| BVF INC/IL | 16M | $298.3M | $87.4M | Added$37.9M |
| Deep Track Capital, LP | 6.41M | $119.5M | $25.2M | Added$58.7M |
| Cormorant Asset Management, LP | 4.48M | $83.5M | $23.8M | Added$26.1M |
| JANUS HENDERSON GROUP PLC | 3.45M | $64.3M | $11.4M | Added$36.6M |
| D. E. Shaw & Co., Inc. | 2.39M | $44.6M | $13.1M | Added$11.9M |
| MPM BIOIMPACT LLC | 1.81M | $33.8M | — | New |
| Weiss Asset Management LP | 1.71M | $31.8M | $1.82M | Added$27.5M |
| Logos Global Management LP | 1.5M | $28M | $8.19M | Added$4.89M |
| Point72 Asset Management, L.P. | 1.37M | $25.5M | $4.22M | Added$15.3M |
| Citadel | 1.32M | $24.7M | $2.08M | Added$19.7M |
| GOLDMAN SACHS GROUP INC | 1.13M | $21.1M | $1.48M | Added$17.5M |
| TWO SIGMA INVESTMENTS, LP | 1.12M | $20.9M | $4.29M | Added$10.6M |
| Balyasny Asset Management L.P. | 1.07M | $19.9M | $5.82M | Cut−$843.7K |
| BlackRock, Inc. | 1.02M | $19M | $1.56M | Added$15.3M |
| Vivo Capital, LLC | 1M | $18.6M | $5.46M | Added$5.46M |
| JPMORGAN CHASE & CO | 1.09M | $18.4M | $3.14M | Added$7.39M |
| Candriam S.C.A. | 818.1K | $15.2M | $733.4K | Added$13.5M |
| BANK OF AMERICA CORP /DE/ | 724.8K | $13.5M | $73.9K | Added$13.3M |
| MORGAN STANLEY | 614.5K | $11.5M | $3.36M | Cut−$2.31M |
| Holocene Advisors, LP | 600K | $11.2M | — | New |
| MILLENNIUM MANAGEMENT LLC | 576.1K | $10.7M | $3.15M | Added$158.5K |
| Jefferies Financial Group Inc. | 500K | $9.32M | $2.73M | Added$2.73M |
| GREAT POINT PARTNERS LLC | 500K | $9.32M | — | New |
| Trexquant Investment LP | 495.3K | $9.23M | $1.01M | Added$6.8M |
| ADAR1 Capital Management, LLC | 457.1K | $8.52M | — | New |
| JANE STREET GROUP, LLC | 453.6K | $8.46M | $2.48M | Cut−$13.7M |
| Casdin Capital, LLC | 450K | $8.39M | — | New |
| Longaeva Partners L.P. | 410K | $7.64M | — | New |
| Voleon Capital Management LP | 373K | $6.95M | $2.04M | Added$375K |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 341.4K | $6.36M | $1.86M | Cut−$874.8K |
| Jump Financial, LLC | 326K | $6.08M | $1.78M | Added$467.2K |
| Walleye Capital LLC | 320.5K | $5.97M | $413.6K | Added$4.98M |
| First Turn Management, LLC | 315.6K | $5.88M | $1.43M | Added$2.42M |
| Renaissance Technologies | 276.8K | $5.16M | $734.2K | Added$3.39M |
| Boxer Capital Management, LLC | 275K | $5.13M | $1.5M | Added$1.5M |
| Susquehanna Portfolio Strategies, LLC | 254K | $4.73M | $1.39M | Added$1.39M |
| BNP PARIBAS FINANCIAL MARKETS | 239.8K | $4.47M | $61.8K | Added$4.32M |
| Rhenman & Partners Asset Management AB | 239.5K | $4.46M | $1.31M | Cut−$333.2K |
| Granahan Investment Management, LLC | 220.6K | $4.11M | $1.08M | Added$1.5M |
| Exome Asset Management LLC | 215.4K | $4.01M | — | New |
| HighVista Strategies LLC | 194K | $3.62M | — | New |
| ACUTA CAPITAL PARTNERS, LLC | 191.8K | $3.57M | $323.7K | Added$2.79M |
| CONGRESS ASSET MANAGEMENT CO | 178.6K | $3.33M | $388.2K | Added$2.39M |
| Kalehua Capital Management LLC | 175.7K | $3.28M | $959.5K | Added$959.5K |
| Ishara Investments LP | 174.3K | $3.25M | — | New |
| RICE HALL JAMES & ASSOCIATES, LLC | 167.8K | $3.13M | $696K | Added$1.45M |
| READYSTATE ASSET MANAGEMENT LP | 144.2K | $2.69M | — | New |
| Fidelity | 143.6K | $2.68M | $783.8K | Added$616.2K |
| TD Asset Management Inc | 142.7K | $2.66M | $692K | Added$989.6K |
| Invesco Ltd. | 139.6K | $2.6M | — | New |
| J. Goldman & Co LP | 136.9K | $2.55M | $554K | Added$1.21M |
| Y-Intercept (Hong Kong) Ltd | 127.1K | $2.37M | $524K | Added$1.1M |
| ExodusPoint Capital Management, LP | 120.3K | $2.24M | $656.9K | Cut−$564.7K |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 119K | $2.22M | $465K | Added$1.09M |
| XTX Topco Ltd | 112K | $2.09M | $125.4K | Added$1.79M |
| MARSHALL WACE, LLP | 111.3K | $2.08M | — | New |
| Squarepoint Ops LLC | 110.2K | $2.05M | $601.8K | Added$451.2K |
| Headlands Technologies LLC | 97.1K | $1.81M | — | New |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 95.3K | $1.78M | — | Held |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 74.2K | $1.38M | — | New |
| GEODE CAPITAL MANAGEMENT, LLC | 72.3K | $1.35M | $394.4K | Added$390K |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 70.1K | $1.31M | — | New |
| Lion Point Capital, LP | 67.5K | $1.26M | $368.6K | Added$368.6K |
| Rock Springs Capital Management LP | 61.7K | $1.15M | $336.9K | Added$336.9K |
| TUDOR INVESTMENT CORP ET AL | 61.6K | $1.15M | $336.2K | Cut−$216.5K |
| Swiss National Bank | 61.5K | $1.15M | $335.8K | Added$335.8K |
| ALPS ADVISORS INC | 58.4K | $1.09M | $317.6K | Added$321.8K |
| State Street | 56.5K | $1.05M | $278.3K | Added$381.1K |
| Avidity Partners Management LP | 50K | $932K | — | New |
| PRELUDE CAPITAL MANAGEMENT, LLC | 48.9K | $911.2K | — | New |
| Icahn Capital | 46.2K | $860.9K | $179.6K | Added$427.5K |
| Mariner, LLC | 45K | $837.8K | $110.1K | Added$572.2K |
| Qube Research & Technologies Ltd | 42.9K | $800K | — | New |
| Nuveen, LLC | 33.4K | $622.9K | $182.5K | Cut−$7.78M |
| Brevan Howard Capital Management LP | 32.5K | $605.9K | $177.5K | Cut−$430.5K |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 29.3K | $546.1K | $160K | Added$160K |
| Schonfeld Strategic Advisors LLC | 28.7K | $534.6K | $156.6K | Cut−$3.71M |
| BARCLAYS PLC | 27.6K | $514.5K | $150.7K | Cut−$147.8K |
| DIMENSIONAL FUND ADVISORS LP | 26.3K | $490.4K | $143.6K | Cut−$1.93M |
| Optimize Financial Inc | 24.4K | $455.2K | — | New |
| VANGUARD ASSET MANAGEMENT, Ltd | 23.8K | $444.2K | — | Held |
| GROUP ONE TRADING LLC | 21.6K | $401.9K | $117.7K | Added$260 |
| Quarry LP | 21.3K | $396.1K | — | New |
| Graham Capital Management, L.P. | 21.1K | $393.1K | $115.1K | Added$72.9K |
| Legal & General Group Plc | 20.6K | $383.2K | $87.8K | Added$171.3K |
| NORTHERN TRUST CORP | 19.5K | $363.1K | $100.9K | Added$119.5K |
| AXQ CAPITAL, LP | 19.2K | $358.7K | — | New |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 19.2K | $358.4K | $74.2K | Added$179.3K |
| Virtus Investment Advisers, LLC | 18.4K | $343.6K | $98.2K | Added$106.6K |
| Vident Advisory, LLC | 18.2K | $339.4K | $84.3K | Added$135.8K |
| OSAIC HOLDINGS, INC. | 15.9K | $296.5K | $49.1K | Added$178K |
| WINTON GROUP Ltd | 15.7K | $292.1K | — | New |
| Jain Global LLC | 15.4K | $286.3K | $83.9K | Cut−$644.3K |
| FOX RUN MANAGEMENT, L.L.C. | 16.5K | $279.6K | $61.9K | Cut−$668.8K |
| CITIGROUP INC | 13.7K | $255.2K | $4.97K | Added$243.2K |
| STATE OF WISCONSIN INVESTMENT BOARD | 12.6K | $234.8K | $67.9K | Added$70.9K |
| WELLS FARGO & COMPANY/MN | 12.5K | $233.4K | $54.6K | Added$101.6K |
| Entropy Technologies, LP | 11.9K | $221K | $64.7K | Cut−$178.4K |
| CAPTRUST FINANCIAL ADVISORS | 11.4K | $213.4K | — | New |
| IMC-Chicago, LLC | 11.4K | $211.6K | $62K | Cut−$269K |
| CAPITAL FUND MANAGEMENT S.A. | 11.3K | $209.9K | — | New |
| State of New Jersey Common Pension Fund D | 10.9K | $202.5K | — | New |
| Crystal Cove Asset Management, LLC | 10K | $186.4K | — | Held |
| Vanguard Investments Australia, Ltd. | 8.94K | $166.5K | — | Held |
| KLP KAPITALFORVALTNING AS | 6.8K | $126.8K | $37.1K | Added$37.1K |
| Ensign Peak Advisors, Inc | 4.49K | $83.7K | $24.5K | Added$24.5K |
| Advisors Asset Management, Inc. | 3.94K | $73.5K | $21.5K | Added$20.9K |
| UBS Group AG | 3.88K | $72.3K | $21.2K | Cut−$3.08M |
| Russell Investments Group, Ltd. | 3.43K | $63.9K | $18.7K | Added$18.7K |
| SIMPLEX TRADING, LLC | 3.08K | $57.3K | $16.8K | Cut−$324.5K |
| Caitong International Asset Management Co., Ltd | 3.06K | $57.1K | $16.7K | Cut−$34.5K |
| EverSource Wealth Advisors, LLC | 2.87K | $53.4K | $4.88K | Added$41.7K |
| US BANCORP \DE\ | 2.32K | $43.3K | $7.25K | Added$25.8K |
| SIGNATUREFD, LLC | 2.27K | $42.3K | $7.72K | Added$23.6K |
| DEUTSCHE BANK AG\ | 2.05K | $38.2K | $11.2K | Added$11.2K |
| Parallel Advisors, LLC | 1.66K | $31K | $8.1K | Added$11.5K |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1.29M | $24.1K | $5.24K | Added$11.5K |
| DecisionPoint Financial, LLC | 1.22K | $22.7K | $6.66K | Added$6.66K |
| Delos Wealth Advisors, LLC | 1K | $18.6K | $5.46K | Cut−$60.4K |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 923 | $17.2K | $17.2K | Added$16.4K |
| Allworth Financial LP | 669 | $12.5K | $2.08K | Added$7.45K |
| Farther Finance Advisors, LLC | 733 | $12.1K | $2.45K | Added$1.95K |
| SUMMIT SECURITIES GROUP LLC | 516 | $9.62K | — | New |
| HRT FINANCIAL LP | 509.9K | $9.5K | $2.78K | Added$1.12K |
| QUADRANT CAPITAL GROUP LLC | 383 | $7.14K | $1.15K | Added$4.37K |
| CWM, LLC | 304 | $5.67K | $1.12K | Added$5.67K |
| Steward Partners Investment Advisory, LLC | 244 | $4.55K | $519 | Added$3.3K |
| SBI Securities Co., Ltd. | 213 | $3.97K | $1.16K | Added$1.16K |
| ALGERT GLOBAL LLC | 151.3K | $2.82K | $825 | Cut−$102 |
| ROYAL BANK OF CANADA | 84 | $2K | $369 | Held |
| Quantbot Technologies LP | 99 | $1.84K | $540 | Cut−$80.7K |
| GSA CAPITAL PARTNERS LLP | 80.2K | $1.5K | $439 | Added$320 |
| CVA Family Office, LLC | 60 | $1.12K | — | New |
| JONES FINANCIAL COMPANIES LLLP | 52 | $901 | — | New |
| Cornerstone Financial Management LLC | 28 | $522 | — | New |
| ACADIAN ASSET MANAGEMENT LLC | 16.5K | $305 | — | New |
| PNC Financial Services Group, Inc. | 12 | $224 | $66 | Cut−$396 |
| Virtu Financial LLC | 10.5K | $196 | $57 | Added$30 |
| SG Americas Securities, LLC | 9.35K | $174 | $51 | Cut−$114 |
| Essential Partners LLC | 8 | $149 | — | New |
| MAI Capital Management | 7 | $131 | — | New |
| ROTHSCHILD INVESTMENT LLC | 6 | $112 | $6 | Added$99 |
| HUNTINGTON NATIONAL BANK | 6 | $112 | — | New |
| Arax Advisory Partners | 5 | $93 | — | New |
| Sunbelt Securities, Inc. | 1 | $19 | — | New |
| Avion Wealth | 500 | $9 | — | New |