| NEA Management Company, LLC | 13.2M | $157.7M | −$7.8M | Cut−$7.8M |
| BlackRock, Inc. | 10.2M | $122.2M | −$5.97M | Cut−$4.61M |
| Frazier Life Sciences Management, L.P. | 9.94M | $118.6M | −$5.86M | Cut−$9.87M |
| Fidelity | 8.04M | $95.9M | −$3.84M | Added$14.5M |
| WELLINGTON MANAGEMENT GROUP LLP | 5.19M | $61.9M | −$2.01M | Added$19.3M |
| Vivo Capital, LLC | 5.09M | $60.8M | −$3.01M | Cut−$3.01M |
| VANGUARD CAPITAL MANAGEMENT LLC | 4.98M | $59.4M | — | Held |
| MARSHALL WACE, LLP | 3.97M | $47.3M | −$2.34M | Cut−$10M |
| Rubric Capital Management LP | 3.71M | $44.3M | −$2.19M | Cut−$2.87M |
| MPM BIOIMPACT LLC | 3.3M | $39.4M | −$1.94M | Cut−$1.8M |
| Viking Global | 3.2M | $38.2M | −$1.89M | Cut−$1.89M |
| ALLIANCEBERNSTEIN L.P. | 2.85M | $35.6M | −$1 | Cut−$2.97M |
| GEODE CAPITAL MANAGEMENT, LLC | 2.78M | $33.2M | −$1.42M | Added$2.94M |
| State Street | 2.67M | $31.8M | −$1.44M | Added$1.31M |
| EVENTIDE ASSET MANAGEMENT, LLC | 2.62M | $31.3M | −$1.55M | Cut−$1.55M |
| ORBIMED ADVISORS LLC | 2.45M | $29.3M | −$1.45M | Cut−$10.7M |
| Logos Global Management LP | 2.4M | $28.6M | −$914.5K | Added$9.23M |
| Vestal Point Capital, LP | 2.17M | $25.8M | — | New |
| ACORN CAPITAL ADVISORS, LLC | 2.14M | $25.6M | −$1.27M | Cut−$1.27M |
| Artia Global Partners LP | 2.01M | $24M | −$1.19M | Cut−$1.19M |
| Affinity Asset Advisors, LLC | 2M | $23.9M | −$1.18M | Cut−$3.06M |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 1.99M | $23.8M | −$654K | Added$9.91M |
| EMERALD ADVISERS, LLC | 1.84M | $21.9M | −$1.09M | Cut−$1.75M |
| Siren, L.L.C. | 1.79M | $21.3M | −$1.05M | Cut−$7.31M |
| Pictet Asset Management Holding SA | 1.71M | $20.4M | −$903.9K | Added$1.17M |
| RAYMOND JAMES FINANCIAL INC | 1.69M | $20.1M | −$995.9K | Cut−$1.98M |
| Soleus Capital Management, L.P. | 1.62M | $19.3M | −$531K | Added$8.06M |
| Pivotal bioVenture Partners Investment Advisor LLC | 1.55M | $18.5M | −$741.5K | Added$2.8M |
| Octagon Capital Advisors LP | 1.49M | $17.7M | −$876.1K | Cut−$17.5M |
| EMERALD MUTUAL FUND ADVISERS TRUST | 1.26M | $15.1M | −$744.9K | Cut−$868.6K |
| GOLDMAN SACHS GROUP INC | 1.23M | $14.6M | −$623.6K | Added$1.42M |
| BANK OF AMERICA CORP /DE/ | 1.22M | $14.5M | −$646K | Added$810.7K |
| Citadel | 1.2M | $14.3M | −$90.2K | Added$12.4M |
| NAN FUNG TRINITY (HK) LTD | 1.14M | $13.6M | −$541.3K | Added$2.15M |
| FLPUTNAM INVESTMENT MANAGEMENT CO | 1.06M | $12.7M | −$621.5K | Cut−$503.7K |
| Woodline Partners LP | 1M | $11.9M | −$590.2K | Cut−$584.2K |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 968.6K | $11.6M | — | Held |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 840.6K | $10M | −$493.7K | Cut−$448.7K |
| NORTHERN TRUST CORP | 806.7K | $9.62M | −$449.6K | Added$83.6K |
| Candriam S.C.A. | 773.6K | $9.23M | — | New |
| MORGAN STANLEY | 731.3K | $8.72M | −$431.4K | Cut−$4.43M |
| VANGUARD FIDUCIARY TRUST CO | 714.6K | $8.53M | — | Held |
| PANAGORA ASSET MANAGEMENT INC | 625.6K | $7.46M | −$369.1K | Cut−$1.21M |
| SPHERA FUNDS MANAGEMENT LTD. | 574K | $6.85M | −$338.7K | Cut−$645.5K |
| MILLENNIUM MANAGEMENT LLC | 571K | $6.81M | −$336.4K | Cut−$327.5K |
| PEREGRINE CAPITAL MANAGEMENT LLC | 530.5K | $6.33M | −$299.5K | Cut−$27.9K |
| BURKEHILL GLOBAL MANAGEMENT, LP | 525K | $6.26M | −$309.7K | Cut−$309.8K |
| SILVERARC CAPITAL MANAGEMENT, LLC | 511.1K | $6.1M | −$301.6K | Cut−$678.6K |
| AMERIPRISE FINANCIAL INC | 504.8K | $6.02M | −$191.3K | Added$1.96M |
| Balyasny Asset Management L.P. | 473.8K | $5.65M | −$103K | Added$3.47M |
| Ensign Peak Advisors, Inc | 464.7K | $5.54M | — | New |
| UBS Group AG | 446.2K | $5.32M | −$162K | Added$1.88M |
| KVP Capital Advisors, LP | 414K | $4.94M | −$244.3K | Cut−$244.3K |
| Jones Hill Capital LP | 370.2K | $4.42M | — | Held |
| Invesco Ltd. | 353K | $4.21M | −$208.3K | Cut−$2.04M |
| Opaleye Management Inc. | 345.1K | $4.12M | −$203.6K | Cut−$203.6K |
| GMT CAPITAL CORP | 317.7K | $3.79M | — | New |
| Swiss Life Asset Management Ltd | 21.4K | $3.66M | — | New |
| Bank of New York Mellon Corp | 260.2K | $3.1M | −$153.5K | Cut−$158.8K |
| SUPERSTRING CAPITAL MANAGEMENT LP | 251.6K | $3M | −$87.5K | Added$1.14M |
| J. Goldman & Co LP | 237K | $2.83M | −$139.8K | Cut−$2.74M |
| F/m Investments LLC | 231.6K | $2.76M | −$136.6K | Cut−$260.4K |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 227.7K | $2.72M | −$134.3K | Cut−$7.62M |
| Propel Bio Management, LLC | 223.8K | $2.65M | — | New |
| Nuveen, LLC | 188.2K | $2.25M | −$108.2K | Cut−$50.3K |
| D. E. Shaw & Co., Inc. | 181.3K | $2.16M | −$83.4K | Added$394.2K |
| Swiss National Bank | 168.2K | $2.01M | −$99.2K | Cut−$99.2K |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 154.2K | $1.84M | −$83K | Added$77.2K |
| STATE OF WISCONSIN INVESTMENT BOARD | 134.7K | $1.61M | −$71.1K | Added$97.9K |
| TRUST CO OF TOLEDO NA /OH/ | 131.5K | $1.57M | −$21.5K | Added$1.11M |
| FIFTH THIRD BANCORP | 128.3K | $1.53M | — | New |
| RHUMBLINE ADVISERS | 109.1K | $1.3M | −$62.5K | Cut−$25K |
| Squarepoint Ops LLC | 104K | $1.24M | — | New |
| OPPENHEIMER & CO INC | 100K | $1.19M | −$59K | Cut−$67.4K |
| LMR Partners LLP | 100K | $1.19M | −$59K | Cut−$59K |
| CITIGROUP INC | 99.9K | $1.19M | −$59K | Cut−$353.8K |
| WEXFORD CAPITAL LP | 90.8K | $1.08M | −$48.4K | Added$55.6K |
| DEUTSCHE BANK AG\ | 84.8K | $1.01M | −$41.8K | Added$124.3K |
| Erste Asset Management GmbH | 90K | $1.01M | −$146.7K | Cut−$146.7K |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 83.4K | $994.9K | −$49.2K | Cut−$54.2K |
| LPL Financial LLC | 80.9K | $964.9K | −$31.2K | Added$301.9K |
| ExodusPoint Capital Management, LP | 79.9K | $952.7K | — | New |
| PFS Partners, LLC | 79K | $942.5K | −$46.6K | Cut−$46.6K |
| SECTORAL ASSET MANAGEMENT INC | 74.4K | $939.5K | $7.43K | Cut−$115.4K |
| SEI INVESTMENTS CO | 78.2K | $933.2K | −$46.2K | Cut−$919K |
| Russell Investments Group, Ltd. | 68.1K | $812.7K | −$35.1K | Added$68.4K |
| JPMORGAN CHASE & CO | 70.6K | $790.4K | −$79.1K | Added$45.7K |
| Simplify Asset Management Inc. | 65.4K | $780.4K | — | New |
| MAI Capital Management | 65.1K | $776.9K | −$38.4K | Cut−$196.7K |
| TUDOR INVESTMENT CORP ET AL | 64.5K | $769.8K | −$38.1K | Cut−$87.6K |
| Legal & General Group Plc | 63.8K | $761.4K | −$37.7K | Cut−$261.2K |
| WealthTrust Axiom LLC | 61.5K | $733.7K | −$36.3K | Cut−$36.3K |
| KENNEDY CAPITAL MANAGEMENT LLC | 61.3K | $731.3K | −$33.2K | Added$26.8K |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 59.9K | $714.2K | −$27.5K | Added$129.7K |
| Vanguard Global Advisers, LLC | 58.9K | $702.7K | — | Held |
| BARCLAYS PLC | 53.6K | $639.3K | −$31.6K | Cut−$6.66M |
| HighVista Strategies LLC | 53.5K | $638.6K | −$31.6K | Cut−$690.6K |
| VANGUARD ASSET MANAGEMENT, Ltd | 53.3K | $635.3K | — | Held |
| MetLife Investment Management, LLC | 51.8K | $618.1K | −$29.6K | Cut−$11K |
| Steward Partners Investment Advisory, LLC | 51.5K | $614.7K | −$26K | Added$62.6K |
| Harbour Capital Advisors, LLC | 40.7K | $602.4K | $80K | Added$275.4K |
| Checkpoint Capital L.P. | 50K | $596.5K | — | New |
| FRANKLIN RESOURCES INC | 49.9K | $595K | −$29.4K | Cut−$29.4K |
| Creative Planning | 45.9K | $547.2K | −$23.7K | Added$43.6K |
| BIT Capital GmbH | 45K | $536.9K | −$26.5K | Cut−$1.09M |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 44.9K | $535.1K | −$24.8K | Added$8.47K |
| VOYA INVESTMENT MANAGEMENT LLC | 44.4K | $529.2K | −$26.2K | Cut−$2.3M |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 43.6K | $519.7K | −$16.5K | Added$169.9K |
| Campbell & CO Investment Adviser LLC | 40K | $477.7K | −$23.6K | Cut−$412.4K |
| Z3 Capital Partners, LLC | 39.5K | $471.8K | −$23.3K | Cut−$22.1K |
| TWO SIGMA INVESTMENTS, LP | 38.4K | $458.3K | −$22.7K | Cut−$590.3K |
| WELLS FARGO & COMPANY/MN | 38.1K | $454K | −$22.5K | Cut−$814K |
| JANUS HENDERSON GROUP PLC | 37.1K | $442.6K | −$21.9K | Cut−$21.9K |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 36.5K | $435K | — | New |
| China Universal Asset Management Co., Ltd. | 32.8K | $390.8K | −$12.3K | Added$129.2K |
| ROYAL BANK OF CANADA | 32.6K | $389K | −$19.5K | Cut−$26K |
| Optimize Financial Inc | 31.9K | $380.4K | −$18.8K | Cut−$389.3K |
| UNITED BANK | 31.2K | $372.2K | −$18.4K | Cut−$18.4K |
| PSP Research LLC | 30K | $357.9K | — | New |
| State of New Jersey Common Pension Fund D | 29.1K | $347.6K | — | New |
| Icahn Capital | 28.1K | $335.8K | −$16.6K | Cut−$29.8K |
| Persistent Asset Partners Ltd | 27.9K | $333K | −$16.5K | Cut−$240.8K |
| NEW YORK STATE COMMON RETIREMENT FUND | 27.8K | $331.2K | −$16.4K | Cut−$16.4K |
| Seven Fleet Capital Management LP | 27.1K | $323.9K | −$4.19K | Added$234.9K |
| GROUP ONE TRADING LLC | 25.9K | $309.3K | — | New |
| STIFEL FINANCIAL CORP | 25.7K | $306.6K | −$15.2K | Cut−$47.5K |
| XTX Topco Ltd | 24.7K | $295.1K | −$14.6K | Cut−$754.3K |
| IMC-Chicago, LLC | 24.3K | $290.2K | −$14.4K | Cut−$195.9K |
| AlphaCentric Advisors LLC | 24K | $286K | −$13.4K | Added$2.17K |
| Police & Firemen's Retirement System of New Jersey | 23.8K | $283.7K | −$14K | Cut−$14K |
| DIVERSIFIED TRUST CO | 23.5K | $280.1K | −$12.4K | Added$17.4K |
| ARIZONA STATE RETIREMENT SYSTEM | 23.4K | $279.3K | −$13.8K | Cut−$21.9K |
| BNP PARIBAS FINANCIAL MARKETS | 23K | $274.7K | −$13K | Cut−$1.45K |
| INTECH INVESTMENT MANAGEMENT LLC | 21.9K | $260.7K | −$12.9K | Cut−$103.3K |
| DIADEMA PARTNERS LP | 21.7K | $258.4K | −$12.8K | Cut−$958.3K |
| PROFUND ADVISORS LLC | 21.1K | $251.9K | −$11.4K | Added$9.28K |
| Vanguard Investments Australia, Ltd. | 20.9K | $249.3K | — | Held |
| SIMPLEX TRADING, LLC | 20.3K | $241.9K | −$12K | Cut−$348.2K |
| CHAPIN DAVIS, INC. | 20.1K | $239.8K | −$11.9K | Cut−$11.9K |
| ProShare Advisors LLC | 19.6K | $233.8K | −$11.6K | Cut−$45K |
| Brevan Howard Capital Management LP | 18.9K | $225.4K | — | New |
| KLP KAPITALFORVALTNING AS | 18.3K | $218.3K | −$10.8K | Cut−$10.8K |
| HSBC HOLDINGS PLC | 17K | $205.3K | — | New |
| NBC SECURITIES, INC. | 17K | $202.8K | −$10K | Cut−$10K |
| DIMENSIONAL FUND ADVISORS LP | 16.1K | $192.1K | −$9.5K | Cut−$265K |
| Kingsview Wealth Management, LLC | 15.8K | $188.1K | −$6.28K | Added$54.9K |
| PRUDENTIAL FINANCIAL INC | 14.7K | $175.7K | −$8.69K | Cut−$6.7M |
| STRS OHIO | 12.8K | $152.7K | −$7.55K | Cut−$144K |
| Rafferty Asset Management, LLC | 12.3K | $146.6K | −$7.25K | Cut−$60K |
| Hudson Bay Capital Management LP | 11.8K | $140.4K | −$6.94K | Cut−$798.6K |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 11.1K | $132.1K | −$6.53K | Cut−$25.7K |
| Maltin Wealth Management, Inc. | 10.6K | $126K | — | New |
| Vontobel Holding Ltd. | 10.4K | $124.3K | −$6.14K | Cut−$10.5K |
| SIH Partners, LLLP | 10K | $119.3K | — | New |
| Farther Finance Advisors, LLC | 9.24K | $107K | −$8.69K | Cut−$9.03K |
| Ameritas Investment Partners, Inc. | 7.63K | $91K | −$4.5K | Cut−$4.5K |
| Mirae Asset Global Investments Co., Ltd. | 6.69K | $79.8K | −$3.68K | Added$1.78K |
| Avidity Partners Management LP | 6.66K | $79.5K | — | New |
| Federation des caisses Desjardins du Quebec | 4.3K | $51.3K | — | New |
| Hilton Head Capital Partners, LLC | 4.25K | $50.7K | −$1.89K | Added$10.6K |
| NISA INVESTMENT ADVISORS, LLC | 3.51K | $41.8K | −$530 | Added$30.6K |
| Tower Research Capital LLC (TRC) | 3.17K | $37.8K | −$1.87K | Cut−$93.2K |
| NATIONAL BANK OF CANADA /FI/ | 2.96K | $35.3K | −$1.75K | Cut−$1.8K |
| GF FUND MANAGEMENT CO. LTD. | 2.87K | $34.2K | −$1.49K | Added$2.64K |
| Chung Wu Investment Group, LLC | 2K | $23.9K | −$1.18K | Cut−$1.18K |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 1.78K | $21.3K | — | New |
| OSAIC HOLDINGS, INC. | 1.54K | $18.3K | — | New |
| Larson Financial Group LLC | 1.05K | $12.5K | −$6 | Added$12.4K |
| JONES FINANCIAL COMPANIES LLLP | 1.01K | $11.4K | −$738 | Added$3.65K |
| QUADRANT CAPITAL GROUP LLC | 789 | $9.41K | −$466 | Cut−$466 |
| Allworth Financial LP | 767 | $9.15K | −$444 | Cut−$277 |
| SIGNATUREFD, LLC | 758 | $9.04K | −$447 | Cut−$1.41K |
| Optiver Holding B.V. | 666 | $7.95K | −$224 | Added$3.21K |
| Sterling Capital Management LLC | 621 | $7.41K | −$342 | Added$135 |
| PNC Financial Services Group, Inc. | 621 | $7.41K | −$366 | Cut−$5.1K |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 555 | $6.62K | $66 | Added$5.65K |
| MassMutual Private Wealth & Trust, FSB | 516 | $6.16K | −$304 | Cut−$304 |
| CWM, LLC | 424 | $5.06K | $4.54K | Added$5.05K |
| Caitong International Asset Management Co., Ltd | 267 | $3.19K | −$158 | Cut−$47.2K |
| Versant Capital Management, Inc | 232 | $2.77K | — | New |
| Parkside Financial Bank & Trust | 140 | $1.67K | −$82 | Cut−$82 |
| GAMMA Investing LLC | 94 | $1.12K | −$56 | Cut−$1.13K |
| US BANCORP \DE\ | 85 | $1.01K | −$2 | Added$964 |
| Cornerstone Financial Management LLC | 78 | $931 | −$46 | Cut−$46 |
| ROTHSCHILD INVESTMENT LLC | 70 | $835 | — | New |
| PRICE T ROWE ASSOCIATES INC /MD/ | 64.7K | $772 | −$30 | Added$142 |
| Bare Financial Services, Inc | 30 | $358 | — | New |
| TWIN PEAKS WEALTH ADVISORS, LLC | 29 | $346 | — | New |
| SBI Securities Co., Ltd. | 29 | $346 | — | New |
| SG Americas Securities, LLC | 28.1K | $335 | −$16 | Cut−$1.23K |
| EverSource Wealth Advisors, LLC | 11 | $131 | — | New |
| Essential Partners LLC | 11 | $131 | −$7 | Cut−$7 |
| Hughes Financial Services, LLC | 3 | $36 | — | New |
| KBC Group NV | 2.46K | $29 | — | New |
| Keating Financial Advisory Services, Inc. | 1 | $12 | — | New |
| Stone House Investment Management, LLC | 1 | $12 | — | New |
| Smartleaf Asset Management LLC | 1 | $11 | −$2 | Cut−$2 |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | $0 | — | Held |
| Covestor Ltd | 12 | $0 | — | New |