| TCG Crossover Management, LLC | 5.67M | $96.5M | — | New |
| RA CAPITAL MANAGEMENT, L.P. | 5.4M | $96.4M | $25.7M | Added$25.7M |
| FCPM III SERVICES B.V. | 4.12M | $73.5M | $17.2M | Added$26.1M |
| VR ADVISER, LLC | 3.04M | $54.3M | $9.25M | Added$28.8M |
| Frazier Life Sciences Management, L.P. | 2.54M | $45.4M | $12.1M | Added$12.1M |
| Caligan Partners LP | 1.93M | $34.3M | $6.54M | Added$24.4M |
| GREAT POINT PARTNERS LLC | 1.75M | $31.2M | $6.52M | Added$13.3M |
| Paradigm Biocapital Advisors LP | 1.75M | $31.2M | $8.33M | Added$8.33M |
| Fidelity | 1.54M | $27.5M | $7.33M | Cut−$5.57M |
| VANGUARD CAPITAL MANAGEMENT LLC | 1.43M | $25.6M | — | Held |
| MARSHALL WACE, LLP | 1.15M | $20.6M | — | New |
| State Street | 1.12M | $20M | $433.4K | Added$18.8M |
| NEXTBio Capital Management LP | 1000K | $17.8M | $4.76M | Added$4.76M |
| BlackRock, Inc. | 794.8K | $14.2M | $2.22M | Added$8.09M |
| Logos Global Management LP | 750K | $13.4M | $476K | Added$12.1M |
| Rosalind Advisors, Inc. | 700K | $12.5M | — | New |
| BOOTHBAY FUND MANAGEMENT, LLC | 555.7K | $9.91M | — | New |
| UBS Group AG | 488.4K | $8.71M | $1.39M | Added$4.89M |
| BRAIDWELL LP | 466.8K | $8.33M | — | New |
| GEODE CAPITAL MANAGEMENT, LLC | 342.6K | $6.11M | $885K | Added$3.68M |
| Clearline Capital LP | 326.2K | $5.82M | — | New |
| SPHERA FUNDS MANAGEMENT LTD. | 321.9K | $5.74M | $1.53M | Added$374.7K |
| Laurion Capital Management LP | 318.7K | $5.69M | $1.51M | Added$1.54M |
| Propel Bio Management, LLC | 314.5K | $5.59M | — | New |
| GOLDMAN SACHS GROUP INC | 261.9K | $4.67M | $693.2K | Added$2.77M |
| MILLENNIUM MANAGEMENT LLC | 258.6K | $4.61M | $1.07M | Added$1.68M |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 232.6K | $4.15M | $70.5K | Added$3.96M |
| VANGUARD FIDUCIARY TRUST CO | 185.5K | $3.31M | — | Held |
| Jump Financial, LLC | 173K | $3.09M | — | New |
| TUDOR INVESTMENT CORP ET AL | 152.6K | $2.72M | $726.2K | Added$528.7K |
| Citadel | 148.8K | $2.65M | $708.1K | Cut−$3.02M |
| Renaissance Technologies | 128.8K | $2.3M | — | New |
| MORGAN STANLEY | 116.7K | $2.08M | $135.5K | Added$1.71M |
| BANK OF AMERICA CORP /DE/ | 112.9K | $2.01M | $1.89K | Added$2.01M |
| AXIOM INVESTORS LLC /DE | 95.7K | $1.71M | — | New |
| Quadrature Capital Ltd | 76.6K | $1.37M | $127.5K | Added$1.02M |
| JANE STREET GROUP, LLC | 75.9K | $1.35M | $361.2K | Added$153K |
| NORTHERN TRUST CORP | 64.5K | $1.15M | $185.4K | Added$642.1K |
| JOHNSON & JOHNSON | 53.7K | $958.6K | $255.8K | Added$255.8K |
| Simplify Asset Management Inc. | 53.5K | $954.6K | — | New |
| Rafferty Asset Management, LLC | 50.5K | $901K | — | New |
| Brevan Howard Capital Management LP | 42.2K | $753.2K | — | New |
| Irenic Capital Management LP | 32.7K | $582.7K | — | New |
| Engineers Gate Manager LP | 26.9K | $479.5K | $127.9K | Added$110.6K |
| Squarepoint Ops LLC | 25.5K | $454.6K | $87.9K | Added$213.2K |
| Sarissa Capital Management LP | 25.4K | $453.1K | $120.9K | Added$120.9K |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 22.2K | $396.3K | — | New |
| PROFUND ADVISORS LLC | 22K | $392.7K | — | New |
| Scientech Research LLC | 15K | $268.4K | — | New |
| AXQ CAPITAL, LP | 15K | $267.9K | — | New |
| INDEPENDENT FINANCIAL GROUP, LLC | 14K | $249.3K | $66.5K | Added$27K |
| SEI INVESTMENTS CO | 13.7K | $244.5K | — | New |
| Vanguard Global Advisers, LLC | 12.9K | $229.7K | — | Held |
| WINTON GROUP Ltd | 11.9K | $211.8K | — | New |
| Cannon Global Investment Management, LLC | 11.7K | $208.7K | — | New |
| Invesco Ltd. | 11.6K | $206.9K | — | New |
| Diametric Capital, LP | 10.1K | $179.6K | — | New |
| GROUP ONE TRADING LLC | 9.06K | $161.7K | — | New |
| China Universal Asset Management Co., Ltd. | 7.37K | $131.4K | $13.1K | Added$95.5K |
| CITIGROUP INC | 5.37K | $95.9K | $25.6K | Added$12.9K |
| JPMORGAN CHASE & CO | 4.36K | $64.2K | $3.75K | Added$33.9K |
| Tower Research Capital LLC (TRC) | 3.47K | $61.8K | $8.23K | Added$39.2K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 3.51K | $51.6K | — | New |
| BNP PARIBAS FINANCIAL MARKETS | 2.84K | $50.7K | $1.39K | Added$46.9K |
| Mirae Asset Global Investments Co., Ltd. | 2.17K | $38.6K | $3.9K | Added$27.9K |
| GF FUND MANAGEMENT CO. LTD. | 372 | $6.64K | $1.57K | Added$2.32K |
| Quantbot Technologies LP | 307 | $5.48K | — | New |
| PNC Financial Services Group, Inc. | 246 | $4.39K | — | New |
| ROYAL BANK OF CANADA | 199 | $4K | $141 | Added$4K |
| BARCLAYS PLC | 136 | $2.43K | $647 | Cut−$15.9K |
| Allworth Financial LP | 73 | $1.3K | $14 | Added$1.26K |
| Parallel Advisors, LLC | 48 | $856 | — | New |
| MAI Capital Management | 40 | $714 | $190 | Added$190 |
| SIGNATUREFD, LLC | 39 | $696 | — | New |
| Ameritas Advisory Services, LLC | 37 | $660 | — | New |
| Fortitude Family Office, LLC | 31 | $553 | — | New |
| Bollard Group LLC | 24K | $428 | $114 | Added$114 |
| WPG Advisers, LLC | 21 | $375 | — | New |
| SBI Securities Co., Ltd. | 3 | $54 | $15 | Added$15 |
| WELLS FARGO & COMPANY/MN | 1 | $18 | $5 | Added$5 |