| NEA Management Company, LLC | 7.69M | $126.5M | $5.92M | Added$5.92M |
| BlackRock, Inc. | 5.64M | $92.7M | $3.22M | Added$27.2M |
| TCG Crossover Management, LLC | 4.62M | $76M | $3.56M | Added$3.56M |
| BVF INC/IL | 4.46M | $73.4M | $2.95M | Added$13.2M |
| BAKER BROS. ADVISORS LP | 4.35M | $71.5M | $3.35M | Added$3.35M |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 4.23M | $69.5M | $2.59M | Added$16.8M |
| Vestal Point Capital, LP | 3.6M | $59.3M | $596.7K | Added$47.1M |
| State Street | 3.35M | $55.2M | $1.62M | Added$22.1M |
| BRAIDWELL LP | 3.21M | $52.7M | $730.2K | Added$37.9M |
| Versant Venture Management, LLC | 3.18M | $52.3M | $2.45M | Cut−$16.4M |
| VANGUARD CAPITAL MANAGEMENT LLC | 3.1M | $51M | — | Held |
| AMERICAN CENTURY COMPANIES INC | 2.81M | $46.2M | $1.02M | Added$25.4M |
| SILVERARC CAPITAL MANAGEMENT, LLC | 2M | $32.9M | $792.4K | Added$16.8M |
| Aisling Capital Management LP | 1.56M | $25.6M | $1.13M | Added$2.5M |
| GEODE CAPITAL MANAGEMENT, LLC | 1.54M | $25.4M | $928.4K | Added$6.46M |
| MARSHALL WACE, LLP | 1.43M | $23.6M | $307.1K | Added$17.3M |
| Bellevue Group AG | 1.25M | $20.6M | — | New |
| MPM BIOIMPACT LLC | 1.18M | $19.4M | $903.5K | Added$961.9K |
| DIMENSIONAL FUND ADVISORS LP | 1.04M | $17.1M | $432.7K | Added$8.21M |
| Fidelity | 1.02M | $16.8M | $788.7K | Cut−$3.54M |
| GOLDMAN SACHS GROUP INC | 1M | $16.5M | $227.8K | Added$11.8M |
| Frazier Life Sciences Management, L.P. | 1M | $16.4M | — | New |
| NORTHERN TRUST CORP | 826.6K | $13.6M | $536.7K | Added$2.67M |
| JANUS HENDERSON GROUP PLC | 685.9K | $11.3M | — | New |
| Alphabet Inc. | 684.3K | $11.3M | $526.9K | Cut−$424.5K |
| MORGAN STANLEY | 684.1K | $11.3M | $526.7K | Cut−$1.38M |
| Icahn Capital | 658.5K | $10.8M | $507K | Cut−$1.48M |
| Nantahala Capital Management, LLC | 652K | $10.7M | $44.7K | Added$9.82M |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 647.7K | $10.7M | $236.9K | Added$5.83M |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 546.7K | $8.99M | $345.5K | Added$1.96M |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 528.7K | $8.7M | $403K | Added$490.5K |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 516K | $8.49M | — | Held |
| VANGUARD FIDUCIARY TRUST CO | 407.1K | $6.7M | — | Held |
| Cormorant Asset Management, LP | 400K | $6.58M | — | New |
| Allspring Global Investments Holdings, LLC | 392.2K | $6.45M | $20.8K | Added$6.03M |
| BANK OF AMERICA CORP /DE/ | 387.5K | $6.38M | $172.1K | Added$2.87M |
| Renaissance Technologies | 379.1K | $6.24M | — | New |
| Fisher Asset Management, LLC | 314.9K | $5.18M | — | New |
| Empowered Funds, LLC | 305.4K | $5.02M | $214.1K | Added$663.5K |
| Nextech Invest, Ltd. | 304.2K | $5M | $215K | Added$626.3K |
| TD Asset Management Inc | 287K | $4.72M | $164.4K | Added$1.37M |
| Balyasny Asset Management L.P. | 256.7K | $4.22M | — | New |
| Citadel | 254.5K | $4.19M | $35.6K | Added$3.46M |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 250K | $4.11M | — | New |
| ADAR1 Capital Management, LLC | 215.8K | $3.55M | $166.1K | Added$166.1K |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 209.8K | $3.45M | $68.8K | Added$1.3M |
| Bank of New York Mellon Corp | 204.7K | $3.37M | $133.4K | Added$649.7K |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 200K | $3.29M | $154K | Added$154K |
| FRANKLIN RESOURCES INC | 199.7K | $3.29M | $65.6K | Added$1.95M |
| Atom Investors LP | 194.5K | $3.2M | $105.7K | Added$1.05M |
| MILLENNIUM MANAGEMENT LLC | 191.4K | $3.15M | $80.1K | Added$1.52M |
| DIADEMA PARTNERS LP | 187.3K | $3.08M | $48K | Added$2.1M |
| Casdin Capital, LLC | 186K | $3.06M | $66.2K | Added$1.71M |
| Jump Financial, LLC | 184.5K | $3.04M | — | New |
| Exome Asset Management LLC | 179.5K | $2.95M | — | New |
| J. Goldman & Co LP | 171.8K | $2.83M | $24.9K | Added$2.32M |
| VICTORY CAPITAL MANAGEMENT INC | 154.7K | $2.54M | — | New |
| UBS Group AG | 152.6K | $2.51M | $94.7K | Added$582K |
| Informed Momentum Co LLC | 130.2K | $2.14M | $53.9K | Added$1.04M |
| WELLINGTON MANAGEMENT GROUP LLP | 128.8K | $2.12M | $99.2K | Cut−$202.9K |
| Nuveen, LLC | 120.9K | $1.99M | $93.1K | Cut−$2.49M |
| Rafferty Asset Management, LLC | 104.6K | $1.72M | $51.9K | Added$663.6K |
| Invesco Ltd. | 102.2K | $1.68M | $78.7K | Cut−$4M |
| OpenArc Corporate Advisory, LLC | 100.2K | $1.65M | — | New |
| VOYA INVESTMENT MANAGEMENT LLC | 82.3K | $1.35M | $20.3K | Added$940.8K |
| SEI INVESTMENTS CO | 77.7K | $1.28M | $46K | Added$342.3K |
| RHUMBLINE ADVISERS | 76.4K | $1.26M | $47.6K | Added$287K |
| Woodline Partners LP | 74.5K | $1.23M | — | New |
| STATE OF WISCONSIN INVESTMENT BOARD | 74.2K | $1.22M | $15.1K | Added$912.8K |
| D. E. Shaw & Co., Inc. | 66.3K | $1.09M | $51.1K | Cut−$249.4K |
| JPMORGAN CHASE & CO | 67.5K | $1.05M | −$3.62K | Added$670.6K |
| HUSSMAN STRATEGIC ADVISORS, INC. | 63K | $1.04M | — | New |
| IEQ CAPITAL, LLC | 62.7K | $1.03M | $48.3K | Cut−$368.3K |
| Swiss National Bank | 61.1K | $1.01M | — | New |
| XTX Topco Ltd | 57.8K | $950.1K | $24K | Added$462.1K |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 56.5K | $929.3K | $38.2K | Added$151.1K |
| PRUDENTIAL FINANCIAL INC | 56.3K | $925.8K | — | New |
| Quantinno Capital Management LP | 54K | $888.3K | $25.9K | Added$361.8K |
| ALLIANCEBERNSTEIN L.P. | 55.7K | $873.4K | $0 | Cut−$122K |
| Trexquant Investment LP | 49.2K | $809K | $37.9K | Cut−$1.54M |
| DEUTSCHE BANK AG\ | 47.9K | $787.3K | $25.5K | Added$268.2K |
| Persistent Asset Partners Ltd | 47.5K | $781.4K | $17.1K | Added$433.1K |
| PROFUND ADVISORS LLC | 46.7K | $768K | $19.4K | Added$372.5K |
| BNP PARIBAS FINANCIAL MARKETS | 45.1K | $741.3K | $4.38K | Added$652K |
| SEVEN GRAND MANAGERS, LLC | 45K | $740.3K | — | New |
| Aquatic Capital Management LLC | 44.9K | $738.2K | $23.8K | Added$253.1K |
| PRELUDE CAPITAL MANAGEMENT, LLC | 43.5K | $715.1K | — | New |
| STRS OHIO | 42.7K | $702.4K | $27.8K | Added$136.4K |
| PRINCIPAL FINANCIAL GROUP INC | 42.4K | $697.3K | — | New |
| Round Rock Advisors LLC | 37.2K | $612.4K | — | New |
| Squarepoint Ops LLC | 37.1K | $610.4K | $7.72K | Added$453.2K |
| Vanguard Global Advisers, LLC | 36K | $592.2K | — | Held |
| AMERIPRISE FINANCIAL INC | 36K | $592.2K | $27.7K | Cut−$1.32M |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 35.8K | $582K | $13.7K | Added$180.2K |
| MetLife Investment Management, LLC | 33.4K | $549.6K | $20.2K | Added$139K |
| KENNEDY CAPITAL MANAGEMENT LLC | 32K | $526K | — | New |
| ADVISORY RESEARCH INC | 31.2K | $513.8K | $24.1K | Cut−$477.5K |
| CWM, LLC | 29.7K | $488.4K | $483.9K | Added$487.9K |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 27.1K | $462.7K | $24.1K | Added$105.9K |
| PSP Research LLC | 28K | $460.6K | — | New |
| ALLSTATE CORP | 28K | $459.9K | — | New |
| Jefferies Financial Group Inc. | 27.5K | $452.5K | — | New |
| OMERS ADMINISTRATION Corp | 27.1K | $445.8K | — | New |
| Rangeley Capital, LLC | 27K | $444.4K | $20.8K | Cut−$614K |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 25.3K | $416.7K | $87.1K | Added$67.9K |
| Man Group plc | 25.3K | $415.6K | $12.6K | Added$159.8K |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 24.8K | $407.2K | $8.4K | Added$236.1K |
| Legal & General Group Plc | 24.3K | $400K | $3.27K | Added$333.5K |
| Creative Planning | 23.9K | $392.6K | $18K | Added$25.6K |
| WELLS FARGO & COMPANY/MN | 23.2K | $381.8K | $17.9K | Cut−$442.8K |
| Seven Fleet Capital Management LP | 22.5K | $370.6K | $3.08K | Added$307.9K |
| ACT CAPITAL MANAGEMENT, LLC | 22.5K | $370.1K | — | New |
| VANGUARD ASSET MANAGEMENT, Ltd | 20.5K | $336.6K | — | Held |
| Harvest Investment Services, LLC | 19.5K | $321.4K | — | New |
| TWO SIGMA INVESTMENTS, LP | 19.3K | $317.5K | $10.8K | Added$98K |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 19.3K | $317.1K | $439 | Added$308.2K |
| Corient Private Wealth LLC | 18.9K | $311K | — | New |
| INTECH INVESTMENT MANAGEMENT LLC | 18.9K | $310.5K | $14.5K | Added$6.48K |
| State of Wyoming | 17.6K | $290.3K | — | New |
| Mariner, LLC | 17.1K | $281.5K | $12.4K | Cut−$58.1K |
| Campbell & CO Investment Adviser LLC | 17K | $279.9K | $13.1K | Cut−$1.14M |
| Virtus Investment Advisers, LLC | 16.7K | $275K | $12.6K | Added$19.3K |
| Police & Firemen's Retirement System of New Jersey | 16.2K | $266.4K | $9.56K | Added$71.7K |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 15.3K | $250.9K | $811 | Added$234.4K |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 14.9K | $245.9K | $11.5K | Added$11.5K |
| SIMPLEX TRADING, LLC | 14.7K | $242K | $11.3K | Cut−$308.8K |
| CITIGROUP INC | 14.6K | $239.8K | $8.23K | Added$72.2K |
| LPL Financial LLC | 14.4K | $237.7K | — | New |
| DRW Securities, LLC | 14.3K | $235.2K | — | New |
| MANGROVE PARTNERS IM, LLC | 13.7K | $225.5K | — | New |
| China Universal Asset Management Co., Ltd. | 13.5K | $222.6K | $10.4K | Cut−$69.3K |
| E Fund Management Co., Ltd. | 13.2K | $216.3K | — | Held |
| Essential Partners LLC | 13K | $214.3K | $10K | Added$8.46K |
| AlphaCentric Advisors LLC | 12.6K | $206.7K | — | New |
| WINTON GROUP Ltd | 12.5K | $205.3K | $9.61K | Cut−$154.2K |
| MARTINGALE ASSET MANAGEMENT L P | 12.4K | $204.4K | $9.56K | Added$9.74K |
| ProShare Advisors LLC | 12.2K | $200.4K | $8.76K | Added$22.1K |
| NEW YORK STATE COMMON RETIREMENT FUND | 12.2K | $200.3K | $9.37K | Added$9.37K |
| MERCER GLOBAL ADVISORS INC /ADV | 12.1K | $199.1K | $8.45K | Added$27.1K |
| AXQ CAPITAL, LP | 11.7K | $192.1K | $8.99K | Cut−$23.3K |
| Focus Partners Wealth | 11.6K | $191K | $8.94K | Cut−$25K |
| BARCLAYS PLC | 11.4K | $186.8K | $8.74K | Cut−$1.95M |
| State of New Jersey Common Pension Fund D | 10.6K | $173.6K | — | New |
| WEALTH EFFECTS LLC | 10.1K | $166.1K | $7.78K | Added$7.78K |
| Mayflower Financial Advisors, LLC | 10K | $164.5K | $7.7K | Added$7.7K |
| Vanguard Investments Australia, Ltd. | 8.85K | $145.6K | — | Held |
| Russell Investments Group, Ltd. | 7.39K | $121.5K | $3.33K | Added$53.8K |
| KLP KAPITALFORVALTNING AS | 6.8K | $111.9K | — | New |
| PRICE T ROWE ASSOCIATES INC /MD/ | 6.72M | $110.5K | $3.94K | Added$30.3K |
| Rockefeller Capital Management L.P. | 5.29K | $87.1K | $817 | Added$70.5K |
| Ameritas Investment Partners, Inc. | 4.95K | $81.5K | $3.22K | Added$15.9K |
| NISA INVESTMENT ADVISORS, LLC | 4.75K | $78.2K | $2.43K | Added$28.7K |
| Mirae Asset Global Investments Co., Ltd. | 3.98K | $65.4K | $2.44K | Added$15.8K |
| Tower Research Capital LLC (TRC) | 3.72K | $61.2K | $529 | Added$50.5K |
| EverSource Wealth Advisors, LLC | 3.63K | $59.6K | $2.53K | Added$8.2K |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 3.29K | $54.1K | $2.21K | Added$9.07K |
| ROYAL BANK OF CANADA | 2.17K | $36K | $2.15K | Cut−$8K |
| GAMMA Investing LLC | 2.03K | $33.4K | $1.47K | Added$3.49K |
| Sterling Capital Management LLC | 2K | $33K | $1.54K | Cut−$116.1K |
| FEDERATED HERMES, INC. | 1.63K | $26.8K | $1.02K | Added$6.04K |
| OSAIC HOLDINGS, INC. | 1.59K | $26.2K | $1.23K | Cut−$27.4K |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 1.53K | $25.1K | — | New |
| GF FUND MANAGEMENT CO. LTD. | 1.45K | $23.9K | $985 | Added$3.85K |
| Allworth Financial LP | 1.31K | $21.5K | $960 | Added$1.93K |
| IFP Advisors, Inc | 1.2K | $19.7K | $921 | Added$560 |
| FIFTH THIRD BANCORP | 596 | $9.8K | — | New |
| Arax Advisory Partners | 323 | $8.92K | $3.85K | Added$1.7K |
| Parkwood LLC | 505K | $8.31K | $389 | Cut−$2.79K |
| PNC Financial Services Group, Inc. | 457 | $7.52K | $352 | Added$352 |
| Farther Finance Advisors, LLC | 298 | $5.12K | $444 | Cut−$1.77K |
| Westfuller Advisors, LLC | 301 | $4.95K | — | New |
| SBI Securities Co., Ltd. | 232 | $3.82K | $178 | Added$84 |
| Optiver Holding B.V. | 228 | $3.75K | $176 | Cut−$420 |
| MAI Capital Management | 227 | $3.73K | $25 | Added$3.22K |
| Larson Financial Group LLC | 181 | $2.98K | $139 | Added$139 |
| MassMutual Private Wealth & Trust, FSB | 103 | $1.69K | — | New |
| ROTHSCHILD INVESTMENT LLC | 91 | $1.5K | $70 | Cut−$71 |
| True Wealth Design, LLC | 91 | $1.5K | $70 | Cut−$244 |
| ACADIAN ASSET MANAGEMENT LLC | 78.5K | $1.29K | $59 | Cut−$2.6K |
| Dogwood Wealth Management LLC | 54 | $888 | — | New |
| Smartleaf Asset Management LLC | 37 | $575 | −$16 | Cut−$16 |
| Fortitude Family Office, LLC | 31 | $510 | — | New |
| SJS Investment Consulting Inc. | 23 | $379 | $18 | Cut−$76 |
| SG Americas Securities, LLC | 20.5K | $337 | $13 | Added$66 |
| US BANCORP \DE\ | 12 | $197 | — | New |
| JPL Wealth Management, LLC | 8 | $132 | — | New |
| Vestcor Inc | 4.23K | $70 | — | New |
| Sunbelt Securities, Inc. | 1 | $16 | $0 | Held |
| Covestor Ltd | 5 | $0 | −$0 | Cut−$6 |