| Vivo Capital, LLC | 1.35M | $10.2M | — | Held |
| Balyasny Asset Management L.P. | 1.35M | $10.2M | — | Held |
| SCOTIA CAPITAL INC. | 1.29M | $9.6M | — | Held |
| GREAT POINT PARTNERS LLC | 1.2M | $9.06M | — | Held |
| Point72 Asset Management, L.P. | 712.1K | $5.38M | — | Held |
| Ikarian Capital, LLC | 610K | $4.61M | — | Held |
| Squadron Capital Management LLC | 500K | $3.77M | — | Held |
| Ally Bridge Group (NY) LLC | 397.9K | $3M | — | Held |
| Velan Capital Investment Management LP | 352K | $2.66M | — | Held |
| Affinity Asset Advisors, LLC | 300K | $2.27M | — | Held |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 278.1K | $2.09M | — | Held |
| BANK OF AMERICA CORP /DE/ | 253.3K | $1.91M | $75.2K | Added$1.64M |
| UBS Group AG | 220K | $1.66M | — | Held |
| ROYAL BANK OF CANADA | 196.3K | $1.48M | — | Held |
| SummitTX Capital, L.P. | 175.9K | $1.33M | — | Held |
| MARSHALL WACE, LLP | 158.1K | $1.19M | — | Held |
| BOOTHBAY FUND MANAGEMENT, LLC | 156.3K | $1.18M | — | Held |
| GOLDMAN SACHS GROUP INC | 58.1K | $438.3K | — | Held |
| CIBC WORLD MARKET INC. | 58K | $436.5K | — | Held |
| RAYMOND JAMES FINANCIAL INC | 53K | $399.9K | — | Held |
| Quadrature Capital Ltd | 43.2K | $325.6K | — | Held |
| BANK OF MONTREAL /CAN/ | 37.3K | $280.1K | — | Held |
| 1832 Asset Management L.P. | 32.1K | $242.6K | — | Held |
| JANE STREET GROUP, LLC | 29.6K | $222.8K | — | Held |
| XTX Topco Ltd | 16.2K | $122.2K | — | Held |
| GEODE CAPITAL MANAGEMENT, LLC | 13.9K | $104.9K | — | Held |
| TCI Wealth Advisors, Inc. | 11K | $83K | — | Held |
| Aptus Capital Advisors, LLC | 10K | $75.5K | — | Held |
| GUARDIAN WEALTH ADVISORS, LLC / NC | 10K | $75.5K | — | Held |
| TD Waterhouse Canada Inc. | 9.6K | $71.7K | — | Held |
| Federation des caisses Desjardins du Quebec | 9.09K | $67.9K | — | Held |
| Beutel, Goodman & Co Ltd. | 3.71M | $27.9K | — | Held |
| NATIONAL BANK OF CANADA /FI/ | 586 | $4.44K | — | Held |
| ACADIAN ASSET MANAGEMENT LLC | 155.8K | $1.17K | — | Held |
| INGALLS & SNYDER LLC | 77.4K | $584 | — | Held |