| DEERFIELD MANAGEMENT COMPANY, L.P. | 17.2M | $1.74B | — | Held |
| Fidelity | 10.9M | $1.09B | — | Held |
| Paradigm Biocapital Advisors LP | 5.27M | $530.1M | — | Held |
| Vanguard | 5.24M | $527.5M | — | Held |
| BlackRock, Inc. | 4.81M | $483.4M | — | Held |
| WELLINGTON MANAGEMENT GROUP LLP | 2.46M | $247.6M | — | Held |
| JPMORGAN CHASE & CO | 2.21M | $221.8M | — | Held |
| RA CAPITAL MANAGEMENT, L.P. | 1.88M | $189.1M | — | Held |
| State Street | 1.86M | $187.6M | — | Held |
| PERCEPTIVE ADVISORS LLC | 1.67M | $167.5M | — | Held |
| Polar Capital Holdings Plc | 1.54M | $154.6M | — | Held |
| JANUS HENDERSON GROUP PLC | 1.5M | $150.8M | — | Held |
| GEODE CAPITAL MANAGEMENT, LLC | 1.24M | $124.6M | — | Held |
| Bellevue Group AG | 1.04M | $104.4M | — | Held |
| BRAIDWELL LP | 821.4K | $82.6M | — | Held |
| ALLIANCEBERNSTEIN L.P. | 785.4K | $79M | — | Held |
| Fairmount Funds Management LLC | 727.6K | $73.2M | — | Held |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 643K | $64.7M | — | Held |
| Woodline Partners LP | 610.5K | $61.4M | — | Held |
| GOLDMAN SACHS GROUP INC | 594.5K | $59.8M | — | Held |
| NORGES BANK | 574.2K | $57.8M | $3.91M | Added$48.4M |
| AMERIPRISE FINANCIAL INC | 564.3K | $56.8M | — | Held |
| Commodore Capital LP | 550K | $55.3M | — | Held |
| Driehaus Capital Management LLC | 483.5K | $48.6M | — | Held |
| Hood River Capital Management LLC | 475.4K | $47.8M | — | Held |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 453.3K | $45.6M | — | Held |
| Invesco Ltd. | 439.3K | $44.2M | — | Held |
| FRANKLIN RESOURCES INC | 411.4K | $41.4M | — | Held |
| NORTHERN TRUST CORP | 410.4K | $41.3M | — | Held |
| UBS Group AG | 399.1K | $40.1M | — | Held |
| AMERICAN CENTURY COMPANIES INC | 374.2K | $37.6M | — | Held |
| First Turn Management, LLC | 368.7K | $37.1M | — | Held |
| Candriam S.C.A. | 358K | $36M | — | Held |
| Pictet Asset Management Holding SA | 355.7K | $35.8M | — | Held |
| Affinity Asset Advisors, LLC | 322.6K | $32.5M | — | Held |
| SILVERARC CAPITAL MANAGEMENT, LLC | 311.4K | $31.3M | — | Held |
| Tri Locum Partners LP | 307.4K | $30.9M | — | Held |
| ArrowMark Colorado Holdings LLC | 296K | $29.8M | — | Held |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 270.5K | $27.2M | — | Held |
| Defilade Capital Management, L.P. | 269K | $27.1M | — | Held |
| MORGAN STANLEY | 267.4K | $26.9M | $3.77M | Added$3.11M |
| Citadel | 195.2K | $19.6M | — | Held |
| BANK OF AMERICA CORP /DE/ | 180.4K | $18.1M | $2.27M | Added$4.2M |
| BNP PARIBAS FINANCIAL MARKETS | 174.1K | $17.5M | — | Held |
| VOYA INVESTMENT MANAGEMENT LLC | 172.5K | $17.4M | — | Held |
| Aberdeen Group plc | 165.2K | $16.6M | — | Held |
| Rhenman & Partners Asset Management AB | 163.3K | $16.4M | — | Held |
| Bank of New York Mellon Corp | 161.6K | $16.3M | — | Held |
| Nicholas Investment Partners, LP | 160.5K | $16.1M | — | Held |
| TD Asset Management Inc | 153.4K | $15.4M | — | Held |
| RAYMOND JAMES FINANCIAL INC | 152K | $15.3M | — | Held |
| BAKER BROS. ADVISORS LP | 143.9K | $14.5M | — | Held |
| BARCLAYS PLC | 125.3K | $12.6M | $1.77M | Added$1.63M |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 124.6K | $12.5M | — | Held |
| Parkman Healthcare Partners LLC | 118.7K | $11.9M | — | Held |
| Nuveen, LLC | 107.6K | $10.8M | — | Held |
| Fisher Asset Management, LLC | 100.7K | $10.1M | — | Held |
| FRED ALGER MANAGEMENT, LLC | 92K | $9.26M | — | Held |
| Russell Investments Group, Ltd. | 91.2K | $9.17M | — | Held |
| Point72 Asset Management, L.P. | 88.4K | $8.89M | — | Held |
| DEUTSCHE BANK AG\ | 83K | $8.35M | — | Held |
| MILLENNIUM MANAGEMENT LLC | 81.9K | $8.23M | — | Held |
| Swiss National Bank | 78.9K | $7.94M | — | Held |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 78.3K | $7.86M | — | Held |
| HighVista Strategies LLC | 73.3K | $7.37M | — | Held |
| Verition Fund Management LLC | 72K | $7.24M | — | Held |
| BURKEHILL GLOBAL MANAGEMENT, LP | 70K | $7.04M | — | Held |
| RHUMBLINE ADVISERS | 63.8K | $6.42M | — | Held |
| WELLS FARGO & COMPANY/MN | 62.2K | $6.25M | — | Held |
| Squarepoint Ops LLC | 61.7K | $6.21M | — | Held |
| Ikarian Capital, LLC | 59.6K | $5.99M | — | Held |
| Ensign Peak Advisors, Inc | 54.2K | $5.45M | — | Held |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 46.7K | $4.7M | — | Held |
| Vestal Point Capital, LP | 46K | $4.63M | — | Held |
| Rafferty Asset Management, LLC | 45.9K | $4.62M | — | Held |
| Connor, Clark & Lunn Investment Management Ltd. | 42.4K | $4.26M | — | Held |
| Legal & General Group Plc | 41.7K | $4.19M | — | Held |
| Granahan Investment Management, LLC | 40.2K | $4.04M | — | Held |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 38.3K | $3.85M | — | Held |
| NEOS Investment Management LLC | 37K | $3.72M | — | Held |
| TEMA ETFS LLC | 36.5K | $3.67M | — | Held |
| CITIGROUP INC | 35.8K | $3.6M | — | Held |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 32.5K | $3.27M | — | Held |
| NEW YORK STATE COMMON RETIREMENT FUND | 32.5K | $3.27M | — | Held |
| Creative Planning | 29.9K | $3.01M | — | Held |
| Jump Financial, LLC | 28K | $2.81M | — | Held |
| MetLife Investment Management, LLC | 27.6K | $2.78M | — | Held |
| Alyeska Investment Group, L.P. | 25.5K | $2.57M | — | Held |
| Icahn Capital | 25.5K | $2.57M | — | Held |
| STATE OF WISCONSIN INVESTMENT BOARD | 25.2K | $2.53M | — | Held |
| SEVEN GRAND MANAGERS, LLC | 25K | $2.51M | — | Held |
| MARSHALL WACE, LLP | 23.9K | $2.41M | — | Held |
| SEI INVESTMENTS CO | 23.2K | $2.33M | — | Held |
| FIRST TRUST ADVISORS LP | 22.2K | $2.23M | — | Held |
| TANG CAPITAL MANAGEMENT LLC | 21.9K | $2.2M | — | Held |
| Legato Capital Management LLC | 21.7K | $2.19M | — | Held |
| COMERICA BANK | 20.2K | $2.03M | — | Held |
| Bridgewater | 18.6K | $1.87M | — | Held |
| BOOTHBAY FUND MANAGEMENT, LLC | 17.8K | $1.79M | — | Held |
| PROFUND ADVISORS LLC | 17.5K | $1.76M | — | Held |
| INTECH INVESTMENT MANAGEMENT LLC | 17.2K | $1.73M | — | Held |
| XTX Topco Ltd | 15.5K | $1.56M | — | Held |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 14.2K | $1.43M | — | Held |
| State of New Jersey Common Pension Fund D | 13.7K | $1.37M | — | Held |
| Police & Firemen's Retirement System of New Jersey | 13.5K | $1.36M | — | Held |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 13.3K | $1.34M | — | Held |
| Seven Fleet Capital Management LP | 12.6K | $1.27M | — | Held |
| ProShare Advisors LLC | 12.3K | $1.24M | — | Held |
| China Universal Asset Management Co., Ltd. | 11.8K | $1.18M | — | Held |
| STRS OHIO | 11.7K | $1.18M | — | Held |
| Erste Asset Management GmbH | 11.5K | $1.17M | — | Held |
| ARIZONA STATE RETIREMENT SYSTEM | 11.2K | $1.12M | — | Held |
| KENNEDY CAPITAL MANAGEMENT LLC | 10.9K | $1.1M | — | Held |
| DIMENSIONAL FUND ADVISORS LP | 10.4K | $1.05M | — | Held |
| VICTORY CAPITAL MANAGEMENT INC | 10.1K | $1.02M | — | Held |
| GUGGENHEIM CAPITAL LLC | 9.8K | $985.5K | — | Held |
| Headlands Technologies LLC | 9.22K | $927.9K | — | Held |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 8.64K | $869.4K | — | Held |
| Allianz Asset Management GmbH | 8.6K | $865.1K | — | Held |
| EVERGREEN CAPITAL MANAGEMENT LLC | 8.58K | $863.5K | — | Held |
| KLP KAPITALFORVALTNING AS | 8.5K | $855K | — | Held |
| Artia Global Partners LP | 8.1K | $814.8K | — | Held |
| Walleye Capital LLC | 7.96K | $800.3K | — | Held |
| Aquatic Capital Management LLC | 7.77K | $781.9K | — | Held |
| Shay Capital LLC | 7.5K | $754.4K | — | Held |
| HSBC HOLDINGS PLC | 6.95K | $708.5K | — | Held |
| ADAR1 Capital Management, LLC | 6.84K | $688.2K | — | Held |
| Entropy Technologies, LP | 6.59K | $662.5K | — | Held |
| POLEN CAPITAL MANAGEMENT LLC | 6.36K | $639.7K | — | Held |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 5.91K | $594K | — | Held |
| Vestmark Advisory Solutions, Inc. | 5.52K | $555.1K | — | Held |
| PSP Research LLC | 5.26K | $529.2K | — | Held |
| ENVESTNET ASSET MANAGEMENT INC | 5.23K | $525.7K | — | Held |
| Vanguard Personalized Indexing Management, LLC | 4.77K | $479.9K | — | Held |
| AlphaCentric Advisors LLC | 4.4K | $443K | — | Held |
| Magnetar Financial LLC | 4.25K | $427.9K | — | Held |
| MARTINGALE ASSET MANAGEMENT L P | 4.21K | $423.4K | — | Held |
| Ameritas Investment Partners, Inc. | 4.06K | $408.8K | — | Held |
| XPONANCE LLC | 3.96K | $398.8K | — | Held |
| Graham Capital Management, L.P. | 3.65K | $367.6K | — | Held |
| Mirae Asset Global Investments Co., Ltd. | 3.51K | $353.1K | — | Held |
| CIBC WORLD MARKETS CORP | 3.31K | $333.2K | — | Held |
| Mariner, LLC | 3.09K | $311.2K | — | Held |
| PRUDENTIAL FINANCIAL INC | 3.06K | $307.8K | — | Held |
| Quantinno Capital Management LP | 3.03K | $304.6K | — | Held |
| High Net Worth Advisory Group LLC | 3K | $301.8K | — | Held |
| FARALLON CAPITAL MANAGEMENT LLC | 3K | $301.8K | $42.3K | Added$42.3K |
| PRINCIPAL FINANCIAL GROUP INC | 2.95K | $296.5K | — | Held |
| Brevan Howard Capital Management LP | 2.8K | $282K | — | Held |
| US BANCORP \DE\ | 2.61K | $262.9K | — | Held |
| LPL Financial LLC | 2.54K | $255.4K | — | Held |
| Virtus Investment Advisers, LLC | 2.54K | $255.3K | — | Held |
| Farther Finance Advisors, LLC | 2.51K | $252.1K | — | Held |
| CIBC Asset Management Inc | 2.5K | $251K | — | Held |
| Allspring Global Investments Holdings, LLC | 2.47K | $249.1K | — | Held |
| FORA Capital, LLC | 2.17K | $218.4K | — | Held |
| Whalen Wealth Management Inc. | 2.15K | $216.1K | — | Held |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2.15M | $216K | — | Held |
| Swiss Life Asset Management Ltd | 2.01K | $202.1K | — | New |
| PORTLAND INVESTMENT COUNSEL INC. | 2K | $201.2K | — | Held |
| PNC Financial Services Group, Inc. | 1.68K | $168.8K | — | Held |
| ROYAL BANK OF CANADA | 1.44K | $146K | — | Held |
| GF FUND MANAGEMENT CO. LTD. | 1.42K | $142.7K | — | Held |
| T. Rowe Price Investment Management, Inc. | 1.32M | $132.8K | — | Held |
| NBC SECURITIES, INC. | 1.25K | $125.4K | — | Held |
| Tower Research Capital LLC (TRC) | 1.14K | $114.6K | — | Held |
| AlphaQuest LLC | 1.01K | $101.7K | — | Held |
| EASTERN BANK | 604 | $60.8K | — | Held |
| NISA INVESTMENT ADVISORS, LLC | 499 | $50.2K | — | Held |
| ANTIPODES PARTNERS Ltd | 391 | $39.3K | — | Held |
| OSAIC HOLDINGS, INC. | 368 | $37K | — | Held |
| GAMMA Investing LLC | 335 | $33.7K | — | Held |
| Sterling Capital Management LLC | 327 | $32.9K | — | Held |
| LORD, ABBETT & CO. LLC | 281.2K | $28.3K | — | Held |
| Kemnay Advisory Services Inc. | 230 | $23.1K | — | Held |
| Optiver Holding B.V. | 220 | $22.1K | — | Held |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 204 | $20K | — | Held |
| SIGNATUREFD, LLC | 188 | $18.9K | — | Held |
| Larson Financial Group LLC | 176 | $17.7K | — | Held |
| FIRST HORIZON CORP | 152 | $15.3K | — | Held |
| EverSource Wealth Advisors, LLC | 138 | $13.9K | — | Held |
| Allworth Financial LP | 94 | $9.46K | $1.21K | Added$2.02K |
| Global Retirement Partners, LLC | 88 | $8.85K | — | Held |
| Smartleaf Asset Management LLC | 88 | $8.83K | — | Held |
| Steward Partners Investment Advisory, LLC | 86 | $8.65K | — | Held |
| Pinnacle Wealth Planning Services, Inc. | 71 | $7.14K | — | Held |
| Mitsubishi UFJ Asset Management Co., Ltd. | 70 | $7.06K | — | Held |
| Aster Capital Management (DIFC) Ltd | 70 | $7.04K | — | Held |
| Salomon & Ludwin, LLC | 71 | $6.95K | — | Held |
| Versant Capital Management, Inc | 69 | $6.94K | — | Held |
| Rockefeller Capital Management L.P. | 65 | $6.54K | — | Held |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 61.1K | $6.15K | — | Held |
| ORG Partners LLC | 61 | $6.13K | — | Held |
| Sound Income Strategies, LLC | 57 | $5.94K | — | Held |
| J.Safra Asset Management Corp | 55 | $5.53K | — | Held |
| ROTHSCHILD INVESTMENT LLC | 53 | $5.33K | — | Held |
| Bare Financial Services, Inc | 52 | $5.23K | — | Held |
| JONES FINANCIAL COMPANIES LLLP | 49 | $4.93K | — | Held |
| Parallel Advisors, LLC | 48 | $4.83K | — | Held |
| Cornerstone Financial Management LLC | 43 | $4.33K | — | Held |
| ASSETMARK, INC | 35 | $3.52K | — | Held |
| IFP Advisors, Inc | 34 | $3.42K | $480 | Added$480 |
| Marquette Asset Management, LLC | 32 | $3.22K | — | Held |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 31 | $3.12K | — | Held |
| Parkside Financial Bank & Trust | 22 | $2.21K | — | Held |
| SG Americas Securities, LLC | 20.3K | $2.04K | — | Held |
| Sankala Group LLC | 17 | $1.73K | — | Held |
| DekaBank Deutsche Girozentrale | 17K | $1.42K | — | Held |
| Handelsbanken Fonder AB | 13.9K | $1.4K | — | Held |
| Physician Wealth Advisors, Inc. | 13 | $1.31K | — | Held |
| SouthState Bank Corp | 12 | $1.21K | — | Held |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 11.8K | $1.18K | — | Held |
| True Wealth Design, LLC | 9 | $906 | — | Held |
| MassMutual Private Wealth & Trust, FSB | 8 | $805 | — | Held |
| Bell Investment Advisors, Inc | 7 | $705 | — | Held |
| Rialto Wealth Management, LLC | 7 | $705 | — | Held |
| Fortitude Family Office, LLC | 7 | $704 | — | Held |
| MAI Capital Management | 6 | $604 | — | Held |
| Essential Partners LLC | 4 | $402 | $56 | Added$56 |
| Blue Trust, Inc. | 4 | $402 | — | Held |
| Keating Financial Advisory Services, Inc. | 3 | $302 | — | Held |
| SBI Securities Co., Ltd. | 3 | $302 | — | Held |
| Kilter Group LLC | 3 | $302 | — | New |
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO | 2.88K | $289 | — | Held |
| Caitong International Asset Management Co., Ltd | 2 | $201 | — | Held |
| CoreCap Advisors, LLC | 2 | $201 | — | Held |
| AMALGAMATED BANK | 1.57K | $158 | — | Held |
| KBC Group NV | 1.53K | $154 | $18 | Added$48 |
| CWM, LLC | 1.32K | $132 | — | Held |
| TD PRIVATE CLIENT WEALTH LLC | 1 | $101 | — | Held |
| Principia Wealth Advisory, LLC | 1 | $101 | — | New |
| Dunhill Financial, LLC | 1 | $82 | — | Held |
| Covestor Ltd | 760 | $76 | — | Held |
| Daiwa Securities Group Inc. | 209 | $21 | — | Held |
| BESSEMER GROUP INC | 25 | $3 | — | Held |
| VALLEY NATIONAL ADVISERS INC | 10 | $1 | — | Held |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | $0 | — | Held |