13F

Stock

Amylyx Pharmaceuticals, Inc.

AMLX · held by 180 managers

Reported value

$1.35B

Holders

180

+1 new · −1 exited

Holders’ est. mark

−$5.28M

Price effect on 10 books still in the name

Largest holder

$199.5M

Fidelity

Notable conviction

Share of each notable manager’s 13F book.

Holder count by quarter

Who holds it

Notable only
InvestorSharesValueEst. markChange
Fidelity16.5M$199.5MHeld
BlackRock, Inc.9.05M$109.4MHeld
PERCEPTIVE ADVISORS LLC8.28M$100.1MHeld
TCG Crossover Management, LLC6.24M$75.4MHeld
Vanguard5.8M$70.1MHeld
Commodore Capital LP5.65M$68.3MHeld
Saturn V Capital Management LP4.5M$54.3MHeld
JANUS HENDERSON GROUP PLC4.47M$54MHeld
First Light Asset Management, LLC3.36M$40.5MHeld
Driehaus Capital Management LLC3.11M$37.6MHeld
ADAGE CAPITAL PARTNERS GP, L.L.C.2.78M$33.5MHeld
GOLDMAN SACHS GROUP INC2.61M$31.6MHeld
MORGAN STANLEY2.36M$28.5M−$2.94MAdded$2M
GEODE CAPITAL MANAGEMENT, LLC2.17M$26.2MHeld
Almitas Capital LLC2.12M$25.6MHeld
State Street2.07M$25MHeld
GREAT POINT PARTNERS LLC1.75M$21.1MHeld
683 Capital Management, LLC1.65M$19.9MHeld
EVENTIDE ASSET MANAGEMENT, LLC1.51M$18.3MHeld
BANK OF AMERICA CORP /DE/1.34M$16.1M−$648.6KAdded$10.3M
DEUTSCHE BANK AG\1.33M$16.1MHeld
FRANKLIN RESOURCES INC1.2M$14.5MHeld
Connor, Clark & Lunn Investment Management Ltd.1M$12.1MHeld
Logos Global Management LP950K$11.5MHeld
NORTHERN TRUST CORP937.8K$11.3MHeld
ADAR1 Capital Management, LLC890.4K$10.8MHeld
Balyasny Asset Management L.P.858.7K$10.4MHeld
Woodline Partners LP845.4K$10.2MHeld
Nantahala Capital Management, LLC835.7K$10.1MHeld
Boxer Capital Management, LLC800K$9.66M−$1.21MCut−$2.57M
DIMENSIONAL FUND ADVISORS LP771.2K$9.32MHeld
CHARLES SCHWAB INVESTMENT MANAGEMENT INC713K$8.61MHeld
STEMPOINT CAPITAL LP565.1K$6.83MHeld
UBS Group AG543.3K$6.56MHeld
Sofinnova Investments, Inc.527.1K$6.37MHeld
SILVERARC CAPITAL MANAGEMENT, LLC506.2K$6.12MHeld
AMERIPRISE FINANCIAL INC502.4K$6.07MHeld
Rock Springs Capital Management LP499.8K$6.04MHeld
FEDERATED HERMES, INC.457.4K$5.53MHeld
Qube Research & Technologies Ltd412.9K$4.99MHeld
Cormorant Asset Management, LP400K$4.83MHeld
Parkman Healthcare Partners LLC381.8K$4.61MHeld
Patient Square Capital LP350K$4.23MHeld
Citadel345K$4.17MHeld
TWO SIGMA INVESTMENTS, LP344.4K$4.16MHeld
Point72 Asset Management, L.P.335K$4.05MHeld
ACUTA CAPITAL PARTNERS, LLC333.3K$4.03MHeld
TWO SIGMA ADVISERS, LP328.4K$3.97MHeld
Alpha Wave Global, LP317.7K$3.84MHeld
BARCLAYS PLC295.2K$3.57M−$445.7KCut−$2.06M
Nuveen, LLC283.9K$3.43MHeld
Tetragon Partners GP Ltd272.8K$3.3MHeld
JANE STREET GROUP, LLC263.2K$3.18MHeld
HighVista Strategies LLC238.8K$2.88MHeld
WELLINGTON MANAGEMENT GROUP LLP225.8K$2.73MHeld
SummitTX Capital, L.P.218.4K$2.64MHeld
Bank of New York Mellon Corp217.3K$2.63MHeld
Aldebaran Capital, LLC198.5K$2.4MHeld
Renaissance Technologies192.5K$2.33MHeld
XTX Topco Ltd189.7K$2.29MHeld
Invesco Ltd.175.9K$2.13MHeld
Swiss National Bank161.7K$1.95MHeld
VOLORIDGE INVESTMENT MANAGEMENT, LLC153.4K$1.85MHeld
WELLS FARGO & COMPANY/MN146.3K$1.77MHeld
Atom Investors LP139.4K$1.68MHeld
BANK OF MONTREAL /CAN/138.5K$1.67MHeld
PFM Health Sciences, LP134.5K$1.63MHeld
Numerai GP LLC112.6K$1.36MHeld
Elmind Capital, LP112K$1.35MHeld
RHUMBLINE ADVISERS99.3K$1.2MHeld
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC98.8K$1.19MHeld
ALPS ADVISORS INC90.2K$1.09MHeld
STATE OF WISCONSIN INVESTMENT BOARD84.1K$1.02MHeld
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM79.1K$955.4KHeld
Campbell & CO Investment Adviser LLC78.8K$951.5KHeld
Squarepoint Ops LLC76.6K$924.9KHeld
D. E. Shaw & Co., Inc.73.2K$884.5KHeld
Legal & General Group Plc72.6K$877.2KHeld
ALLIANCEBERNSTEIN L.P.71.5K$863.7KHeld
SUSQUEHANNA INTERNATIONAL GROUP, LLP68.9K$832.2KHeld
JPMORGAN CHASE & CO66.5K$803.9KHeld
Russell Investments Group, Ltd.65.4K$790.5KHeld
Kennondale Capital Management LLC53.4K$645.4KHeld
Informed Momentum Co LLC53.3K$643.3KHeld
SEI INVESTMENTS CO52.9K$638.5KHeld
MetLife Investment Management, LLC49.7K$599.8KHeld
Trexquant Investment LP48.1K$581.2KHeld
MILLENNIUM MANAGEMENT LLC46.5K$561.2KHeld
Mariner, LLC46.3K$559.9KHeld
PSP Research LLC44.2K$534.2KHeld
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.41.2K$497.3KHeld
CITIGROUP INC38K$459.4KHeld
Zurcher Kantonalbank (Zurich Cantonalbank)35.9K$433.4KHeld
FOX RUN MANAGEMENT, L.L.C.35.4K$427.7KHeld
INTECH INVESTMENT MANAGEMENT LLC32K$386.6KHeld
Persistent Asset Partners Ltd31.1K$376.3K−$34.6KAdded$64.9K
Headlands Technologies LLC30.5K$369KHeld
Verition Fund Management LLC29.5K$356.2KHeld
Icahn Capital27.8K$336.4KHeld
Integrated Quantitative Investments LLC27.2K$329KHeld
MANUFACTURERS LIFE INSURANCE COMPANY, THE27K$326KHeld
GUGGENHEIM CAPITAL LLC25.2K$304.9KHeld
BNP PARIBAS FINANCIAL MARKETS25.2K$304.4KHeld
Aquatic Capital Management LLC24.4K$294.2KHeld
Police & Firemen's Retirement System of New Jersey23.8K$286.9KHeld
ARIZONA STATE RETIREMENT SYSTEM22.9K$276.8KHeld
TUDOR INVESTMENT CORP ET AL22.4K$270.6KNew
NEW YORK STATE COMMON RETIREMENT FUND21.9K$264.6KHeld
PARSONS CAPITAL MANAGEMENT INC/RI21.6K$261.5KHeld
ProShare Advisors LLC21.1K$254.5KHeld
Schonfeld Strategic Advisors LLC21.1K$254.3KHeld
Vanguard Personalized Indexing Management, LLC20.8K$251.7KHeld
PROFUND ADVISORS LLC20.6K$248.7KHeld
Virtus Investment Advisers, LLC20.3K$245.3KHeld
Premier Path Wealth Partners, LLC20.3K$244.8KHeld
BROWN ADVISORY INC19.9K$240.8KHeld
Engineers Gate Manager LP18.4K$221.8KHeld
China Universal Asset Management Co., Ltd.17.9K$216.2KHeld
Rafferty Asset Management, LLC17.7K$213.5KHeld
KLP KAPITALFORVALTNING AS17.4K$210.2KHeld
JUPITER ASSET MANAGEMENT LTD15.6K$188.1KHeld
ROYAL BANK OF CANADA15.6K$188KHeld
Quadrature Capital Ltd15.5K$186.8KHeld
VOYA INVESTMENT MANAGEMENT LLC15.2K$184.2KHeld
Valeo Financial Advisors, LLC15K$181.2KHeld
LANDSCAPE CAPITAL MANAGEMENT, L.L.C.12.2K$147.7KHeld
TEACHER RETIREMENT SYSTEM OF TEXAS12.2K$147.1KHeld
Seven Fleet Capital Management LP11.6K$139.8KHeld
VICTORY CAPITAL MANAGEMENT INC10.6K$127.5KHeld
EntryPoint Capital, LLC10.5K$126.7KHeld
ACT CAPITAL MANAGEMENT, LLC9K$108.7KHeld
Tower Research Capital LLC (TRC)8.1K$97.8KHeld
Ameritas Investment Partners, Inc.7.2K$87KHeld
AlphaQuest LLC7.2K$86.9KHeld
Walleye Capital LLC5.74K$69.3KHeld
Mirae Asset Global Investments Co., Ltd.5.34K$64.5KHeld
Caitong International Asset Management Co., Ltd3.86K$46.6KHeld
SIMPLEX TRADING, LLC3.73K$45KHeld
STRS OHIO3.4K$41.1KHeld
Walleye Trading LLC2.83K$34.1KHeld
Arax Advisory Partners2.55K$30.8KHeld
LORING WOLCOTT & COOLIDGE FIDUCIARY ADVISORS LLP/MA1.8K$27.9KHeld
GF FUND MANAGEMENT CO. LTD.2.16K$26.1KHeld
MEEDER ASSET MANAGEMENT INC2.1K$25.4KHeld
US BANCORP \DE\2K$24.2KHeld
Sterling Capital Management LLC1.63K$19.7KHeld
Steward Partners Investment Advisory, LLC1.5K$18.1KHeld
State of Wyoming1.38K$16.7KHeld
LOS ANGELES CAPITAL MANAGEMENT LLC852$12KHeld
NISA INVESTMENT ADVISORS, LLC922$11.1KHeld
Westfuller Advisors, LLC819$9.89KHeld
Dunhill Financial, LLC600$7.25KHeld
PNC Financial Services Group, Inc.438$5.29KHeld
Physician Wealth Advisors, Inc.274$3.31KHeld
GAMMA Investing LLC267$3.23KHeld
Rockefeller Capital Management L.P.261$3.15KHeld
ACADIAN ASSET MANAGEMENT LLC254.3K$3.07KHeld
OSAIC HOLDINGS, INC.249$3.01KHeld
EVOLUTION WEALTH MANAGEMENT INC.165$1.99K−$249Cut−$249
MassMutual Private Wealth & Trust, FSB153$1.85KHeld
J.Safra Asset Management Corp123$1.49KHeld
PRICE T ROWE ASSOCIATES INC /MD/107.5K$1.3KHeld
HARBOUR INVESTMENTS, INC.90$1.09KHeld
Catherine Avery Investment Management LLC87$1.05K−$131Cut−$131
Larson Financial Group LLC41$495Held
GSA CAPITAL PARTNERS LLP36.8K$444Held
JONES FINANCIAL COMPANIES LLLP30$362Held
FINANCIAL CONSULATE, INC25$302Held
EverSource Wealth Advisors, LLC25$302Held
SG Americas Securities, LLC20.8K$252Held
Farther Finance Advisors, LLC20$242Held
Essential Partners LLC17$205−$24Cut−$12
Allworth Financial LP12$145−$19Cut−$19
T. Rowe Price Investment Management, Inc.4.52K$55Held
AMALGAMATED BANK2.79K$34Held
BNP PARIBAS ASSET MANAGEMENT Holding S.A.1.31K$16Held
CWM, LLC1.19K$14Held
IFP Advisors, Inc1$12−$2Cut−$2
SBI Securities Co., Ltd.1$12Held
Daiwa Securities Group Inc.266$3Held

Who left

Positions as of Q4 2025. 13F filings arrive up to 45 days after quarter-end and omit shorts. Values are quarter-end marks, as filed. Estimated mark is the price effect on shares still held — not realized P&L or investment advice.