| NEA Management Company, LLC | 7.69M | $120.6M | — | Held |
| TCG Crossover Management, LLC | 4.62M | $72.5M | — | Held |
| Versant Venture Management, LLC | 4.38M | $68.7M | — | Held |
| BAKER BROS. ADVISORS LP | 4.35M | $68.1M | — | Held |
| BlackRock, Inc. | 4.18M | $65.6M | — | Held |
| BVF INC/IL | 3.84M | $60.1M | — | Held |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 3.36M | $52.7M | — | Held |
| Vanguard | 3.25M | $50.9M | — | Held |
| State Street | 2.11M | $33M | — | Held |
| Aisling Capital Management LP | 1.47M | $23.1M | — | Held |
| AMERICAN CENTURY COMPANIES INC | 1.33M | $20.8M | — | Held |
| Fidelity | 1.3M | $20.4M | — | Held |
| GEODE CAPITAL MANAGEMENT, LLC | 1.2M | $18.9M | — | Held |
| MPM BIOIMPACT LLC | 1.17M | $18.4M | — | Held |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1.03M | $16.1M | — | Held |
| BRAIDWELL LP | 948.3K | $14.9M | — | Held |
| MORGAN STANLEY | 805.5K | $12.6M | $5.34M | Added$7.85M |
| Icahn Capital | 785.1K | $12.3M | — | Held |
| Vestal Point Capital, LP | 775K | $12.2M | — | Held |
| Alphabet Inc. | 744.9K | $11.7M | — | Held |
| NORTHERN TRUST CORP | 697K | $10.9M | — | Held |
| DIMENSIONAL FUND ADVISORS LP | 568.4K | $8.91M | — | Held |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 523.4K | $8.21M | — | Held |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 448.7K | $7.04M | — | Held |
| MARSHALL WACE, LLP | 398.9K | $6.25M | — | Held |
| Invesco Ltd. | 362.2K | $5.68M | — | Held |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 307.7K | $4.82M | — | Held |
| GOLDMAN SACHS GROUP INC | 295.9K | $4.64M | — | Held |
| Nuveen, LLC | 285.9K | $4.48M | — | Held |
| Nextech Invest, Ltd. | 279.2K | $4.38M | — | Held |
| Empowered Funds, LLC | 278.1K | $4.36M | — | Held |
| BANK OF AMERICA CORP /DE/ | 223.6K | $3.51M | $1.85M | Added$1.51M |
| ADAR1 Capital Management, LLC | 215.8K | $3.38M | — | Held |
| TD Asset Management Inc | 213.5K | $3.35M | — | Held |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 200K | $3.14M | — | Held |
| Bank of New York Mellon Corp | 173.3K | $2.72M | — | Held |
| Trexquant Investment LP | 149.7K | $2.35M | — | Held |
| WELLINGTON MANAGEMENT GROUP LLP | 148.1K | $2.32M | — | Held |
| Atom Investors LP | 137.3K | $2.15M | — | Held |
| JANE STREET GROUP, LLC | 137K | $2.15M | — | Held |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 134.7K | $2.15M | — | Held |
| BARCLAYS PLC | 136K | $2.13M | $603.3K | Added$1.59M |
| UBS Group AG | 123K | $1.93M | — | Held |
| AMERIPRISE FINANCIAL INC | 122.2K | $1.92M | — | Held |
| MILLENNIUM MANAGEMENT LLC | 104K | $1.63M | — | Held |
| Campbell & CO Investment Adviser LLC | 90.8K | $1.42M | — | Held |
| IEQ CAPITAL, LLC | 89.3K | $1.4M | — | Held |
| Casdin Capital, LLC | 86K | $1.35M | — | Held |
| D. E. Shaw & Co., Inc. | 85.5K | $1.34M | — | Held |
| FRANKLIN RESOURCES INC | 85.2K | $1.34M | — | Held |
| Informed Momentum Co LLC | 70K | $1.1M | — | Held |
| CANADA PENSION PLAN INVESTMENT BOARD | 68.1K | $1.07M | — | Held |
| Rangeley Capital, LLC | 67.5K | $1.06M | — | Held |
| Rafferty Asset Management, LLC | 67.4K | $1.06M | — | Held |
| ALLIANCEBERNSTEIN L.P. | 63.5K | $995.4K | — | Held |
| ADVISORY RESEARCH INC | 63.2K | $991.3K | — | Held |
| DIADEMA PARTNERS LP | 62.3K | $976.6K | — | Held |
| RHUMBLINE ADVISERS | 61.9K | $969.9K | — | Held |
| STEMPOINT CAPITAL LP | 61.6K | $965.5K | — | Held |
| SEI INVESTMENTS CO | 59.7K | $935.6K | — | Held |
| Nantahala Capital Management, LLC | 58K | $909.3K | — | Held |
| WELLS FARGO & COMPANY/MN | 52.6K | $824.6K | — | Held |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 49.6K | $778.2K | — | Held |
| Citadel | 46.3K | $725.4K | — | Held |
| STRS OHIO | 36.1K | $566K | — | Held |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 35.8K | $561.1K | — | Held |
| SIMPLEX TRADING, LLC | 35.1K | $550.7K | — | Held |
| Quantinno Capital Management LP | 33.6K | $526.5K | — | Held |
| DEUTSCHE BANK AG\ | 33.1K | $519.1K | — | Held |
| J. Goldman & Co LP | 32.3K | $506.3K | — | Held |
| XTX Topco Ltd | 31.1K | $488K | — | Held |
| Aquatic Capital Management LLC | 30.9K | $485.1K | — | Held |
| AlphaQuest LLC | 28.3K | $444.1K | — | Held |
| Allspring Global Investments Holdings, LLC | 27K | $422.7K | — | Held |
| VOYA INVESTMENT MANAGEMENT LLC | 26.4K | $413.7K | — | Held |
| MetLife Investment Management, LLC | 26.2K | $410.6K | — | Held |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 25.6K | $401.8K | — | Held |
| PROFUND ADVISORS LLC | 25.2K | $395.4K | — | Held |
| NEOS Investment Management LLC | 25.1K | $394.1K | — | Held |
| TEMA ETFS LLC | 24.8K | $388.3K | — | Held |
| JPMORGAN CHASE & CO | 24.1K | $378.2K | — | Held |
| Creative Planning | 23.4K | $367K | — | Held |
| WINTON GROUP Ltd | 22.9K | $359.5K | — | Held |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 22.3K | $356.8K | — | Held |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 26.8K | $348.7K | — | Held |
| Persistent Asset Partners Ltd | 22.2K | $348.3K | — | New |
| Mariner, LLC | 21.6K | $339.7K | — | Held |
| STATE OF WISCONSIN INVESTMENT BOARD | 19.6K | $307.8K | — | Held |
| Brookwood Investment Group LLC | 19.5K | $306.3K | — | Held |
| INTECH INVESTMENT MANAGEMENT LLC | 19.4K | $304.1K | — | Held |
| China Universal Asset Management Co., Ltd. | 18.6K | $291.8K | — | Held |
| Man Group plc | 16.3K | $255.8K | — | Held |
| Virtus Investment Advisers, LLC | 16.3K | $255.7K | — | Held |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 14.9K | $234.4K | — | Held |
| TWO SIGMA INVESTMENTS, LP | 14K | $219.5K | — | Held |
| Focus Partners Wealth | 13.8K | $216K | — | Held |
| AXQ CAPITAL, LP | 13.7K | $215.5K | — | Held |
| Brevan Howard Capital Management LP | 13.3K | $208.9K | — | Held |
| Essential Partners LLC | 13.1K | $205.8K | $107.7K | Added$109.4K |
| Police & Firemen's Retirement System of New Jersey | 12.4K | $194.7K | — | Held |
| MARTINGALE ASSET MANAGEMENT L P | 12.4K | $194.6K | — | Held |
| NEW YORK STATE COMMON RETIREMENT FUND | 12.2K | $190.9K | — | Held |
| ProShare Advisors LLC | 11.4K | $178.3K | — | Held |
| Pallas Capital Advisors LLC | 11.3K | $177.5K | — | Held |
| Baader Bank Aktiengesellschaft | 11K | $172.5K | — | Held |
| MERCER GLOBAL ADVISORS INC /ADV | 11K | $172K | — | Held |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 10.9K | $171K | — | Held |
| CITIGROUP INC | 10.7K | $167.6K | — | Held |
| WEALTH EFFECTS LLC | 10.1K | $158.4K | — | Held |
| Squarepoint Ops LLC | 10K | $157.3K | — | Held |
| Mayflower Financial Advisors, LLC | 10K | $156.8K | — | Held |
| Sterling Capital Management LLC | 9.51K | $149.1K | — | Held |
| BNP PARIBAS FINANCIAL MARKETS | 5.69K | $89.3K | — | Held |
| PRICE T ROWE ASSOCIATES INC /MD/ | 5.12M | $80.3K | — | Held |
| Russell Investments Group, Ltd. | 4.32K | $67.7K | — | Held |
| Legal & General Group Plc | 4.25K | $66.6K | — | Held |
| Ameritas Investment Partners, Inc. | 4.18K | $65.6K | — | Held |
| Seven Fleet Capital Management LP | 4K | $62.7K | — | Held |
| OSAIC HOLDINGS, INC. | 3.42K | $53.6K | — | Held |
| EverSource Wealth Advisors, LLC | 3.28K | $51.4K | — | Held |
| Mirae Asset Global Investments Co., Ltd. | 3.16K | $49.6K | — | Held |
| NISA INVESTMENT ADVISORS, LLC | 3.15K | $49.4K | — | Held |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 2.87K | $45K | — | Held |
| ROYAL BANK OF CANADA | 2.82K | $44K | — | Held |
| GAMMA Investing LLC | 1.91K | $29.9K | — | Held |
| FEDERATED HERMES, INC. | 1.32K | $20.7K | — | Held |
| GF FUND MANAGEMENT CO. LTD. | 1.28K | $20.1K | — | Held |
| Allworth Financial LP | 1.25K | $19.6K | $4.94K | Added$15.1K |
| IFP Advisors, Inc | 1.22K | $19.1K | $9.53K | Added$10.6K |
| Rockefeller Capital Management L.P. | 1.06K | $16.6K | — | Held |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 1.05K | $16.5K | — | Held |
| Parkwood LLC | 708K | $11.1K | — | Held |
| Tower Research Capital LLC (TRC) | 686 | $10.8K | — | Held |
| COMERICA BANK | 596 | $9.35K | — | Held |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 570 | $8.94K | — | Held |
| Spire Wealth Management | 509 | $7.98K | — | Held |
| Arax Advisory Partners | 460 | $7.21K | — | Held |
| PNC Financial Services Group, Inc. | 457 | $7.17K | — | Held |
| Farther Finance Advisors, LLC | 439 | $6.88K | — | Held |
| Optiver Holding B.V. | 266 | $4.17K | — | Held |
| ACADIAN ASSET MANAGEMENT LLC | 247.9K | $3.88K | — | Held |
| SBI Securities Co., Ltd. | 238 | $3.73K | — | Held |
| Larson Financial Group LLC | 181 | $2.84K | — | Held |
| True Wealth Design, LLC | 111 | $1.74K | — | Held |
| ROTHSCHILD INVESTMENT LLC | 100 | $1.57K | — | Held |
| Smartleaf Asset Management LLC | 37 | $591 | — | Held |
| MAI Capital Management | 33 | $518 | — | Held |
| CWM, LLC | 29.4K | $462 | — | Held |
| SJS Investment Consulting Inc. | 29 | $455 | — | Held |
| Caitong International Asset Management Co., Ltd | 27 | $423 | — | Held |
| Virtu Financial LLC | 18.7K | $293 | — | Held |
| SG Americas Securities, LLC | 17.3K | $271 | — | Held |
| Turning Point Benefit Group, Inc. | 14 | $219 | — | Held |
| GSA CAPITAL PARTNERS LLP | 13K | $204 | — | Held |
| Clearstead Advisors, LLC | 8 | $126 | — | Held |
| AMALGAMATED BANK | 1.47K | $23 | — | Held |
| Sunbelt Securities, Inc. | 1 | $16 | — | Held |
| Covestor Ltd | 387 | $6 | — | Held |
| Daiwa Securities Group Inc. | 203 | $3 | — | Held |
| BESSEMER GROUP INC | 34 | $1 | — | Held |