| SUVRETTA CAPITAL MANAGEMENT, LLC | 9.07M | $53.9M | $3.95M | Added$24.8M |
| VR ADVISER, LLC | 6.43M | $38.3M | $3.8M | Added$10.3M |
| JPMORGAN CHASE & CO | 4.46M | $25.3M | $1.96M | Added$1.89M |
| GREAT POINT PARTNERS LLC | 4.22M | $25.1M | $2.71M | Added$5.09M |
| BRAIDWELL LP | 3.99M | $23.7M | $2.26M | Added$7.07M |
| Siren, L.L.C. | 3.73M | $22.2M | $923K | Added$15.4M |
| Commodore Capital LP | 3.25M | $19.3M | — | New |
| Pfizer Inc | 2.84M | $16.8M | $1.96M | Added$1.27M |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2.75M | $16.4M | $1.95M | Added$1.95M |
| Affinity Asset Advisors, LLC | 2.56M | $15.3M | $1.29M | Added$5.75M |
| MILLENNIUM MANAGEMENT LLC | 1.51M | $8.97M | $733.2K | Added$3.56M |
| ARMISTICE CAPITAL, LLC | 1.51M | $8.97M | $1.07M | Added$792.3K |
| Cormorant Asset Management, LP | 1.45M | $8.63M | — | New |
| QVT Financial LP | 1.31M | $7.8M | — | New |
| Ikarian Capital, LLC | 1.19M | $7.1M | $569.6K | Added$2.9M |
| EcoR1 Capital, LLC | 1.18M | $7.02M | — | New |
| Boxer Capital Management, LLC | 900K | $5.36M | $35.5K | Added$5.09M |
| MORGAN STANLEY | 873K | $5.19M | $619.8K | Cut−$2.72M |
| Point72 Asset Management, L.P. | 872.7K | $5.19M | $161.1K | Added$4M |
| MARSHALL WACE, LLP | 852.3K | $5.07M | $605.2K | Added$471.9K |
| STEMPOINT CAPITAL LP | 753.5K | $4.48M | — | New |
| Saturn V Capital Management LP | 740K | $4.4M | — | New |
| ADAR1 Capital Management, LLC | 630.4K | $3.75M | $399.1K | Added$805.7K |
| SILVERARC CAPITAL MANAGEMENT, LLC | 560.7K | $3.34M | — | New |
| Fidelity | 529.3K | $3.15M | $375.8K | Added$376.1K |
| GEODE CAPITAL MANAGEMENT, LLC | 527.7K | $3.14M | $287.6K | Added$1.02M |
| Vestal Point Capital, LP | 511K | $3.04M | — | New |
| VANGUARD CAPITAL MANAGEMENT LLC | 486.9K | $2.9M | — | Held |
| BlackRock, Inc. | 457.4K | $2.72M | $262.2K | Added$785.8K |
| Qube Research & Technologies Ltd | 450.3K | $2.68M | $42.5K | Added$2.37M |
| Foresite Capital Management VI LLC | 450K | $2.68M | — | New |
| BOOTHBAY FUND MANAGEMENT, LLC | 374.5K | $2.23M | $186.2K | Added$853.9K |
| KVP Capital Advisors, LP | 373.1K | $2.22M | — | New |
| TWO SIGMA INVESTMENTS, LP | 318.2K | $1.89M | $225.9K | Cut−$267.9K |
| Renaissance Technologies | 313.3K | $1.86M | $215.2K | Added$275.9K |
| JANE STREET GROUP, LLC | 278.9K | $1.66M | $198K | Cut−$1.79M |
| UBS Group AG | 241K | $1.43M | $171.1K | Cut−$1.03M |
| VANGUARD FIDUCIARY TRUST CO | 231.9K | $1.38M | — | Held |
| State Street | 195K | $1.16M | $111K | Added$340.7K |
| BARCLAYS PLC | 169.8K | $1.01M | $34.6K | Added$755.5K |
| GOLDMAN SACHS GROUP INC | 152.9K | $909.8K | $108.6K | Cut−$226.2K |
| BANK OF AMERICA CORP /DE/ | 136.5K | $812.3K | $3.12K | Added$789.3K |
| Alberta Investment Management Corp | 133.2K | $792.5K | $94.6K | Added$94.6K |
| XTX Topco Ltd | 119.7K | $712.3K | $47.2K | Added$364.1K |
| WELLINGTON MANAGEMENT GROUP LLP | 116.7K | $694.3K | — | New |
| 683 Capital Management, LLC | 110K | $654.5K | $78.1K | Cut−$703.5K |
| NORTHERN TRUST CORP | 104.1K | $619.6K | $71.6K | Added$91.2K |
| Verdad Advisers, LP | 97.1K | $577.8K | — | New |
| Hudson Bay Capital Management LP | 95.4K | $567.4K | $44.8K | Added$236.8K |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 85.3K | $507.8K | $60.6K | Cut−$110.5K |
| GROUP ONE TRADING LLC | 84.9K | $504.9K | $142 | Added$503.9K |
| BURKEHILL GLOBAL MANAGEMENT, LP | 75K | $446.3K | — | New |
| Brevan Howard Capital Management LP | 72K | $428.6K | — | New |
| ALPS ADVISORS INC | 70.2K | $417.6K | $37.9K | Added$137.9K |
| RBF Capital, LLC | 58.2K | $346.2K | $41.3K | Cut−$11.1K |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 47.9K | $284.9K | $34K | Cut−$1.2M |
| Squarepoint Ops LLC | 44.9K | $267.4K | $24K | Added$90.3K |
| FOX RUN MANAGEMENT, L.L.C. | 46.1K | $261.6K | — | New |
| DIMENSIONAL FUND ADVISORS LP | 43.1K | $256.7K | $16.7K | Added$133.3K |
| AMERICAN CENTURY COMPANIES INC | 33.7K | $200.7K | $15.2K | Added$88.7K |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 31.1K | $185K | — | New |
| OMERS ADMINISTRATION Corp | 29.8K | $177.3K | $21.2K | Cut−$174.8K |
| Jump Financial, LLC | 28.1K | $167K | $19.9K | Cut−$240.2K |
| Brendel Financial Advisors LLC | 28.1K | $166.9K | — | New |
| RAYMOND JAMES FINANCIAL INC | 26.9K | $160K | $18.8K | Added$21.1K |
| INSIGNEO ADVISORY SERVICES, LLC | 25.6K | $152.6K | $18.2K | Cut−$139K |
| Ghisallo Capital Management LLC | 25K | $148.8K | — | New |
| Mariner, LLC | 24.7K | $147.2K | $17.6K | Cut−$44.7K |
| China Universal Asset Management Co., Ltd. | 21.6K | $128.5K | — | New |
| SIMPLEX TRADING, LLC | 18.5K | $110K | $13.1K | Cut−$53.3K |
| Citadel | 17.9K | $106.5K | $12.7K | Cut−$1.51M |
| Vanguard Global Advisers, LLC | 16.8K | $100.1K | — | Held |
| Schonfeld Strategic Advisors LLC | 16.1K | $96.1K | — | New |
| Diametric Capital, LP | 15.7K | $93.3K | — | New |
| Catalyst Funds Management Pty Ltd | 15.3K | $91K | — | New |
| Forefront Analytics, LLC | 14.9K | $88.7K | $10.6K | Cut−$13.9K |
| MANGROVE PARTNERS IM, LLC | 14.8K | $88K | — | New |
| Allworth Financial LP | 13.3K | $79.2K | $4.08K | Added$49.1K |
| Abel Hall, LLC | 13.2K | $78.5K | $9.36K | Added$9.36K |
| CITIGROUP INC | 9.41K | $56K | $6.68K | Cut−$152.4K |
| Rockefeller Capital Management L.P. | 7.5K | $44.6K | — | New |
| BNP PARIBAS FINANCIAL MARKETS | 7.33K | $43.6K | $5.21K | Cut−$54.6K |
| MAI Capital Management | 4K | $23.8K | $2.84K | Added$2.84K |
| Steward Partners Investment Advisory, LLC | 1K | $5.95K | $710 | Added$710 |
| NISA INVESTMENT ADVISORS, LLC | 702 | $4.18K | $499 | Added$499 |
| US BANCORP \DE\ | 318 | $1.89K | — | New |
| CWM, LLC | 116 | $690 | $689 | Added$689 |
| SBI Securities Co., Ltd. | 106 | $631 | $76 | Cut−$92 |
| HRT FINANCIAL LP | 77.5K | $461 | — | New |
| State of Wyoming | 55 | $327 | — | New |
| Arax Advisory Partners | 24 | $143 | $17 | Added$17 |
| Optiver Holding B.V. | 16 | $95 | $11 | Added$11 |
| Caitong International Asset Management Co., Ltd | 1 | $6 | — | New |