| Redmile Group, LLC | 14.5M | $80.6M | $5.23M | Added$30.2M |
| BlackRock, Inc. | 10.9M | $60.6M | $4.66M | Added$15.6M |
| Fidelity | 10.6M | $58.9M | $5.32M | Added$7.6M |
| BVF INC/IL | 8.7M | $48.2M | $4.52M | Added$2.36M |
| State Street | 6.92M | $38.3M | $2.42M | Added$15M |
| VANGUARD CAPITAL MANAGEMENT LLC | 5.96M | $33M | — | Held |
| Bain Capital Life Sciences Investors, LLC | 5.21M | $28.9M | $2.71M | Added$2.53M |
| Bellevue Group AG | 5.16M | $28.6M | $2.68M | Added$2.68M |
| MAK CAPITAL ONE LLC | 4.72M | $26.2M | $1.54M | Added$11.3M |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 4.3M | $23.8M | $2.24M | Cut−$3.79M |
| BANK OF AMERICA CORP /DE/ | 4.26M | $23.6M | $834.9K | Added$15.5M |
| Nuveen, LLC | 4.25M | $23.5M | $1.52M | Added$8.89M |
| Siren, L.L.C. | 3.96M | $21.9M | — | New |
| Balyasny Asset Management L.P. | 3.89M | $21.5M | $1.72M | Added$4.97M |
| AMERIPRISE FINANCIAL INC | 3.45M | $19.1M | $1.79M | Cut−$2.72M |
| GEODE CAPITAL MANAGEMENT, LLC | 3.38M | $18.7M | $1.51M | Added$4.14M |
| Qube Research & Technologies Ltd | 3.11M | $17.3M | $1.24M | Added$5.3M |
| Palo Alto Investors LP | 2.95M | $16.3M | $1.24M | Added$4.36M |
| MORGAN STANLEY | 2.74M | $15.2M | $1.42M | Added$819.4K |
| GREAT POINT PARTNERS LLC | 2.5M | $13.8M | — | New |
| Woodline Partners LP | 2.34M | $12.9M | $1.22M | Cut−$7.13M |
| Opaleye Management Inc. | 2.33M | $12.9M | $1.21M | Cut−$134K |
| GOLDMAN SACHS GROUP INC | 2.15M | $11.9M | $919.7K | Added$3.05M |
| Point72 Asset Management, L.P. | 1.87M | $10.4M | $193K | Added$8.51M |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 1.48M | $8.22M | — | Held |
| Y-Intercept (Hong Kong) Ltd | 1.32M | $7.31M | — | New |
| Tetragon Partners GP Ltd | 1.29M | $7.16M | $672.1K | Cut−$3.04M |
| UBS Group AG | 1.25M | $6.9M | $196.1K | Added$5.01M |
| MILLENNIUM MANAGEMENT LLC | 1.24M | $6.86M | $644.1K | Cut−$7.38M |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1.1M | $6.11M | $549.7K | Added$801.1K |
| NORTHERN TRUST CORP | 1.09M | $6.02M | $411.8K | Added$2.05M |
| DIMENSIONAL FUND ADVISORS LP | 924.1K | $5.12M | $370.5K | Added$1.51M |
| KENNEDY CAPITAL MANAGEMENT LLC | 912.3K | $5.05M | $332.7K | Added$1.84M |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 903.4K | $5M | $469.8K | Added$469.4K |
| VANGUARD FIDUCIARY TRUST CO | 888.6K | $4.92M | — | Held |
| MARSHALL WACE, LLP | 861.5K | $4.77M | $270.9K | Added$2.16M |
| Icahn Capital | 777.3K | $4.31M | $403.7K | Added$408.9K |
| Invesco Ltd. | 763K | $4.23M | $396.8K | Cut−$654.6K |
| Russell Investments Group, Ltd. | 711.4K | $3.94M | $355.2K | Added$512.3K |
| D. E. Shaw & Co., Inc. | 702.8K | $3.89M | $365.5K | Cut−$1.36M |
| WELLS FARGO & COMPANY/MN | 698.7K | $3.87M | $298.3K | Added$990.8K |
| Parkman Healthcare Partners LLC | 674K | $3.73M | $312.6K | Added$716K |
| Ensign Peak Advisors, Inc | 625.1K | $3.46M | — | New |
| Longaeva Partners L.P. | 620.4K | $3.44M | $322.6K | Cut−$12.1M |
| Citadel | 600.1K | $3.32M | $143.2K | Added$1.94M |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 583.9K | $3.23M | $303.6K | Added$303.6K |
| Ikarian Capital, LLC | 580.2K | $3.21M | $119.7K | Added$2.06M |
| SIRIOS CAPITAL MANAGEMENT L P | 575.1K | $3.19M | $299K | Cut−$379.6K |
| DEUTSCHE BANK AG\ | 562.2K | $3.11M | $291.6K | Added$299.5K |
| Renaissance Technologies | 544.3K | $3.02M | $283K | Cut−$1.01M |
| WELLINGTON MANAGEMENT GROUP LLP | 521.4K | $2.89M | $207K | Added$890.1K |
| Hennion & Walsh Asset Management, Inc. | 509.7K | $2.82M | $265K | Added$138K |
| SILVERARC CAPITAL MANAGEMENT, LLC | 496.5K | $2.75M | — | New |
| Board of Trustees of The Leland Stanford Junior University | 482.6K | $2.67M | $250.9K | Added$250.9K |
| TWO SIGMA INVESTMENTS, LP | 471.4K | $2.61M | $172.7K | Added$944.7K |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 462.1K | $2.56M | — | New |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 416.7K | $2.31M | $216.7K | Cut−$914.5K |
| Trexquant Investment LP | 403.7K | $2.24M | — | New |
| Bank of New York Mellon Corp | 395K | $2.19M | $188.1K | Added$372.8K |
| Susquehanna Portfolio Strategies, LLC | 360.3K | $2M | $185.4K | Added$205.9K |
| JPMORGAN CHASE & CO | 323.9K | $1.61M | −$3.22K | Added$1.34M |
| Cinctive Capital Management LP | 268.6K | $1.49M | $139.7K | Cut−$313.8K |
| BNP PARIBAS FINANCIAL MARKETS | 255.4K | $1.41M | $32K | Added$1.11M |
| Swiss National Bank | 236K | $1.31M | — | New |
| Rafferty Asset Management, LLC | 203.3K | $1.13M | $73.7K | Added$415.1K |
| SEI INVESTMENTS CO | 203.2K | $1.13M | $30.3K | Added$833.5K |
| Rosalind Advisors, Inc. | 200K | $1.11M | — | New |
| IEQ CAPITAL, LLC | 195.8K | $1.08M | $95.2K | Added$166K |
| Ishara Investments LP | 174.3K | $965.3K | $90.6K | Cut−$2.8M |
| Engineers Gate Manager LP | 174.1K | $964.7K | — | New |
| J. Goldman & Co LP | 170.8K | $946.3K | $88.8K | Cut−$4.04M |
| BOOTHBAY FUND MANAGEMENT, LLC | 166.2K | $920.5K | $33.3K | Added$598.9K |
| RHUMBLINE ADVISERS | 159.7K | $884.6K | $65.8K | Added$249.7K |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 158.6K | $878.9K | $82.5K | Cut−$52.4K |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 148.9K | $825.1K | $77.4K | Cut−$2.61M |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 134.8K | $746.7K | $65.7K | Added$91.6K |
| DIADEMA PARTNERS LP | 132.9K | $736.4K | $69.1K | Cut−$1.02M |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 130.6K | $723.8K | — | New |
| Schonfeld Strategic Advisors LLC | 123.3K | $683K | $64.1K | Cut−$1.94M |
| DAFNA Capital Management LLC | 117.8K | $652.7K | $61.3K | Cut−$716.8K |
| VICTORY CAPITAL MANAGEMENT INC | 115.5K | $640K | $7.67K | Added$565.9K |
| Man Group plc | 109.2K | $605.1K | — | New |
| ALLIANCEBERNSTEIN L.P. | 119K | $597.6K | −$0 | Cut−$108.9K |
| SCS Capital Management LLC | 99K | $548.5K | — | New |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 97.8K | $541.8K | $50.9K | Cut−$149.9K |
| Connor, Clark & Lunn Investment Management Ltd. | 92.7K | $513.6K | — | New |
| PROFUND ADVISORS LLC | 91K | $503.9K | $27.6K | Added$237.8K |
| J. Safra Sarasin Holding AG | 90.5K | $501.3K | $47.1K | Cut−$89.9K |
| DNB Asset Management AS | 88.6K | $490.9K | $46.1K | Cut−$103K |
| XTX Topco Ltd | 80.5K | $445.9K | $41.9K | Cut−$775.5K |
| Legal & General Group Plc | 80K | $443.5K | $4.84K | Added$396.7K |
| VANGUARD ASSET MANAGEMENT, Ltd | 79.5K | $440.4K | — | Held |
| CAPTRUST FINANCIAL ADVISORS | 79.2K | $438.6K | $16.4K | Added$280.1K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 76.3K | $414.1K | $22.3K | Added$139K |
| MetLife Investment Management, LLC | 72.4K | $401.3K | $20.3K | Added$205.3K |
| POLEN CAPITAL MANAGEMENT LLC | 70.2K | $388.6K | — | New |
| Squarepoint Ops LLC | 68K | $376.5K | — | New |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 62.1K | $343.9K | — | New |
| JANUS HENDERSON GROUP PLC | 59.1K | $327.7K | — | New |
| Brevan Howard Capital Management LP | 58.4K | $323.7K | $30.4K | Cut−$297.5K |
| AXQ CAPITAL, LP | 58.2K | $322.3K | $15.1K | Added$176.2K |
| China Universal Asset Management Co., Ltd. | 57.7K | $319.6K | $18.8K | Added$138.4K |
| STRS OHIO | 55.5K | $307.5K | — | New |
| ADAR1 Capital Management, LLC | 55K | $304.7K | $25K | Added$63.7K |
| Virtus Investment Advisers, LLC | 54.9K | $304K | $27.8K | Added$35.3K |
| DRW Securities, LLC | 54.5K | $301.8K | — | New |
| Vanguard Global Advisers, LLC | 54.1K | $299.5K | — | Held |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 53.9K | $298.4K | — | New |
| Verdad Advisers, LP | 53.3K | $295.2K | — | New |
| Mariner, LLC | 53.2K | $294.8K | $16.1K | Added$137.4K |
| EntryPoint Capital, LLC | 51.4K | $284.9K | $22.2K | Added$70.1K |
| BIT Capital GmbH | 50K | $277K | — | New |
| STATE OF WISCONSIN INVESTMENT BOARD | 49.7K | $275.6K | — | New |
| JANE STREET GROUP, LLC | 47.1K | $261K | $24.5K | Cut−$2.32M |
| Creative Planning | 45.9K | $254.4K | $12.5K | Added$133.9K |
| Allegheny Financial Group | 42.9K | $237.7K | $22.3K | Added$22.3K |
| CANADA PENSION PLAN INVESTMENT BOARD | 40.8K | $226K | $9.15K | Added$137.7K |
| State of New Jersey Common Pension Fund D | 40.8K | $225.8K | — | New |
| CWM, LLC | 39.7K | $219.7K | $167.7K | Added$219.5K |
| Police & Firemen's Retirement System of New Jersey | 36K | $199.6K | $14.6K | Added$58.5K |
| FIFTH THIRD BANCORP | 35.4K | $196.1K | — | New |
| Vanguard Investments Australia, Ltd. | 35K | $194.1K | — | Held |
| Persistent Asset Partners Ltd | 33.6K | $186.3K | $17.5K | Cut−$283.9K |
| ARIZONA STATE RETIREMENT SYSTEM | 32.8K | $181.5K | — | New |
| Lido Advisors, LLC | 31K | $171.7K | $77.2K | Added$65.1K |
| CITIGROUP INC | 30.8K | $170.7K | $12.3K | Added$52.1K |
| INTECH INVESTMENT MANAGEMENT LLC | 29.9K | $165.8K | $15.6K | Cut−$47.7K |
| NEW YORK STATE COMMON RETIREMENT FUND | 29.6K | $163.8K | $15.4K | Added$15.4K |
| MIRABELLA FINANCIAL SERVICES LLP | 28.7K | $159.2K | — | New |
| KLP KAPITALFORVALTNING AS | 26.3K | $145.7K | — | New |
| ProShare Advisors LLC | 25.6K | $141.8K | $12.8K | Added$17.8K |
| E Fund Management Co., Ltd. | 25.6K | $141.6K | — | Held |
| AlphaCentric Advisors LLC | 24.5K | $135.8K | — | New |
| BARCLAYS PLC | 24.3K | $134.6K | $12.6K | Cut−$1.32M |
| WINTON GROUP Ltd | 24.1K | $133.5K | $12.5K | Cut−$134.6K |
| SBI Securities Co., Ltd. | 23.2K | $128.7K | $13 | Added$128.5K |
| TD Asset Management Inc | 22.8K | $126.1K | $11.8K | Cut−$109.1K |
| VOYA INVESTMENT MANAGEMENT LLC | 22.2K | $123.1K | $10K | Added$26.2K |
| PRELUDE CAPITAL MANAGEMENT, LLC | 22.2K | $123K | $6.24K | Added$62.7K |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 21.9K | $120.6K | $7.82K | Added$20.9K |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 21.5K | $119.2K | $5.21K | Added$68.9K |
| Quarry LP | 21.3K | $117.7K | $11.1K | Cut−$258.8K |
| PRUDENTIAL FINANCIAL INC | 20.2K | $111.8K | — | New |
| Corient Private Wealth LLC | 19.7K | $109.2K | $10.2K | Added$10.3K |
| RAYMOND JAMES FINANCIAL INC | 19.4K | $107.3K | $10.1K | Cut−$17.5K |
| MERCER GLOBAL ADVISORS INC /ADV | 18.7K | $103.7K | $5.4K | Added$51.5K |
| Cerity Partners LLC | 18K | $99.6K | $7.7K | Added$25.3K |
| Scientech Research LLC | 17.3K | $95.9K | $8.95K | Added$9.51K |
| Coastal Bridge Advisors, LLC | 17K | $94.2K | $8.84K | Added$8.84K |
| Quadrature Capital Ltd | 16.9K | $93.6K | $8.79K | Cut−$150.2K |
| Pictet Asset Management Holding SA | 16.7K | $92.5K | — | New |
| FOX RUN MANAGEMENT, L.L.C. | 17.7K | $87.7K | — | New |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 15.1K | $83.6K | — | New |
| Balefire, LLC | 15K | $83.1K | $7.8K | Added$7.8K |
| ExodusPoint Capital Management, LP | 14.9K | $82.8K | — | New |
| Vontobel Holding Ltd. | 14.5K | $80.4K | — | New |
| Forefront Analytics, LLC | 14.2K | $78.9K | $6.88K | Added$12.5K |
| Magnetar Financial LLC | 14.2K | $78.7K | — | New |
| LPL Financial LLC | 13.2K | $73.2K | — | New |
| Vanguard Personalized Indexing Management, LLC | 12.9K | $71.7K | $6.71K | Added$6.9K |
| Tower Research Capital LLC (TRC) | 12.7K | $70.2K | $1.02K | Added$60.4K |
| AMERICAN CENTURY COMPANIES INC | 12.5K | $69K | $6.48K | Cut−$1.19M |
| nVerses Capital, LLC | 11.9K | $65.9K | — | New |
| XPONANCE LLC | 11.2K | $62.1K | — | New |
| Abel Hall, LLC | 10.9K | $60.5K | — | New |
| Ameritas Investment Partners, Inc. | 10.8K | $59.8K | $5.04K | Added$11.1K |
| Merit Financial Group, LLC | 10.7K | $59.5K | — | New |
| Integrated Wealth Concepts LLC | 10.2K | $56.7K | — | New |
| Shay Capital LLC | 10K | $55.4K | — | New |
| Harbor Advisors LLC | 10K | $55.4K | $5.2K | Added$5.2K |
| Mirae Asset Global Investments Co., Ltd. | 7.55K | $41.8K | $3.66K | Added$6.51K |
| NISA INVESTMENT ADVISORS, LLC | 7.41K | $41.1K | $1.36K | Added$28K |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 7.17K | $39.7K | $3.2K | Added$8.8K |
| Geneos Wealth Management Inc. | 6K | $33.2K | $3.12K | Added$3.12K |
| Sterling Capital Management LLC | 4.37K | $24.2K | $2.27K | Cut−$5.75K |
| GF FUND MANAGEMENT CO. LTD. | 3.23K | $17.9K | $1.48K | Added$3.64K |
| JONES FINANCIAL COMPANIES LLLP | 3.56K | $17.8K | −$60 | Added$2.83K |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 2.37K | $13.1K | — | New |
| Larson Financial Group LLC | 2.02K | $11.2K | $1.04K | Added$1.13K |
| Rockefeller Capital Management L.P. | 1.66K | $9.21K | $173 | Added$7.53K |
| Farther Finance Advisors, LLC | 1.36K | $7.32K | $105 | Added$5.76K |
| OSAIC HOLDINGS, INC. | 1.27K | $7.03K | $660 | Cut−$732.8K |
| PNC Financial Services Group, Inc. | 1.13K | $6.27K | $588 | Added$588 |
| Optiver Holding B.V. | 1.12K | $6.22K | $275 | Added$3.56K |
| Essential Partners LLC | 1.09K | $6.05K | $565 | Added$593 |
| ROYAL BANK OF CANADA | 1.16K | $6K | −$95 | Cut−$9K |
| Allworth Financial LP | 1.06K | $5.88K | $216 | Added$3.79K |
| Trask Adam Roland | 1K | $5.54K | — | Held |
| Caitong International Asset Management Co., Ltd | 835 | $4.63K | $434 | Cut−$91.7K |
| MAI Capital Management | 795 | $4.41K | $32 | Added$4.09K |
| ACADIAN ASSET MANAGEMENT LLC | 758.2K | $4.2K | $392 | Cut−$125 |
| FEDERATED HERMES, INC. | 753 | $4.17K | $392 | Added$392 |
| IFP Advisors, Inc | 645 | $3.57K | $284 | Added$827 |
| EverSource Wealth Advisors, LLC | 591 | $3.27K | $280 | Added$568 |
| Arax Advisory Partners | 588 | $3.26K | $10 | Added$3.16K |
| ROTHSCHILD INVESTMENT LLC | 437 | $2.42K | $122 | Added$1.24K |
| PRICE T ROWE ASSOCIATES INC /MD/ | 428.7K | $2.38K | $223 | Added$141 |
| True Wealth Design, LLC | 322 | $1.78K | $109 | Added$724 |
| GAMMA Investing LLC | 316 | $1.75K | — | New |
| Quantbot Technologies LP | 308 | $1.71K | — | New |
| HighMark Wealth Management LLC | 300 | $1.66K | $156 | Added$156 |
| Physician Wealth Advisors, Inc. | 269 | $1.49K | $140 | Added$140 |
| ALGERT GLOBAL LLC | 154.8K | $858 | — | New |
| Sunbelt Securities, Inc. | 110 | $609 | $57 | Added$57 |
| Root Financial Partners, LLC | 94 | $521 | — | New |
| Fortitude Family Office, LLC | 87 | $482 | — | New |
| US BANCORP \DE\ | 77 | $427 | — | New |
| GSA CAPITAL PARTNERS LLP | 31.7K | $176 | — | New |
| Virtu Financial LLC | 28.4K | $158 | — | New |
| Advisory Services Network, LLC | 23 | $127 | — | New |
| Cygnus Capital Advisors, LLC | 22.2K | $123 | $6 | Added$63 |
| CANADA LIFE ASSURANCE Co | 21.6K | $121 | — | New |
| Stone House Investment Management, LLC | 20 | $111 | — | New |
| SJS Investment Consulting Inc. | 17 | $95 | — | New |
| JPL Wealth Management, LLC | 13 | $73 | — | New |
| MOUNT VERNON ASSOCIATES INC /MD/ | 10.5K | $58 | $5 | Added$5 |
| Cambridge Investment Research Advisors, Inc. | 10.1K | $56 | $5 | Added$2 |