| Fidelity | 16.5M | $199.5M | — | Held |
| BlackRock, Inc. | 9.05M | $109.4M | — | Held |
| PERCEPTIVE ADVISORS LLC | 8.28M | $100.1M | — | Held |
| TCG Crossover Management, LLC | 6.24M | $75.4M | — | Held |
| Vanguard | 5.8M | $70.1M | — | Held |
| Commodore Capital LP | 5.65M | $68.3M | — | Held |
| Saturn V Capital Management LP | 4.5M | $54.3M | — | Held |
| JANUS HENDERSON GROUP PLC | 4.47M | $54M | — | Held |
| First Light Asset Management, LLC | 3.36M | $40.5M | — | Held |
| Driehaus Capital Management LLC | 3.11M | $37.6M | — | Held |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2.78M | $33.5M | — | Held |
| GOLDMAN SACHS GROUP INC | 2.61M | $31.6M | — | Held |
| MORGAN STANLEY | 2.36M | $28.5M | −$2.94M | Added$2M |
| GEODE CAPITAL MANAGEMENT, LLC | 2.17M | $26.2M | — | Held |
| Almitas Capital LLC | 2.12M | $25.6M | — | Held |
| State Street | 2.07M | $25M | — | Held |
| GREAT POINT PARTNERS LLC | 1.75M | $21.1M | — | Held |
| 683 Capital Management, LLC | 1.65M | $19.9M | — | Held |
| EVENTIDE ASSET MANAGEMENT, LLC | 1.51M | $18.3M | — | Held |
| BANK OF AMERICA CORP /DE/ | 1.34M | $16.1M | −$648.6K | Added$10.3M |
| DEUTSCHE BANK AG\ | 1.33M | $16.1M | — | Held |
| FRANKLIN RESOURCES INC | 1.2M | $14.5M | — | Held |
| Connor, Clark & Lunn Investment Management Ltd. | 1M | $12.1M | — | Held |
| Logos Global Management LP | 950K | $11.5M | — | Held |
| NORTHERN TRUST CORP | 937.8K | $11.3M | — | Held |
| ADAR1 Capital Management, LLC | 890.4K | $10.8M | — | Held |
| Balyasny Asset Management L.P. | 858.7K | $10.4M | — | Held |
| Woodline Partners LP | 845.4K | $10.2M | — | Held |
| Nantahala Capital Management, LLC | 835.7K | $10.1M | — | Held |
| Boxer Capital Management, LLC | 800K | $9.66M | −$1.21M | Cut−$2.57M |
| DIMENSIONAL FUND ADVISORS LP | 771.2K | $9.32M | — | Held |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 713K | $8.61M | — | Held |
| STEMPOINT CAPITAL LP | 565.1K | $6.83M | — | Held |
| UBS Group AG | 543.3K | $6.56M | — | Held |
| Sofinnova Investments, Inc. | 527.1K | $6.37M | — | Held |
| SILVERARC CAPITAL MANAGEMENT, LLC | 506.2K | $6.12M | — | Held |
| AMERIPRISE FINANCIAL INC | 502.4K | $6.07M | — | Held |
| Rock Springs Capital Management LP | 499.8K | $6.04M | — | Held |
| FEDERATED HERMES, INC. | 457.4K | $5.53M | — | Held |
| Qube Research & Technologies Ltd | 412.9K | $4.99M | — | Held |
| Cormorant Asset Management, LP | 400K | $4.83M | — | Held |
| Parkman Healthcare Partners LLC | 381.8K | $4.61M | — | Held |
| Patient Square Capital LP | 350K | $4.23M | — | Held |
| Citadel | 345K | $4.17M | — | Held |
| TWO SIGMA INVESTMENTS, LP | 344.4K | $4.16M | — | Held |
| Point72 Asset Management, L.P. | 335K | $4.05M | — | Held |
| ACUTA CAPITAL PARTNERS, LLC | 333.3K | $4.03M | — | Held |
| TWO SIGMA ADVISERS, LP | 328.4K | $3.97M | — | Held |
| Alpha Wave Global, LP | 317.7K | $3.84M | — | Held |
| BARCLAYS PLC | 295.2K | $3.57M | −$445.7K | Cut−$2.06M |
| Nuveen, LLC | 283.9K | $3.43M | — | Held |
| Tetragon Partners GP Ltd | 272.8K | $3.3M | — | Held |
| JANE STREET GROUP, LLC | 263.2K | $3.18M | — | Held |
| HighVista Strategies LLC | 238.8K | $2.88M | — | Held |
| WELLINGTON MANAGEMENT GROUP LLP | 225.8K | $2.73M | — | Held |
| SummitTX Capital, L.P. | 218.4K | $2.64M | — | Held |
| Bank of New York Mellon Corp | 217.3K | $2.63M | — | Held |
| Aldebaran Capital, LLC | 198.5K | $2.4M | — | Held |
| Renaissance Technologies | 192.5K | $2.33M | — | Held |
| XTX Topco Ltd | 189.7K | $2.29M | — | Held |
| Invesco Ltd. | 175.9K | $2.13M | — | Held |
| Swiss National Bank | 161.7K | $1.95M | — | Held |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 153.4K | $1.85M | — | Held |
| WELLS FARGO & COMPANY/MN | 146.3K | $1.77M | — | Held |
| Atom Investors LP | 139.4K | $1.68M | — | Held |
| BANK OF MONTREAL /CAN/ | 138.5K | $1.67M | — | Held |
| PFM Health Sciences, LP | 134.5K | $1.63M | — | Held |
| Numerai GP LLC | 112.6K | $1.36M | — | Held |
| Elmind Capital, LP | 112K | $1.35M | — | Held |
| RHUMBLINE ADVISERS | 99.3K | $1.2M | — | Held |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 98.8K | $1.19M | — | Held |
| ALPS ADVISORS INC | 90.2K | $1.09M | — | Held |
| STATE OF WISCONSIN INVESTMENT BOARD | 84.1K | $1.02M | — | Held |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 79.1K | $955.4K | — | Held |
| Campbell & CO Investment Adviser LLC | 78.8K | $951.5K | — | Held |
| Squarepoint Ops LLC | 76.6K | $924.9K | — | Held |
| D. E. Shaw & Co., Inc. | 73.2K | $884.5K | — | Held |
| Legal & General Group Plc | 72.6K | $877.2K | — | Held |
| ALLIANCEBERNSTEIN L.P. | 71.5K | $863.7K | — | Held |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 68.9K | $832.2K | — | Held |
| JPMORGAN CHASE & CO | 66.5K | $803.9K | — | Held |
| Russell Investments Group, Ltd. | 65.4K | $790.5K | — | Held |
| Kennondale Capital Management LLC | 53.4K | $645.4K | — | Held |
| Informed Momentum Co LLC | 53.3K | $643.3K | — | Held |
| SEI INVESTMENTS CO | 52.9K | $638.5K | — | Held |
| MetLife Investment Management, LLC | 49.7K | $599.8K | — | Held |
| Trexquant Investment LP | 48.1K | $581.2K | — | Held |
| MILLENNIUM MANAGEMENT LLC | 46.5K | $561.2K | — | Held |
| Mariner, LLC | 46.3K | $559.9K | — | Held |
| PSP Research LLC | 44.2K | $534.2K | — | Held |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 41.2K | $497.3K | — | Held |
| CITIGROUP INC | 38K | $459.4K | — | Held |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 35.9K | $433.4K | — | Held |
| FOX RUN MANAGEMENT, L.L.C. | 35.4K | $427.7K | — | Held |
| INTECH INVESTMENT MANAGEMENT LLC | 32K | $386.6K | — | Held |
| Persistent Asset Partners Ltd | 31.1K | $376.3K | −$34.6K | Added$64.9K |
| Headlands Technologies LLC | 30.5K | $369K | — | Held |
| Verition Fund Management LLC | 29.5K | $356.2K | — | Held |
| Icahn Capital | 27.8K | $336.4K | — | Held |
| Integrated Quantitative Investments LLC | 27.2K | $329K | — | Held |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 27K | $326K | — | Held |
| GUGGENHEIM CAPITAL LLC | 25.2K | $304.9K | — | Held |
| BNP PARIBAS FINANCIAL MARKETS | 25.2K | $304.4K | — | Held |
| Aquatic Capital Management LLC | 24.4K | $294.2K | — | Held |
| Police & Firemen's Retirement System of New Jersey | 23.8K | $286.9K | — | Held |
| ARIZONA STATE RETIREMENT SYSTEM | 22.9K | $276.8K | — | Held |
| TUDOR INVESTMENT CORP ET AL | 22.4K | $270.6K | — | New |
| NEW YORK STATE COMMON RETIREMENT FUND | 21.9K | $264.6K | — | Held |
| PARSONS CAPITAL MANAGEMENT INC/RI | 21.6K | $261.5K | — | Held |
| ProShare Advisors LLC | 21.1K | $254.5K | — | Held |
| Schonfeld Strategic Advisors LLC | 21.1K | $254.3K | — | Held |
| Vanguard Personalized Indexing Management, LLC | 20.8K | $251.7K | — | Held |
| PROFUND ADVISORS LLC | 20.6K | $248.7K | — | Held |
| Virtus Investment Advisers, LLC | 20.3K | $245.3K | — | Held |
| Premier Path Wealth Partners, LLC | 20.3K | $244.8K | — | Held |
| BROWN ADVISORY INC | 19.9K | $240.8K | — | Held |
| Engineers Gate Manager LP | 18.4K | $221.8K | — | Held |
| China Universal Asset Management Co., Ltd. | 17.9K | $216.2K | — | Held |
| Rafferty Asset Management, LLC | 17.7K | $213.5K | — | Held |
| KLP KAPITALFORVALTNING AS | 17.4K | $210.2K | — | Held |
| JUPITER ASSET MANAGEMENT LTD | 15.6K | $188.1K | — | Held |
| ROYAL BANK OF CANADA | 15.6K | $188K | — | Held |
| Quadrature Capital Ltd | 15.5K | $186.8K | — | Held |
| VOYA INVESTMENT MANAGEMENT LLC | 15.2K | $184.2K | — | Held |
| Valeo Financial Advisors, LLC | 15K | $181.2K | — | Held |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 12.2K | $147.7K | — | Held |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 12.2K | $147.1K | — | Held |
| Seven Fleet Capital Management LP | 11.6K | $139.8K | — | Held |
| VICTORY CAPITAL MANAGEMENT INC | 10.6K | $127.5K | — | Held |
| EntryPoint Capital, LLC | 10.5K | $126.7K | — | Held |
| ACT CAPITAL MANAGEMENT, LLC | 9K | $108.7K | — | Held |
| Tower Research Capital LLC (TRC) | 8.1K | $97.8K | — | Held |
| Ameritas Investment Partners, Inc. | 7.2K | $87K | — | Held |
| AlphaQuest LLC | 7.2K | $86.9K | — | Held |
| Walleye Capital LLC | 5.74K | $69.3K | — | Held |
| Mirae Asset Global Investments Co., Ltd. | 5.34K | $64.5K | — | Held |
| Caitong International Asset Management Co., Ltd | 3.86K | $46.6K | — | Held |
| SIMPLEX TRADING, LLC | 3.73K | $45K | — | Held |
| STRS OHIO | 3.4K | $41.1K | — | Held |
| Walleye Trading LLC | 2.83K | $34.1K | — | Held |
| Arax Advisory Partners | 2.55K | $30.8K | — | Held |
| LORING WOLCOTT & COOLIDGE FIDUCIARY ADVISORS LLP/MA | 1.8K | $27.9K | — | Held |
| GF FUND MANAGEMENT CO. LTD. | 2.16K | $26.1K | — | Held |
| MEEDER ASSET MANAGEMENT INC | 2.1K | $25.4K | — | Held |
| US BANCORP \DE\ | 2K | $24.2K | — | Held |
| Sterling Capital Management LLC | 1.63K | $19.7K | — | Held |
| Steward Partners Investment Advisory, LLC | 1.5K | $18.1K | — | Held |
| State of Wyoming | 1.38K | $16.7K | — | Held |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 852 | $12K | — | Held |
| NISA INVESTMENT ADVISORS, LLC | 922 | $11.1K | — | Held |
| Westfuller Advisors, LLC | 819 | $9.89K | — | Held |
| Dunhill Financial, LLC | 600 | $7.25K | — | Held |
| PNC Financial Services Group, Inc. | 438 | $5.29K | — | Held |
| Physician Wealth Advisors, Inc. | 274 | $3.31K | — | Held |
| GAMMA Investing LLC | 267 | $3.23K | — | Held |
| Rockefeller Capital Management L.P. | 261 | $3.15K | — | Held |
| ACADIAN ASSET MANAGEMENT LLC | 254.3K | $3.07K | — | Held |
| OSAIC HOLDINGS, INC. | 249 | $3.01K | — | Held |
| EVOLUTION WEALTH MANAGEMENT INC. | 165 | $1.99K | −$249 | Cut−$249 |
| MassMutual Private Wealth & Trust, FSB | 153 | $1.85K | — | Held |
| J.Safra Asset Management Corp | 123 | $1.49K | — | Held |
| PRICE T ROWE ASSOCIATES INC /MD/ | 107.5K | $1.3K | — | Held |
| HARBOUR INVESTMENTS, INC. | 90 | $1.09K | — | Held |
| Catherine Avery Investment Management LLC | 87 | $1.05K | −$131 | Cut−$131 |
| Larson Financial Group LLC | 41 | $495 | — | Held |
| GSA CAPITAL PARTNERS LLP | 36.8K | $444 | — | Held |
| JONES FINANCIAL COMPANIES LLLP | 30 | $362 | — | Held |
| FINANCIAL CONSULATE, INC | 25 | $302 | — | Held |
| EverSource Wealth Advisors, LLC | 25 | $302 | — | Held |
| SG Americas Securities, LLC | 20.8K | $252 | — | Held |
| Farther Finance Advisors, LLC | 20 | $242 | — | Held |
| Essential Partners LLC | 17 | $205 | −$24 | Cut−$12 |
| Allworth Financial LP | 12 | $145 | −$19 | Cut−$19 |
| T. Rowe Price Investment Management, Inc. | 4.52K | $55 | — | Held |
| AMALGAMATED BANK | 2.79K | $34 | — | Held |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 1.31K | $16 | — | Held |
| CWM, LLC | 1.19K | $14 | — | Held |
| IFP Advisors, Inc | 1 | $12 | −$2 | Cut−$2 |
| SBI Securities Co., Ltd. | 1 | $12 | — | Held |
| Daiwa Securities Group Inc. | 266 | $3 | — | Held |