LLC | 1.35K | $33.6K | — | Held |
| NISA INVESTMENT ADVISORS, LLC | 1.16K | $28.8K | — | Held |
| Quantbot Technologies LP | 774 | $19.2K | — | Held |
| Caitong International Asset Management Co., Ltd | 710 | $17.6K | — | Held |
| Farther Finance Advisors, LLC | 659 | $16.4K | — | Held |
| Parallel Advisors, LLC | 626 | $15.5K | — | Held |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 489 | $12.1K | — | Held |
| Sterling Capital Management LLC | 448 | $11.1K | — | Held |
| OSAIC HOLDINGS, INC. | 408 | $10.1K | — | Held |
| SIGNATUREFD, LLC | 363 | $9.01K | — | Held |
| MassMutual Private Wealth & Trust, FSB | 294 | $7.3K | — | Held |
| Larson Financial Group LLC | 225 | $5.58K | — | Held |
| EASTERN BANK | 223 | $5.53K | — | Held |
| SBI Securities Co., Ltd. | 207 | $5.14K | — | Held |
| Rockefeller Capital Management L.P. | 182 | $4.52K | — | Held |
| Smartleaf Asset Management LLC | 173 | $4.25K | — | Held |
| Optiver Holding B.V. | 161 | $4K | — | Held |
| Fortitude Family Office, LLC | 160 | $3.97K | — | Held |
| EverSource Wealth Advisors, LLC | 156 | $3.87K | — | Held |
| Aster Capital Management (DIFC) Ltd | 152 | $3.77K | — | Held |
| ROTHSCHILD INVESTMENT LLC | 135 | $3.35K | — | Held |
| BFSG, LLC | 100 | $2.48K | — | Held |
| Versant Capital Management, Inc | 95 | $2.36K | — | Held |
| SG Americas Securities, LLC | 88.7K | $2.2K | — | Held |
| Arax Advisory Partners | 87 | $2.16K | — | Held |
| PNC Financial Services Group, Inc. | 75 | $1.86K | — | Held |
| DekaBank Deutsche Girozentrale | 80K | $1.56K | — | Held |
| PRICE T ROWE ASSOCIATES INC /MD/ | 57.3K | $1.42K | — | Held |
| Allworth Financial LP | 56 | $1.39K | $283 | Added$854 |
| COMERICA BANK | 35 | $890 | — | Held |
| Parkside Financial Bank & Trust | 35 | $869 | — | Held |
| Handelsbanken Fonder AB | 31.1K | $772 | — | Held |
| Bare Financial Services, Inc | 18 | $447 | — | Held |
| GSA CAPITAL PARTNERS LLP | 14.1K | $350 | — | Held |
| SageView Advisory Group, LLC | 11 | $273 | — | Held |
| CIBC Private Wealth Group LLC | 4 | $99 | — | Held |
| IFP Advisors, Inc | 4 | $99 | $34 | Added$34 |
| Cygnus Capital Advisors, LLC | 3.43K | $85 | — | Held |
| Essential Partners LLC | 3 | $74 | — | New |
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO | 2.85K | $71 | — | Held |
| BESSEMER GROUP INC | 2.35K | $58 | — | Held |
| AMALGAMATED BANK | 2.12K | $53 | — | Held |
| ACADIAN ASSET MANAGEMENT LLC | 1.73K | $42 | — | Held |
| Winthrop Capital Management, LLC | 1.38K | $34 | — | Held |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 728 | $18 | — | Held |
| Daiwa Securities Group Inc. | 344 | $9 | — | Held |
| CWM, LLC | 279 | $7 | — | Held |
| Covestor Ltd | 8 | $0 | — | Held |