| RA CAPITAL MANAGEMENT, L.P. | 11.3M | $77.4M | −$348.5K | Cut−$299.8K |
| MPM BIOIMPACT LLC | 2.59M | $17.8M | $7.39M | Added$7.08M |
| BRAIDWELL LP | 1.53M | $10.5M | — | New |
| GREAT POINT PARTNERS LLC | 1.33M | $9.14M | $2.79M | Added$5.22M |
| MILLENNIUM MANAGEMENT LLC | 1.28M | $8.74M | $844.5K | Added$7.56M |
| VANGUARD CAPITAL MANAGEMENT LLC | 1.18M | $8.07M | — | Held |
| Kynam Capital Management, LP | 1M | $6.87M | $2.86M | Added$2.76M |
| MARSHALL WACE, LLP | 773.1K | $5.3M | $866.4K | Added$4.08M |
| Affinity Asset Advisors, LLC | 700K | $4.79M | $1.99M | Cut−$405K |
| SILVERARC CAPITAL MANAGEMENT, LLC | 684.9K | $4.69M | — | New |
| Driehaus Capital Management LLC | 600.9K | $4.12M | $1.71M | Added$1.71M |
| ADAR1 Capital Management, LLC | 597.7K | $4.09M | $1.7M | Cut−$1.64M |
| NAN FUNG TRINITY (HK) LTD | 420.5K | $2.88M | $1.2M | Added$1.03M |
| SPHERA FUNDS MANAGEMENT LTD. | 419.2K | $2.87M | $1.19M | Cut−$857.1K |
| BlackRock, Inc. | 401.6K | $2.75M | $1.11M | Added$1.19M |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 387.4K | $2.65M | $1.1M | Added$872.3K |
| Citadel | 345.7K | $2.37M | $681.3K | Added$1.41M |
| GEODE CAPITAL MANAGEMENT, LLC | 313K | $2.15M | $886.1K | Added$901.5K |
| TWO SIGMA INVESTMENTS, LP | 310.6K | $2.13M | $885.2K | Cut−$139.2K |
| DIADEMA PARTNERS LP | 286.1K | $1.96M | — | New |
| TD Asset Management Inc | 250.1K | $1.71M | $701.7K | Added$728.4K |
| MORGAN STANLEY | 234.2K | $1.6M | $423.3K | Added$1.01M |
| Longaeva Partners L.P. | 217.8K | $1.49M | — | New |
| Renaissance Technologies | 217.3K | $1.49M | $619.3K | Added$206.1K |
| SUPERSTRING CAPITAL MANAGEMENT LP | 199.2K | $1.36M | — | New |
| JANE STREET GROUP, LLC | 171.4K | $1.17M | $488.4K | Added$424.3K |
| VANGUARD FIDUCIARY TRUST CO | 158.7K | $1.09M | — | Held |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 156.3K | $1.07M | $396.6K | Added$504.1K |
| GOLDMAN SACHS GROUP INC | 150K | $1.03M | $427.4K | Added$127.8K |
| Verdad Advisers, LP | 144.5K | $990.1K | — | New |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 134.3K | $920K | $382.8K | Added$282.8K |
| State Street | 132K | $904.2K | $367.4K | Added$388.6K |
| Seven Fleet Capital Management LP | 130.7K | $895K | $217.7K | Added$589.4K |
| NORTHERN TRUST CORP | 127.9K | $876.1K | $355.3K | Added$377.5K |
| ArchPoint Investors | 121.4K | $831.6K | $346K | Added$346K |
| Peapod Lane Capital LLC | 108.9K | $739.8K | $304.3K | Cut−$1.52M |
| DIMENSIONAL FUND ADVISORS LP | 104.4K | $714.5K | — | New |
| Qube Research & Technologies Ltd | 104.2K | $713.9K | $98.6K | Added$575.5K |
| BOOTHBAY FUND MANAGEMENT, LLC | 92.3K | $632.2K | — | New |
| 683 Capital Management, LLC | 90K | $616.5K | $256.5K | Cut−$190.1K |
| UBS Group AG | 85.9K | $588.7K | $203.3K | Added$303.4K |
| Persistent Asset Partners Ltd | 72.3K | $495.4K | $26.3K | Added$458.5K |
| LPL Financial LLC | 60.4K | $413.6K | $172.1K | Added$165.6K |
| Point72 Asset Management, L.P. | 59.1K | $404.8K | $168.4K | Cut−$2.46M |
| Brevan Howard Capital Management LP | 56.6K | $387.9K | — | New |
| Hudson Bay Capital Management LP | 54.5K | $373.1K | $138.9K | Added$178.1K |
| BANK OF AMERICA CORP /DE/ | 52.9K | $362.5K | $14.4K | Added$342.3K |
| XTX Topco Ltd | 51.9K | $355.6K | $99.3K | Added$216.2K |
| BARCLAYS PLC | 48.9K | $335.2K | $139.5K | Added$87.8K |
| Squarepoint Ops LLC | 43K | $294.4K | — | New |
| CANTOR FITZGERALD, L. P. | 30K | $205.5K | — | New |
| BNP PARIBAS FINANCIAL MARKETS | 29.1K | $199.5K | $1.46K | Added$197.5K |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | 24.6K | $168.4K | — | New |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 22.1K | $151K | — | New |
| FOX RUN MANAGEMENT, L.L.C. | 19.3K | $126.1K | — | New |
| RAYMOND JAMES FINANCIAL INC | 17.7K | $121.4K | — | New |
| OMERS ADMINISTRATION Corp | 16.7K | $114.4K | $47.6K | Cut−$227.5K |
| BLAIR WILLIAM & CO/IL | 12K | $82.2K | $31.3K | Added$38.2K |
| Diametric Capital, LP | 11.2K | $76.8K | — | New |
| Vanguard Personalized Indexing Management, LLC | 11.2K | $76.7K | $31.7K | Added$32.2K |
| Susquehanna Portfolio Strategies, LLC | 11.1K | $75.7K | — | New |
| Vanguard Global Advisers, LLC | 10.1K | $68.9K | — | Held |
| Balyasny Asset Management L.P. | 6.96K | $47.7K | $19.8K | Cut−$9.28K |
| Fidelity | 6.4K | $43.8K | $18.1K | Added$18.4K |
| Tower Research Capital LLC (TRC) | 5.84K | $40K | $9.57K | Added$26.5K |
| CITIGROUP INC | 5.79K | $39.7K | $16.5K | Cut−$1.64K |
| OSAIC HOLDINGS, INC. | 3.4K | $23.3K | $1.71K | Added$20.9K |
| Advisory Services Network, LLC | 2.03K | $13.9K | — | New |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1.92M | $13.1K | $5.46K | Added$5.44K |
| NISA INVESTMENT ADVISORS, LLC | 573 | $3.92K | $1.63K | Added$1.63K |
| JONES FINANCIAL COMPANIES LLLP | 266 | $1.87K | — | New |
| Fortitude Family Office, LLC | 92 | $630 | — | New |
| Russell Investments Group, Ltd. | 79 | $541 | — | New |
| Allworth Financial LP | 45 | $309 | — | New |
| JPMORGAN CHASE & CO | 46 | $301 | $117 | Added$117 |
| HRT FINANCIAL LP | 37.2K | $254 | — | New |
| CWM, LLC | 18 | $123 | $123 | Added$123 |
| Arax Advisory Partners | 51 | $110 | — | New |
| DEUTSCHE BANK AG\ | 1 | $7 | $3 | Added$3 |
| ROYAL BANK OF CANADA | 79 | $0 | −$194 | Cut−$1K |