| NEA Management Company, LLC | 13.2M | $165.5M | — | Held |
| Frazier Life Sciences Management, L.P. | 10.3M | $128.4M | — | Held |
| BlackRock, Inc. | 10.1M | $126.8M | — | Held |
| Fidelity | 6.5M | $81.4M | — | Held |
| Vanguard | 6.43M | $80.6M | — | Held |
| Vivo Capital, LLC | 5.09M | $63.8M | — | Held |
| MARSHALL WACE, LLP | 4.58M | $57.3M | — | Held |
| Rubric Capital Management LP | 3.77M | $47.2M | — | Held |
| WELLINGTON MANAGEMENT GROUP LLP | 3.4M | $42.6M | — | Held |
| MPM BIOIMPACT LLC | 3.29M | $41.2M | — | Held |
| Viking Global | 3.2M | $40M | — | Held |
| ORBIMED ADVISORS LLC | 3.19M | $39.9M | — | Held |
| ALLIANCEBERNSTEIN L.P. | 3.08M | $38.6M | — | Held |
| Octagon Capital Advisors LP | 2.81M | $35.2M | — | Held |
| EVENTIDE ASSET MANAGEMENT, LLC | 2.62M | $32.8M | — | Held |
| State Street | 2.44M | $30.5M | — | Held |
| GEODE CAPITAL MANAGEMENT, LLC | 2.41M | $30.2M | — | Held |
| Siren, L.L.C. | 2.29M | $28.6M | — | Held |
| Affinity Asset Advisors, LLC | 2.15M | $26.9M | — | Held |
| ACORN CAPITAL ADVISORS, LLC | 2.14M | $26.9M | — | Held |
| Artia Global Partners LP | 2.01M | $25.2M | — | Held |
| EMERALD ADVISERS, LLC | 1.89M | $23.7M | — | Held |
| RAYMOND JAMES FINANCIAL INC | 1.77M | $22.1M | — | Held |
| Logos Global Management LP | 1.55M | $19.4M | — | Held |
| Pictet Asset Management Holding SA | 1.53M | $19.2M | — | Held |
| EMERALD MUTUAL FUND ADVISERS TRUST | 1.27M | $15.9M | — | Held |
| Pivotal bioVenture Partners Investment Advisor LLC | 1.26M | $15.7M | — | Held |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 1.11M | $13.9M | — | Held |
| BANK OF AMERICA CORP /DE/ | 1.09M | $13.7M | $3.69M | Cut−$3.1M |
| GOLDMAN SACHS GROUP INC | 1.06M | $13.2M | — | Held |
| FLPUTNAM INVESTMENT MANAGEMENT CO | 1.05M | $13.2M | — | Held |
| MORGAN STANLEY | 1.05M | $13.1M | $3.54M | Cut−$26.2M |
| Woodline Partners LP | 1M | $12.5M | — | Held |
| Point72 Asset Management, L.P. | 1M | $12.5M | — | Held |
| NAN FUNG TRINITY (HK) LTD | 917.5K | $11.5M | — | Held |
| Soleus Capital Management, L.P. | 900K | $11.3M | — | Held |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 836.8K | $10.5M | — | Held |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 825.5K | $10.3M | — | Held |
| NORTHERN TRUST CORP | 762K | $9.54M | — | Held |
| PANAGORA ASSET MANAGEMENT INC | 693K | $8.68M | — | Held |
| SPHERA FUNDS MANAGEMENT LTD. | 598.5K | $7.49M | — | Held |
| BARCLAYS PLC | 582.7K | $7.29M | $730.9K | Added$5.31M |
| MILLENNIUM MANAGEMENT LLC | 570.2K | $7.14M | — | Held |
| PRUDENTIAL FINANCIAL INC | 549.2K | $6.88M | — | Held |
| Informed Momentum Co LLC | 541.2K | $6.78M | — | Held |
| SILVERARC CAPITAL MANAGEMENT, LLC | 541.2K | $6.78M | — | Held |
| BURKEHILL GLOBAL MANAGEMENT, LP | 525K | $6.57M | — | Held |
| PEREGRINE CAPITAL MANAGEMENT LLC | 507.7K | $6.36M | — | Held |
| Invesco Ltd. | 498.9K | $6.25M | — | Held |
| J. Goldman & Co LP | 444.4K | $5.56M | — | Held |
| KVP Capital Advisors, LP | 414K | $5.18M | — | Held |
| STEMPOINT CAPITAL LP | 399.6K | $5M | — | Held |
| Opaleye Management Inc. | 345.1K | $4.32M | — | Held |
| AMERIPRISE FINANCIAL INC | 324.2K | $4.06M | — | Held |
| UBS Group AG | 274.6K | $3.44M | — | Held |
| Bank of New York Mellon Corp | 260.6K | $3.26M | — | Held |
| F/m Investments LLC | 241.5K | $3.02M | — | Held |
| VOYA INVESTMENT MANAGEMENT LLC | 226.2K | $2.83M | — | Held |
| Velan Capital Investment Management LP | 205K | $2.57M | — | Held |
| Nuveen, LLC | 183.3K | $2.3M | — | Held |
| Balyasny Asset Management L.P. | 174.6K | $2.19M | — | Held |
| Swiss National Bank | 168.2K | $2.11M | — | Held |
| FRED ALGER MANAGEMENT, LLC | 158K | $1.98M | — | Held |
| Citadel | 152.9K | $1.91M | — | Held |
| SUPERSTRING CAPITAL MANAGEMENT LP | 148.3K | $1.86M | — | Held |
| SEI INVESTMENTS CO | 147.9K | $1.85M | — | Held |
| D. E. Shaw & Co., Inc. | 141.3K | $1.77M | — | Held |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 140.7K | $1.76M | — | Held |
| BIT Capital GmbH | 130K | $1.63M | — | Held |
| CITIGROUP INC | 123.5K | $1.55M | — | Held |
| STATE OF WISCONSIN INVESTMENT BOARD | 120.6K | $1.51M | — | Held |
| HighVista Strategies LLC | 106.2K | $1.33M | — | Held |
| RHUMBLINE ADVISERS | 105.9K | $1.33M | — | Held |
| WELLS FARGO & COMPANY/MN | 101.3K | $1.27M | — | Held |
| OPPENHEIMER & CO INC | 100.7K | $1.26M | — | Held |
| LMR Partners LLP | 100K | $1.25M | — | Held |
| Rosalind Advisors, Inc. | 100K | $1.25M | — | Held |
| DIADEMA PARTNERS LP | 97.2K | $1.22M | — | Held |
| Erste Asset Management GmbH | 90K | $1.15M | — | Held |
| SECTORAL ASSET MANAGEMENT INC | 84.3K | $1.05M | — | Held |
| XTX Topco Ltd | 83.8K | $1.05M | — | Held |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 83.8K | $1.05M | — | Held |
| TWO SIGMA INVESTMENTS, LP | 83.8K | $1.05M | — | Held |
| COMERICA BANK | 83K | $1.04M | — | Held |
| WEXFORD CAPITAL LP | 82K | $1.03M | — | Held |
| Legal & General Group Plc | 81.7K | $1.02M | — | Held |
| PFS Partners, LLC | 79K | $989.1K | — | Held |
| MAI Capital Management | 77.8K | $973.7K | — | Held |
| Hudson Bay Capital Management LP | 75K | $939K | — | New |
| Campbell & CO Investment Adviser LLC | 71.1K | $890.1K | — | Held |
| DEUTSCHE BANK AG\ | 70.8K | $886.8K | — | Held |
| TUDOR INVESTMENT CORP ET AL | 68.5K | $857.4K | — | New |
| WealthTrust Axiom LLC | 61.5K | $770K | — | Held |
| Optimize Financial Inc | 61.5K | $769.8K | — | Held |
| JPMORGAN CHASE & CO | 59.5K | $744.6K | — | Held |
| Russell Investments Group, Ltd. | 59.4K | $744.2K | — | Held |
| KENNEDY CAPITAL MANAGEMENT LLC | 56.3K | $704.5K | — | Held |
| LPL Financial LLC | 53K | $663.1K | — | Held |
| Allianz Asset Management GmbH | 52.8K | $661.1K | — | Held |
| MetLife Investment Management, LLC | 50.3K | $629.1K | — | Held |
| FRANKLIN RESOURCES INC | 49.9K | $624.5K | — | Held |
| SIMPLEX TRADING, LLC | 47.1K | $590.1K | — | Held |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 46.7K | $584.4K | — | Held |
| JANE STREET GROUP, LLC | 46K | $575.9K | — | Held |
| Persistent Asset Partners Ltd | 45.8K | $573.8K | $66.3K | Added$393.6K |
| Steward Partners Investment Advisory, LLC | 44.1K | $552.1K | — | Held |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 42.1K | $526.6K | — | Held |
| Creative Planning | 40.2K | $503.6K | — | Held |
| Z3 Capital Partners, LLC | 39.5K | $493.9K | — | Held |
| IMC-Chicago, LLC | 38.8K | $486.1K | — | Held |
| JANUS HENDERSON GROUP PLC | 37.1K | $464.5K | — | Held |
| DIMENSIONAL FUND ADVISORS LP | 36.5K | $457.1K | — | Held |
| TRUST CO OF TOLEDO NA /OH/ | 36.5K | $457K | — | Held |
| ROYAL BANK OF CANADA | 33.1K | $415K | — | Held |
| Verition Fund Management LLC | 32.1K | $402.1K | — | Held |
| FOX RUN MANAGEMENT, L.L.C. | 31.3K | $392.5K | — | Held |
| UNITED BANK | 31.2K | $390.6K | — | Held |
| Icahn Capital | 29.2K | $365.6K | — | Held |
| INTECH INVESTMENT MANAGEMENT LLC | 29.1K | $364K | — | Held |
| STIFEL FINANCIAL CORP | 28.3K | $354.2K | — | Held |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 27.9K | $349.8K | — | Held |
| NEW YORK STATE COMMON RETIREMENT FUND | 27.8K | $347.6K | — | Held |
| Harbour Capital Advisors, LLC | 27.5K | $327K | — | Held |
| ARIZONA STATE RETIREMENT SYSTEM | 24.1K | $301.3K | — | Held |
| Police & Firemen's Retirement System of New Jersey | 23.8K | $297.7K | — | Held |
| STRS OHIO | 23.7K | $296.7K | — | Held |
| AlphaCentric Advisors LLC | 22.7K | $283.8K | — | Held |
| Qube Research & Technologies Ltd | 22.6K | $283.2K | — | Held |
| ProShare Advisors LLC | 22.3K | $278.8K | — | Held |
| AXQ CAPITAL, LP | 22.2K | $278K | — | Held |
| BNP PARIBAS FINANCIAL MARKETS | 22.1K | $276.1K | — | Held |
| DIVERSIFIED TRUST CO | 21K | $262.7K | — | Held |
| China Universal Asset Management Co., Ltd. | 20.9K | $261.6K | — | Held |
| CHAPIN DAVIS, INC. | 20.1K | $251.7K | — | Held |
| DYMON ASIA CAPITAL (SINGAPORE) PTE. LTD. | 20K | $250.4K | — | Held |
| PROFUND ADVISORS LLC | 19.4K | $242.6K | — | Held |
| KLP KAPITALFORVALTNING AS | 18.3K | $229.1K | — | Held |
| NBC SECURITIES, INC. | 17K | $212.8K | — | Held |
| Rafferty Asset Management, LLC | 16.5K | $206.6K | — | Held |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 12.6K | $157.8K | — | Held |
| Vontobel Holding Ltd. | 10.8K | $134.8K | — | Held |
| Kingsview Wealth Management, LLC | 10.6K | $133.2K | — | Held |
| Tower Research Capital LLC (TRC) | 10.5K | $131K | — | Held |
| Abel Hall, LLC | 10.2K | $127.6K | — | Held |
| DLD Asset Management, LP | 10K | $125.2K | — | Held |
| Farther Finance Advisors, LLC | 9.27K | $116.1K | — | Held |
| AlphaQuest LLC | 7.99K | $100K | — | Held |
| Ameritas Investment Partners, Inc. | 7.63K | $95.6K | — | Held |
| Bellevue Group AG | 7.6K | $95.2K | — | Held |
| Seven Fleet Capital Management LP | 7.11K | $89K | — | Held |
| Mirae Asset Global Investments Co., Ltd. | 6.23K | $78K | — | Held |
| Caitong International Asset Management Co., Ltd | 4.02K | $50.4K | — | Held |
| Hilton Head Capital Partners, LLC | 3.21K | $40.1K | — | Held |
| NATIONAL BANK OF CANADA /FI/ | 2.97K | $37.1K | — | Held |
| GF FUND MANAGEMENT CO. LTD. | 2.52K | $31.5K | — | Held |
| Chung Wu Investment Group, LLC | 2K | $25K | — | Held |
| Aquatic Capital Management LLC | 1.98K | $24.8K | — | Held |
| PNC Financial Services Group, Inc. | 999 | $12.5K | — | Held |
| NISA INVESTMENT ADVISORS, LLC | 899 | $11.3K | — | Held |
| SIGNATUREFD, LLC | 835 | $10.5K | — | Held |
| QUADRANT CAPITAL GROUP LLC | 789 | $9.88K | — | Held |
| Allworth Financial LP | 753 | $9.43K | $179 | Added$8.94K |
| JONES FINANCIAL COMPANIES LLLP | 620 | $7.76K | — | Held |
| Aster Capital Management (DIFC) Ltd | 602 | $7.54K | — | Held |
| Sterling Capital Management LLC | 581 | $7.27K | — | Held |
| MassMutual Private Wealth & Trust, FSB | 516 | $6.46K | — | Held |
| Optiver Holding B.V. | 378 | $4.73K | — | Held |
| Arax Advisory Partners | 206 | $2.58K | — | Held |
| GAMMA Investing LLC | 180 | $2.25K | — | Held |
| Parkside Financial Bank & Trust | 140 | $1.75K | — | Held |
| HRT FINANCIAL LP | 125.1K | $1.57K | — | Held |
| SG Americas Securities, LLC | 124.6K | $1.56K | — | Held |
| Cornerstone Financial Management LLC | 78 | $977 | — | Held |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 87 | $972 | — | Held |
| PRICE T ROWE ASSOCIATES INC /MD/ | 50.3K | $630 | — | Held |
| SageView Advisory Group, LLC | 49 | $614 | — | Held |
| Essential Partners LLC | 11 | $138 | $37 | Added$37 |
| Larson Financial Group LLC | 9 | $113 | — | Held |
| US BANCORP \DE\ | 4 | $50 | — | Held |
| AMALGAMATED BANK | 2.85K | $36 | — | Held |
| BESSEMER GROUP INC | 1.56K | $20 | — | Held |
| Smartleaf Asset Management LLC | 1 | $13 | — | Held |
| Daiwa Securities Group Inc. | 427 | $5 | — | Held |
| CWM, LLC | 381 | $5 | — | Held |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | $0 | — | Held |