| JANUS HENDERSON GROUP PLC | 6.31M | $38.8M | — | Held |
| 5AM Venture Management, LLC | 5.87M | $36M | — | Held |
| Fidelity | 4.92M | $30.1M | — | Held |
| Vivo Capital, LLC | 4.25M | $26M | — | Held |
| ENAVATE SCIENCES GP, LLC | 3.04M | $18.6M | — | Held |
| Balyasny Asset Management L.P. | 2.44M | $14.9M | — | Held |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2.18M | $13.4M | — | Held |
| a16z Capital Management, L.L.C. | 2.13M | $13M | — | Held |
| Trails Edge Capital Partners, LP | 1.98M | $12.2M | — | Held |
| Vanguard | 1.67M | $10.3M | — | Held |
| HarbourVest Partners LLC | 1.27M | $7.8M | — | Held |
| BlackRock, Inc. | 390.2K | $2.39M | — | Held |
| GEODE CAPITAL MANAGEMENT, LLC | 336.3K | $2.06M | — | Held |
| EcoR1 Capital, LLC | 325K | $1.99M | — | Held |
| Stonepine Capital Management, LLC | 228.9K | $1.4M | — | Held |
| Alyeska Investment Group, L.P. | 200K | $1.23M | — | Held |
| 683 Capital Management, LLC | 126.4K | $774.6K | — | Held |
| TWO SIGMA INVESTMENTS, LP | 94.5K | $579.5K | — | Held |
| VICTORY CAPITAL MANAGEMENT INC | 82.8K | $507.5K | — | Held |
| NORTHERN TRUST CORP | 74.5K | $456.7K | — | Held |
| BARCLAYS PLC | 73.6K | $451.2K | $219 | Added$451K |
| State Street | 39.7K | $243.4K | — | Held |
| ExodusPoint Capital Management, LP | 34.7K | $212.8K | — | Held |
| JANE STREET GROUP, LLC | 25.5K | $156.5K | — | Held |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 25K | $153.3K | — | Held |
| CITIGROUP INC | 21.4K | $131.2K | — | Held |
| GOLDMAN SACHS GROUP INC | 18.8K | $115.4K | — | Held |
| OMERS ADMINISTRATION Corp | 18.8K | $115.2K | — | Held |
| Bank of New York Mellon Corp | 18.7K | $114.7K | — | Held |
| Mariner, LLC | 15.4K | $94.2K | — | Held |
| Jefferies Financial Group Inc. | 11.4K | $69.6K | — | Held |
| MILLENNIUM MANAGEMENT LLC | 10.1K | $61.9K | — | Held |
| China Universal Asset Management Co., Ltd. | 10K | $61.3K | — | Held |
| MORGAN STANLEY | 9.91K | $60.8K | $9 | Added$60.8K |
| UBS Group AG | 5.14K | $31.5K | — | Held |
| Tower Research Capital LLC (TRC) | 406 | $2.49K | — | Held |
| BNP PARIBAS FINANCIAL MARKETS | 33 | $202 | — | Held |
| BANK OF AMERICA CORP /DE/ | 22 | $135 | $69 | Cut−$714 |
| SBI Securities Co., Ltd. | 10 | $61 | — | Held |
| ROYAL BANK OF CANADA | 18 | $0 | — | Held |