| JANUS HENDERSON GROUP PLC | 6.31M | $27.9M | −$10.9M | Cut−$10.9M |
| 5AM Venture Management, LLC | 5.87M | $25.9M | −$10.1M | Cut−$10.1M |
| Fidelity | 4.93M | $21.8M | −$8.46M | Cut−$8.39M |
| Vivo Capital, LLC | 4.25M | $18.7M | −$7.3M | Cut−$7.3M |
| Balyasny Asset Management L.P. | 2.63M | $11.6M | −$4.19M | Cut−$3.33M |
| ENAVATE SCIENCES GP, LLC | 2.19M | $9.66M | −$3.77M | Cut−$8.95M |
| a16z Capital Management, L.L.C. | 2.13M | $9.37M | −$3.66M | Cut−$3.66M |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1.96M | $8.65M | −$3.37M | Cut−$4.73M |
| Trails Edge Capital Partners, LP | 1.94M | $8.55M | −$3.34M | Cut−$3.61M |
| VANGUARD CAPITAL MANAGEMENT LLC | 1.53M | $6.77M | — | Held |
| Stonepine Capital Management, LLC | 1.39M | $6.13M | −$393.7K | Added$4.73M |
| HarbourVest Partners LLC | 1.27M | $5.61M | −$2.19M | Cut−$2.19M |
| SILVERARC CAPITAL MANAGEMENT, LLC | 653.6K | $2.88M | — | New |
| BlackRock, Inc. | 456.4K | $2.01M | −$671.1K | Cut−$379.1K |
| GEODE CAPITAL MANAGEMENT, LLC | 382.8K | $1.69M | −$578.8K | Cut−$373.5K |
| SummitTX Capital, L.P. | 339.5K | $1.5M | — | New |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 336K | $1.48M | — | New |
| VANGUARD FIDUCIARY TRUST CO | 195K | $860K | — | Held |
| State Street | 146.9K | $647.8K | −$68.3K | Added$404.5K |
| TWO SIGMA INVESTMENTS, LP | 108.9K | $480.1K | −$162.6K | Cut−$99.3K |
| 683 Capital Management, LLC | 108K | $476.3K | −$185.8K | Cut−$298.3K |
| MILLENNIUM MANAGEMENT LLC | 85.9K | $378.9K | −$17.4K | Added$317K |
| VICTORY CAPITAL MANAGEMENT INC | 82.5K | $363.6K | −$141.8K | Cut−$143.9K |
| GOLDMAN SACHS GROUP INC | 78.3K | $345.5K | −$32.4K | Added$230.1K |
| NORTHERN TRUST CORP | 70.7K | $311.6K | −$121.5K | Cut−$145.1K |
| Hudson Bay Capital Management LP | 48.5K | $213.9K | — | New |
| BARCLAYS PLC | 34.7K | $153K | −$59.7K | Cut−$298.2K |
| BANK OF AMERICA CORP /DE/ | 31.2K | $137.6K | −$38 | Added$137.4K |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 25K | $110.3K | −$43K | Cut−$43K |
| Qube Research & Technologies Ltd | 24.8K | $109.4K | — | New |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 20K | $88.2K | — | New |
| Bank of New York Mellon Corp | 18.7K | $82.5K | −$32.2K | Cut−$32.2K |
| Point72 Asset Management, L.P. | 17.3K | $76.4K | — | New |
| China Universal Asset Management Co., Ltd. | 16K | $70.6K | −$17.2K | Added$9.26K |
| Diametric Capital, LP | 14.4K | $63.7K | — | New |
| Scientech Research LLC | 12.7K | $56.2K | — | New |
| Vanguard Global Advisers, LLC | 11.6K | $51.2K | — | Held |
| CITIGROUP INC | 9.89K | $43.6K | −$17K | Cut−$87.6K |
| MORGAN STANLEY | 9.51K | $41.9K | −$16.3K | Cut−$18.9K |
| UBS Group AG | 9.08K | $40K | −$8.85K | Added$8.51K |
| Tower Research Capital LLC (TRC) | 1.41K | $6.2K | −$699 | Added$3.71K |
| ROYAL BANK OF CANADA | 236 | $1K | $76 | Added$1K |
| Caitong International Asset Management Co., Ltd | 74 | $326 | — | New |
| BNP PARIBAS FINANCIAL MARKETS | 36 | $159 | −$56 | Cut−$43 |
| HRT FINANCIAL LP | 30.7K | $135 | — | New |
| SBI Securities Co., Ltd. | 10 | $44 | −$17 | Cut−$17 |