| TANG CAPITAL MANAGEMENT LLC | 16.8M | $88.8M | −$1.34M | Cut−$1.34M |
| ORBIMED ADVISORS LLC | 15.2M | $80.5M | −$1.22M | Cut−$1.22M |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 14.3M | $75.7M | −$1.13M | Cut−$473.3K |
| Vivo Capital, LLC | 9.55M | $50.5M | −$763.6K | Cut−$763.6K |
| BlackRock, Inc. | 9.51M | $50.3M | −$751.1K | Cut−$129.7K |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 8.49M | $44.9M | −$354.9K | Added$21.1M |
| ENAVATE SCIENCES GP, LLC | 7.79M | $41.2M | −$623.1K | Cut−$623.1K |
| BVF INC/IL | 7.76M | $41.1M | −$621.2K | Cut−$621.2K |
| State Street | 6.69M | $35.4M | −$391.2K | Added$9.15M |
| VANGUARD CAPITAL MANAGEMENT LLC | 6.04M | $31.9M | — | Held |
| RTW INVESTMENTS, LP | 4.19M | $22.1M | −$200K | Added$8.72M |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 3.61M | $19.1M | −$288.5K | Cut−$288.5K |
| GEODE CAPITAL MANAGEMENT, LLC | 3.57M | $18.9M | −$280.1K | Added$54.5K |
| Rock Springs Capital Management LP | 3.31M | $17.5M | −$264.4K | Cut−$3.6M |
| Logos Global Management LP | 3.15M | $16.7M | −$92K | Added$10.5M |
| Blue Owl Capital Holdings LP | 3.34M | $16.1M | −$1.88M | Cut−$2.55M |
| Qube Research & Technologies Ltd | 2.55M | $13.5M | −$35.3K | Added$11.1M |
| UBS Group AG | 2.39M | $12.7M | −$13.4K | Added$11.7M |
| Sofinnova Investments, Inc. | 2.06M | $10.9M | −$164.5K | Cut−$7.2M |
| GOLDMAN SACHS GROUP INC | 2M | $10.6M | −$121.4K | Added$2.41M |
| BRAIDWELL LP | 1.97M | $10.4M | −$157.2K | Cut−$4.57M |
| Blackstone Inc. | 1.86M | $9.83M | −$148.6K | Cut−$23.1M |
| Fidelity | 1.8M | $9.53M | −$144.1K | Cut−$4.32M |
| ROYCE & ASSOCIATES LP | 1.62M | $8.57M | −$22.9K | Added$7.03M |
| AMERIPRISE FINANCIAL INC | 1.6M | $8.45M | −$65.9K | Added$4.03M |
| Palo Alto Investors LP | 1.51M | $8.01M | −$121.2K | Cut−$5.59M |
| Birchview Capital, LP | 1.47M | $7.75M | −$117.3K | Cut−$799.6K |
| GREAT POINT PARTNERS LLC | 1.35M | $7.14M | — | New |
| Fisher Asset Management, LLC | 1.35M | $7.13M | — | New |
| Balyasny Asset Management L.P. | 1.12M | $5.92M | −$89.5K | Cut−$2.64M |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 1.08M | $5.73M | — | Held |
| Schonfeld Strategic Advisors LLC | 1.08M | $5.69M | −$36.2K | Added$3.26M |
| NORTHERN TRUST CORP | 1.05M | $5.55M | −$77.8K | Added$322.2K |
| VANGUARD FIDUCIARY TRUST CO | 998.1K | $5.28M | — | Held |
| Seven Fleet Capital Management LP | 940.5K | $4.98M | −$45.5K | Added$1.92M |
| BANK OF AMERICA CORP /DE/ | 865.6K | $4.58M | −$21.3K | Added$3.15M |
| SILVERARC CAPITAL MANAGEMENT, LLC | 859K | $4.54M | −$68.7K | Cut−$1.1M |
| ACUTA CAPITAL PARTNERS, LLC | 849.1K | $4.49M | −$67.9K | Cut−$1.38M |
| NEXTBio Capital Management LP | 848.2K | $4.49M | −$67.9K | Cut−$1.5M |
| MILLENNIUM MANAGEMENT LLC | 846.2K | $4.48M | −$67.7K | Cut−$12.2M |
| Y-Intercept (Hong Kong) Ltd | 828.9K | $4.38M | −$37K | Added$1.9M |
| JPMORGAN CHASE & CO | 847.7K | $4.32M | −$228.9K | Cut−$348.7K |
| BARCLAYS PLC | 790K | $4.18M | −$47.6K | Added$985.4K |
| Citadel | 721.4K | $3.82M | −$8.45K | Added$3.25M |
| BURKEHILL GLOBAL MANAGEMENT, LP | 700K | $3.7M | −$56K | Cut−$56K |
| CITIGROUP INC | 598.2K | $3.16M | −$21K | Added$1.76M |
| Atle Fund Management AB | 41.8K | $3.05M | $2.83M | Cut−$86.8K |
| ArrowMark Colorado Holdings LLC | 514.8K | $2.72M | — | New |
| KVP Capital Advisors, LP | 500K | $2.65M | — | New |
| Connor, Clark & Lunn Investment Management Ltd. | 497.8K | $2.63M | −$15.3K | Added$1.6M |
| PRUDENTIAL FINANCIAL INC | 494.3K | $2.61M | −$25.2K | Added$924.6K |
| DIMENSIONAL FUND ADVISORS LP | 439.8K | $2.32M | −$29.5K | Added$489.4K |
| DV Trading LLC | 423.6K | $2.24M | −$1.94K | Added$2.11M |
| Trexquant Investment LP | 421.8K | $2.23M | — | New |
| VOYA INVESTMENT MANAGEMENT LLC | 375.3K | $1.99M | −$1.81K | Added$1.86M |
| Jump Financial, LLC | 371.4K | $1.96M | — | New |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 371.1K | $1.96M | −$29.7K | Cut−$239.6K |
| MORGAN STANLEY | 360.4K | $1.91M | −$28.8K | Cut−$55K |
| WELLINGTON MANAGEMENT GROUP LLP | 360.1K | $1.91M | −$25.3K | Added$203.6K |
| Atom Investors LP | 344.9K | $1.82M | −$6.18K | Added$1.41M |
| Bank of New York Mellon Corp | 297.3K | $1.57M | −$23.8K | Cut−$105.3K |
| Nuveen, LLC | 291K | $1.54M | −$23.1K | Cut−$12.3K |
| Monashee Investment Management LLC | 258.9K | $1.37M | −$20.7K | Cut−$4M |
| Swiss National Bank | 220.7K | $1.17M | — | New |
| Icahn Capital | 200.4K | $1.06M | −$12.4K | Added$226.7K |
| STATE OF WISCONSIN INVESTMENT BOARD | 200.3K | $1.06M | −$14.8K | Added$63.8K |
| Rafferty Asset Management, LLC | 195.9K | $1.04M | −$12.1K | Added$221.3K |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 157K | $830.7K | −$3.58K | Added$590.4K |
| RHUMBLINE ADVISERS | 147K | $777.7K | −$10.8K | Added$54.9K |
| ALPS ADVISORS INC | 146.6K | $775.6K | −$11.7K | Cut−$8.68K |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 139.6K | $738.7K | — | New |
| ADAR1 Capital Management, LLC | 139K | $735.3K | −$11.1K | Cut−$11.1K |
| Tidal Investments LLC | 138.3K | $731.5K | — | New |
| TEMA ETFS LLC | 138.3K | $731.5K | −$8.01K | Added$193.5K |
| DEUTSCHE BANK AG\ | 133.4K | $705.4K | −$8.74K | Added$118.6K |
| RAYMOND JAMES FINANCIAL INC | 121.9K | $644.8K | −$6.41K | Added$214.4K |
| Rhenman & Partners Asset Management AB | 115.1K | $608.9K | — | New |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 112.3K | $594.2K | −$645 | Added$550.9K |
| Creative Planning | 106.2K | $561.8K | −$8.5K | Cut−$19K |
| Invesco Ltd. | 101.2K | $535.4K | −$5.11K | Added$192.2K |
| Vanguard Global Advisers, LLC | 94.9K | $502.1K | — | Held |
| TUDOR INVESTMENT CORP ET AL | 88.9K | $470.4K | — | New |
| PROFUND ADVISORS LLC | 87.7K | $463.8K | −$4.58K | Added$156.4K |
| Harvest Investment Services, LLC | 87.7K | $463.7K | — | New |
| ALLIANCEBERNSTEIN L.P. | 83.9K | $450.8K | $0 | Held |
| Optimize Financial Inc | 80.4K | $425.5K | — | New |
| AMERICAN CENTURY COMPANIES INC | 78.3K | $414.4K | −$3.23K | Added$197.3K |
| DRW Securities, LLC | 76.5K | $404.6K | — | New |
| Legal & General Group Plc | 75.1K | $397.3K | −$1.02K | Added$328.8K |
| VANGUARD ASSET MANAGEMENT, Ltd | 74.7K | $395.1K | — | Held |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 74.1K | $389.3K | −$8.09K | Added$15.6K |
| Aquatic Capital Management LLC | 73.3K | $388K | — | New |
| Persistent Asset Partners Ltd | 72.2K | $381.9K | −$4.58K | Added$74.5K |
| Engineers Gate Manager LP | 71.8K | $379.6K | — | New |
| XTX Topco Ltd | 70.1K | $370.9K | −$5.61K | Cut−$250K |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 67.5K | $356.9K | −$3.23K | Added$140.3K |
| FRANKLIN RESOURCES INC | 66.6K | $352.4K | −$5.33K | Cut−$5.33K |
| D. E. Shaw & Co., Inc. | 66K | $349K | −$4.12K | Added$72.5K |
| MetLife Investment Management, LLC | 64.2K | $339.6K | −$5.14K | Cut−$57.7K |
| JANUS HENDERSON GROUP PLC | 55.6K | $293.8K | — | New |
| Virtus Investment Advisers, LLC | 52.8K | $279.6K | −$4.13K | Added$2.7K |
| Squarepoint Ops LLC | 50.2K | $265.6K | −$4.02K | Cut−$412.1K |
| Cinctive Capital Management LP | 48.7K | $257.8K | — | New |
| WELLS FARGO & COMPANY/MN | 47.7K | $252.5K | −$3.82K | Cut−$525K |
| ExodusPoint Capital Management, LP | 44K | $232.9K | — | New |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 43.9K | $232.3K | — | New |
| State of New Jersey Common Pension Fund D | 38.1K | $201.6K | — | New |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 35.9K | $190K | — | New |
| BNP PARIBAS FINANCIAL MARKETS | 35.8K | $189.2K | −$1.25K | Added$105.2K |
| Police & Firemen's Retirement System of New Jersey | 35.5K | $187.8K | −$2.84K | Cut−$2.84K |
| LPL Financial LLC | 35.5K | $187.6K | −$2.84K | Cut−$51.2K |
| SmartHarvest Portfolios, LLC | 34.7K | $183.6K | −$2.78K | Cut−$2.79K |
| Vanguard Investments Australia, Ltd. | 33.4K | $176.8K | — | Held |
| TWO SIGMA INVESTMENTS, LP | 33.1K | $175.1K | — | New |
| BLAIR WILLIAM & CO/IL | 30.8K | $162.7K | — | New |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 30.7K | $162.2K | — | New |
| ARIZONA STATE RETIREMENT SYSTEM | 30.6K | $162K | — | New |
| NEW YORK STATE COMMON RETIREMENT FUND | 30.4K | $160.9K | −$2.43K | Cut−$2.43K |
| VARCOV Co. | 30.4K | $160.8K | — | New |
| GROUP ONE TRADING LLC | 30.2K | $159.9K | −$419 | Added$131.8K |
| PSP Research LLC | 30K | $158.7K | — | New |
| INTECH INVESTMENT MANAGEMENT LLC | 29.8K | $157.7K | −$2.38K | Cut−$51.4K |
| EntryPoint Capital, LLC | 29.3K | $154.8K | −$1.05K | Added$84.1K |
| Simplicity Wealth,LLC | 28.4K | $150K | −$2.27K | Cut−$31.9K |
| STIFEL FINANCIAL CORP | 27.5K | $145.5K | −$1.92K | Added$16.7K |
| SIMPLEX TRADING, LLC | 25.9K | $136.8K | −$713 | Added$88.9K |
| CANADA PENSION PLAN INVESTMENT BOARD | 25.1K | $132.8K | −$1.19K | Added$52.8K |
| AXQ CAPITAL, LP | 25.1K | $132.6K | −$2K | Cut−$89.6K |
| Walleye Trading LLC | 25K | $132.3K | −$2K | Cut−$2K |
| E Fund Management Co., Ltd. | 24.6K | $130.3K | — | Held |
| KLP KAPITALFORVALTNING AS | 24.6K | $130.1K | — | New |
| Graham Capital Management, L.P. | 23.6K | $124.6K | −$1.88K | Cut−$162.3K |
| Tower Research Capital LLC (TRC) | 23.3K | $123K | −$136 | Added$113.9K |
| INDEPENDENT FINANCIAL GROUP, LLC | 22.8K | $120.5K | −$1.82K | Cut−$1.82K |
| CAPTRUST FINANCIAL ADVISORS | 21.7K | $114.7K | −$1.68K | Added$2.71K |
| Welch & Forbes LLC | 19K | $100.5K | −$1.52K | Cut−$1.52K |
| ProShare Advisors LLC | 18.7K | $98.9K | −$1.5K | Cut−$29.8K |
| PRELUDE CAPITAL MANAGEMENT, LLC | 18K | $95.2K | −$800 | Added$41.5K |
| Ikarian Capital, LLC | 18K | $95.2K | −$1.44K | Cut−$4.2M |
| Independent Advisor Alliance | 17.9K | $94.7K | −$1.43K | Cut−$1.43K |
| Strategic Wealth Partners, Ltd. | 16.8K | $89K | −$968 | Added$24K |
| Scientech Research LLC | 16.7K | $88.2K | — | New |
| NEUBERGER BERMAN GROUP LLC | 16.4K | $86.5K | −$1.03K | Added$17.7K |
| Invst, LLC | 16K | $84.6K | — | New |
| Sequoia Financial Advisors, LLC | 15.5K | $82.2K | −$1.24K | Cut−$3.17K |
| M&T Bank Corp | 15K | $79.6K | −$1.19K | Cut−$403 |
| OSAIC HOLDINGS, INC. | 14.7K | $77.6K | −$4 | Added$77.3K |
| SIG BROKERAGE, LP | 14.5K | $76.7K | −$1.16K | Cut−$15K |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 14.5K | $76.5K | — | New |
| Pictet Asset Management Holding SA | 14.4K | $76.3K | — | New |
| Focus Partners Wealth | 14.3K | $75.6K | −$1.14K | Cut−$24.2K |
| Quadrature Capital Ltd | 13.8K | $73.2K | −$983 | Added$7.23K |
| VICTORY CAPITAL MANAGEMENT INC | 13.7K | $72.6K | −$1.1K | Cut−$4.22K |
| Magnetar Financial LLC | 13K | $69K | — | New |
| North Star Investment Management Corp. | 12.5K | $66.1K | −$1K | Cut−$1K |
| XPONANCE LLC | 11.8K | $62.6K | −$816 | Added$7.83K |
| PNC Financial Services Group, Inc. | 11K | $58.4K | −$33 | Added$56.2K |
| Russell Investments Group, Ltd. | 10.9K | $57.7K | −$872 | Cut−$4.41K |
| Ameritas Investment Partners, Inc. | 10.6K | $56.2K | −$850 | Cut−$850 |
| Abel Hall, LLC | 10.5K | $55.7K | −$842 | Cut−$67.2K |
| Stonebrook Private Inc. | 10.4K | $54.8K | −$818 | Cut−$104 |
| Brevan Howard Capital Management LP | 10.2K | $54K | −$816 | Cut−$582.5K |
| Rockefeller Capital Management L.P. | 10.2K | $53.9K | −$164 | Added$42.9K |
| EverSource Wealth Advisors, LLC | 6.14K | $32.5K | −$350 | Added$9.02K |
| MCF Advisors LLC | 5.54K | $29.3K | −$443 | Cut−$443 |
| Parallel Advisors, LLC | 5.25K | $27.8K | — | New |
| NISA INVESTMENT ADVISORS, LLC | 5.25K | $27.8K | −$420 | Cut−$420 |
| CWM, LLC | 4.32K | $22.8K | $16.2K | Added$22.8K |
| VSM Wealth Advisory, LLC | 3K | $15.9K | −$240 | Cut−$240 |
| Sterling Capital Management LLC | 2.44K | $12.9K | −$195 | Cut−$7.62K |
| Fortitude Family Office, LLC | 1.92K | $10.1K | −$154 | Cut−$14.5K |
| Optiver Holding B.V. | 1.34K | $7.07K | −$89 | Added$1.18K |
| Federation des caisses Desjardins du Quebec | 1K | $5.29K | −$40 | Added$2.6K |
| Quantbot Technologies LP | 720 | $3.81K | — | New |
| Caitong International Asset Management Co., Ltd | 719 | $3.8K | −$57 | Cut−$128.2K |
| Farther Finance Advisors, LLC | 655 | $3.56K | $39 | Cut−$95 |
| MAI Capital Management | 614 | $3.25K | −$2 | Added$3.12K |
| Allworth Financial LP | 592 | $3.13K | −$2 | Added$3.02K |
| QUADRANT CAPITAL GROUP LLC | 405 | $2.14K | −$32 | Cut−$32 |
| ROTHSCHILD INVESTMENT LLC | 279 | $1.48K | −$13 | Added$595 |
| NATIONAL BANK OF CANADA /FI/ | 235 | $1.24K | −$21 | Cut−$59 |
| GAMMA Investing LLC | 224 | $1.19K | −$3 | Added$1.03K |
| Marshall & Sterling Wealth Advisors Inc. | 200 | $1.06K | −$16 | Cut−$16 |
| SBI Securities Co., Ltd. | 184 | $973 | −$15 | Cut−$300 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 99.5K | $527 | −$6 | Added$148 |
| US BANCORP \DE\ | 77 | $407 | — | New |
| Smartleaf Asset Management LLC | 69 | $352 | −$19 | Cut−$19 |
| SG Americas Securities, LLC | 47.7K | $252 | −$4 | Cut−$320 |
| Virtu Financial LLC | 43.1K | $228 | — | New |
| ALGERT GLOBAL LLC | 36.8K | $195 | — | New |
| SJS Investment Consulting Inc. | 27 | $143 | −$2 | Cut−$2 |
| Larson Financial Group LLC | 23 | $122 | — | New |
| HRT FINANCIAL LP | 19.9K | $105 | — | New |
| Cygnus Capital Advisors, LLC | 18K | $95 | −$1 | Added$41 |
| Stone House Investment Management, LLC | 15 | $79 | — | New |
| Essential Partners LLC | 9 | $48 | $0 | Held |
| Sunbelt Securities, Inc. | 8 | $42 | −$1 | Cut−$1 |
| IFP Advisors, Inc | 6 | $32 | $0 | Held |
| Hughes Financial Services, LLC | 3 | $16 | $0 | Added$11 |
| ROYAL BANK OF CANADA | 6 | $0 | −$33 | Cut−$21K |