| RA CAPITAL MANAGEMENT, L.P. | 5.4M | $70.7M | — | Held |
| FCPM III SERVICES B.V. | 3.62M | $47.3M | — | Held |
| Frazier Life Sciences Management, L.P. | 2.54M | $33.3M | — | Held |
| Fidelity | 2.53M | $33M | — | Held |
| VR ADVISER, LLC | 1.94M | $25.4M | — | Held |
| Paradigm Biocapital Advisors LP | 1.75M | $22.9M | — | Held |
| GREAT POINT PARTNERS LLC | 1.37M | $17.9M | — | Held |
| NEXTBio Capital Management LP | 1000K | $13.1M | — | Held |
| Vanguard | 770.3K | $10.1M | — | Held |
| Caligan Partners LP | 925.1K | $9.96M | — | Held |
| BlackRock, Inc. | 465.6K | $6.09M | — | Held |
| Citadel | 433.9K | $5.68M | — | Held |
| SPHERA FUNDS MANAGEMENT LTD. | 410.4K | $5.37M | — | Held |
| Laurion Capital Management LP | 317.2K | $4.15M | — | Held |
| UBS Group AG | 292.1K | $3.82M | — | Held |
| FINDELL CAPITAL MANAGEMENT LLC | 231K | $3.02M | — | Held |
| MILLENNIUM MANAGEMENT LLC | 224.5K | $2.94M | — | Held |
| GEODE CAPITAL MANAGEMENT, LLC | 185.8K | $2.43M | — | Held |
| TUDOR INVESTMENT CORP ET AL | 167.7K | $2.19M | — | New |
| AMERIPRISE FINANCIAL INC | 163.1K | $2.13M | — | Held |
| GOLDMAN SACHS GROUP INC | 145.6K | $1.9M | — | Held |
| Logos Global Management LP | 100K | $1.31M | — | Held |
| JANE STREET GROUP, LLC | 91.8K | $1.2M | — | Held |
| State Street | 91.1K | $1.19M | — | Held |
| JOHNSON & JOHNSON | 53.7K | $702.8K | −$1.92M | Cut−$1.92M |
| NORTHERN TRUST CORP | 38.9K | $509.4K | — | Held |
| MORGAN STANLEY | 28.5K | $372.3K | −$158.8K | Added$155.2K |
| Engineers Gate Manager LP | 28.2K | $368.9K | — | Held |
| Quadrature Capital Ltd | 26.8K | $350.4K | — | Held |
| Sarissa Capital Management LP | 25.4K | $332.2K | — | Held |
| OMERS ADMINISTRATION Corp | 20.7K | $270.8K | — | Held |
| Squarepoint Ops LLC | 18.5K | $241.4K | — | Held |
| XTX Topco Ltd | 17.5K | $229.4K | — | Held |
| INDEPENDENT FINANCIAL GROUP, LLC | 17K | $222.4K | — | New |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 14.8K | $193.8K | — | Held |
| Persistent Asset Partners Ltd | 10.8K | $141.2K | — | New |
| Shay Capital LLC | 10.7K | $140.5K | — | Held |
| Susquehanna Portfolio Strategies, LLC | 10.2K | $133.5K | — | Held |
| Chung Wu Investment Group, LLC | 8.3K | $108.6K | — | Held |
| CITIGROUP INC | 6.34K | $82.9K | — | Held |
| Hudson Bay Capital Management LP | 5.11K | $66.8K | — | New |
| China Universal Asset Management Co., Ltd. | 2.75K | $35.9K | — | Held |
| JPMORGAN CHASE & CO | 2.31K | $30.2K | — | Held |
| Tower Research Capital LLC (TRC) | 1.73K | $22.6K | — | Held |
| BARCLAYS PLC | 1.4K | $18.3K | — | New |
| Mirae Asset Global Investments Co., Ltd. | 819 | $10.7K | — | Held |
| BANK OF AMERICA CORP /DE/ | 396 | $5.18K | −$14.1K | Cut−$226.4K |
| GF FUND MANAGEMENT CO. LTD. | 330 | $4.32K | — | Held |
| BNP PARIBAS FINANCIAL MARKETS | 291 | $3.81K | — | Held |
| MAI Capital Management | 40 | $524 | — | Held |
| Bollard Group LLC | 24K | $314 | — | Held |
| Allworth Financial LP | 3 | $40 | −$107 | Cut−$107 |
| SBI Securities Co., Ltd. | 3 | $39 | — | Held |
| WELLS FARGO & COMPANY/MN | 1 | $13 | — | Held |
| ROYAL BANK OF CANADA | 7 | $0 | — | Held |