| VR ADVISER, LLC | 8.49M | $641.1M | — | Held |
| Fidelity | 8.23M | $620.8M | — | Held |
| WELLINGTON MANAGEMENT GROUP LLP | 4.75M | $358.3M | — | Held |
| BlackRock, Inc. | 3.78M | $285.6M | — | Held |
| Vanguard | 2.86M | $215.7M | — | Held |
| RTW INVESTMENTS, LP | 2.71M | $204.7M | — | Held |
| PERCEPTIVE ADVISORS LLC | 2.33M | $175.9M | — | Held |
| Driehaus Capital Management LLC | 2.18M | $164.8M | — | Held |
| JANUS HENDERSON GROUP PLC | 2.06M | $155.7M | — | Held |
| Fairmount Funds Management LLC | 2.05M | $154.6M | — | Held |
| State Street | 1.69M | $127.6M | — | Held |
| JPMORGAN CHASE & CO | 1.37M | $103.6M | — | Held |
| Affinity Asset Advisors, LLC | 1.23M | $93.2M | — | Held |
| Paradigm Biocapital Advisors LP | 1.12M | $84.8M | — | Held |
| ALLIANCEBERNSTEIN L.P. | 1.09M | $82.5M | — | Held |
| GEODE CAPITAL MANAGEMENT, LLC | 1.06M | $80M | — | Held |
| UBS Group AG | 974.8K | $73.6M | — | Held |
| MERCER GLOBAL ADVISORS INC /ADV | 890.7K | $67.2M | — | Held |
| MORGAN STANLEY | 890.3K | $67.2M | $16.6M | Added$48.7M |
| BANK OF AMERICA CORP /DE/ | 793.7K | $59.9M | $14.1M | Added$44.3M |
| Citadel | 767K | $57.9M | — | Held |
| JENNISON ASSOCIATES LLC | 578.6K | $43.7M | — | Held |
| BRAIDWELL LP | 575.1K | $43.4M | — | Held |
| NOVO HOLDINGS A/S | 570K | $43M | — | Held |
| GOLDMAN SACHS GROUP INC | 565.4K | $42.7M | — | Held |
| Vestal Point Capital, LP | 550K | $41.5M | — | Held |
| Sofinnova Investments, Inc. | 534.8K | $40.4M | — | Held |
| Polar Capital Holdings Plc | 503.5K | $38M | — | Held |
| Avoro Capital Advisors LLC | 500K | $37.7M | — | Held |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 480.5K | $36.3M | — | Held |
| First Turn Management, LLC | 474.8K | $35.8M | — | Held |
| FRANKLIN RESOURCES INC | 451K | $34M | — | Held |
| EVENTIDE ASSET MANAGEMENT, LLC | 436K | $32.9M | — | Held |
| Opaleye Management Inc. | 388.3K | $29.3M | — | Held |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 381.4K | $28.8M | — | Held |
| GREAT POINT PARTNERS LLC | 374K | $28.2M | — | Held |
| NORTHERN TRUST CORP | 327.4K | $24.7M | — | Held |
| Pictet Asset Management Holding SA | 312.9K | $23.6M | — | Held |
| First Light Asset Management, LLC | 285K | $21.5M | — | Held |
| LOOMIS SAYLES & CO L P | 255.4K | $19.3M | — | Held |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 240K | $18.1M | — | Held |
| Woodline Partners LP | 210.5K | $15.9M | — | Held |
| Trails Edge Capital Partners, LP | 192K | $14.5M | — | Held |
| Candriam S.C.A. | 191.3K | $14.4M | — | Held |
| MILLENNIUM MANAGEMENT LLC | 140.7K | $10.6M | — | Held |
| BARCLAYS PLC | 133.2K | $10.1M | $4.76M | Cut−$15.5M |
| Parkman Healthcare Partners LLC | 130.1K | $9.82M | — | Held |
| TD Asset Management Inc | 129.3K | $9.76M | — | Held |
| FEDERATED HERMES, INC. | 127.9K | $9.66M | — | Held |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 127.6K | $9.63M | — | Held |
| Capital World Investors | 127.6K | $9.63M | — | Held |
| KENNEDY CAPITAL MANAGEMENT LLC | 125K | $9.43M | — | Held |
| AMERIPRISE FINANCIAL INC | 122.9K | $9.28M | — | Held |
| Nuveen, LLC | 121K | $9.14M | — | Held |
| Bank of New York Mellon Corp | 118.1K | $8.91M | — | Held |
| Nicholas Investment Partners, LP | 112.9K | $8.52M | — | Held |
| ArrowMark Colorado Holdings LLC | 109.4K | $8.26M | — | Held |
| VICTORY CAPITAL MANAGEMENT INC | 108.3K | $8.17M | — | Held |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 105K | $7.95M | — | Held |
| TWO SIGMA INVESTMENTS, LP | 105.2K | $7.94M | — | Held |
| NEUBERGER BERMAN GROUP LLC | 99.6K | $7.52M | — | Held |
| Granahan Investment Management, LLC | 94.7K | $7.15M | — | Held |
| HighVista Strategies LLC | 89.2K | $6.74M | — | Held |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 80.8K | $6.12M | — | Held |
| STEMPOINT CAPITAL LP | 80.6K | $6.08M | — | Held |
| DEUTSCHE BANK AG\ | 79.4K | $5.99M | — | Held |
| NOMURA HOLDINGS INC | 76.9K | $5.8M | — | Held |
| Invesco Ltd. | 70.7K | $5.34M | — | Held |
| Boxer Capital Management, LLC | 70K | $5.28M | $1.79M | Added$3.3M |
| PLATINUM INVESTMENT MANAGEMENT LTD | 69.2K | $5.22M | — | Held |
| D. E. Shaw & Co., Inc. | 63.3K | $4.77M | — | Held |
| Swiss National Bank | 62.9K | $4.75M | — | Held |
| SIMPLEX TRADING, LLC | 62.8K | $4.74M | — | Held |
| PRUDENTIAL FINANCIAL INC | 54.3K | $4.1M | — | Held |
| Blackstone Inc. | 51.8K | $3.91M | — | New |
| MARSHALL WACE, LLP | 50.7K | $3.83M | — | Held |
| SEVEN GRAND MANAGERS, LLC | 50K | $3.77M | — | Held |
| Russell Investments Group, Ltd. | 50K | $3.77M | — | Held |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 49.8K | $3.76M | — | Held |
| Rafferty Asset Management, LLC | 48.6K | $3.67M | — | Held |
| RHUMBLINE ADVISERS | 46K | $3.47M | — | Held |
| ALPS ADVISORS INC | 44.9K | $3.39M | — | Held |
| WELLS FARGO & COMPANY/MN | 42.5K | $3.21M | — | Held |
| BANQUE PICTET & CIE SA | 41.8K | $3.16M | — | Held |
| Aberdeen Group plc | 36.1K | $2.73M | — | Held |
| COMERICA BANK | 35.9K | $2.71M | — | Held |
| Cinctive Capital Management LP | 33.3K | $2.51M | — | Held |
| Legal & General Group Plc | 32.9K | $2.48M | — | Held |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 30.8K | $2.32M | — | Held |
| TUDOR INVESTMENT CORP ET AL | 30K | $2.27M | — | New |
| Schonfeld Strategic Advisors LLC | 29.1K | $2.2M | — | Held |
| Erste Asset Management GmbH | 24K | $1.83M | — | Held |
| NEW YORK STATE COMMON RETIREMENT FUND | 22.5K | $1.7M | — | Held |
| MetLife Investment Management, LLC | 21.3K | $1.61M | — | Held |
| SummitTX Capital, L.P. | 21K | $1.58M | — | Held |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 20.7K | $1.56M | — | Held |
| STATE OF WISCONSIN INVESTMENT BOARD | 20.3K | $1.53M | — | Held |
| B Group, Inc. | 20K | $1.51M | — | Held |
| XTX Topco Ltd | 19K | $1.44M | — | Held |
| VOYA INVESTMENT MANAGEMENT LLC | 18.5K | $1.4M | — | Held |
| PROFUND ADVISORS LLC | 18.3K | $1.38M | — | Held |
| FORA Capital, LLC | 18.2K | $1.37M | — | Held |
| Moody Aldrich Partners LLC | 17.2K | $1.3M | — | Held |
| SEI INVESTMENTS CO | 16.3K | $1.23M | — | Held |
| Birchview Capital, LP | 16K | $1.21M | — | Held |
| Qube Research & Technologies Ltd | 14.3K | $1.08M | — | Held |
| INTECH INVESTMENT MANAGEMENT LLC | 13.7K | $1.03M | — | Held |
| Legato Capital Management LLC | 13.6K | $1.02M | — | Held |
| Verition Fund Management LLC | 12.7K | $958.6K | — | Held |
| Connor, Clark & Lunn Investment Management Ltd. | 12.7K | $957.8K | — | Held |
| Vestmark Advisory Solutions, Inc. | 12.7K | $956.6K | — | Held |
| JANE STREET GROUP, LLC | 12.2K | $920.3K | — | Held |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 11.9K | $896.6K | — | Held |
| LMR Partners LLP | 11.5K | $865.1K | — | Held |
| Man Group plc | 11.2K | $842.6K | — | Held |
| Neo Ivy Capital Management | 10.9K | $823.5K | — | Held |
| State of New Jersey Common Pension Fund D | 10.9K | $821.1K | — | Held |
| AlphaCentric Advisors LLC | 10.8K | $811.5K | — | Held |
| Police & Firemen's Retirement System of New Jersey | 10.3K | $779.7K | — | Held |
| BNP PARIBAS FINANCIAL MARKETS | 9.96K | $752.2K | — | Held |
| ProShare Advisors LLC | 9.46K | $714.3K | — | Held |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 9.35K | $705.7K | — | Held |
| Mariner, LLC | 9.1K | $686.9K | — | Held |
| China Universal Asset Management Co., Ltd. | 8.94K | $674.4K | — | Held |
| Creative Planning | 8.9K | $672.1K | — | Held |
| CITIGROUP INC | 8.88K | $670.4K | — | Held |
| ARIZONA STATE RETIREMENT SYSTEM | 8.76K | $661.4K | — | Held |
| GLENMEDE TRUST CO NA | 8.51K | $642.5K | — | Held |
| Global Endowment Management, LP | 7.8K | $589K | — | Held |
| COMMONWEALTH EQUITY SERVICES, LLC | 7.15K | $539.8K | — | Held |
| ACT CAPITAL MANAGEMENT, LLC | 7K | $528.4K | — | Held |
| PSP Research LLC | 6.98K | $527.2K | — | Held |
| KLP KAPITALFORVALTNING AS | 6.8K | $513.3K | — | Held |
| FOX RUN MANAGEMENT, L.L.C. | 6.37K | $480.9K | — | Held |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | 6.32K | $477.3K | — | Held |
| DNB Asset Management AS | 5.78K | $435.9K | — | Held |
| Allspring Global Investments Holdings, LLC | 5.43K | $411.9K | — | Held |
| STIFEL FINANCIAL CORP | 5.21K | $393.6K | — | Held |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 4.71K | $355.1K | — | Held |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 4.63K | $349.8K | — | Held |
| Tower Research Capital LLC (TRC) | 3.67K | $277K | — | Held |
| J. Goldman & Co LP | 3.47K | $261.6K | — | Held |
| Virtus Investment Advisers, LLC | 3.45K | $260.5K | — | Held |
| FIRST TRUST ADVISORS LP | 3.42K | $258K | — | Held |
| Quantbot Technologies LP | 3.34K | $252.1K | — | Held |
| STRS OHIO | 3.3K | $249.1K | — | Held |
| Boyer Financial Services, Inc. | 3.13K | $236.9K | — | Held |
| Ameritas Investment Partners, Inc. | 3.13K | $235.9K | — | Held |
| Baader Bank Aktiengesellschaft | 3.1K | $234K | — | Held |
| XPONANCE LLC | 3.02K | $227.6K | — | Held |
| Vident Advisory, LLC | 2.89K | $218.2K | — | Held |
| T. Rowe Price Investment Management, Inc. | 2.73M | $206.2K | — | Held |
| Mirae Asset Global Investments Co., Ltd. | 2.67K | $201.2K | — | Held |
| AlphaQuest LLC | 2.52K | $190.5K | — | Held |
| Quarry LP | 2.5K | $188.7K | — | Held |
| Persistent Asset Partners Ltd | 2.44K | $184.5K | $87.4K | Cut−$404.2K |
| Ensign Peak Advisors, Inc | 2.25K | $169.8K | — | Held |
| Seven Fleet Capital Management LP | 1.8K | $135.9K | — | Held |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1.24M | $93.4K | — | Held |
| ROYAL BANK OF CANADA | 1.14K | $85K | — | Held |
| GF FUND MANAGEMENT CO. LTD. | 1.08K | $81.3K | — | Held |
| GROUP ONE TRADING LLC | 1.06K | $79.8K | — | Held |
| OSAIC HOLDINGS, INC. | 959 | $72.4K | — | Held |
| ANTIPODES PARTNERS Ltd | 723 | $54.6K | — | Held |
| NISA INVESTMENT ADVISORS, LLC | 701 | $52.9K | — | Held |
| Remedium Capital Partners, LLC | 583.6K | $44K | — | Held |
| EverSource Wealth Advisors, LLC | 399 | $30.1K | — | Held |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 490 | $27.5K | — | Held |
| US BANCORP \DE\ | 346 | $26.1K | — | Held |
| Rockefeller Capital Management L.P. | 337 | $25.4K | — | Held |
| Smartleaf Asset Management LLC | 276 | $20.9K | — | Held |
| Sterling Capital Management LLC | 252 | $19K | — | Held |
| Versant Capital Management, Inc | 229 | $17.3K | — | Held |
| GAMMA Investing LLC | 216 | $16.3K | — | Held |
| Larson Financial Group LLC | 157 | $11.8K | — | Held |
| Optiver Holding B.V. | 156 | $11.8K | — | Held |
| Kemnay Advisory Services Inc. | 118 | $8.91K | — | Held |
| JONES FINANCIAL COMPANIES LLLP | 98 | $7.4K | — | Held |
| QUADRANT CAPITAL GROUP LLC | 91 | $6.87K | — | Held |
| PNC Financial Services Group, Inc. | 82 | $6.19K | — | Held |
| ROTHSCHILD INVESTMENT LLC | 77 | $5.81K | — | Held |
| SG Americas Securities, LLC | 73.3K | $5.53K | — | Held |
| Red Tortoise LLC | 69 | $5.21K | — | Held |
| Exane Asset Management | 52 | $4.61K | — | Held |
| Farther Finance Advisors, LLC | 50 | $3.77K | — | Held |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 39.8K | $3.01K | — | Held |
| Parkside Financial Bank & Trust | 31 | $2.34K | — | Held |
| Cornerstone Financial Management LLC | 30 | $2.26K | — | Held |
| Arax Advisory Partners | 26 | $1.96K | — | Held |
| BELLEVUE ASSET MANAGEMENT, LLC | 24 | $1.81K | — | Held |
| Hughes Financial Services, LLC | 18 | $1.36K | — | Held |
| TD PRIVATE CLIENT WEALTH LLC | 18 | $1.36K | — | Held |
| Bare Financial Services, Inc | 15 | $1.13K | — | Held |
| SIGNATUREFD, LLC | 13 | $981 | — | Held |
| Handelsbanken Fonder AB | 12.7K | $959 | — | Held |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 11.6K | $879 | — | Held |
| Blue Trust, Inc. | 8 | $604 | — | Held |
| SBI Securities Co., Ltd. | 6 | $453 | — | Held |
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO | 4.92K | $371 | — | Held |
| Sunbelt Securities, Inc. | 3 | $226 | — | Held |
| IFP Advisors, Inc | 2 | $151 | $72 | Added$72 |
| AMALGAMATED BANK | 1.21K | $91 | — | Held |
| Allworth Financial LP | 1 | $76 | $36 | Added$36 |
| BESSEMER GROUP INC | 516 | $39 | — | Held |
| Daiwa Securities Group Inc. | 166 | $13 | — | Held |
| CWM, LLC | 58 | $4 | — | Held |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | $0 | — | Held |
| Covestor Ltd | 2 | $0 | — | Held |