| RA CAPITAL MANAGEMENT, L.P. | 9.91M | $407.5M | — | Held |
| TPG GP A, LLC | 6.74M | $277.5M | — | Held |
| ORBIMED ADVISORS LLC | 3.56M | $146.5M | — | Held |
| Viking Global | 3.2M | $131.4M | — | Held |
| Atlas Venture Life Science Advisors, LLC | 3M | $123.2M | — | Held |
| ENAVATE SCIENCES GP, LLC | 2.48M | $101.9M | — | Held |
| BlackRock, Inc. | 1.29M | $53.1M | — | Held |
| JPMORGAN CHASE & CO | 1.23M | $50.7M | — | Held |
| Vanguard | 1.18M | $48.7M | — | Held |
| PERCEPTIVE ADVISORS LLC | 1.18M | $48.5M | — | Held |
| JENNISON ASSOCIATES LLC | 1.12M | $45.9M | — | Held |
| Citadel | 1.09M | $44.7M | — | Held |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 970.6K | $39.9M | — | Held |
| Aberdeen Group plc | 840K | $34.6M | — | Held |
| State Street | 693.4K | $28.5M | — | Held |
| EVENTIDE ASSET MANAGEMENT, LLC | 639K | $26.3M | — | Held |
| BAKER BROS. ADVISORS LP | 400K | $16.5M | — | Held |
| GEODE CAPITAL MANAGEMENT, LLC | 380K | $15.6M | — | Held |
| Siren, L.L.C. | 300K | $12.3M | — | Held |
| Soleus Capital Management, L.P. | 268.5K | $11M | — | Held |
| Kalehua Capital Management LLC | 197.1K | $8.11M | — | Held |
| SUPERSTRING CAPITAL MANAGEMENT LP | 180.6K | $7.43M | — | Held |
| FRANKLIN RESOURCES INC | 175.5K | $7.22M | — | Held |
| Alyeska Investment Group, L.P. | 136.2K | $5.6M | — | Held |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 123.7K | $5.09M | — | Held |
| Artia Global Partners LP | 119.7K | $4.93M | — | Held |
| TD Asset Management Inc | 113.4K | $4.66M | — | Held |
| NORTHERN TRUST CORP | 112.1K | $4.61M | — | Held |
| Invesco Ltd. | 111.2K | $4.57M | — | Held |
| AMERIPRISE FINANCIAL INC | 101.6K | $4.18M | — | Held |
| Rock Springs Capital Management LP | 99.4K | $4.09M | — | Held |
| UBS Group AG | 89.2K | $3.67M | — | Held |
| Driehaus Capital Management LLC | 83.8K | $3.45M | — | Held |
| MILLENNIUM MANAGEMENT LLC | 80.5K | $3.31M | — | Held |
| Ensign Peak Advisors, Inc | 79.9K | $3.29M | — | Held |
| Longaeva Partners L.P. | 79.7K | $3.28M | — | Held |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 69.4K | $2.87M | — | Held |
| SEVEN GRAND MANAGERS, LLC | 50K | $2.06M | — | Held |
| MORGAN STANLEY | 49.9K | $2.05M | $267.9K | Added$1.38M |
| BARCLAYS PLC | 48.2K | $1.98M | $207K | Added$1.46M |
| BANK OF AMERICA CORP /DE/ | 43.6K | $1.79M | $76.7K | Added$1.6M |
| SILVERARC CAPITAL MANAGEMENT, LLC | 41.5K | $1.71M | — | Held |
| WELLINGTON MANAGEMENT GROUP LLP | 38.3K | $1.58M | — | Held |
| ALPS ADVISORS INC | 36.6K | $1.51M | — | Held |
| GOLDMAN SACHS GROUP INC | 36.3K | $1.49M | — | Held |
| Bank of New York Mellon Corp | 35.1K | $1.45M | — | Held |
| POLEN CAPITAL MANAGEMENT LLC | 31.3K | $1.29M | — | Held |
| Rafferty Asset Management, LLC | 24.7K | $1.02M | — | Held |
| Nuveen, LLC | 23.7K | $976.4K | — | Held |
| Russell Investments Group, Ltd. | 21.9K | $902.7K | — | Held |
| RHUMBLINE ADVISERS | 17.7K | $727.9K | — | Held |
| WELLS FARGO & COMPANY/MN | 17.6K | $722K | — | Held |
| Squarepoint Ops LLC | 16.4K | $673K | — | Held |
| ALLIANCEBERNSTEIN L.P. | 15.6K | $642.6K | — | Held |
| China Universal Asset Management Co., Ltd. | 10.3K | $422.6K | — | Held |
| DEUTSCHE BANK AG\ | 10K | $412.6K | — | Held |
| PROFUND ADVISORS LLC | 9.21K | $379K | — | Held |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 8.91K | $367.1K | — | Held |
| MetLife Investment Management, LLC | 8.56K | $352.4K | — | Held |
| INTECH INVESTMENT MANAGEMENT LLC | 7.59K | $312.2K | — | Held |
| KENNEDY CAPITAL MANAGEMENT LLC | 6.75K | $277.8K | — | Held |
| TWO SIGMA INVESTMENTS, LP | 6.4K | $263.3K | — | Held |
| Virtus Investment Advisers, LLC | 6.22K | $255.9K | — | Held |
| AMERICAN CENTURY COMPANIES INC | 6.18K | $254.2K | — | Held |
| DARK FOREST CAPITAL MANAGEMENT LP | 5.99K | $246.5K | — | Held |
| D. E. Shaw & Co., Inc. | 5.74K | $236.2K | — | Held |
| NEW YORK STATE COMMON RETIREMENT FUND | 5.3K | $218K | — | Held |
| CITIGROUP INC | 5.18K | $213.3K | — | Held |
| XTX Topco Ltd | 4.93K | $202.7K | — | Held |
| ProShare Advisors LLC | 4.9K | $201.7K | — | Held |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 5.19K | $197.2K | — | Held |
| CIBC Private Wealth Group LLC | 4.5K | $185.1K | — | Held |
| Police & Firemen's Retirement System of New Jersey | 4.23K | $174.1K | — | Held |
| AlphaCentric Advisors LLC | 2.72K | $111.9K | — | Held |
| BNP PARIBAS FINANCIAL MARKETS | 2.26K | $93.1K | — | Held |
| Mirae Asset Global Investments Co., Ltd. | 2.17K | $89.2K | — | Held |
| Legal & General Group Plc | 1.68K | $69.2K | — | Held |
| Balyasny Asset Management L.P. | 1.41K | $57.8K | — | Held |
| Ameritas Investment Partners, Inc. | 1.3K | $53.6K | — | Held |
| Tower Research Capital LLC (TRC) | 1.13K | $46.4K | — | Held |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 988 | $40.6K | — | Held |
| GF FUND MANAGEMENT CO. LTD. | 876 | $36K | — | Held |
| PRICE T ROWE ASSOCIATES INC /MD/ | 831.4K | $34.2K | — | Held |
| ROYAL BANK OF CANADA | 489 | $21K | — | Held |
| Fidelity | 384 | $15.8K | — | Held |
| Farther Finance Advisors, LLC | 190 | $7.82K | — | Held |
| GAMMA Investing LLC | 177 | $7.28K | — | Held |
| Sterling Capital Management LLC | 105 | $4.32K | — | Held |
| US BANCORP \DE\ | 65 | $2.67K | — | Held |
| Rockefeller Capital Management L.P. | 48 | $1.98K | — | Held |
| Aster Capital Management (DIFC) Ltd | 37 | $1.52K | — | Held |
| Allworth Financial LP | 28 | $1.15K | $257 | Added$504 |
| Hughes Financial Services, LLC | 25 | $1.03K | — | Held |
| EverSource Wealth Advisors, LLC | 20 | $823 | — | Held |
| SG Americas Securities, LLC | 10.7K | $440 | — | Held |
| PNC Financial Services Group, Inc. | 5 | $206 | — | Held |
| Cygnus Capital Advisors, LLC | 2.4K | $99 | — | Held |
| ROTHSCHILD INVESTMENT LLC | 1 | $41 | — | Held |
| AMALGAMATED BANK | 504 | $21 | — | Held |
| Daiwa Securities Group Inc. | 149 | $6 | — | Held |
| CWM, LLC | 80 | $3 | — | Held |