| EQT Fund Management S.a r.l. | 4.93M | $84.4M | — | Held |
| RA CAPITAL MANAGEMENT, L.P. | 3.46M | $59.2M | — | Held |
| Pivotal bioVenture Partners Investment Advisor LLC | 1.93M | $33M | — | Held |
| ANDERA PARTNERS | 1.9M | $32.5M | — | Held |
| Nan Fung Group Holdings Ltd | 1.44M | $24.7M | — | Held |
| JPMORGAN CHASE & CO | 1.31M | $22.4M | — | Held |
| RTW INVESTMENTS, LP | 1.28M | $22M | — | Held |
| SymBiosis Capital Partners, LLC | 1.28M | $21.9M | — | Held |
| MARSHALL WACE, LLP | 988.2K | $16.9M | — | Held |
| EVENTIDE ASSET MANAGEMENT, LLC | 961.5K | $16.5M | — | Held |
| SECTORAL ASSET MANAGEMENT INC | 589K | $10.1M | — | Held |
| Verition Fund Management LLC | 565.2K | $9.68M | — | Held |
| Aberdeen Group plc | 525.4K | $8.99M | — | Held |
| Velan Capital Investment Management LP | 506.8K | $8.68M | — | Held |
| Vanguard | 502.6K | $8.6M | — | Held |
| Octagon Capital Advisors LP | 500K | $8.56M | — | Held |
| AMERICAN CENTURY COMPANIES INC | 417.5K | $7.15M | — | Held |
| FEDERATED HERMES, INC. | 325K | $5.56M | — | Held |
| GREAT POINT PARTNERS LLC | 325K | $5.56M | — | Held |
| NEXTBio Capital Management LP | 228.3K | $3.91M | — | Held |
| Defilade Capital Management, L.P. | 215.4K | $3.69M | — | Held |
| Kynam Capital Management, LP | 185.5K | $3.18M | — | Held |
| ADAR1 Capital Management, LLC | 184.1K | $3.15M | — | Held |
| Monashee Investment Management LLC | 183.2K | $3.14M | — | Held |
| SPHERA FUNDS MANAGEMENT LTD. | 166.1K | $2.84M | — | Held |
| Sofinnova Investments, Inc. | 153.3K | $2.62M | — | Held |
| BlackRock, Inc. | 142.4K | $2.44M | — | Held |
| Integral Health Asset Management, LLC | 125K | $2.14M | — | Held |
| MPM BIOIMPACT LLC | 113K | $1.93M | — | Held |
| GEODE CAPITAL MANAGEMENT, LLC | 109.8K | $1.88M | — | Held |
| AMERIPRISE FINANCIAL INC | 104.6K | $1.79M | — | Held |
| SEVEN GRAND MANAGERS, LLC | 75K | $1.28M | — | Held |
| STEMPOINT CAPITAL LP | 68.2K | $1.17M | — | Held |
| Balyasny Asset Management L.P. | 65K | $1.11M | — | Held |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 62.7K | $1.07M | — | Held |
| GOLDMAN SACHS GROUP INC | 61.7K | $1.06M | — | Held |
| Capricorn Fund Managers Ltd | 60K | $1.03M | — | Held |
| Citadel | 50.6K | $865.6K | — | Held |
| BURKEHILL GLOBAL MANAGEMENT, LP | 50K | $856K | — | Held |
| TD Asset Management Inc | 44.6K | $764.1K | — | Held |
| Point72 Asset Management, L.P. | 34.4K | $588.7K | — | Held |
| TUDOR INVESTMENT CORP ET AL | 32K | $547K | — | New |
| State Street | 31.5K | $539.3K | — | Held |
| Qube Research & Technologies Ltd | 24.1K | $411.9K | — | Held |
| NORTHERN TRUST CORP | 22.6K | $387.5K | — | Held |
| TWO SIGMA INVESTMENTS, LP | 21.3K | $365.1K | — | Held |
| OXFORD ASSET MANAGEMENT LLP | 19.6K | $335K | — | New |
| XTX Topco Ltd | 18.8K | $321.5K | — | Held |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 10.2K | $179.1K | — | Held |
| MORGAN STANLEY | 8.35K | $142.9K | — | New |
| UBS Group AG | 3.41K | $58.4K | — | Held |
| BANK OF AMERICA CORP /DE/ | 2.94K | $50.3K | — | New |
| Tower Research Capital LLC (TRC) | 2.75K | $47K | — | Held |
| NATIONAL BANK OF CANADA /FI/ | 2.2K | $37.5K | — | Held |
| China Universal Asset Management Co., Ltd. | 2K | $34.2K | — | Held |
| PRICE T ROWE ASSOCIATES INC /MD/ | 782.1K | $13.4K | — | Held |
| ROYAL BANK OF CANADA | 585 | $10K | — | Held |
| Legal & General Group Plc | 400 | $6.85K | — | Held |
| COMERICA BANK | 20 | $330 | — | Held |