| Deep Track Capital, LP | 3.35M | $82.7M | $8.05M | Added$8.05M |
| BlackRock, Inc. | 2.47M | $60.9M | $5.37M | Added$11.1M |
| RA CAPITAL MANAGEMENT, L.P. | 2.21M | $54.5M | $5.3M | Added$5.3M |
| TCG Crossover Management, LLC | 1.84M | $45.3M | $4.11M | Added$6.44M |
| Commodore Capital LP | 1.5M | $37M | $3.6M | Added$3.6M |
| Caligan Partners LP | 1.44M | $34.6M | — | New |
| Spruce Street Capital LP | 1.38M | $33.6M | $2.2M | Added$11.3M |
| JPMORGAN CHASE & CO | 1.43M | $33.2M | $1.41M | Cut−$2.68M |
| Trails Edge Capital Partners, LP | 1.32M | $32.5M | $3.17M | Added$1.47M |
| Nantahala Capital Management, LLC | 1.05M | $26M | $1.62M | Added$10.9M |
| Balyasny Asset Management L.P. | 923.7K | $22.8M | $2.15M | Added$2.82M |
| Logos Global Management LP | 915K | $22.6M | $2.2M | Cut−$4.15M |
| VANGUARD CAPITAL MANAGEMENT LLC | 894.7K | $22.1M | — | Held |
| Alyeska Investment Group, L.P. | 863.9K | $21.3M | $1.6M | Added$6.26M |
| Vivo Capital, LLC | 800K | $19.7M | $1.92M | Added$1.92M |
| Nan Fung Group Holdings Ltd | 630.7K | $15.6M | $720K | Added$8.87M |
| JENNISON ASSOCIATES LLC | 538.2K | $13.3M | $1.29M | Cut−$5.02M |
| GEODE CAPITAL MANAGEMENT, LLC | 518.2K | $12.8M | $1.06M | Added$2.95M |
| State Street | 504.4K | $12.4M | $600.1K | Added$6.87M |
| Citadel | 416.9K | $10.3M | $978.4K | Added$1.21M |
| GOLDMAN SACHS GROUP INC | 363.8K | $8.97M | $727.5K | Added$2.22M |
| GREAT POINT PARTNERS LLC | 300K | $7.4M | — | New |
| Fidelity | 222.5K | $5.49M | $532.5K | Added$548.3K |
| BAKER BROS. ADVISORS LP | 200K | $4.93M | $480K | Added$480K |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 186.1K | $4.59M | $426.3K | Added$635.4K |
| HighVista Strategies LLC | 173.6K | $4.28M | $336.3K | Added$1.16M |
| VANGUARD FIDUCIARY TRUST CO | 157.4K | $3.88M | — | Held |
| NORTHERN TRUST CORP | 154.4K | $3.81M | $345.5K | Added$602.8K |
| Integral Health Asset Management, LLC | 150K | $3.7M | $240K | Added$1.47M |
| UBS Group AG | 137.9K | $3.4M | $121.7K | Added$2.27M |
| MILLENNIUM MANAGEMENT LLC | 137K | $3.38M | — | New |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 112.5K | $2.77M | — | Held |
| AMERIPRISE FINANCIAL INC | 108.3K | $2.67M | $259.9K | Cut−$1.64M |
| Eversept Partners, LP | 100.2K | $2.47M | — | New |
| Russell Investments Group, Ltd. | 72.1K | $1.78M | $3.66K | Added$1.74M |
| Boxer Capital Management, LLC | 70K | $1.73M | $168K | Added$168K |
| JANUS HENDERSON GROUP PLC | 65.4K | $1.61M | — | New |
| WELLINGTON MANAGEMENT GROUP LLP | 52.6K | $1.3M | — | New |
| STEMPOINT CAPITAL LP | 50K | $1.23M | — | New |
| MORGAN STANLEY | 47.3K | $1.17M | $59.1K | Added$617.4K |
| Bank of New York Mellon Corp | 45.5K | $1.12M | $97.2K | Added$219.1K |
| ACUTA CAPITAL PARTNERS, LLC | 28.9K | $713.1K | $69.4K | Added$45.3K |
| Calamos Advisors LLC | 24.1K | $593.4K | — | New |
| Nuveen, LLC | 23K | $566.3K | $55.1K | Added$55.1K |
| Focus Partners Wealth | 19.8K | $488.6K | $47.6K | Added$41.3K |
| RHUMBLINE ADVISERS | 17.1K | $421.8K | $39.1K | Added$59.3K |
| BANK OF AMERICA CORP /DE/ | 16.6K | $409.8K | $39.9K | Cut−$564.3K |
| DEUTSCHE BANK AG\ | 15.4K | $378.8K | $31.9K | Added$82.7K |
| MEYER HANDELMAN CO | 15.1K | $372.2K | — | New |
| Opaleye Management Inc. | 14.5K | $357.7K | — | New |
| TWO SIGMA INVESTMENTS, LP | 12.7K | $313.7K | $30.5K | Added$30.5K |
| MetLife Investment Management, LLC | 11.1K | $273.8K | $26.6K | Added$26.6K |
| Invesco Ltd. | 10.7K | $264.6K | $25.7K | Added$20.7K |
| Soleus Capital Management, L.P. | 10K | $246.6K | $24K | Added$24K |
| Quadrature Capital Ltd | 9.93K | $244.9K | — | New |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 9.17K | $226.1K | $21.5K | Added$26.5K |
| Vanguard Global Advisers, LLC | 8.75K | $215.8K | — | Held |
| WELLS FARGO & COMPANY/MN | 8.62K | $212.6K | $20.7K | Cut−$283.8K |
| NEW YORK STATE COMMON RETIREMENT FUND | 6.1K | $150.4K | — | New |
| Police & Firemen's Retirement System of New Jersey | 6.04K | $149K | $10.6K | Added$50.5K |
| CITIGROUP INC | 5.57K | $137.3K | $1.04K | Added$127.6K |
| STRS OHIO | 5.1K | $125.8K | $8.16K | Added$50.1K |
| FEDERATED HERMES, INC. | 5K | $123.3K | $12K | Added$12K |
| BARCLAYS PLC | 4.53K | $111.7K | $10.9K | Cut−$560.9K |
| BNP PARIBAS FINANCIAL MARKETS | 4.05K | $99.9K | $9.62K | Added$10.7K |
| Legal & General Group Plc | 1.72K | $42.5K | $4.14K | Added$685 |
| Tower Research Capital LLC (TRC) | 1.66K | $41K | $3.27K | Added$10.7K |
| Ameritas Investment Partners, Inc. | 1.56K | $38.5K | $3.75K | Added$3.75K |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1.04K | $25.7K | $2.5K | Cut−$685 |
| Sterling Capital Management LLC | 368 | $9.07K | $883 | Cut−$4.1K |
| GAMMA Investing LLC | 162 | $4K | $33 | Added$3.68K |
| PNC Financial Services Group, Inc. | 145 | $3.58K | — | New |
| MassMutual Private Wealth & Trust, FSB | 54 | $1.33K | — | New |
| CWM, LLC | 29 | $715 | $197 | Added$715 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 13.2K | $327 | $27 | Added$80 |
| Allworth Financial LP | 1 | $25 | — | New |
| EverSource Wealth Advisors, LLC | 1 | $25 | — | New |