| ORBIMED ADVISORS LLC | 7.17M | $55.2M | — | Held |
| BlackRock, Inc. | 5.06M | $38.9M | — | Held |
| Vanguard | 3.87M | $29.8M | — | Held |
| MORGAN STANLEY | 3.57M | $27.5M | $203.7K | Added$22.9M |
| ADAMS STREET PARTNERS LLC | 3.28M | $25.2M | — | Held |
| Point72 Asset Management, L.P. | 2.88M | $22.1M | — | Held |
| State Street | 2.79M | $21.5M | — | Held |
| MPM BIOIMPACT LLC | 2.74M | $21.1M | — | Held |
| Vivo Capital, LLC | 2.23M | $17.2M | — | Held |
| GEODE CAPITAL MANAGEMENT, LLC | 1.47M | $11.3M | — | Held |
| Foresite Capital Management VI LLC | 1.38M | $10.6M | — | Held |
| DCF Advisers, LLC | 729K | $5.61M | — | Held |
| PERCEPTIVE ADVISORS LLC | 692.4K | $5.33M | — | Held |
| MILLENNIUM MANAGEMENT LLC | 688.8K | $5.3M | — | Held |
| GOLDMAN SACHS GROUP INC | 553.3K | $4.26M | — | Held |
| Logos Global Management LP | 500K | $3.85M | — | Held |
| ADAR1 Capital Management, LLC | 465.9K | $3.59M | — | Held |
| RTW INVESTMENTS, LP | 447.6K | $3.45M | — | Held |
| NORTHERN TRUST CORP | 429.8K | $3.31M | — | Held |
| SPHERA FUNDS MANAGEMENT LTD. | 407.7K | $3.14M | — | Held |
| BARCLAYS PLC | 394.8K | $3.04M | $102K | Added$761.3K |
| JANE STREET GROUP, LLC | 378.3K | $2.91M | — | Held |
| WELLINGTON MANAGEMENT GROUP LLP | 314.7K | $2.42M | — | Held |
| BANK OF AMERICA CORP /DE/ | 236.5K | $1.82M | $50.1K | Added$701K |
| MARSHALL WACE, LLP | 216.2K | $1.67M | — | Held |
| UBS Group AG | 212K | $1.63M | — | Held |
| Citadel | 208.2K | $1.6M | — | Held |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 171.2K | $1.32M | — | Held |
| Empirical Financial Services, LLC d.b.a. Empirical Wealth Management | 167.4K | $1.29M | — | Held |
| FRED ALGER MANAGEMENT, LLC | 144.4K | $1.11M | — | Held |
| TWO SIGMA INVESTMENTS, LP | 143.6K | $1.11M | — | Held |
| TOWERVIEW LLC | 140K | $1.08M | — | Held |
| Bank of New York Mellon Corp | 131.6K | $1.01M | — | Held |
| RAYMOND JAMES FINANCIAL INC | 121.2K | $932.9K | — | Held |
| Qube Research & Technologies Ltd | 114.5K | $881.6K | — | Held |
| Squarepoint Ops LLC | 104.8K | $807.1K | — | Held |
| Rafferty Asset Management, LLC | 99.7K | $767.9K | — | Held |
| ExodusPoint Capital Management, LP | 86.7K | $667.7K | — | Held |
| NEOS Investment Management LLC | 80.9K | $622.9K | — | Held |
| TEMA ETFS LLC | 79.7K | $613.7K | — | Held |
| RHUMBLINE ADVISERS | 70.7K | $544.6K | — | Held |
| Nuveen, LLC | 68.1K | $524.1K | — | Held |
| OSAIC HOLDINGS, INC. | 68K | $523.5K | — | Held |
| D. E. Shaw & Co., Inc. | 64.9K | $499.8K | — | Held |
| JACKSON SQUARE CAPITAL, LLC | 63.8K | $491.1K | — | Held |
| WELLS FARGO & COMPANY/MN | 62.6K | $482.2K | — | Held |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 61.8K | $475.5K | — | Held |
| ALPS ADVISORS INC | 61.3K | $472.1K | — | Held |
| HSBC HOLDINGS PLC | 59.3K | $451K | — | Held |
| DEUTSCHE BANK AG\ | 56K | $431.5K | — | Held |
| Caption Management, LLC | 49.3K | $379.8K | — | Held |
| Ancora Advisors LLC | 47.7K | $367K | — | Held |
| Invesco Ltd. | 43.6K | $335.6K | — | Held |
| Creative Planning | 39.2K | $301.7K | — | Held |
| PROFUND ADVISORS LLC | 37.1K | $285.4K | — | Held |
| INTECH INVESTMENT MANAGEMENT LLC | 36K | $277K | — | Held |
| AlphaQuest LLC | 36K | $277K | — | Held |
| AVITY INVESTMENT MANAGEMENT INC. | 32.7K | $251.6K | — | Held |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 32.4K | $248.3K | — | Held |
| Virtus Investment Advisers, LLC | 31.8K | $244.7K | — | Held |
| MetLife Investment Management, LLC | 30.8K | $237K | — | Held |
| JPMORGAN CHASE & CO | 30.7K | $236K | — | Held |
| Argent Advisors, Inc. | 30K | $231K | — | Held |
| Connor, Clark & Lunn Investment Management Ltd. | 28.1K | $216.5K | — | Held |
| VOYA INVESTMENT MANAGEMENT LLC | 27.7K | $213K | — | Held |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 26.7K | $205.6K | — | Held |
| GROUP ONE TRADING LLC | 26.7K | $205.3K | — | Held |
| Palumbo Wealth Management LLC | 26.3K | $202.2K | — | Held |
| Balyasny Asset Management L.P. | 25K | $192.7K | — | Held |
| DRW Securities, LLC | 23.4K | $180.1K | — | Held |
| Three Bridge Wealth Advisors, LLC | 22.4K | $172.3K | — | Held |
| Verition Fund Management LLC | 21.4K | $164.6K | — | Held |
| COMMERCE BANK | 20K | $154K | — | Held |
| Graham Capital Management, L.P. | 19.3K | $148.4K | — | Held |
| TWO SIGMA ADVISERS, LP | 18.9K | $145.5K | — | Held |
| NEW YORK STATE COMMON RETIREMENT FUND | 18.8K | $144.8K | — | Held |
| China Universal Asset Management Co., Ltd. | 18.2K | $139.9K | — | Held |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 17.5K | $134.7K | — | Held |
| ALLIANCEBERNSTEIN L.P. | 17.1K | $131.8K | — | Held |
| Sowell Financial Services LLC | 17K | $130.9K | — | Held |
| SHELTON WEALTH MANAGEMENT, LLC | 15.6K | $120.4K | — | Held |
| Police & Firemen's Retirement System of New Jersey | 15.5K | $119.6K | — | Held |
| CITIGROUP INC | 14.9K | $114.4K | — | Held |
| ProShare Advisors LLC | 13.8K | $106K | — | Held |
| AXQ CAPITAL, LP | 12.6K | $97K | — | Held |
| FOX RUN MANAGEMENT, L.L.C. | 11.2K | $86.4K | — | Held |
| CAPTRUST FINANCIAL ADVISORS | 11.1K | $85.1K | — | Held |
| Truvestments Capital LLC | 10.3K | $79K | — | Held |
| OneDigital Investment Advisors LLC | 10K | $77K | — | Held |
| WHITTIER TRUST CO OF NEVADA INC | 11.2K | $74.8K | — | Held |
| ROTHSCHILD INVESTMENT LLC | 7K | $53.9K | — | Held |
| Russell Investments Group, Ltd. | 6.66K | $51.3K | — | Held |
| BNP PARIBAS FINANCIAL MARKETS | 6.57K | $50.6K | — | Held |
| Legal & General Group Plc | 5.79K | $44.6K | — | Held |
| Ameritas Investment Partners, Inc. | 5.35K | $41.2K | — | Held |
| Mirae Asset Global Investments Co., Ltd. | 3.63K | $27.9K | — | Held |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 3.52K | $27.1K | — | Held |
| Northwest Capital Management Inc | 3.4K | $26.2K | — | Held |
| Fidelity | 2.29K | $17.6K | — | Held |
| Western Pacific Wealth Management, LP | 2K | $15.4K | — | Held |
| ROYAL BANK OF CANADA | 1.62K | $12K | — | Held |
| GF FUND MANAGEMENT CO. LTD. | 1.47K | $11.3K | — | Held |
| SBI Securities Co., Ltd. | 1K | $7.73K | — | Held |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 725 | $5.58K | — | Held |
| Tower Research Capital LLC (TRC) | 631 | $4.86K | — | Held |
| Sterling Capital Management LLC | 392 | $3.02K | — | Held |
| Farther Finance Advisors, LLC | 323 | $2.49K | — | Held |
| Clearstead Advisors, LLC | 203 | $1.57K | — | Held |
| Physician Wealth Advisors, Inc. | 177 | $1.36K | — | Held |
| GAMMA Investing LLC | 143 | $1.1K | — | Held |
| PNC Financial Services Group, Inc. | 137 | $1.05K | — | Held |
| Caitong International Asset Management Co., Ltd | 115 | $886 | — | Held |
| SIGNATUREFD, LLC | 76 | $585 | — | Held |
| KELLEHER FINANCIAL ADVISORS | 75 | $578 | — | Held |
| Hikari Power Ltd | 50K | $385 | — | Held |
| PRICE T ROWE ASSOCIATES INC /MD/ | 34.1K | $263 | — | Held |
| SageView Advisory Group, LLC | 30 | $231 | — | Held |
| SG Americas Securities, LLC | 20K | $154 | — | Held |
| Allworth Financial LP | 17 | $131 | — | New |
| GSA CAPITAL PARTNERS LLP | 14.2K | $109 | — | Held |
| Arax Advisory Partners | 10 | $77 | — | Held |
| AMALGAMATED BANK | 1.8K | $14 | — | Held |
| CWM, LLC | 205 | $2 | — | Held |
| Daiwa Securities Group Inc. | 225 | $2 | — | Held |