| RA CAPITAL MANAGEMENT, L.P. | 11.3M | $77.7M | — | Held |
| MPM BIOIMPACT LLC | 2.67M | $10.7M | — | Held |
| ADAR1 Capital Management, LLC | 1.43M | $5.73M | — | Held |
| Vanguard | 1.34M | $5.36M | — | Held |
| Affinity Asset Advisors, LLC | 1.3M | $5.2M | — | Held |
| Kynam Capital Management, LP | 1.03M | $4.11M | — | Held |
| GREAT POINT PARTNERS LLC | 979.5K | $3.92M | — | Held |
| SPHERA FUNDS MANAGEMENT LTD. | 932.2K | $3.73M | — | Held |
| Point72 Asset Management, L.P. | 716.7K | $2.87M | — | Held |
| Driehaus Capital Management LLC | 600.9K | $2.4M | — | Held |
| TWO SIGMA INVESTMENTS, LP | 566.7K | $2.27M | — | Held |
| Peapod Lane Capital LLC | 566K | $2.26M | — | Held |
| NAN FUNG TRINITY (HK) LTD | 463.7K | $1.85M | — | Held |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 445.3K | $1.78M | — | Held |
| KOTLER KEVIN | 400K | $1.6M | — | Held |
| BlackRock, Inc. | 389.3K | $1.56M | — | Held |
| Renaissance Technologies | 320.6K | $1.28M | — | Held |
| GEODE CAPITAL MANAGEMENT, LLC | 310.8K | $1.24M | — | Held |
| MARSHALL WACE, LLP | 304K | $1.22M | — | Held |
| MILLENNIUM MANAGEMENT LLC | 296.3K | $1.19M | — | Held |
| TD Asset Management Inc | 246.2K | $984.8K | — | Held |
| Citadel | 239K | $956.2K | — | Held |
| GOLDMAN SACHS GROUP INC | 224.9K | $899.5K | — | Held |
| 683 Capital Management, LLC | 201.7K | $806.6K | — | Held |
| JANE STREET GROUP, LLC | 187.4K | $749.6K | — | Held |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 159.3K | $637.2K | — | Held |
| MORGAN STANLEY | 148.5K | $594.2K | $171.8K | Added$420.6K |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 140.6K | $566.6K | — | Held |
| AMERIPRISE FINANCIAL INC | 139.5K | $558.1K | — | Held |
| State Street | 128.9K | $515.6K | — | Held |
| TWO SIGMA ADVISERS, LP | 124.7K | $498.8K | — | Held |
| NORTHERN TRUST CORP | 124.7K | $498.7K | — | Held |
| ArchPoint Investors | 121.4K | $485.6K | — | Held |
| Squadron Capital Management LLC | 100K | $400K | — | Held |
| OMERS ADMINISTRATION Corp | 85.5K | $341.9K | — | Held |
| Seven Fleet Capital Management LP | 76.4K | $305.6K | — | Held |
| UBS Group AG | 71.3K | $285.3K | — | Held |
| LPL Financial LLC | 62K | $248K | — | Held |
| BARCLAYS PLC | 61.9K | $247.4K | $49.3K | Added$197.7K |
| Hudson Bay Capital Management LP | 48.7K | $194.9K | — | New |
| XTX Topco Ltd | 34.9K | $139.4K | — | Held |
| Qube Research & Technologies Ltd | 34.6K | $138.4K | — | Held |
| CITIZENS FINANCIAL GROUP INC/RI | 28.2K | $112.7K | — | Held |
| HSBC HOLDINGS PLC | 24.7K | $99.2K | — | Held |
| PRELUDE CAPITAL MANAGEMENT, LLC | 19.9K | $79.7K | — | Held |
| Balyasny Asset Management L.P. | 14.2K | $56.9K | — | Held |
| Chicago Partners Investment Group LLC | 11K | $55K | — | Held |
| Vanguard Personalized Indexing Management, LLC | 11.1K | $44.5K | — | Held |
| BLAIR WILLIAM & CO/IL | 11K | $44K | — | Held |
| Scientech Research LLC | 10.4K | $41.7K | — | Held |
| CITIGROUP INC | 10.3K | $41.3K | — | Held |
| Persistent Asset Partners Ltd | 9.23K | $36.9K | $18.4K | Cut−$19.8K |
| Fidelity | 6.35K | $25.4K | — | Held |
| BANK OF AMERICA CORP /DE/ | 5.06K | $20.3K | $10.1K | Added$8.69K |
| Tower Research Capital LLC (TRC) | 3.36K | $13.4K | — | Held |
| HARBOUR INVESTMENTS, INC. | 2K | $8K | — | Held |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1.92M | $7.7K | — | Held |
| OSAIC HOLDINGS, INC. | 600 | $2.4K | — | Held |
| NISA INVESTMENT ADVISORS, LLC | 573 | $2.29K | — | Held |
| BNP PARIBAS FINANCIAL MARKETS | 513 | $2.05K | — | Held |
| ROYAL BANK OF CANADA | 408 | $1K | — | Held |
| JPMORGAN CHASE & CO | 46 | $184 | — | Held |
| Virtu Financial LLC | 10.7K | $43 | — | Held |
| DEUTSCHE BANK AG\ | 1 | $4 | — | Held |
| CWM, LLC | 29 | $0 | — | Held |