| Frazier Life Sciences Management, L.P. | 4.57M | $189.2M | — | Held |
| TRV GP IV, LLC | 4.47M | $185.4M | — | Held |
| Deep Track Capital, LP | 4.25M | $175.9M | — | Held |
| ARCH Venture Management, LLC | 4.12M | $170.7M | — | Held |
| JANUS HENDERSON GROUP PLC | 3.14M | $130.2M | — | Held |
| BlackRock, Inc. | 2.29M | $94.8M | — | Held |
| a16z Capital Management, L.L.C. | 1.7M | $70.5M | — | Held |
| Vanguard | 1.7M | $70.3M | — | Held |
| VR ADVISER, LLC | 1.55M | $64.2M | — | Held |
| Alphabet Inc. | 1.39M | $57.5M | — | Held |
| General Catalyst Group Management, LLC | 1.04M | $42.9M | — | Held |
| Woodline Partners LP | 1.04M | $42.9M | — | Held |
| TRV GP V, LLC | 950.8K | $39.4M | — | Held |
| Logos Global Management LP | 950K | $39.4M | — | Held |
| Bellevue Group AG | 887.7K | $36.8M | — | Held |
| MARSHALL WACE, LLP | 847.5K | $35.1M | — | Held |
| ArrowMark Colorado Holdings LLC | 767.4K | $31.8M | — | Held |
| Casdin Capital, LLC | 758.9K | $31.4M | — | Held |
| Fidelity | 728.6K | $30.2M | — | Held |
| Ikarian Capital, LLC | 644.7K | $26.7M | — | Held |
| Caligan Partners LP | 550.2K | $22.8M | — | Held |
| State Street | 533K | $22.1M | — | Held |
| GEODE CAPITAL MANAGEMENT, LLC | 527.3K | $21.9M | — | Held |
| Foresite Capital Management IV, LLC | 522.7K | $21.7M | — | Held |
| Squadron Capital Management LLC | 490K | $20.3M | — | Held |
| Matrix Capital Management Company, LP | 480K | $19.9M | — | Held |
| HHLR ADVISORS, LTD. | 457.5K | $19M | — | Held |
| Citadel | 448.2K | $18.6M | — | Held |
| BOOTHBAY FUND MANAGEMENT, LLC | 409.4K | $17M | — | Held |
| Driehaus Capital Management LLC | 378K | $15.7M | — | Held |
| EVENTIDE ASSET MANAGEMENT, LLC | 324K | $13.4M | — | Held |
| WASHINGTON UNIVERSITY | 280.8K | $11.6M | — | Held |
| MORGAN STANLEY | 258.1K | $10.7M | $3.3M | Added$5.18M |
| Mass General Brigham, Inc | 240K | $9.94M | — | Held |
| Parkman Healthcare Partners LLC | 209.3K | $8.67M | — | Held |
| Balyasny Asset Management L.P. | 199.2K | $8.25M | — | Held |
| Alyeska Investment Group, L.P. | 196.1K | $8.13M | — | Held |
| Ensign Peak Advisors, Inc | 185.8K | $7.7M | — | Held |
| ADAR1 Capital Management, LLC | 179.5K | $7.44M | — | Held |
| NORTHERN TRUST CORP | 176.3K | $7.3M | — | Held |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 176K | $7.29M | — | Held |
| TCG Crossover Management, LLC | 173.8K | $7.2M | — | Held |
| HighVista Strategies LLC | 170.4K | $7.06M | — | Held |
| MILLENNIUM MANAGEMENT LLC | 154.5K | $6.4M | — | Held |
| Invesco Ltd. | 134K | $5.55M | — | Held |
| STEMPOINT CAPITAL LP | 125.9K | $5.22M | — | Held |
| Freestone Grove Partners LP | 118.9K | $4.93M | — | Held |
| GOLDMAN SACHS GROUP INC | 114.5K | $4.74M | — | Held |
| Integral Health Asset Management, LLC | 100K | $4.14M | — | Held |
| AMERIPRISE FINANCIAL INC | 96.7K | $4.01M | — | Held |
| Foresite Capital Management V, LLC | 86.3K | $3.58M | — | Held |
| MPM BIOIMPACT LLC | 81.1K | $3.36M | — | Held |
| SPHERA FUNDS MANAGEMENT LTD. | 71.8K | $2.98M | — | Held |
| SummitTX Capital, L.P. | 69.6K | $2.88M | — | Held |
| RAYMOND JAMES FINANCIAL INC | 67.7K | $2.81M | — | Held |
| WELLINGTON MANAGEMENT GROUP LLP | 61.2K | $2.54M | — | Held |
| Bank of New York Mellon Corp | 60.4K | $2.5M | — | Held |
| OSAIC HOLDINGS, INC. | 59.8K | $2.48M | — | Held |
| Nuveen, LLC | 57.3K | $2.37M | — | Held |
| FRANKLIN RESOURCES INC | 55.2K | $2.29M | — | Held |
| Trexquant Investment LP | 52.5K | $2.17M | — | Held |
| SEVEN GRAND MANAGERS, LLC | 50K | $2.07M | — | Held |
| Schonfeld Strategic Advisors LLC | 48.2K | $2M | — | Held |
| BARCLAYS PLC | 39.5K | $1.64M | $426.5K | Added$923.3K |
| D. E. Shaw & Co., Inc. | 33.7K | $1.4M | — | Held |
| ALLIANCEBERNSTEIN L.P. | 33.2K | $1.38M | — | Held |
| XTX Topco Ltd | 33K | $1.37M | — | Held |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 31.3K | $1.3M | — | Held |
| Cinctive Capital Management LP | 29.1K | $1.21M | — | Held |
| UBS Group AG | 28.7K | $1.19M | — | Held |
| Icahn Capital | 27.4K | $1.14M | — | Held |
| Renaissance Technologies | 27.1K | $1.12M | — | Held |
| TUDOR INVESTMENT CORP ET AL | 24.1K | $996.8K | — | New |
| WELLS FARGO & COMPANY/MN | 24K | $994.7K | — | Held |
| RHUMBLINE ADVISERS | 23.7K | $983.2K | — | Held |
| GILDER GAGNON HOWE & CO LLC | 23.3K | $964.6K | — | Held |
| Russell Investments Group, Ltd. | 22.5K | $934K | — | Held |
| Verition Fund Management LLC | 22.5K | $932.7K | — | Held |
| AMERICAN CENTURY COMPANIES INC | 21.5K | $891.1K | — | Held |
| JPMORGAN CHASE & CO | 20K | $828.9K | — | Held |
| ACUTA CAPITAL PARTNERS, LLC | 20K | $828.6K | — | Held |
| BANK OF AMERICA CORP /DE/ | 18.4K | $761.5K | $148.4K | Added$513.3K |
| DEUTSCHE BANK AG\ | 15.5K | $643.1K | — | Held |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 19.1K | $634.5K | — | Held |
| TWO SIGMA ADVISERS, LP | 14.8K | $613.2K | — | Held |
| PSP Research LLC | 12.7K | $525K | — | Held |
| MetLife Investment Management, LLC | 11.8K | $488.9K | — | Held |
| China Universal Asset Management Co., Ltd. | 11.4K | $474K | — | Held |
| CITIGROUP INC | 11.3K | $466.2K | — | Held |
| STRS OHIO | 11.2K | $464K | — | Held |
| Falcon Wealth Planning | 10K | $415.5K | — | Held |
| TWO SIGMA INVESTMENTS, LP | 7.25K | $300.2K | — | Held |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 6.9K | $285.7K | — | Held |
| Virtus Investment Advisers, LLC | 6.85K | $283.6K | — | Held |
| NEW YORK STATE COMMON RETIREMENT FUND | 6.7K | $277.6K | — | Held |
| Persistent Asset Partners Ltd | 6.61K | $273.6K | — | New |
| INTECH INVESTMENT MANAGEMENT LLC | 6.44K | $266.9K | — | Held |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 6.05K | $250.7K | — | Held |
| ProShare Advisors LLC | 6.05K | $250.5K | — | Held |
| PROFUND ADVISORS LLC | 6.02K | $249.2K | — | Held |
| Police & Firemen's Retirement System of New Jersey | 5.96K | $247K | — | Held |
| SEI INVESTMENTS CO | 5.67K | $234.8K | — | Held |
| BNP PARIBAS FINANCIAL MARKETS | 5.47K | $226.7K | — | Held |
| CIBC Private Wealth Group LLC | 5.4K | $223.7K | — | Held |
| Legal & General Group Plc | 5.38K | $222.9K | — | Held |
| Rafferty Asset Management, LLC | 5.24K | $217.3K | — | Held |
| Quantbot Technologies LP | 5.22K | $216.3K | — | Held |
| WestHill Financial Advisors, Inc. | 5.19K | $214.9K | — | Held |
| Brevan Howard Capital Management LP | 5.04K | $208.9K | — | Held |
| IFP Advisors, Inc | 3.51K | $145.6K | — | New |
| Caitong International Asset Management Co., Ltd | 3.5K | $145K | — | Held |
| Mirae Asset Global Investments Co., Ltd. | 2.34K | $96.9K | — | Held |
| Ameritas Investment Partners, Inc. | 1.63K | $67.6K | — | Held |
| Tower Research Capital LLC (TRC) | 1.35K | $55.9K | — | Held |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1.32K | $54.7K | — | Held |
| Sterling Capital Management LLC | 1.16K | $48.1K | — | Held |
| GF FUND MANAGEMENT CO. LTD. | 944 | $39.1K | — | Held |
| ROYAL BANK OF CANADA | 646 | $27K | — | Held |
| BESSEMER GROUP INC | 481.8K | $20K | — | Held |
| Farther Finance Advisors, LLC | 359 | $14.9K | — | Held |
| NISA INVESTMENT ADVISORS, LLC | 204 | $8.45K | — | Held |
| GAMMA Investing LLC | 172 | $7.13K | — | Held |
| EverSource Wealth Advisors, LLC | 149 | $6.17K | — | Held |
| PRICE T ROWE ASSOCIATES INC /MD/ | 115.7K | $4.79K | — | Held |
| Torren Management, LLC | 112 | $4.64K | — | Held |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 99 | $4.1K | — | Held |
| JONES FINANCIAL COMPANIES LLLP | 90 | $3.73K | — | Held |
| SBI Securities Co., Ltd. | 67 | $2.78K | — | Held |
| PNC Financial Services Group, Inc. | 58 | $2.4K | — | Held |
| SageView Advisory Group, LLC | 54 | $2.24K | — | Held |
| US BANCORP \DE\ | 41 | $1.7K | — | Held |
| Cornerstone Financial Management LLC | 28 | $1.16K | — | Held |
| SIGNATUREFD, LLC | 14 | $580 | — | Held |
| Sunbelt Securities, Inc. | 12 | $497 | — | Held |
| ROTHSCHILD INVESTMENT LLC | 10 | $414 | — | Held |
| SG Americas Securities, LLC | 8.49K | $352 | — | Held |
| Essential Partners LLC | 7 | $290 | $108 | Added$108 |
| Rachor Investment Advisory Services, LLC | 6 | $249 | — | Held |
| Allworth Financial LP | 5 | $208 | — | New |
| True Wealth Design, LLC | 5 | $208 | — | Held |
| CWM, LLC | 2.23K | $92 | — | Held |
| AMALGAMATED BANK | 674 | $28 | — | Held |
| Daiwa Securities Group Inc. | 160 | $7 | — | Held |