| Fidelity | 13.8M | $638.3M | — | Held |
| JANUS HENDERSON GROUP PLC | 13.4M | $617.7M | — | Held |
| Vanguard | 12.2M | $562.6M | — | Held |
| RA CAPITAL MANAGEMENT, L.P. | 10.7M | $494.8M | — | Held |
| BlackRock, Inc. | 10.2M | $472.8M | — | Held |
| WELLINGTON MANAGEMENT GROUP LLP | 5.97M | $275.3M | — | Held |
| State Street | 4.98M | $229.8M | — | Held |
| Paradigm Biocapital Advisors LP | 4.07M | $187.7M | — | Held |
| Deep Track Capital, LP | 4M | $184.6M | — | Held |
| D. E. Shaw & Co., Inc. | 3.63M | $167.5M | — | Held |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 3.54M | $163.3M | — | Held |
| Kynam Capital Management, LP | 2.92M | $134.8M | — | Held |
| GEODE CAPITAL MANAGEMENT, LLC | 2.87M | $132.3M | — | Held |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1.73M | $79.6M | — | Held |
| Caligan Partners LP | 1.7M | $78.7M | — | Held |
| Polar Capital Holdings Plc | 1.67M | $77.2M | — | Held |
| Pivotal bioVenture Partners Investment Advisor LLC | 1.37M | $63.3M | — | Held |
| MAVERICK CAPITAL LTD | 1.35M | $62.5M | — | Held |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1.29M | $59.7M | — | Held |
| NORGES BANK | 1.23M | $56.7M | $7.54M | Added$22.7M |
| Eversept Partners, LP | 1.2M | $55.3M | — | Held |
| UBS Group AG | 1.09M | $50.5M | — | Held |
| JPMORGAN CHASE & CO | 1.09M | $50.1M | — | Held |
| GOLDMAN SACHS GROUP INC | 1.08M | $49.7M | — | Held |
| NORTHERN TRUST CORP | 1.03M | $47.7M | — | Held |
| Aberdeen Group plc | 979.8K | $45.2M | — | Held |
| EVENTIDE ASSET MANAGEMENT, LLC | 917.1K | $42.3M | — | Held |
| NOVO HOLDINGS A/S | 916.2K | $42.3M | — | Held |
| Pictet Asset Management Holding SA | 881.4K | $40.7M | — | Held |
| Capital Research Global Investors | 843K | $38.9M | — | Held |
| MORGAN STANLEY | 835.4K | $38.5M | $7.94M | Added$10.3M |
| Saturn V Capital Management LP | 798.9K | $36.9M | — | Held |
| Trails Edge Capital Partners, LP | 737.5K | $34M | — | Held |
| BANK OF AMERICA CORP /DE/ | 701.6K | $32.4M | $6.43M | Added$9.5M |
| JENNISON ASSOCIATES LLC | 677.6K | $31.3M | — | Held |
| Logos Global Management LP | 650K | $30M | — | Held |
| Soleus Capital Management, L.P. | 609K | $28.1M | — | Held |
| BROWN ADVISORY INC | 566.9K | $26.2M | — | Held |
| VICTORY CAPITAL MANAGEMENT INC | 549.5K | $25.4M | — | Held |
| Assenagon Asset Management S.A. | 544.7K | $25.1M | — | Held |
| Ensign Peak Advisors, Inc | 527.7K | $24.3M | — | Held |
| FEDERATED HERMES, INC. | 523.5K | $24.2M | — | Held |
| BOOTHBAY FUND MANAGEMENT, LLC | 497.7K | $23M | — | Held |
| EcoR1 Capital, LLC | 450K | $20.8M | — | Held |
| Bank of New York Mellon Corp | 449.4K | $20.7M | — | Held |
| MILLENNIUM MANAGEMENT LLC | 424.3K | $19.6M | — | Held |
| Spruce Street Capital LP | 400.4K | $18.5M | — | Held |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 389K | $17.9M | — | Held |
| Ikarian Capital, LLC | 378.7K | $17.5M | — | Held |
| TD Asset Management Inc | 363.7K | $16.8M | — | Held |
| AMERICAN CENTURY COMPANIES INC | 357.3K | $16.5M | — | Held |
| DEUTSCHE BANK AG\ | 342.9K | $15.8M | — | Held |
| FRANKLIN RESOURCES INC | 336.1K | $15.5M | — | Held |
| Citadel | 326.6K | $15.1M | — | Held |
| ADAR1 Capital Management, LLC | 315.6K | $14.6M | — | Held |
| Nuveen, LLC | 307.2K | $14.2M | — | Held |
| AMERIPRISE FINANCIAL INC | 305.2K | $14.1M | — | Held |
| Artisan Partners Limited Partnership | 304K | $14M | — | Held |
| BARCLAYS PLC | 296.2K | $13.7M | $3M | Cut−$522.3K |
| Elmind Capital, LP | 291.5K | $13.4M | — | Held |
| JANE STREET GROUP, LLC | 279.6K | $12.9M | — | Held |
| TANG CAPITAL MANAGEMENT LLC | 275K | $12.7M | — | Held |
| Woodline Partners LP | 274.7K | $12.7M | — | Held |
| University of Wisconsin Foundation | 247K | $11.4M | — | Held |
| Alyeska Investment Group, L.P. | 244.8K | $11.3M | — | Held |
| CITIGROUP INC | 241.9K | $11.2M | — | Held |
| Swiss National Bank | 230.4K | $10.6M | — | Held |
| Qube Research & Technologies Ltd | 207.1K | $9.56M | — | Held |
| SEGALL BRYANT & HAMILL, LLC | 193.4K | $8.92M | — | Held |
| DIMENSIONAL FUND ADVISORS LP | 191.8K | $8.85M | — | Held |
| RAYMOND JAMES FINANCIAL INC | 185.9K | $8.45M | — | Held |
| Point72 Asset Management, L.P. | 161.6K | $7.46M | — | Held |
| RHUMBLINE ADVISERS | 150.9K | $6.96M | — | Held |
| SILVERARC CAPITAL MANAGEMENT, LLC | 148.8K | $6.87M | — | Held |
| California Public Employees Retirement System | 144.6K | $6.67M | — | Held |
| NAN FUNG TRINITY (HK) LTD | 142.9K | $6.59M | — | Held |
| Invesco Ltd. | 141.2K | $6.52M | — | Held |
| WELLS FARGO & COMPANY/MN | 134.1K | $6.19M | — | Held |
| ALLIANCEBERNSTEIN L.P. | 133.9K | $6.18M | — | Held |
| Rafferty Asset Management, LLC | 133.8K | $6.17M | — | Held |
| READYSTATE ASSET MANAGEMENT LP | 131.6K | $6.07M | — | Held |
| Cormorant Asset Management, LP | 125K | $5.77M | — | Held |
| Legal & General Group Plc | 120.3K | $5.55M | — | Held |
| NEW YORK STATE COMMON RETIREMENT FUND | 116.8K | $5.39M | — | Held |
| HighVista Strategies LLC | 114K | $5.26M | — | Held |
| TWO SIGMA INVESTMENTS, LP | 111.3K | $5.14M | — | Held |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 110.9K | $5.12M | — | Held |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 108.4K | $4.97M | — | Held |
| Creative Planning | 102.7K | $4.74M | — | Held |
| NEXTBio Capital Management LP | 95.5K | $4.41M | — | Held |
| Jump Financial, LLC | 89.8K | $4.14M | — | Held |
| TWINBEECH CAPITAL LP | 78.2K | $3.61M | — | Held |
| BANQUE PICTET & CIE SA | 71.8K | $3.31M | — | Held |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 70.1K | $3.24M | — | Held |
| Man Group plc | 68.9K | $3.18M | — | Held |
| STATE OF WISCONSIN INVESTMENT BOARD | 68.3K | $3.15M | — | Held |
| Renaissance Technologies | 65.2K | $3.01M | — | Held |
| LAZARD ASSET MANAGEMENT LLC | 65K | $3M | — | Held |
| MetLife Investment Management, LLC | 63.8K | $2.94M | — | Held |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 61K | $2.81M | — | Held |
| INTECH INVESTMENT MANAGEMENT LLC | 58.2K | $2.69M | — | Held |
| FRED ALGER MANAGEMENT, LLC | 57.8K | $2.67M | — | Held |
| ENVESTNET ASSET MANAGEMENT INC | 50.8K | $2.34M | — | Held |
| BNP PARIBAS FINANCIAL MARKETS | 50.8K | $2.34M | — | Held |
| PROFUND ADVISORS LLC | 50.4K | $2.33M | — | Held |
| Ishara Investments LP | 50K | $2.31M | — | Held |
| VOYA INVESTMENT MANAGEMENT LLC | 47.8K | $2.2M | — | Held |
| Rock Springs Capital Management LP | 47K | $2.17M | — | Held |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 40K | $1.85M | — | Held |
| ArrowMark Colorado Holdings LLC | 40K | $1.85M | — | Held |
| State of New Jersey Common Pension Fund D | 39.9K | $1.84M | — | Held |
| BROWN BROTHERS HARRIMAN & CO | 38K | $1.75M | — | Held |
| GUGGENHEIM CAPITAL LLC | 34.5K | $1.59M | — | Held |
| Brevan Howard Capital Management LP | 34.4K | $1.58M | — | Held |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 34.1K | $1.57M | — | Held |
| ARIZONA STATE RETIREMENT SYSTEM | 32.8K | $1.51M | — | Held |
| Voleon Capital Management LP | 31.8K | $1.47M | — | Held |
| Headlands Technologies LLC | 31.7K | $1.46M | — | Held |
| Police & Firemen's Retirement System of New Jersey | 31.1K | $1.44M | — | Held |
| SEI INVESTMENTS CO | 30.9K | $1.43M | — | Held |
| Alberta Investment Management Corp | 30.1K | $1.39M | — | New |
| Balyasny Asset Management L.P. | 26.9K | $1.24M | — | Held |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 26.7K | $1.23M | — | Held |
| ProShare Advisors LLC | 26.7K | $1.23M | — | Held |
| Seven Fleet Capital Management LP | 25.4K | $1.17M | — | Held |
| Vanguard Personalized Indexing Management, LLC | 25.2K | $1.16M | — | Held |
| KLP KAPITALFORVALTNING AS | 25K | $1.15M | — | Held |
| Mirae Asset Global Investments Co., Ltd. | 24.6K | $1.13M | — | Held |
| Aquatic Capital Management LLC | 24.5K | $1.13M | — | Held |
| Pathstone Holdings, LLC | 24.2K | $1.12M | — | Held |
| MARTINGALE ASSET MANAGEMENT L P | 24K | $1.11M | — | Held |
| Progeny 3, Inc. | 23.3K | $1.08M | — | Held |
| DIADEMA PARTNERS LP | 23K | $1.06M | — | Held |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 22K | $984.8K | — | Held |
| China Universal Asset Management Co., Ltd. | 21.3K | $984.2K | — | Held |
| LPL Financial LLC | 20.5K | $945.4K | — | Held |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 20K | $923K | — | Held |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 17.3K | $797.8K | — | Held |
| DNB Asset Management AS | 16.5K | $760K | — | Held |
| Russell Investments Group, Ltd. | 16.5K | $759.3K | — | Held |
| PRUDENTIAL FINANCIAL INC | 16.4K | $757.9K | — | Held |
| Odyssean, LLC | 16.2K | $746.6K | — | Held |
| GILDER GAGNON HOWE & CO LLC | 16.1K | $743.3K | — | Held |
| Verition Fund Management LLC | 15.7K | $725.8K | — | Held |
| XTX Topco Ltd | 15.3K | $704.1K | — | Held |
| PNC Financial Services Group, Inc. | 14.9K | $688.3K | — | Held |
| SummitTX Capital, L.P. | 14.9K | $686.1K | — | Held |
| Walleye Capital LLC | 14.8K | $683.1K | — | Held |
| Icahn Capital | 14.8K | $681.1K | — | Held |
| Quantinno Capital Management LP | 14.5K | $669.1K | — | Held |
| Baird Financial Group, Inc. | 13.8K | $636.2K | — | Held |
| Baker Avenue Asset Management, LP | 13.1K | $606.4K | — | Held |
| T. Rowe Price Investment Management, Inc. | 11.3M | $521.2K | — | Held |
| AlphaQuest LLC | 10.5K | $485.1K | — | Held |
| CANADA PENSION PLAN INVESTMENT BOARD | 10.4K | $479.9K | — | Held |
| STRS OHIO | 10.3K | $475.2K | — | Held |
| Avior Wealth Management, LLC | 9.49K | $437.7K | — | Held |
| Ameritas Investment Partners, Inc. | 9.29K | $428.8K | — | Held |
| ROYAL BANK OF CANADA | 9.22K | $426K | — | Held |
| XPONANCE LLC | 9.08K | $419K | — | Held |
| Perbak Capital Partners LLP | 8.9K | $410.6K | — | Held |
| Vident Advisory, LLC | 8.82K | $407K | — | Held |
| Mariner, LLC | 8.54K | $393.9K | — | Held |
| Sumitomo Mitsui Trust Group, Inc. | 8.28K | $382.2K | — | Held |
| Meeder Advisory Services, Inc. | 8.1K | $373.9K | — | Held |
| HSBC HOLDINGS PLC | 7.8K | $363.4K | — | Held |
| Cetera Investment Advisers | 7.8K | $359.8K | — | Held |
| CIBC Private Wealth Group LLC | 7.76K | $357.9K | — | Held |
| CIBC WORLD MARKETS CORP | 7.58K | $349.5K | — | Held |
| Tower Research Capital LLC (TRC) | 7.16K | $330.3K | — | Held |
| Allianz Asset Management GmbH | 7.1K | $327.6K | — | Held |
| J.Safra Asset Management Corp | 7.05K | $325.5K | — | Held |
| MACKENZIE FINANCIAL CORP | 7.17K | $325.1K | — | Held |
| Qsemble Capital Management, LP | 6.7K | $309.2K | — | Held |
| Sterling Capital Management LLC | 6.61K | $305.2K | — | Held |
| SIGNATUREFD, LLC | 6.17K | $284.5K | — | Held |
| Virtus Investment Advisers, LLC | 5.98K | $275.9K | — | Held |
| Allspring Global Investments Holdings, LLC | 5.85K | $271.8K | — | Held |
| Leonteq Securities AG | 5.49K | $253.1K | $55.5K | Added$9.59K |
| Quantbot Technologies LP | 5.4K | $249.1K | — | Held |
| Swiss Life Asset Management Ltd | 5.4K | $249.1K | — | New |
| Persistent Asset Partners Ltd | 5.33K | $246.1K | $54K | Cut−$1.56M |
| Amundi | 5.09K | $234.9K | — | Held |
| TWO SIGMA SECURITIES, LLC | 5.03K | $231.9K | — | Held |
| FARALLON CAPITAL MANAGEMENT LLC | 5K | $230.7K | — | New |
| Quarry LP | 5K | $230.7K | — | Held |
| PRINCIPAL FINANCIAL GROUP INC | 4.93K | $227.6K | — | Held |
| Neo Ivy Capital Management | 4.8K | $221.6K | — | Held |
| Values First Advisors, Inc. | 4.68K | $216K | — | Held |
| Sanctuary Advisors, LLC | 4.67K | $215.4K | $52.5K | Cut−$277.6K |
| Empowered Funds, LLC | 4.58K | $211.1K | — | Held |
| CIBC Asset Management Inc | 4.52K | $208.4K | — | Held |
| NEUBERGER BERMAN GROUP LLC | 4.4K | $203K | — | Held |
| Clearstead Advisors, LLC | 3.63K | $167.7K | — | Held |
| VIRTUS ADVISERS, LLC | 3.5K | $161.5K | — | New |
| OSAIC HOLDINGS, INC. | 3.44K | $158.8K | — | Held |
| NISA INVESTMENT ADVISORS, LLC | 3.11K | $143.7K | — | Held |
| GF FUND MANAGEMENT CO. LTD. | 2.57K | $118.7K | — | Held |
| DANSKE BANK A/S | 2.1K | $96.9K | $28.6K | Added$28.6K |
| Advisors Asset Management, Inc. | 1.92K | $88.7K | — | Held |
| ASSETMARK, INC | 1.9K | $87.4K | — | Held |
| QUADRANT CAPITAL GROUP LLC | 1.86K | $85.9K | — | Held |
| IFP Advisors, Inc | 1.59K | $73.6K | $16.1K | Added$15.7K |
| SIMPLEX TRADING, LLC | 1.55K | $71.5K | — | Held |
| US BANCORP \DE\ | 1.47K | $68K | — | Held |
| Eurizon Capital SGR S.p.A. | 1.38K | $62.7K | — | Held |
| Allworth Financial LP | 1.26K | $58K | $12.4K | Added$14K |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1.18M | $54.2K | — | Held |
| Blue Trust, Inc. | 1.16K | $53.7K | — | Held |
| COMERICA BANK | 1.1K | $50.9K | — | Held |
| Rockefeller Capital Management L.P. | 995 | $45.9K | — | Held |
| GAMMA Investing LLC | 922 | $42.5K | — | Held |
| Pinnacle Wealth Planning Services, Inc. | 890 | $41.1K | — | Held |
| GROUP ONE TRADING LLC | 831 | $38.3K | — | Held |
| Caitong International Asset Management Co., Ltd | 830 | $38.3K | — | Held |
| EverSource Wealth Advisors, LLC | 741 | $34.2K | — | Held |
| MassMutual Private Wealth & Trust, FSB | 597 | $27.5K | — | Held |
| Smartleaf Asset Management LLC | 597 | $27.1K | — | Held |
| Parallel Advisors, LLC | 586 | $27K | — | Held |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 495 | $22.8K | — | Held |
| Kemnay Advisory Services Inc. | 460 | $21.2K | — | Held |
| Versant Capital Management, Inc | 434 | $20K | — | Held |
| CALDWELL SUTTER CAPITAL, INC. | 432 | $19.9K | — | Held |
| Westside Investment Management, Inc. | 414 | $19.2K | — | Held |
| Cullen/Frost Bankers, Inc. | 406 | $18.7K | — | Held |
| Mitsubishi UFJ Asset Management Co., Ltd. | 372 | $17.3K | — | Held |
| HUNTINGTON NATIONAL BANK | 369 | $17K | — | Held |
| Farther Finance Advisors, LLC | 343 | $15.8K | — | Held |
| Optiver Holding B.V. | 336 | $15.5K | — | Held |
| FINANCIAL CONSULATE, INC | 250 | $11.5K | — | Held |
| Sankala Group LLC | 186 | $11.5K | — | Held |
| Larson Financial Group LLC | 246 | $11.3K | — | Held |
| INTERNATIONAL ASSETS INVESTMENT MANAGEMENT, LLC | 200 | $9.23K | — | Held |
| Private Wealth Management Group, LLC | 196 | $9.04K | — | Held |
| C WorldWide Group Holding A/S | 195K | $9K | — | Held |
| Federation des caisses Desjardins du Quebec | 192 | $8.86K | — | Held |
| Global Retirement Partners, LLC | 181 | $8.35K | — | Held |
| ROTHSCHILD INVESTMENT LLC | 161 | $7.43K | — | Held |
| West Branch Capital LLC | 135 | $6.23K | — | Held |
| SageView Advisory Group, LLC | 114 | $5.26K | — | Held |
| HRT FINANCIAL LP | 114K | $5.26K | — | Held |
| JONES FINANCIAL COMPANIES LLLP | 110 | $5.08K | — | Held |
| Parkside Financial Bank & Trust | 105 | $4.84K | — | Held |
| MCF Advisors LLC | 97 | $4.48K | — | Held |
| Physician Wealth Advisors, Inc. | 96 | $4.43K | — | Held |
| Arax Advisory Partners | 92 | $4.25K | — | Held |
| Dynamic Wealth Strategies, LLC | 86 | $3.97K | — | Held |
| HARBOUR INVESTMENTS, INC. | 78 | $3.6K | — | Held |
| Bell Investment Advisors, Inc | 75 | $3.46K | — | Held |
| ALGERT GLOBAL LLC | 67.4K | $3.11K | — | Held |