| TANG CAPITAL MANAGEMENT LLC | 16.8M | $90.2M | — | Held |
| ORBIMED ADVISORS LLC | 15.2M | $81.7M | — | Held |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 14.2M | $76.2M | — | Held |
| Vivo Capital, LLC | 9.55M | $51.3M | — | Held |
| BlackRock, Inc. | 9.39M | $50.4M | — | Held |
| Vanguard | 8.05M | $43.2M | — | Held |
| ENAVATE SCIENCES GP, LLC | 7.79M | $41.8M | — | Held |
| BVF INC/IL | 7.76M | $41.7M | — | Held |
| Blackstone Inc. | 6.13M | $32.9M | — | New |
| State Street | 4.89M | $26.3M | — | Held |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 4.44M | $23.8M | — | Held |
| Rock Springs Capital Management LP | 3.93M | $21.1M | — | Held |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 3.61M | $19.4M | — | Held |
| GEODE CAPITAL MANAGEMENT, LLC | 3.5M | $18.8M | — | Held |
| Blue Owl Capital Holdings LP | 3.47M | $18.6M | — | Held |
| Sofinnova Investments, Inc. | 3.37M | $18.1M | — | Held |
| MILLENNIUM MANAGEMENT LLC | 3.11M | $16.7M | — | Held |
| BRAIDWELL LP | 2.79M | $15M | — | Held |
| Fidelity | 2.58M | $13.9M | — | Held |
| Palo Alto Investors LP | 2.53M | $13.6M | — | Held |
| RTW INVESTMENTS, LP | 2.5M | $13.4M | — | Held |
| Balyasny Asset Management L.P. | 1.59M | $8.56M | — | Held |
| Birchview Capital, LP | 1.59M | $8.55M | — | Held |
| GOLDMAN SACHS GROUP INC | 1.52M | $8.15M | — | Held |
| Trails Edge Capital Partners, LP | 1.42M | $7.6M | — | Held |
| MARSHALL WACE, LLP | 1.26M | $6.79M | — | Held |
| Logos Global Management LP | 1.15M | $6.18M | — | Held |
| NEXTBio Capital Management LP | 1.11M | $5.98M | — | Held |
| ACUTA CAPITAL PARTNERS, LLC | 1.09M | $5.87M | — | Held |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1.05M | $5.65M | — | Held |
| Monashee Investment Management LLC | 1M | $5.37M | — | Held |
| NORTHERN TRUST CORP | 972.9K | $5.22M | — | Held |
| JPMORGAN CHASE & CO | 870K | $4.67M | — | Held |
| AMERIPRISE FINANCIAL INC | 823.2K | $4.42M | — | Held |
| Ikarian Capital, LLC | 800K | $4.3M | — | Held |
| BURKEHILL GLOBAL MANAGEMENT, LP | 700K | $3.76M | — | Held |
| BARCLAYS PLC | 594.8K | $3.19M | $415.9K | Added$2.42M |
| Atle Fund Management AB | 584.3K | $3.14M | — | Held |
| Seven Fleet Capital Management LP | 568.7K | $3.05M | — | Held |
| Y-Intercept (Hong Kong) Ltd | 462.2K | $2.48M | — | Held |
| Schonfeld Strategic Advisors LLC | 452.4K | $2.43M | — | Held |
| Qube Research & Technologies Ltd | 441.8K | $2.37M | — | Held |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 410.2K | $2.2M | — | Held |
| MORGAN STANLEY | 365.2K | $1.96M | $349.6K | Added$1.31M |
| DIMENSIONAL FUND ADVISORS LP | 341.6K | $1.83M | — | Held |
| WELLINGTON MANAGEMENT GROUP LLP | 316.8K | $1.7M | — | Held |
| PRUDENTIAL FINANCIAL INC | 314.8K | $1.69M | — | Held |
| Bank of New York Mellon Corp | 312.5K | $1.68M | — | Held |
| Nuveen, LLC | 288.9K | $1.55M | — | Held |
| ROYCE & ASSOCIATES LP | 286K | $1.54M | — | Held |
| BANK OF AMERICA CORP /DE/ | 266.4K | $1.43M | $138K | Added$1.17M |
| CITIGROUP INC | 261.9K | $1.41M | — | Held |
| HighVista Strategies LLC | 245.5K | $1.32M | — | Held |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 210.2K | $1.13M | — | Held |
| BOOTHBAY FUND MANAGEMENT, LLC | 205K | $1.1M | — | Held |
| Connor, Clark & Lunn Investment Management Ltd. | 191.7K | $1.03M | — | Held |
| STATE OF WISCONSIN INVESTMENT BOARD | 185.4K | $995.7K | — | Held |
| UBS Group AG | 167.9K | $901.4K | — | Held |
| Icahn Capital | 155.2K | $833.5K | — | Held |
| Rafferty Asset Management, LLC | 151.7K | $814.9K | — | Held |
| ALPS ADVISORS INC | 146K | $784.2K | — | Held |
| WELLS FARGO & COMPANY/MN | 144.8K | $777.6K | — | Held |
| ADAR1 Capital Management, LLC | 139K | $746.4K | — | Held |
| RHUMBLINE ADVISERS | 134.6K | $722.8K | — | Held |
| Squarepoint Ops LLC | 126.2K | $677.7K | — | Held |
| Brevan Howard Capital Management LP | 118.5K | $636.5K | — | Held |
| XTX Topco Ltd | 115.6K | $621K | — | Held |
| DEUTSCHE BANK AG\ | 109.3K | $586.8K | — | Held |
| Creative Planning | 108.1K | $580.7K | — | Held |
| Citadel | 105.7K | $567.5K | — | Held |
| NEOS Investment Management LLC | 101.7K | $546K | — | Held |
| TEMA ETFS LLC | 100.2K | $537.9K | — | Held |
| CM Management, LLC | 100K | $537K | — | Held |
| ALLIANCEBERNSTEIN L.P. | 83.9K | $450.8K | — | Held |
| SummitTX Capital, L.P. | 81.4K | $437.4K | — | Held |
| RAYMOND JAMES FINANCIAL INC | 80.1K | $430.4K | — | Held |
| Atom Investors LP | 77.3K | $415K | — | Held |
| MetLife Investment Management, LLC | 74K | $397.3K | — | Held |
| JANE STREET GROUP, LLC | 70.1K | $376.2K | — | Held |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 69.6K | $373.7K | — | Held |
| FRANKLIN RESOURCES INC | 66.6K | $357.7K | — | Held |
| Invesco Ltd. | 63.9K | $343.1K | — | Held |
| Persistent Asset Partners Ltd | 57.3K | $307.4K | — | New |
| PROFUND ADVISORS LLC | 57.2K | $307.4K | — | Held |
| Graham Capital Management, L.P. | 53.4K | $286.9K | — | Held |
| Virtus Investment Advisers, LLC | 51.6K | $276.9K | — | Held |
| D. E. Shaw & Co., Inc. | 51.5K | $276.5K | — | Held |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 44.7K | $240.3K | — | Held |
| LPL Financial LLC | 44.5K | $238.8K | — | Held |
| AXQ CAPITAL, LP | 41.4K | $222.2K | — | Held |
| AMERICAN CENTURY COMPANIES INC | 40.4K | $217K | — | Held |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 40.3K | $216.5K | — | Held |
| INTECH INVESTMENT MANAGEMENT LLC | 38.9K | $209.1K | — | Held |
| Police & Firemen's Retirement System of New Jersey | 35.5K | $190.7K | — | Held |
| SmartHarvest Portfolios, LLC | 34.7K | $186.4K | — | Held |
| Simplicity Wealth,LLC | 33.9K | $181.9K | — | Held |
| NEW YORK STATE COMMON RETIREMENT FUND | 30.4K | $163.3K | — | Held |
| CAXTON CORP | 29.5K | $158.4K | — | Held |
| Avanza Fonder AB | 27.3K | $146.9K | — | Held |
| Walleye Trading LLC | 25K | $134.3K | — | Held |
| Caitong International Asset Management Co., Ltd | 24.6K | $132K | — | Held |
| DV Trading LLC | 24.2K | $130K | — | Held |
| STIFEL FINANCIAL CORP | 24K | $128.7K | — | Held |
| ProShare Advisors LLC | 24K | $128.7K | — | Held |
| Abel Hall, LLC | 22.9K | $122.9K | — | Held |
| INDEPENDENT FINANCIAL GROUP, LLC | 22.8K | $122.3K | — | New |
| VOYA INVESTMENT MANAGEMENT LLC | 22.6K | $121.5K | — | Held |
| CAPTRUST FINANCIAL ADVISORS | 20.8K | $111.9K | — | Held |
| Welch & Forbes LLC | 19K | $102K | — | Held |
| Focus Partners Wealth | 18.6K | $99.9K | — | Held |
| Independent Advisor Alliance | 17.9K | $96.1K | — | Held |
| SIG BROKERAGE, LP | 17.1K | $91.7K | — | Held |
| Sequoia Financial Advisors, LLC | 15.9K | $85.4K | — | Held |
| BNP PARIBAS FINANCIAL MARKETS | 15.6K | $84K | — | Held |
| TWO SIGMA ADVISERS, LP | 15.2K | $81.6K | — | Held |
| CANADA PENSION PLAN INVESTMENT BOARD | 14.9K | $80K | — | Held |
| M&T Bank Corp | 14.9K | $80K | — | Held |
| VICTORY CAPITAL MANAGEMENT INC | 14.3K | $76.8K | — | Held |
| EntryPoint Capital, LLC | 13.2K | $70.7K | — | Held |
| NEUBERGER BERMAN GROUP LLC | 12.8K | $68.8K | — | Held |
| Legal & General Group Plc | 12.8K | $68.5K | — | Held |
| North Star Investment Management Corp. | 12.5K | $67.1K | — | Held |
| Quadrature Capital Ltd | 12.3K | $66K | — | Held |
| Strategic Wealth Partners, Ltd. | 12.1K | $65K | — | Held |
| Russell Investments Group, Ltd. | 11.6K | $62.1K | — | Held |
| Ameritas Investment Partners, Inc. | 10.6K | $57K | — | Held |
| Stonebrook Private Inc. | 10.2K | $54.9K | — | Held |
| XPONANCE LLC | 10.2K | $54.8K | — | Held |
| PRELUDE CAPITAL MANAGEMENT, LLC | 10K | $53.7K | — | Held |
| SIMPLEX TRADING, LLC | 8.91K | $47.9K | — | Held |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 8.06K | $43.3K | — | Held |
| FLAGSHIP HARBOR ADVISORS, LLC | 6K | $32.2K | — | New |
| MCF Advisors LLC | 5.54K | $29.8K | — | Held |
| NISA INVESTMENT ADVISORS, LLC | 5.25K | $28.2K | — | Held |
| GROUP ONE TRADING LLC | 5.24K | $28.2K | — | Held |
| Fortitude Family Office, LLC | 4.59K | $24.7K | — | Held |
| EverSource Wealth Advisors, LLC | 4.37K | $23.5K | — | Held |
| ROYAL BANK OF CANADA | 3.82K | $21K | — | Held |
| Sterling Capital Management LLC | 3.83K | $20.6K | — | Held |
| VSM Wealth Advisory, LLC | 3K | $16.1K | — | Held |
| Rockefeller Capital Management L.P. | 2.04K | $11K | — | Held |
| Cape Investment Advisory, Inc. | 2K | $10.8K | $2.46K | Added$6.14K |
| Tower Research Capital LLC (TRC) | 1.7K | $9.12K | — | Held |
| Optiver Holding B.V. | 1.1K | $5.89K | — | Held |
| Farther Finance Advisors, LLC | 680 | $3.65K | — | Held |
| Federation des caisses Desjardins du Quebec | 500 | $2.69K | — | Held |
| PNC Financial Services Group, Inc. | 413 | $2.22K | — | Held |
| QUADRANT CAPITAL GROUP LLC | 405 | $2.17K | — | Held |
| NATIONAL BANK OF CANADA /FI/ | 242 | $1.3K | — | Held |
| SBI Securities Co., Ltd. | 237 | $1.27K | — | Held |
| Marshall & Sterling Wealth Advisors Inc. | 200 | $1.07K | — | Held |
| ROTHSCHILD INVESTMENT LLC | 164 | $881 | — | Held |
| GSA CAPITAL PARTNERS LLP | 133.8K | $719 | — | Held |
| SG Americas Securities, LLC | 106.5K | $572 | — | Held |
| PRICE T ROWE ASSOCIATES INC /MD/ | 70.5K | $379 | — | Held |
| Smartleaf Asset Management LLC | 69 | $371 | — | Held |
| OSAIC HOLDINGS, INC. | 57 | $306 | — | Held |
| CIBC Private Wealth Group LLC | 38 | $204 | — | Held |
| GAMMA Investing LLC | 29 | $156 | — | Held |
| SJS Investment Consulting Inc. | 27 | $145 | — | Held |
| MAI Capital Management | 24 | $129 | — | Held |
| Allworth Financial LP | 20 | $108 | $8 | Added$94 |
| Arax Advisory Partners | 18 | $97 | — | Held |
| ROVIN CAPITAL /UT/ /ADV | 13.5K | $72 | — | Held |
| Cygnus Capital Advisors, LLC | 10K | $54 | — | Held |
| Essential Partners LLC | 9 | $48 | $16 | Cut−$19 |
| Sunbelt Securities, Inc. | 8 | $43 | — | Held |
| IFP Advisors, Inc | 6 | $32 | $11 | Added$11 |
| ACADIAN ASSET MANAGEMENT LLC | 4.87K | $26 | — | Held |
| AMALGAMATED BANK | 4.11K | $22 | — | Held |
| CWM, LLC | 3.06K | $16 | — | Held |
| Hughes Financial Services, LLC | 1 | $5 | — | Held |
| BESSEMER GROUP INC | 526 | $3 | — | Held |