| Deep Track Capital, LP | 3.35M | $74.6M | — | Held |
| BlackRock, Inc. | 2.24M | $49.8M | — | Held |
| RA CAPITAL MANAGEMENT, L.P. | 2.21M | $49.2M | — | Held |
| TCG Crossover Management, LLC | 1.75M | $38.8M | — | Held |
| JPMORGAN CHASE & CO | 1.61M | $35.9M | — | Held |
| Commodore Capital LP | 1.5M | $33.4M | — | Held |
| Trails Edge Capital Partners, LP | 1.4M | $31.1M | — | Held |
| Logos Global Management LP | 1.2M | $26.7M | — | Held |
| Vanguard | 1.11M | $24.8M | — | Held |
| Spruce Street Capital LP | 1.01M | $22.4M | — | Held |
| Balyasny Asset Management L.P. | 896.8K | $20M | — | Held |
| JENNISON ASSOCIATES LLC | 821.9K | $18.3M | — | Held |
| Vivo Capital, LLC | 800K | $17.8M | — | Held |
| Alyeska Investment Group, L.P. | 675K | $15M | — | Held |
| Nantahala Capital Management, LLC | 675K | $15M | — | Held |
| GEODE CAPITAL MANAGEMENT, LLC | 441.5K | $9.83M | — | Held |
| Citadel | 407.7K | $9.07M | — | Held |
| GOLDMAN SACHS GROUP INC | 303.1K | $6.75M | — | Held |
| Nan Fung Group Holdings Ltd | 300K | $6.68M | — | Held |
| State Street | 250K | $5.57M | — | Held |
| Fidelity | 221.9K | $4.94M | — | Held |
| BAKER BROS. ADVISORS LP | 200K | $4.45M | — | Held |
| AMERIPRISE FINANCIAL INC | 193.5K | $4.31M | — | Held |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 177.6K | $3.95M | — | Held |
| NORTHERN TRUST CORP | 144K | $3.2M | — | Held |
| HighVista Strategies LLC | 140.1K | $3.12M | — | Held |
| Integral Health Asset Management, LLC | 100K | $2.23M | — | Held |
| Longbow Finance SA | 82.3K | $1.83M | — | Held |
| Boxer Capital Management, LLC | 70K | $1.56M | $452.9K | Added$452.9K |
| UBS Group AG | 50.7K | $1.13M | — | Held |
| BANK OF AMERICA CORP /DE/ | 43.8K | $974.1K | $11K | Added$947.2K |
| Bank of New York Mellon Corp | 40.5K | $901.9K | — | Held |
| JANE STREET GROUP, LLC | 31.7K | $706.4K | — | Held |
| BARCLAYS PLC | 30.2K | $672.6K | $195.5K | Added$185.6K |
| ACUTA CAPITAL PARTNERS, LLC | 30K | $667.8K | — | Held |
| MORGAN STANLEY | 24.6K | $548.5K | $62.1K | Added$396.8K |
| Nuveen, LLC | 23K | $511.2K | — | Held |
| WELLS FARGO & COMPANY/MN | 22.3K | $496.5K | — | Held |
| Focus Partners Wealth | 20.1K | $447.3K | — | Held |
| NORGES BANK | 20K | $445.2K | — | New |
| XTX Topco Ltd | 19.1K | $425.6K | — | Held |
| MARSHALL WACE, LLP | 18K | $401K | — | Held |
| RHUMBLINE ADVISERS | 16.3K | $362.5K | — | Held |
| DEUTSCHE BANK AG\ | 13.3K | $296K | — | Held |
| TWO SIGMA INVESTMENTS, LP | 12.7K | $283.1K | — | Held |
| Jefferies Financial Group Inc. | 12.4K | $277K | — | Held |
| MetLife Investment Management, LLC | 11.1K | $247.2K | — | Held |
| Invesco Ltd. | 11K | $243.9K | — | Held |
| Soleus Capital Management, L.P. | 10K | $222.6K | — | Held |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 8.97K | $199.6K | — | Held |
| FEDERATED HERMES, INC. | 5K | $111.3K | — | Held |
| Police & Firemen's Retirement System of New Jersey | 4.42K | $98.5K | — | Held |
| Persistent Asset Partners Ltd | 4.08K | $90.8K | — | New |
| BNP PARIBAS FINANCIAL MARKETS | 4.01K | $89.2K | — | Held |
| STRS OHIO | 3.4K | $75.7K | — | Held |
| Legal & General Group Plc | 1.88K | $41.8K | — | Held |
| Ameritas Investment Partners, Inc. | 1.56K | $34.8K | — | Held |
| Russell Investments Group, Ltd. | 1.52K | $33.9K | — | Held |
| Tower Research Capital LLC (TRC) | 1.36K | $30.3K | — | Held |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1.18K | $26.4K | — | Held |
| ROYAL BANK OF CANADA | 767 | $17K | — | Held |
| Sterling Capital Management LLC | 592 | $13.2K | — | Held |
| CITIGROUP INC | 435 | $9.68K | — | Held |
| GAMMA Investing LLC | 14 | $312 | — | Held |
| PRICE T ROWE ASSOCIATES INC /MD/ | 11.1K | $247 | — | Held |
| SG Americas Securities, LLC | 6.43K | $143 | — | Held |
| AMALGAMATED BANK | 605 | $13 | — | Held |
| CWM, LLC | 8 | $0 | — | Held |