| BVF INC/IL | 19.8M | $260.3M | — | Held |
| Deep Track Capital, LP | 4.61M | $60.8M | — | Held |
| Cormorant Asset Management, LP | 4.36M | $57.4M | — | Held |
| D. E. Shaw & Co., Inc. | 2.48M | $32.7M | — | Held |
| JANUS HENDERSON GROUP PLC | 2.1M | $27.7M | — | Held |
| Logos Global Management LP | 1.75M | $23.1M | — | Held |
| JANE STREET GROUP, LLC | 1.68M | $22.2M | — | Held |
| Balyasny Asset Management L.P. | 1.57M | $20.7M | — | Held |
| MORGAN STANLEY | 1.04M | $13.8M | $1.54M | Added$11.9M |
| Vivo Capital, LLC | 1M | $13.2M | — | Held |
| JPMORGAN CHASE & CO | 837.7K | $11M | — | Held |
| MILLENNIUM MANAGEMENT LLC | 802.7K | $10.6M | — | Held |
| TWO SIGMA INVESTMENTS, LP | 784.8K | $10.3M | — | Held |
| Point72 Asset Management, L.P. | 772.5K | $10.2M | — | Held |
| Nuveen, LLC | 637.4K | $8.4M | — | Held |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 549.2K | $7.24M | — | Held |
| Jefferies Financial Group Inc. | 500K | $6.59M | — | Held |
| Voleon Capital Management LP | 499.1K | $6.58M | — | Held |
| Jump Financial, LLC | 425.6K | $5.61M | — | Held |
| Soleus Capital Management, L.P. | 400K | $5.27M | — | Held |
| Citadel | 380.9K | $5.02M | — | Held |
| Rhenman & Partners Asset Management AB | 364K | $4.8M | — | Held |
| STEMPOINT CAPITAL LP | 348.4K | $4.59M | — | Held |
| Weiss Asset Management LP | 333K | $4.39M | — | New |
| Schonfeld Strategic Advisors LLC | 322.3K | $4.25M | — | Held |
| BlackRock, Inc. | 286.6K | $3.78M | — | Held |
| Boxer Capital Management, LLC | 275K | $3.62M | $1.5M | Added$1.83M |
| GOLDMAN SACHS GROUP INC | 270.7K | $3.57M | — | Held |
| Vanguard | 266.1K | $3.51M | — | Held |
| First Turn Management, LLC | 262.6K | $3.46M | — | Held |
| Susquehanna Portfolio Strategies, LLC | 254K | $3.35M | — | Held |
| UBS Group AG | 239K | $3.15M | — | Held |
| ExodusPoint Capital Management, LP | 213K | $2.81M | — | Held |
| Granahan Investment Management, LLC | 198.3K | $2.61M | — | Held |
| Eagle Health Investments LP | 187.6K | $2.47M | — | Held |
| Trexquant Investment LP | 184.3K | $2.43M | — | Held |
| DIMENSIONAL FUND ADVISORS LP | 183.6K | $2.42M | — | Held |
| Kalehua Capital Management LLC | 175.7K | $2.32M | — | Held |
| Fidelity | 156.3K | $2.06M | — | Held |
| Renaissance Technologies | 134.5K | $1.77M | — | Held |
| Candriam S.C.A. | 134.3K | $1.77M | — | Held |
| TWO SIGMA ADVISERS, LP | 131.7K | $1.74M | — | Held |
| AMERIPRISE FINANCIAL INC | 131K | $1.73M | — | Held |
| RICE HALL JAMES & ASSOCIATES, LLC | 127.5K | $1.68M | — | Held |
| TD Asset Management Inc | 126.7K | $1.67M | — | Held |
| Squarepoint Ops LLC | 121.6K | $1.6M | — | Held |
| TUDOR INVESTMENT CORP ET AL | 103.5K | $1.36M | — | New |
| J. Goldman & Co LP | 101.5K | $1.34M | — | Held |
| Y-Intercept (Hong Kong) Ltd | 96K | $1.26M | — | Held |
| Walleye Trading LLC | 87.4K | $1.15M | — | Held |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 85.6K | $1.13M | — | Held |
| Brevan Howard Capital Management LP | 78.6K | $1.04M | — | Held |
| Walleye Capital LLC | 75.8K | $998.4K | — | Held |
| GEODE CAPITAL MANAGEMENT, LLC | 72.6K | $956.4K | — | Held |
| FOX RUN MANAGEMENT, L.L.C. | 72K | $948.5K | — | Held |
| CONGRESS ASSET MANAGEMENT CO | 71.1K | $937K | — | Held |
| Jain Global LLC | 70.6K | $930.7K | — | Held |
| Lion Point Capital, LP | 67.5K | $889.6K | — | Held |
| Rock Springs Capital Management LP | 61.7K | $813.2K | — | Held |
| Swiss National Bank | 61.5K | $810.6K | — | Held |
| ACUTA CAPITAL PARTNERS, LLC | 59.3K | $781.3K | — | Held |
| ALPS ADVISORS INC | 58.2K | $766.7K | — | Held |
| State Street | 51K | $671.8K | — | Held |
| BARCLAYS PLC | 50.3K | $662.3K | $96 | Added$662.2K |
| Quadrature Capital Ltd | 50.2K | $661.9K | — | Held |
| Woodline Partners LP | 49.2K | $648K | — | Held |
| Cinctive Capital Management LP | 37.2K | $490.2K | — | Held |
| IMC-Chicago, LLC | 36.5K | $480.6K | — | Held |
| Icahn Capital | 32.9K | $433.4K | — | Held |
| GROUP ONE TRADING LLC | 30.5K | $401.7K | — | Held |
| Entropy Technologies, LP | 30.3K | $399.4K | — | Held |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 29.3K | $386.1K | — | Held |
| SIMPLEX TRADING, LLC | 29K | $381.9K | — | Held |
| AXIOM INVESTORS LLC /DE | 26K | $342.7K | — | Held |
| Graham Capital Management, L.P. | 24.3K | $320.2K | — | Held |
| XTX Topco Ltd | 23K | $302.8K | — | Held |
| Mariner, LLC | 20.2K | $265.7K | — | Held |
| NORTHERN TRUST CORP | 18.5K | $243.6K | — | Held |
| Virtus Investment Advisers, LLC | 18K | $237.1K | — | Held |
| Legal & General Group Plc | 16.1K | $211.9K | — | Held |
| Brooklyn Investment Group | 14.9K | $204.3K | — | Held |
| Vident Advisory, LLC | 15.4K | $203.6K | — | Held |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 13.6K | $179.1K | — | Held |
| BANK OF AMERICA CORP /DE/ | 13.5K | $178.4K | $27.2K | Added$145.9K |
| Campbell & CO Investment Adviser LLC | 13.4K | $177.2K | — | Held |
| STATE OF WISCONSIN INVESTMENT BOARD | 12.4K | $163.9K | — | Held |
| Centiva Capital, LP | 12.3K | $162K | — | Held |
| BNP PARIBAS FINANCIAL MARKETS | 11.3K | $149.1K | — | Held |
| HSBC HOLDINGS PLC | 11.1K | $146.7K | — | Held |
| WELLS FARGO & COMPANY/MN | 10K | $131.8K | — | Held |
| OSAIC HOLDINGS, INC. | 8.98K | $118.4K | — | Held |
| Persistent Asset Partners Ltd | 8.52K | $112.3K | — | New |
| Caitong International Asset Management Co., Ltd | 6.95K | $91.6K | — | Held |
| KLP KAPITALFORVALTNING AS | 6.8K | $89.6K | — | Held |
| Quantbot Technologies LP | 6.27K | $82.6K | — | Held |
| Delos Wealth Advisors, LLC | 6K | $79.1K | — | Held |
| Ensign Peak Advisors, Inc | 4.49K | $59.2K | — | Held |
| Advisors Asset Management, Inc. | 3.99K | $52.6K | — | Held |
| Russell Investments Group, Ltd. | 3.43K | $45.2K | — | Held |
| DEUTSCHE BANK AG\ | 2.05K | $27K | — | Held |
| Kestra Advisory Services, LLC | 2K | $26.4K | — | Held |
| ACT CAPITAL MANAGEMENT, LLC | 1.5K | $19.8K | — | Held |
| Parallel Advisors, LLC | 1.48K | $19.6K | — | Held |
| SIGNATUREFD, LLC | 1.41K | $18.6K | — | Held |
| US BANCORP \DE\ | 1.33K | $17.5K | — | Held |
| DecisionPoint Financial, LLC | 1.22K | $16.1K | — | Held |
| PRICE T ROWE ASSOCIATES INC /MD/ | 959.6K | $12.6K | — | Held |
| CITIGROUP INC | 910 | $12K | — | Held |
| EverSource Wealth Advisors, LLC | 893 | $11.8K | — | Held |
| Farther Finance Advisors, LLC | 771 | $10.2K | — | Held |
| Tower Research Capital LLC (TRC) | 704 | $9.28K | — | Held |
| HRT FINANCIAL LP | 635.9K | $8.38K | — | Held |
| Allworth Financial LP | 381 | $5.02K | $96 | Added$4.91K |
| ALGERT GLOBAL LLC | 221.6K | $2.92K | — | Held |
| SBI Securities Co., Ltd. | 213 | $2.81K | — | Held |
| QUADRANT CAPITAL GROUP LLC | 210 | $2.77K | — | Held |
| ROYAL BANK OF CANADA | 103 | $2K | — | Held |
| Steward Partners Investment Advisory, LLC | 95 | $1.25K | — | Held |
| GSA CAPITAL PARTNERS LLP | 89.2K | $1.18K | — | Held |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 61.9K | $817 | — | Held |
| PNC Financial Services Group, Inc. | 47 | $620 | — | Held |
| SG Americas Securities, LLC | 21.9K | $288 | — | Held |
| Virtu Financial LLC | 12.6K | $166 | — | Held |
| T. Rowe Price Investment Management, Inc. | 3.56K | $47 | — | Held |
| WPG Advisers, LLC | 3 | $40 | — | Held |
| Global Retirement Partners, LLC | 1 | $13 | — | Held |
| IFP Advisors, Inc | 1 | $13 | $6 | Cut−$7.88K |
| ROTHSCHILD INVESTMENT LLC | 1 | $13 | — | Held |
| CWM, LLC | 60 | $1 | — | Held |
| BESSEMER GROUP INC | 0 | $0 | — | Held |