| Affinity Asset Advisors, LLC | 1.59M | $11.5M | −$93K | Added$9.24M |
| Balyasny Asset Management L.P. | 1.35M | $9.77M | −$418.5K | Cut−$418.5K |
| Vivo Capital, LLC | 1.35M | $9.77M | −$418.5K | Cut−$418.5K |
| Ikarian Capital, LLC | 1.21M | $8.79M | −$189.1K | Added$4.19M |
| GREAT POINT PARTNERS LLC | 1.2M | $8.69M | −$372K | Cut−$372K |
| SCOTIA CAPITAL INC. | 1.34M | $7.24M | −$2.66M | Cut−$2.36M |
| Point72 Asset Management, L.P. | 967.6K | $7.01M | −$220.7K | Added$1.63M |
| UBS Group AG | 762.6K | $5.52M | −$68.2K | Added$3.86M |
| Seven Fleet Capital Management LP | 709.5K | $5.14M | — | New |
| Redmile Group, LLC | 700K | $5.07M | — | New |
| Rubric Capital Management LP | 691.2K | $5M | — | New |
| Squadron Capital Management LLC | 680K | $4.92M | −$155K | Added$1.15M |
| Ally Bridge Group (NY) LLC | 660.4K | $4.78M | −$123.3K | Added$1.78M |
| PFM Health Sciences, LP | 540.9K | $3.92M | — | New |
| AMERIPRISE FINANCIAL INC | 524.3K | $3.8M | — | New |
| Woodline Partners LP | 440.6K | $3.19M | — | New |
| Alyeska Investment Group, L.P. | 375K | $2.71M | — | New |
| Velan Capital Investment Management LP | 352K | $2.55M | −$109.1K | Cut−$109.1K |
| SummitTX Capital, L.P. | 328K | $2.37M | −$54.5K | Added$1.05M |
| Aisling Capital Management LP | 325K | $2.35M | — | New |
| BOOTHBAY FUND MANAGEMENT, LLC | 323.8K | $2.34M | −$48.5K | Added$1.16M |
| DV Trading LLC | 276K | $2M | — | New |
| BANK OF AMERICA CORP /DE/ | 268.2K | $1.94M | −$78.5K | Added$29.3K |
| ROYAL BANK OF CANADA | 261.4K | $1.89M | −$60.5K | Added$411K |
| Citadel | 230.2K | $1.67M | — | New |
| MARSHALL WACE, LLP | 158.1K | $1.14M | −$49K | Cut−$49K |
| CIBC WORLD MARKET INC. | 150.9K | $1.09M | −$17.4K | Added$653.3K |
| Hudson Bay Capital Management LP | 92.3K | $668.6K | — | New |
| TD Waterhouse Canada Inc. | 81.7K | $589.8K | −$2.41K | Added$518.1K |
| 1832 Asset Management L.P. | 60K | $434.4K | −$9.96K | Added$191.8K |
| GOLDMAN SACHS GROUP INC | 53.1K | $384.3K | −$16.5K | Cut−$54K |
| RAYMOND JAMES FINANCIAL INC | 50.6K | $366.1K | −$15.7K | Cut−$33.9K |
| DIADEMA PARTNERS LP | 40K | $289.6K | — | New |
| BANK OF MONTREAL /CAN/ | 38.3K | $276.1K | −$11.2K | Cut−$3.97K |
| Persistent Asset Partners Ltd | 37.9K | $274.6K | — | New |
| JANE STREET GROUP, LLC | 35.2K | $254K | −$9.07K | Added$31.3K |
| TORONTO DOMINION BANK | 32.9K | $237.5K | — | New |
| GEODE CAPITAL MANAGEMENT, LLC | 25.6K | $185.4K | −$4.31K | Added$80.5K |
| AXQ CAPITAL, LP | 15.8K | $114.1K | — | New |
| Integrated Wealth Concepts LLC | 12K | $86.9K | — | New |
| TCI Wealth Advisors, Inc. | 11K | $79.6K | −$3.41K | Cut−$3.41K |
| TWO SIGMA INVESTMENTS, LP | 10.8K | $78.2K | — | New |
| GUARDIAN WEALTH ADVISORS, LLC / NC | 10.5K | $76K | −$3.1K | Added$520 |
| Aptus Capital Advisors, LLC | 10.5K | $76K | −$3.1K | Added$520 |
| China Universal Asset Management Co., Ltd. | 10K | $72.4K | — | New |
| MORGAN STANLEY | 8.82K | $63.9K | — | New |
| Federation des caisses Desjardins du Quebec | 9.09K | $49K | −$18.9K | Cut−$18.9K |
| BNP PARIBAS FINANCIAL MARKETS | 6.43K | $46.5K | — | New |
| Beutel, Goodman & Co Ltd. | 3.67M | $26.4K | −$1.23K | Cut−$1.55K |
| JPMORGAN CHASE & CO | 573 | $3.79K | — | New |
| NATIONAL BANK OF CANADA /FI/ | 359 | $812 | −$1.91K | Cut−$3.63K |
| ACADIAN ASSET MANAGEMENT LLC | 93.6K | $671 | −$31 | Cut−$497 |
| INGALLS & SNYDER LLC | 75.7K | $548 | −$23 | Cut−$36 |
| Caitong International Asset Management Co., Ltd | 1 | $7 | — | New |