| BVF INC/IL | 1.36M | $24.6M | — | Held |
| Nantahala Capital Management, LLC | 1.24M | $22.4M | — | Held |
| ORBIMED ADVISORS LLC | 1.19M | $21.6M | — | Held |
| Affinity Asset Advisors, LLC | 1.05M | $19.1M | — | Held |
| Caligan Partners LP | 881.5K | $16M | — | Held |
| Vanguard | 804.1K | $14.6M | — | Held |
| RA CAPITAL MANAGEMENT, L.P. | 663K | $12M | — | Held |
| MILLENNIUM MANAGEMENT LLC | 660K | $12M | — | Held |
| Point72 Asset Management, L.P. | 627.5K | $11.4M | — | Held |
| BANK OF AMERICA CORP /DE/ | 621.4K | $11.3M | $3.3M | Added$3.58M |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 550K | $9.99M | — | Held |
| SILVERARC CAPITAL MANAGEMENT, LLC | 524.4K | $9.52M | — | Held |
| MARSHALL WACE, LLP | 507.6K | $9.22M | — | Held |
| Commodore Capital LP | 483K | $8.77M | — | Held |
| TCG Crossover Management, LLC | 483K | $8.77M | — | Held |
| UBS Group AG | 477.8K | $8.68M | — | Held |
| JENNISON ASSOCIATES LLC | 475.6K | $8.64M | — | Held |
| Soleus Capital Management, L.P. | 442K | $8.03M | — | Held |
| Balyasny Asset Management L.P. | 439.3K | $7.98M | — | Held |
| Citadel | 419.5K | $7.62M | — | Held |
| Patient Square Capital LP | 312K | $5.67M | — | Held |
| BlackRock, Inc. | 289.6K | $5.26M | — | Held |
| Boxer Capital Management, LLC | 275K | $4.99M | $681.2K | Added$3.41M |
| MORGAN STANLEY | 264.9K | $4.81M | $55 | Added$4.81M |
| Velan Capital Investment Management LP | 263.6K | $4.79M | — | Held |
| Fidelity | 220.3K | $4M | — | Held |
| AMERIPRISE FINANCIAL INC | 218K | $3.96M | — | Held |
| Jain Global LLC | 217.3K | $3.95M | — | Held |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 211K | $3.83M | — | Held |
| BOOTHBAY FUND MANAGEMENT, LLC | 202.1K | $3.67M | — | Held |
| BNP PARIBAS FINANCIAL MARKETS | 197.7K | $3.59M | — | Held |
| SummitTX Capital, L.P. | 195.9K | $3.56M | — | Held |
| NAN FUNG TRINITY (HK) LTD | 189K | $3.43M | — | Held |
| JANE STREET GROUP, LLC | 178.9K | $3.25M | — | Held |
| GEODE CAPITAL MANAGEMENT, LLC | 166.2K | $3.02M | — | Held |
| SUPERSTRING CAPITAL MANAGEMENT LP | 153.3K | $2.78M | — | Held |
| DEUTSCHE BANK AG\ | 150K | $2.72M | — | Held |
| TWO SIGMA INVESTMENTS, LP | 148.2K | $2.69M | — | Held |
| PERCEPTIVE ADVISORS LLC | 139.7K | $2.54M | — | Held |
| STEMPOINT CAPITAL LP | 135.6K | $2.46M | — | Held |
| Moody Aldrich Partners LLC | 133.2K | $2.42M | — | Held |
| Squadron Capital Management LLC | 130K | $2.36M | — | Held |
| GREAT POINT PARTNERS LLC | 124.7K | $2.26M | — | Held |
| BARCLAYS PLC | 105.8K | $1.92M | $50.9K | Added$1.8M |
| HighVista Strategies LLC | 95.6K | $1.74M | — | Held |
| Aberdeen Group plc | 95.4K | $1.73M | — | Held |
| FRED ALGER MANAGEMENT, LLC | 80.1K | $1.45M | — | Held |
| State Street | 79.3K | $1.44M | — | Held |
| Sio Capital Management, LLC | 72.2K | $1.31M | — | Held |
| GOLDMAN SACHS GROUP INC | 65.3K | $1.19M | — | Held |
| Qube Research & Technologies Ltd | 64.5K | $1.17M | — | Held |
| Seven Fleet Capital Management LP | 63.3K | $1.15M | — | Held |
| 683 Capital Management, LLC | 56.9K | $1.03M | — | Held |
| Quadrature Capital Ltd | 53K | $963.3K | — | Held |
| Caption Management, LLC | 52.6K | $956K | — | Held |
| Woodline Partners LP | 52K | $945.1K | — | Held |
| Atom Investors LP | 51.2K | $929.7K | — | Held |
| TWO SIGMA ADVISERS, LP | 49.4K | $897.1K | — | Held |
| JPMORGAN CHASE & CO | 44.4K | $806.9K | — | Held |
| Walleye Capital LLC | 41.7K | $757.1K | — | Held |
| Artia Global Partners LP | 41.6K | $754.9K | — | Held |
| Squarepoint Ops LLC | 40.9K | $741.9K | — | Held |
| XTX Topco Ltd | 40.5K | $734.7K | — | Held |
| ExodusPoint Capital Management, LP | 32.3K | $586K | — | Held |
| NORTHERN TRUST CORP | 32.2K | $584.8K | — | Held |
| Ikarian Capital, LLC | 31.1K | $564.9K | — | Held |
| GLENMEDE TRUST CO NA | 20.4K | $371.4K | — | Held |
| OMERS ADMINISTRATION Corp | 19.6K | $355.9K | — | Held |
| Renaissance Technologies | 18.3K | $332.3K | — | Held |
| Hudson Bay Capital Management LP | 16.8K | $304.6K | — | New |
| ENVESTNET ASSET MANAGEMENT INC | 16K | $291.3K | — | Held |
| Persistent Asset Partners Ltd | 15.1K | $274K | — | New |
| Jump Financial, LLC | 13.1K | $237.8K | — | Held |
| Tower Research Capital LLC (TRC) | 8.74K | $158.7K | — | Held |
| Belvedere Trading LLC | 4.53K | $82.2K | — | Held |
| US BANCORP \DE\ | 2.73K | $49.6K | — | Held |
| PFS Partners, LLC | 2K | $36.3K | — | Held |
| CITIGROUP INC | 1.14K | $20.8K | — | Held |
| ACADIAN ASSET MANAGEMENT LLC | 1.47K | $26 | — | Held |
| Activest Wealth Management | 1 | $18 | — | Held |
| OSAIC HOLDINGS, INC. | 1 | $18 | — | Held |
| Parallel Advisors, LLC | 1 | $18 | — | Held |
| GROUP ONE TRADING LLC | 1 | $18 | — | Held |
| Key Financial Inc | 1 | $18 | — | Held |