| Fidelity | 10.2M | $51.3M | — | Held |
| Redmile Group, LLC | 10.1M | $50.5M | — | Held |
| BVF INC/IL | 9.13M | $45.8M | — | Held |
| BlackRock, Inc. | 8.96M | $45M | — | Held |
| Vanguard | 7.75M | $38.9M | — | Held |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 5.5M | $27.6M | — | Held |
| Bain Capital Life Sciences Investors, LLC | 5.25M | $26.4M | — | Held |
| Bellevue Group AG | 5.16M | $25.9M | — | Held |
| State Street | 4.65M | $23.4M | — | Held |
| AMERIPRISE FINANCIAL INC | 4.35M | $21.8M | — | Held |
| Woodline Partners LP | 4M | $20.1M | — | Held |
| Balyasny Asset Management L.P. | 3.3M | $16.6M | — | Held |
| Longaeva Partners L.P. | 3.1M | $15.6M | — | Held |
| MAK CAPITAL ONE LLC | 2.96M | $14.9M | — | Held |
| Nuveen, LLC | 2.92M | $14.6M | — | Held |
| GEODE CAPITAL MANAGEMENT, LLC | 2.9M | $14.6M | — | Held |
| MORGAN STANLEY | 2.86M | $14.3M | $5.63M | Added$5.1M |
| MILLENNIUM MANAGEMENT LLC | 2.84M | $14.2M | — | Held |
| Opaleye Management Inc. | 2.6M | $13.1M | — | Held |
| Palo Alto Investors LP | 2.38M | $12M | — | Held |
| Qube Research & Technologies Ltd | 2.38M | $12M | — | Held |
| Tetragon Partners GP Ltd | 2.03M | $10.2M | — | Held |
| GOLDMAN SACHS GROUP INC | 1.77M | $8.88M | — | Held |
| BANK OF AMERICA CORP /DE/ | 1.61M | $8.06M | $2.55M | Added$4.11M |
| SPHERA FUNDS MANAGEMENT LTD. | 1.32M | $6.61M | — | Held |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1.06M | $5.31M | — | Held |
| D. E. Shaw & Co., Inc. | 1.05M | $5.25M | — | Held |
| J. Goldman & Co LP | 993.8K | $4.99M | — | Held |
| Invesco Ltd. | 972.4K | $4.88M | — | Held |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 903.4K | $4.54M | — | Held |
| Renaissance Technologies | 802.6K | $4.03M | — | Held |
| NORTHERN TRUST CORP | 792K | $3.98M | — | Held |
| Icahn Capital | 776.3K | $3.9M | — | Held |
| Ishara Investments LP | 750K | $3.77M | — | Held |
| DIMENSIONAL FUND ADVISORS LP | 718.7K | $3.61M | — | Held |
| SIRIOS CAPITAL MANAGEMENT L P | 710.3K | $3.57M | — | Held |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 683.9K | $3.43M | — | Held |
| Russell Investments Group, Ltd. | 683K | $3.43M | — | Held |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 642K | $3.22M | — | Held |
| KENNEDY CAPITAL MANAGEMENT LLC | 639.9K | $3.21M | — | Held |
| Parkman Healthcare Partners LLC | 601.2K | $3.02M | — | Held |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 583.9K | $2.93M | — | Held |
| WELLS FARGO & COMPANY/MN | 573.7K | $2.88M | — | Held |
| DEUTSCHE BANK AG\ | 560.7K | $2.81M | — | Held |
| Hennion & Walsh Asset Management, Inc. | 535K | $2.69M | — | Held |
| Schonfeld Strategic Advisors LLC | 522.8K | $2.62M | — | Held |
| MARSHALL WACE, LLP | 521K | $2.62M | — | Held |
| JANE STREET GROUP, LLC | 513.8K | $2.58M | — | Held |
| Board of Trustees of The Leland Stanford Junior University | 482.6K | $2.42M | — | Held |
| SummitTX Capital, L.P. | 438.5K | $2.2M | — | Held |
| WELLINGTON MANAGEMENT GROUP LLP | 398.1K | $2M | — | Held |
| UBS Group AG | 377.1K | $1.89M | — | Held |
| Point72 Asset Management, L.P. | 371.2K | $1.86M | — | Held |
| Bank of New York Mellon Corp | 361.7K | $1.82M | — | Held |
| Cinctive Capital Management LP | 359K | $1.8M | — | Held |
| Susquehanna Portfolio Strategies, LLC | 356.6K | $1.79M | — | Held |
| DIADEMA PARTNERS LP | 350K | $1.76M | — | Held |
| TWO SIGMA INVESTMENTS, LP | 332K | $1.67M | — | Held |
| BARCLAYS PLC | 290K | $1.46M | $291.4K | Added$1M |
| Citadel | 275.3K | $1.38M | — | Held |
| DAFNA Capital Management LLC | 272.8K | $1.37M | — | Held |
| AMERICAN CENTURY COMPANIES INC | 251.2K | $1.26M | — | Held |
| XTX Topco Ltd | 243.3K | $1.22M | — | Held |
| Ikarian Capital, LLC | 230.2K | $1.16M | — | Held |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 185.5K | $931.3K | — | Held |
| IEQ CAPITAL, LLC | 183K | $918.6K | — | Held |
| OSAIC HOLDINGS, INC. | 147.4K | $739.8K | — | Held |
| Rafferty Asset Management, LLC | 141.6K | $711.1K | — | Held |
| ALLIANCEBERNSTEIN L.P. | 140.7K | $706.5K | — | Held |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 137.8K | $691.8K | — | Held |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 130.1K | $655.1K | — | Held |
| RHUMBLINE ADVISERS | 126.5K | $634.8K | — | Held |
| Brevan Howard Capital Management LP | 123.8K | $621.2K | — | Held |
| Jump Financial, LLC | 122.9K | $616.7K | — | Held |
| Caption Management, LLC | 119.5K | $599.8K | — | Held |
| DNB Asset Management AS | 118.3K | $594K | — | Held |
| J. Safra Sarasin Holding AG | 117.8K | $591.2K | — | Held |
| Persistent Asset Partners Ltd | 93.7K | $470.2K | — | New |
| Quarry LP | 75K | $376.5K | — | Held |
| BOOTHBAY FUND MANAGEMENT, LLC | 64.1K | $321.6K | — | Held |
| BNP PARIBAS FINANCIAL MARKETS | 61.6K | $309.1K | — | Held |
| SEI INVESTMENTS CO | 58.3K | $292.5K | — | Held |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 54.8K | $275.1K | — | Held |
| JPMORGAN CHASE & CO | 53.7K | $269.7K | — | Held |
| Virtus Investment Advisers, LLC | 53.5K | $268.7K | — | Held |
| WINTON GROUP Ltd | 53.4K | $268.1K | — | Held |
| PROFUND ADVISORS LLC | 53K | $266.1K | — | Held |
| Quadrature Capital Ltd | 48.6K | $243.8K | — | Held |
| ADAR1 Capital Management, LLC | 48K | $241K | — | Held |
| TD Asset Management Inc | 46.8K | $235.2K | — | Held |
| Allegheny Financial Group | 42.9K | $215.4K | — | Held |
| EntryPoint Capital, LLC | 42.8K | $214.7K | — | Held |
| INTECH INVESTMENT MANAGEMENT LLC | 42.5K | $213.5K | — | Held |
| CITIZENS FINANCIAL GROUP INC/RI | 40K | $200.8K | — | Held |
| MetLife Investment Management, LLC | 39.1K | $196.1K | — | Held |
| Pale Fire Capital SE | 38.6K | $193.8K | — | Held |
| China Universal Asset Management Co., Ltd. | 36.1K | $181.1K | — | Held |
| Landing Point Financial Group, LLC | 34.9K | $175.2K | — | Held |
| COMERICA BANK | 32.4K | $162.4K | — | Held |
| CAPTRUST FINANCIAL ADVISORS | 31.6K | $158.6K | — | Held |
| Mariner, LLC | 31.3K | $157.4K | — | Held |
| NEW YORK STATE COMMON RETIREMENT FUND | 29.6K | $148.4K | — | Held |
| AXQ CAPITAL, LP | 29.1K | $146.1K | — | Held |
| Police & Firemen's Retirement System of New Jersey | 28.1K | $141.1K | — | Held |
| HSBC HOLDINGS PLC | 25.7K | $130.2K | — | Held |
| RAYMOND JAMES FINANCIAL INC | 24.9K | $124.8K | — | Held |
| ProShare Advisors LLC | 24.7K | $124K | — | Held |
| Creative Planning | 24K | $120.5K | — | Held |
| CITIGROUP INC | 23.6K | $118.7K | — | Held |
| Lido Advisors, LLC | 35K | $106.6K | — | Held |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 19.6K | $99.7K | — | Held |
| Corient Private Wealth LLC | 19.7K | $98.9K | — | Held |
| VOYA INVESTMENT MANAGEMENT LLC | 19.3K | $97K | — | Held |
| Caitong International Asset Management Co., Ltd | 19.2K | $96.4K | — | Held |
| CANADA PENSION PLAN INVESTMENT BOARD | 17.6K | $88.4K | — | Held |
| Scientech Research LLC | 17.2K | $86.4K | — | Held |
| Coastal Bridge Advisors, LLC | 17K | $85.3K | — | Held |
| Balefire, LLC | 15K | $75.3K | — | Held |
| Cerity Partners LLC | 14.8K | $74.3K | — | Held |
| VICTORY CAPITAL MANAGEMENT INC | 14.8K | $74.1K | — | Held |
| GROUP ONE TRADING LLC | 14.2K | $71.2K | — | Held |
| Forefront Analytics, LLC | 13.2K | $66.4K | — | Held |
| Vanguard Personalized Indexing Management, LLC | 12.9K | $64.8K | — | Held |
| PRELUDE CAPITAL MANAGEMENT, LLC | 12K | $60.2K | — | Held |
| MERCER GLOBAL ADVISORS INC /ADV | 10.4K | $52.1K | — | Held |
| SIMPLEX TRADING, LLC | 10.3K | $51.5K | — | Held |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 10K | $50.3K | — | Held |
| Harbor Advisors LLC | 10K | $50.2K | — | Held |
| Ameritas Investment Partners, Inc. | 9.69K | $48.6K | — | Held |
| Legal & General Group Plc | 9.31K | $46.7K | — | Held |
| Mirae Asset Global Investments Co., Ltd. | 7.03K | $35.3K | — | Held |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 6.16K | $30.9K | — | Held |
| Geneos Wealth Management Inc. | 6K | $30.1K | — | Held |
| Sterling Capital Management LLC | 5.97K | $30K | — | Held |
| ROYAL BANK OF CANADA | 2.85K | $15K | — | Held |
| JONES FINANCIAL COMPANIES LLLP | 2.99K | $15K | — | Held |
| GF FUND MANAGEMENT CO. LTD. | 2.84K | $14.3K | — | Held |
| NISA INVESTMENT ADVISORS, LLC | 2.61K | $13.1K | — | Held |
| Larson Financial Group LLC | 2K | $10K | — | Held |
| Tower Research Capital LLC (TRC) | 1.97K | $9.87K | — | Held |
| PNC Financial Services Group, Inc. | 1.13K | $5.68K | — | Held |
| Essential Partners LLC | 1.09K | $5.46K | $577 | Added$4.56K |
| ACADIAN ASSET MANAGEMENT LLC | 861.2K | $4.32K | — | Held |
| FEDERATED HERMES, INC. | 753 | $3.78K | — | Held |
| IFP Advisors, Inc | 547 | $2.75K | $689 | Added$1.68K |
| EverSource Wealth Advisors, LLC | 539 | $2.71K | — | Held |
| Optiver Holding B.V. | 530 | $2.66K | — | Held |
| PRICE T ROWE ASSOCIATES INC /MD/ | 445.1K | $2.23K | — | Held |
| Allworth Financial LP | 416 | $2.09K | $299 | Added$1.63K |
| Rockefeller Capital Management L.P. | 334 | $1.68K | — | Held |
| ASSETMARK, INC | 333 | $1.67K | — | Held |
| Farther Finance Advisors, LLC | 309 | $1.55K | — | Held |
| HighMark Wealth Management LLC | 300 | $1.51K | — | Held |
| Physician Wealth Advisors, Inc. | 269 | $1.35K | — | Held |
| ROTHSCHILD INVESTMENT LLC | 236 | $1.19K | — | Held |
| True Wealth Design, LLC | 211 | $1.06K | — | Held |
| Sunbelt Securities, Inc. | 110 | $552 | — | Held |
| MAI Capital Management | 63 | $317 | — | Held |
| CWM, LLC | 30.3K | $152 | — | Held |
| SG Americas Securities, LLC | 28.1K | $141 | — | Held |
| SBI Securities Co., Ltd. | 25 | $126 | — | Held |
| Arax Advisory Partners | 19 | $95 | — | Held |
| Cygnus Capital Advisors, LLC | 12K | $60 | — | Held |
| Cambridge Investment Research Advisors, Inc. | 10.7K | $54 | — | Held |
| MOUNT VERNON ASSOCIATES INC /MD/ | 10.5K | $53 | — | Held |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 4 | $20 | — | Held |
| AMALGAMATED BANK | 3.14K | $16 | — | Held |
| Daiwa Securities Group Inc. | 352 | $2 | — | Held |