| BAKER BROS. ADVISORS LP | 12.1M | $127M | — | Held |
| RTW INVESTMENTS, LP | 11.4M | $120.1M | — | Held |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 11.2M | $117.5M | — | Held |
| PERCEPTIVE ADVISORS LLC | 10.4M | $109M | — | Held |
| Vestal Point Capital, LP | 6.13M | $64.3M | — | Held |
| Jefferies Financial Group Inc. | 5.06M | $53.1M | — | Held |
| Sofinnova Investments, Inc. | 3.44M | $36.1M | — | Held |
| MORGAN STANLEY | 2.09M | $21.9M | $4.14M | Added$3.15M |
| Point72 Asset Management, L.P. | 1.75M | $18.4M | — | Held |
| Citadel | 1.71M | $18M | — | Held |
| WELLINGTON MANAGEMENT GROUP LLP | 1.64M | $17.2M | — | Held |
| Woodline Partners LP | 1M | $10.5M | — | Held |
| Lynx1 Capital Management LP | 922K | $9.68M | — | Held |
| SPHERA FUNDS MANAGEMENT LTD. | 861.1K | $9.04M | — | Held |
| Alyeska Investment Group, L.P. | 789.2K | $8.29M | — | Held |
| Aberdeen Group plc | 714.6K | $7.5M | — | Held |
| UNIVERSITY OF TEXAS/TEXAS AM INVESTMENT MANAGEMENT CO | 697.4K | $7.32M | — | Held |
| STEMPOINT CAPITAL LP | 610.3K | $6.41M | — | Held |
| Balyasny Asset Management L.P. | 592.4K | $6.22M | — | Held |
| UBS Group AG | 563.5K | $5.92M | — | Held |
| Caption Management, LLC | 550.9K | $5.78M | — | Held |
| WASATCH ADVISORS LP | 515.1K | $5.41M | — | Held |
| TD Asset Management Inc | 500.7K | $5.26M | — | Held |
| State Street | 444.7K | $4.67M | — | Held |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 402.4K | $4.05M | — | Held |
| GOLDMAN SACHS GROUP INC | 323K | $3.39M | — | Held |
| DAFNA Capital Management LLC | 261.1K | $2.74M | — | Held |
| Verition Fund Management LLC | 206.6K | $2.17M | — | Held |
| NORTHERN TRUST CORP | 203.4K | $2.14M | — | Held |
| Monashee Investment Management LLC | 160.3K | $1.68M | — | Held |
| BURKEHILL GLOBAL MANAGEMENT, LP | 150K | $1.57M | — | Held |
| Qube Research & Technologies Ltd | 147.3K | $1.55M | — | Held |
| JPMORGAN CHASE & CO | 147K | $1.54M | — | Held |
| GEODE CAPITAL MANAGEMENT, LLC | 134.8K | $1.42M | — | Held |
| MYDA Advisors LLC | 120K | $1.26M | — | Held |
| BNP PARIBAS FINANCIAL MARKETS | 116.6K | $1.22M | — | Held |
| ALPS ADVISORS INC | 110.1K | $1.16M | — | Held |
| JANE STREET GROUP, LLC | 104.9K | $1.1M | — | Held |
| SummitTX Capital, L.P. | 96.8K | $1.02M | — | Held |
| MILLENNIUM MANAGEMENT LLC | 83.1K | $872.8K | — | Held |
| Ishara Investments LP | 80K | $840K | — | Held |
| SECTORAL ASSET MANAGEMENT INC | 63K | $661.7K | — | Held |
| CITIGROUP INC | 56.4K | $591.9K | — | Held |
| TUDOR INVESTMENT CORP ET AL | 54.7K | $574.6K | — | New |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 55.3K | $556.9K | — | Held |
| Jump Financial, LLC | 50.9K | $534.1K | — | Held |
| Vanguard Personalized Indexing Management, LLC | 49.4K | $518.4K | — | Held |
| Ikarian Capital, LLC | 48.6K | $510K | — | Held |
| Longaeva Partners L.P. | 44.6K | $468.3K | — | Held |
| MERCER GLOBAL ADVISORS INC /ADV | 30K | $314.9K | — | Held |
| BARCLAYS PLC | 28.2K | $295.9K | $50.1K | Added$80.3K |
| Virtus Investment Advisers, LLC | 26.5K | $278.2K | — | Held |
| BlackRock, Inc. | 25.6K | $268.3K | — | Held |
| J. Goldman & Co LP | 22.8K | $239.3K | — | Held |
| T. Rowe Price Investment Management, Inc. | 21.5M | $225.3K | — | Held |
| Aquatic Capital Management LLC | 20.2K | $212.3K | — | Held |
| Graham Capital Management, L.P. | 19.6K | $206.1K | — | Held |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 17K | $178.8K | — | Held |
| Mitsubishi UFJ Asset Management Co., Ltd. | 17K | $177.2K | — | Held |
| GUGGENHEIM CAPITAL LLC | 16.4K | $172.2K | — | Held |
| Pale Fire Capital SE | 16.3K | $170.9K | — | Held |
| BANK OF AMERICA CORP /DE/ | 13.5K | $142.2K | $15.9K | Added$73.9K |
| Mariner, LLC | 13.4K | $140.7K | — | Held |
| FOX RUN MANAGEMENT, L.L.C. | 12.3K | $129.2K | — | Held |
| XTX Topco Ltd | 11.2K | $118K | — | Held |
| Quarry LP | 8K | $84K | — | Held |
| OSAIC HOLDINGS, INC. | 5.17K | $54.3K | — | Held |
| PRICE T ROWE ASSOCIATES INC /MD/ | 748K | $7.86K | — | Held |
| WELLS FARGO & COMPANY/MN | 651 | $6.84K | — | Held |
| Farther Finance Advisors, LLC | 528 | $5.54K | — | Held |
| SG Americas Securities, LLC | 208.5K | $2.19K | — | Held |
| NewEdge Advisors, LLC | 100 | $1.05K | — | Held |
| SBI Securities Co., Ltd. | 25 | $263 | — | Held |
| Clearstead Advisors, LLC | 25 | $261 | — | Held |
| HUNTINGTON NATIONAL BANK | 1 | $11 | — | Held |