| JANUS HENDERSON GROUP PLC | 13.9M | $271.6M | — | Held |
| Vanguard | 11.2M | $219.4M | — | Held |
| BlackRock, Inc. | 11.2M | $218.9M | — | Held |
| Atlas Venture Life Science Advisors, LLC | 9.13M | $178.6M | — | Held |
| State Street | 6.69M | $130.9M | — | Held |
| Fidelity | 6.57M | $128.5M | — | Held |
| FCPM III SERVICES B.V. | 5.46M | $106.9M | — | Held |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 5.17M | $101.2M | — | Held |
| Orbis Allan Gray Ltd | 4.8M | $93.9M | — | Held |
| TCG Crossover Management, LLC | 4.62M | $90.3M | — | Held |
| JPMORGAN CHASE & CO | 3.55M | $69.4M | — | Held |
| Siren, L.L.C. | 3.5M | $68.5M | — | Held |
| PERCEPTIVE ADVISORS LLC | 3.48M | $68M | — | Held |
| GEODE CAPITAL MANAGEMENT, LLC | 3.26M | $63.8M | — | Held |
| ARMISTICE CAPITAL, LLC | 3.25M | $63.6M | — | Held |
| Frazier Life Sciences Management, L.P. | 3.15M | $61.7M | — | Held |
| Deep Track Capital, LP | 2.65M | $51.8M | — | Held |
| Vivo Capital, LLC | 2.61M | $51.1M | — | Held |
| GOLDMAN SACHS GROUP INC | 2.28M | $44.7M | — | Held |
| Sofinnova Investments, Inc. | 2.25M | $44.1M | — | Held |
| ORBIMED ADVISORS LLC | 2.2M | $43.1M | — | Held |
| VR ADVISER, LLC | 2.17M | $42.5M | — | Held |
| FRANKLIN RESOURCES INC | 2.01M | $39.2M | — | Held |
| Saturn V Capital Management LP | 1.79M | $35M | — | Held |
| SAMLYN CAPITAL, LLC | 1.49M | $29.2M | — | Held |
| BRAIDWELL LP | 1.48M | $28.9M | — | Held |
| Palo Alto Investors LP | 1.47M | $28.8M | — | Held |
| MPM BIOIMPACT LLC | 1.41M | $27.5M | — | Held |
| Polar Capital Holdings Plc | 1.27M | $24.8M | — | Held |
| Logos Global Management LP | 1.25M | $24.4M | — | Held |
| MORGAN STANLEY | 1.21M | $23.7M | $8.39M | Added$5.79M |
| Citadel | 1.17M | $22.9M | — | Held |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1.15M | $22.5M | — | Held |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 1.14M | $22.3M | — | Held |
| Aberdeen Group plc | 1.11M | $21.7M | — | Held |
| NORTHERN TRUST CORP | 1.09M | $21.4M | — | Held |
| Candriam S.C.A. | 1.06M | $20.7M | — | Held |
| Rock Springs Capital Management LP | 913K | $17.9M | — | Held |
| MILLENNIUM MANAGEMENT LLC | 904.4K | $17.7M | — | Held |
| BANK OF AMERICA CORP /DE/ | 882.9K | $17.3M | $5.26M | Added$7.64M |
| STEMPOINT CAPITAL LP | 835.2K | $16.3M | — | Held |
| BAKER BROS. ADVISORS LP | 813.4K | $15.9M | — | Held |
| ArrowMark Colorado Holdings LLC | 700.7K | $13.7M | — | Held |
| EVENTIDE ASSET MANAGEMENT, LLC | 680.3K | $13.3M | — | Held |
| MARSHALL WACE, LLP | 677K | $13.2M | — | Held |
| Artisan Partners Limited Partnership | 649.7K | $12.7M | — | Held |
| Nuveen, LLC | 621.3K | $12.2M | — | Held |
| RAYMOND JAMES FINANCIAL INC | 530.3K | $10.4M | — | Held |
| Catalio Capital Management, LP | 519.7K | $10.2M | — | Held |
| Ensign Peak Advisors, Inc | 496.6K | $9.71M | — | Held |
| Renaissance Technologies | 470.6K | $9.21M | — | Held |
| FEDERATED HERMES, INC. | 464.8K | $9.09M | — | Held |
| BARCLAYS PLC | 448.7K | $8.78M | $3.1M | Added$2.69M |
| Balyasny Asset Management L.P. | 433K | $8.47M | — | Held |
| TD Asset Management Inc | 419.8K | $8.21M | — | Held |
| University of Wisconsin Foundation | 416.8K | $8.15M | — | Held |
| Qube Research & Technologies Ltd | 412.4K | $8.07M | — | Held |
| Clearbridge Investments, LLC | 407.8K | $7.98M | — | Held |
| WASATCH ADVISORS LP | 407K | $7.96M | — | Held |
| SPHERA FUNDS MANAGEMENT LTD. | 392.9K | $7.69M | — | Held |
| UBS Group AG | 381K | $7.45M | — | Held |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 387K | $7.43M | — | Held |
| Bank of New York Mellon Corp | 353.5K | $6.91M | — | Held |
| Y-Intercept (Hong Kong) Ltd | 343.7K | $6.72M | — | Held |
| Point72 Asset Management, L.P. | 329.3K | $6.44M | — | Held |
| CANADA PENSION PLAN INVESTMENT BOARD | 284K | $5.56M | — | Held |
| Squarepoint Ops LLC | 255.2K | $4.99M | — | Held |
| Fisher Asset Management, LLC | 250.1K | $4.89M | — | Held |
| Tetragon Partners GP Ltd | 248K | $4.85M | — | Held |
| SummitTX Capital, L.P. | 243.3K | $4.76M | — | Held |
| Neo Ivy Capital Management | 237.5K | $4.64M | — | Held |
| Rafferty Asset Management, LLC | 233.8K | $4.57M | — | Held |
| Russell Investments Group, Ltd. | 232K | $4.54M | — | Held |
| Swiss National Bank | 222.5K | $4.35M | — | Held |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 214.5K | $4.2M | — | Held |
| AMERIPRISE FINANCIAL INC | 197.7K | $3.87M | — | Held |
| DEUTSCHE BANK AG\ | 196.1K | $3.84M | — | Held |
| PDT Partners, LLC | 183K | $3.58M | — | Held |
| RHUMBLINE ADVISERS | 175K | $3.42M | — | Held |
| AMERICAN CENTURY COMPANIES INC | 168.3K | $3.29M | — | Held |
| NEUBERGER BERMAN GROUP LLC | 165.5K | $3.24M | — | Held |
| Jain Global LLC | 162K | $3.17M | — | Held |
| Brevan Howard Capital Management LP | 158K | $3.09M | — | Held |
| First Light Asset Management, LLC | 155.2K | $3.04M | — | Held |
| BURKEHILL GLOBAL MANAGEMENT, LP | 155K | $3.03M | — | Held |
| Lisanti Capital Growth, LLC | 154.4K | $3.02M | — | Held |
| WELLS FARGO & COMPANY/MN | 147.8K | $2.89M | — | Held |
| TUDOR INVESTMENT CORP ET AL | 147.6K | $2.89M | — | New |
| Invesco Ltd. | 137.7K | $2.69M | — | Held |
| ALLIANCEBERNSTEIN L.P. | 134.3K | $2.63M | — | Held |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 120.8K | $2.36M | — | Held |
| Woodline Partners LP | 120.8K | $2.36M | — | Held |
| Vestal Point Capital, LP | 120K | $2.35M | — | Held |
| Legal & General Group Plc | 118.1K | $2.31M | — | Held |
| Darwin Wealth Management, LLC | 115.3K | $2.25M | — | Held |
| Monashee Investment Management LLC | 114.5K | $2.24M | — | Held |
| AXXCESS WEALTH MANAGEMENT, LLC | 113.8K | $2.23M | — | Held |
| Baird Financial Group, Inc. | 103.3K | $2.02M | — | Held |
| Trexquant Investment LP | 100.6K | $1.97M | — | Held |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 98.2K | $1.92M | — | Held |
| DIMENSIONAL FUND ADVISORS LP | 98.1K | $1.92M | — | Held |
| PROFUND ADVISORS LLC | 86.7K | $1.7M | — | Held |
| VOYA INVESTMENT MANAGEMENT LLC | 86.4K | $1.69M | — | Held |
| COMERICA BANK | 85.3K | $1.67M | — | Held |
| NEW YORK STATE COMMON RETIREMENT FUND | 79.3K | $1.55M | — | Held |
| Aegis Wealth Management LLC | 75.9K | $1.48M | — | Held |
| Headlands Technologies LLC | 75.2K | $1.47M | — | Held |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 71.2K | $1.39M | — | Held |
| Icahn Capital | 70.7K | $1.38M | — | Held |
| JANE STREET GROUP, LLC | 70.3K | $1.38M | — | Held |
| Seven Fleet Capital Management LP | 70.2K | $1.37M | — | Held |
| MetLife Investment Management, LLC | 69.6K | $1.36M | — | Held |
| CIBC WORLD MARKET INC. | 68.8K | $1.35M | — | Held |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 67.5K | $1.32M | — | Held |
| STATE OF WISCONSIN INVESTMENT BOARD | 63.7K | $1.25M | — | Held |
| HighVista Strategies LLC | 59.6K | $1.17M | — | Held |
| SEI INVESTMENTS CO | 58.8K | $1.15M | — | Held |
| XTX Topco Ltd | 56.7K | $1.11M | — | Held |
| VICTORY CAPITAL MANAGEMENT INC | 51.5K | $1.01M | — | Held |
| NORGES BANK | 49.3K | $964.7K | $448.8K | Cut−$185.1K |
| ARCADIA INVESTMENT MANAGEMENT CORP/MI | 47.9K | $936.4K | — | Held |
| WELLINGTON MANAGEMENT GROUP LLP | 47.1K | $921.2K | — | Held |
| J. Goldman & Co LP | 46K | $900K | — | Held |
| INTECH INVESTMENT MANAGEMENT LLC | 44.3K | $866.3K | — | Held |
| ADAR1 Capital Management, LLC | 42.7K | $834.7K | — | Held |
| Legato Capital Management LLC | 42.7K | $834.5K | — | Held |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 37.3K | $729.7K | — | Held |
| CITIGROUP INC | 36.7K | $717K | — | Held |
| Graham Capital Management, L.P. | 36.2K | $707.4K | — | Held |
| Jump Financial, LLC | 35.3K | $689.7K | — | Held |
| SEVEN GRAND MANAGERS, LLC | 35K | $684.6K | — | Held |
| Lighthouse Investment Partners, LLC | 34K | $665K | — | Held |
| Police & Firemen's Retirement System of New Jersey | 33.5K | $656.2K | — | Held |
| State of New Jersey Common Pension Fund D | 31.6K | $617.4K | — | Held |
| ARIZONA STATE RETIREMENT SYSTEM | 31.4K | $614.5K | — | Held |
| Optimize Financial Inc | 30.3K | $592.9K | — | Held |
| ProShare Advisors LLC | 28.9K | $565.8K | — | Held |
| Walleye Capital LLC | 27.8K | $543K | — | Held |
| KLP KAPITALFORVALTNING AS | 25.4K | $496.8K | — | Held |
| MARTINGALE ASSET MANAGEMENT L P | 25.2K | $492K | — | Held |
| BNP PARIBAS FINANCIAL MARKETS | 24.5K | $479.3K | — | Held |
| Elevate Capital Advisors, LLC | 24.1K | $471.7K | — | Held |
| China Universal Asset Management Co., Ltd. | 23.3K | $455.2K | — | Held |
| Engineers Gate Manager LP | 21.6K | $422.9K | — | Held |
| PSP Research LLC | 21.5K | $421.2K | — | Held |
| WINTON GROUP Ltd | 21.3K | $416.6K | — | Held |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 20.6K | $403K | — | Held |
| Creative Planning | 19.8K | $386.7K | — | Held |
| ROYAL BANK OF CANADA | 18.5K | $363K | — | Held |
| Lion Point Capital, LP | 18K | $352.1K | — | Held |
| T. Rowe Price Investment Management, Inc. | 17.5M | $343.1K | — | Held |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 13.7K | $322.4K | — | Held |
| FOX RUN MANAGEMENT, L.L.C. | 16.4K | $321.8K | — | Held |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 16.1K | $314.4K | — | Held |
| AlphaQuest LLC | 16K | $312.2K | — | Held |
| LPL Financial LLC | 15.3K | $298.3K | — | Held |
| Z3 Capital Partners, LLC | 15.1K | $294.4K | — | Held |
| BIT Capital GmbH | 15K | $293.4K | — | Held |
| Allianz Asset Management GmbH | 15K | $293.4K | — | Held |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 14.4K | $281.6K | — | Held |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | 14.4K | $281.3K | — | Held |
| Rockefeller Capital Management L.P. | 14.3K | $279.1K | — | Held |
| Virtus Investment Advisers, LLC | 13.8K | $270K | — | Held |
| Pictet Asset Management Holding SA | 13K | $253.6K | — | Held |
| CAPSTONE INVESTMENT ADVISORS, LLC | 12.7K | $248.4K | — | Held |
| Quantinno Capital Management LP | 12.6K | $246.3K | — | Held |
| Bridgefront Capital, LLC | 12K | $235.1K | — | Held |
| GUGGENHEIM CAPITAL LLC | 11.1K | $216.5K | — | Held |
| NISA INVESTMENT ADVISORS, LLC | 10.5K | $205.4K | — | Held |
| Verition Fund Management LLC | 10.5K | $204.5K | — | Held |
| Ameritas Investment Partners, Inc. | 10.4K | $204.2K | — | Held |
| Soleus Capital Management, L.P. | 10K | $195.6K | — | Held |
| FARALLON CAPITAL MANAGEMENT LLC | 10K | $195.6K | $69.1K | Added$69.1K |
| SIMPLEX TRADING, LLC | 9.19K | $179.7K | — | Held |
| Mirae Asset Global Investments Co., Ltd. | 6.94K | $135.7K | — | Held |
| Sterling Capital Management LLC | 5.17K | $101K | — | Held |
| Keating Financial Advisory Services, Inc. | 5K | $97.8K | — | Held |
| Steward Partners Investment Advisory, LLC | 4.88K | $95.5K | — | Held |
| Aster Capital Management (DIFC) Ltd | 4.31K | $84.3K | — | Held |
| GF FUND MANAGEMENT CO. LTD. | 2.81K | $54.9K | — | Held |
| Chung Wu Investment Group, LLC | 2.8K | $54.8K | — | Held |
| STRS OHIO | 2.6K | $50.9K | — | Held |
| Caption Management, LLC | 2.5K | $48.9K | — | Held |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2.32M | $45.5K | — | Held |
| JONES FINANCIAL COMPANIES LLLP | 1.2K | $23.5K | — | Held |
| Versant Capital Management, Inc | 859 | $16.8K | — | Held |
| GAMMA Investing LLC | 841 | $16.4K | — | Held |
| Tower Research Capital LLC (TRC) | 730 | $14.3K | — | Held |
| GROUP ONE TRADING LLC | 650 | $12.7K | — | Held |
| OSAIC HOLDINGS, INC. | 635 | $12.4K | — | Held |
| Allworth Financial LP | 559 | $10.9K | $3.42K | Added$4.67K |
| Smartleaf Asset Management LLC | 555 | $10.7K | — | Held |
| Essential Partners LLC | 445 | $8.7K | $3.03K | Added$3.15K |
| PNC Financial Services Group, Inc. | 418 | $8.18K | — | Held |
| US BANCORP \DE\ | 400 | $7.82K | — | Held |
| Optiver Holding B.V. | 395 | $7.73K | — | Held |
| FIRST HORIZON CORP | 382 | $7.47K | — | Held |
| SIGNATUREFD, LLC | 320 | $6.26K | — | Held |
| Truvestments Capital LLC | 295 | $5.77K | — | Held |
| ALGERT GLOBAL LLC | 271.3K | $5.31K | — | Held |
| SG Americas Securities, LLC | 265.4K | $5.19K | — | Held |
| MassMutual Private Wealth & Trust, FSB | 243 | $4.75K | — | Held |
| Aspect Partners, LLC | 225 | $4.4K | — | Held |
| FLAGSHIP HARBOR ADVISORS, LLC | 200 | $3.91K | — | New |
| FIDEURAM - INTESA SANPAOLO PRIVATE BANKING S.P.A. | 200 | $3.91K | — | Held |
| NATIONAL BANK OF CANADA /FI/ | 200 | $3.91K | — | Held |
| ROTHSCHILD INVESTMENT LLC | 170 | $3.33K | — | Held |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 165.7K | $3.24K | — | Held |
| SBI Securities Co., Ltd. | 150 | $2.93K | — | Held |
| Geneos Wealth Management Inc. | 138 | $2.7K | — | Held |
| EverSource Wealth Advisors, LLC | 97 | $1.9K | — | Held |
| DekaBank Deutsche Girozentrale | 60K | $1.86K | — | Held |
| IFP Advisors, Inc | 95 | $1.86K | $657 | Added$644 |
| HRT FINANCIAL LP | 75.4K | $1.47K | — | Held |
| MRP Capital Investments, LLC | 75 | $1.47K | — | New |
| Parkside Financial Bank & Trust | 70 | $1.37K | — | Held |
| QUADRANT CAPITAL GROUP LLC | 67 | $1.31K | — | Held |
| Cornerstone Financial Management LLC | 40 | $782 | — | Held |
| GSA CAPITAL PARTNERS LLP | 31.4K | $615 | — | Held |
| Parallel Advisors, LLC | 27 | $528 | — | Held |
| Bell Investment Advisors, Inc | 26 | $509 | — | Held |
| Larson Financial Group LLC | 22 | $430 | — | Held |
| Arax Advisory Partners | 18 | $352 | — | Held |
| Farther Finance Advisors, LLC | 17 | $333 | — | Held |
| Thrivent Financial for Lutherans | 14.4K | $281 | — | Held |
| True Wealth Design, LLC | 13 | $255 | — | Held |
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO | 5.74K | $112 | — | Held |
| CWM, LLC | 4.03K | $79 | — | Held |
| AMALGAMATED BANK | 3.89K | $76 | — | Held |
| KBC Group NV | 3.13K | $61 | $21 | Added$21 |
| Dunhill Financial, LLC | 1 | $17 | — | Held |
| Daiwa Securities Group Inc. | 424 | $8 | — | Held |