| RA CAPITAL MANAGEMENT, L.P. | 20.1M | $130.6M | — | Held |
| Viking Global | 3.48M | $22.7M | — | Held |
| Commodore Capital LP | 3.4M | $22.1M | — | Held |
| Vivo Capital, LLC | 2.33M | $15.1M | — | Held |
| Point72 Asset Management, L.P. | 2.27M | $14.8M | — | Held |
| Vanguard | 2.21M | $14.4M | — | Held |
| Laurion Capital Management LP | 2.05M | $13.4M | — | Held |
| BVF INC/IL | 1.92M | $12.5M | — | Held |
| Nantahala Capital Management, LLC | 1.55M | $10.1M | — | Held |
| JANUS HENDERSON GROUP PLC | 1.5M | $9.79M | — | Held |
| Pictet Asset Management Holding SA | 1.35M | $8.8M | — | Held |
| Woodline Partners LP | 1.31M | $8.53M | — | Held |
| AWM Investment Company, Inc. | 1.3M | $8.46M | — | Held |
| BlackRock, Inc. | 1.23M | $8.04M | — | Held |
| MORGAN STANLEY | 1.08M | $7.06M | $1.09M | Added$4.4M |
| Balyasny Asset Management L.P. | 866.3K | $5.64M | — | Held |
| PERCEPTIVE ADVISORS LLC | 829.9K | $5.4M | — | Held |
| Octagon Capital Advisors LP | 700K | $4.56M | — | Held |
| Siren, L.L.C. | 700K | $4.56M | — | Held |
| GEODE CAPITAL MANAGEMENT, LLC | 542.1K | $3.53M | — | Held |
| Ikarian Capital, LLC | 447.2K | $2.91M | — | Held |
| BOOTHBAY FUND MANAGEMENT, LLC | 418K | $2.72M | — | Held |
| Boxer Capital Management, LLC | 373.9K | $2.43M | $472.5K | Added$1.28M |
| BANK OF AMERICA CORP /DE/ | 351.1K | $2.29M | $5.08K | Added$2.27M |
| Driehaus Capital Management LLC | 315K | $2.05M | — | Held |
| MARSHALL WACE, LLP | 290.6K | $1.89M | — | Held |
| Citadel | 267.8K | $1.74M | — | Held |
| TWO SIGMA INVESTMENTS, LP | 267.4K | $1.74M | — | Held |
| Walleye Capital LLC | 256K | $1.67M | — | Held |
| GOLDMAN SACHS GROUP INC | 241.6K | $1.57M | — | Held |
| State Street | 217.5K | $1.42M | — | Held |
| Artia Global Partners LP | 205.3K | $1.34M | — | Held |
| MILLENNIUM MANAGEMENT LLC | 197.9K | $1.29M | — | Held |
| JANE STREET GROUP, LLC | 192.7K | $1.25M | — | Held |
| 683 Capital Management, LLC | 186.9K | $1.22M | — | Held |
| Polymer Capital Management (HK) LTD | 160K | $1.04M | — | Held |
| Renaissance Technologies | 147.9K | $962.8K | — | Held |
| MONIMUS CAPITAL MANAGEMENT, LP | 138.4K | $901K | — | Held |
| DIMENSIONAL FUND ADVISORS LP | 135.2K | $880.1K | — | Held |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 125.5K | $817K | — | Held |
| SPHERA FUNDS MANAGEMENT LTD. | 121.5K | $790.8K | — | Held |
| ExodusPoint Capital Management, LP | 120.7K | $785.9K | — | Held |
| NORTHERN TRUST CORP | 118.3K | $769.9K | — | Held |
| READYSTATE ASSET MANAGEMENT LP | 113.5K | $738.9K | — | Held |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 100K | $651K | — | Held |
| XTX Topco Ltd | 98K | $638.2K | — | Held |
| RBF Capital, LLC | 95K | $618.7K | — | Held |
| BNP PARIBAS FINANCIAL MARKETS | 89.6K | $583.1K | — | Held |
| Connor, Clark & Lunn Investment Management Ltd. | 73.3K | $477.2K | — | Held |
| Hudson Bay Capital Management LP | 69.4K | $451.7K | — | New |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 63K | $410.1K | — | Held |
| BARCLAYS PLC | 55.7K | $362.7K | $2.18K | Added$357.4K |
| Jump Financial, LLC | 55.4K | $360.9K | — | Held |
| Resolute Capital Asset Partners LLC | 50K | $325.5K | — | Held |
| SIMPLEX TRADING, LLC | 43.2K | $281.2K | — | Held |
| ADAR1 Capital Management, LLC | 36.8K | $239.8K | — | Held |
| Rangeley Capital, LLC | 36.2K | $235.7K | — | Held |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 36.1K | $235.2K | — | Held |
| Rathbones Group PLC | 32K | $208.3K | — | Held |
| CITIGROUP INC | 31.3K | $204K | — | Held |
| Qube Research & Technologies Ltd | 31.2K | $203.3K | — | Held |
| Squarepoint Ops LLC | 31.2K | $203.2K | — | Held |
| OMERS ADMINISTRATION Corp | 27.6K | $179.7K | — | Held |
| Trexquant Investment LP | 24.3K | $158.2K | — | Held |
| TWO SIGMA ADVISERS, LP | 20.8K | $135.4K | — | Held |
| AMERICAN CENTURY COMPANIES INC | 15.8K | $102.5K | — | Held |
| Lighthouse Investment Partners, LLC | 14.6K | $94.9K | — | Held |
| Jefferies Financial Group Inc. | 13.7K | $89.4K | — | Held |
| China Universal Asset Management Co., Ltd. | 11.2K | $72.9K | — | Held |
| BANK OF MONTREAL /CAN/ | 10K | $65.1K | — | Held |
| Tower Research Capital LLC (TRC) | 9.49K | $61.8K | — | Held |
| UBS Group AG | 8.07K | $52.5K | — | Held |
| JPMORGAN CHASE & CO | 5.24K | $34.1K | — | Held |
| Mirae Asset Global Investments Co., Ltd. | 3.34K | $21.8K | — | Held |
| Fidelity | 1.66K | $10.8K | — | Held |
| GF FUND MANAGEMENT CO. LTD. | 1.35K | $8.79K | — | Held |
| ROYAL BANK OF CANADA | 383 | $2K | — | Held |
| NISA INVESTMENT ADVISORS, LLC | 195 | $1.27K | — | Held |
| Parallel Advisors, LLC | 135 | $879 | — | Held |
| Cornerstone Financial Management LLC | 121 | $788 | — | Held |
| OPTIMA CAPITAL LLC | 108 | $703 | — | Held |
| GSA CAPITAL PARTNERS LLP | 43.4K | $283 | — | Held |
| Allworth Financial LP | 28 | $183 | — | New |
| ACADIAN ASSET MANAGEMENT LLC | 20.8K | $134 | — | Held |
| Larson Financial Group LLC | 13 | $85 | — | Held |
| OSAIC HOLDINGS, INC. | 8 | $52 | — | Held |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | $0 | — | Held |
| CWM, LLC | 5 | $0 | — | Held |