| BML Capital Management, LLC | 14.3M | $53.4M | $10.5M | Added$10.5M |
| Deep Track Capital, LP | 9.35M | $35M | — | New |
| BlackRock, Inc. | 7.41M | $27.8M | $5.04M | Added$7.29M |
| RA CAPITAL MANAGEMENT, L.P. | 6.8M | $25.5M | — | New |
| Vivo Capital, LLC | 6.67M | $25M | $4.93M | Cut−$1.76M |
| VANGUARD CAPITAL MANAGEMENT LLC | 5.17M | $19.4M | — | Held |
| Frazier Life Sciences Management, L.P. | 4.93M | $18.5M | — | New |
| Rock Springs Capital Management LP | 4.47M | $16.8M | $3.3M | Added$3.37M |
| Decheng Capital LLC | 4.04M | $15.2M | $2.99M | Added$2.99M |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 3.87M | $14.5M | $2.49M | Added$4.37M |
| Balyasny Asset Management L.P. | 3.36M | $12.6M | — | New |
| MORGAN STANLEY | 2.75M | $10.3M | $2.03M | Added$18.3K |
| GEODE CAPITAL MANAGEMENT, LLC | 2.42M | $9.09M | $1.77M | Added$1.89M |
| Citadel | 2.25M | $8.43M | $891.9K | Added$4.81M |
| State Street | 2.01M | $7.53M | $1.11M | Added$3M |
| Kalehua Capital Management LLC | 1.83M | $6.87M | — | New |
| BRAIDWELL LP | 1.7M | $6.37M | — | New |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 1.66M | $6.21M | — | Held |
| Palo Alto Investors LP | 1.61M | $6.05M | $1.16M | Added$1.33M |
| Woodline Partners LP | 1.49M | $5.57M | $549.1K | Added$3.34M |
| Connor, Clark & Lunn Investment Management Ltd. | 1.42M | $5.32M | $1.05M | Added$1M |
| DEUTSCHE BANK AG\ | 997.9K | $3.74M | $730.6K | Added$770K |
| Aldebaran Capital, LLC | 947.2K | $3.55M | $700.9K | Added$679.5K |
| D. E. Shaw & Co., Inc. | 900.8K | $3.38M | $666.6K | Cut−$2.93M |
| MILLENNIUM MANAGEMENT LLC | 756.1K | $2.84M | $559.5K | Cut−$334.8K |
| NORTHERN TRUST CORP | 728.2K | $2.73M | $491.6K | Added$731.4K |
| Three Bridge Wealth Advisors, LLC | 714.8K | $2.68M | $529K | Added$529K |
| MARSHALL WACE, LLP | 713K | $2.67M | $359.3K | Added$1.21M |
| VANGUARD FIDUCIARY TRUST CO | 628.9K | $2.36M | — | Held |
| GOLDMAN SACHS GROUP INC | 588.7K | $2.21M | $435.6K | Added$303.8K |
| DIMENSIONAL FUND ADVISORS LP | 511.5K | $1.91M | $199.1K | Added$1.1M |
| Renaissance Technologies | 502.6K | $1.88M | $371.9K | Cut−$1.5M |
| PANAGORA ASSET MANAGEMENT INC | 502.3K | $1.88M | $50.5K | Added$1.68M |
| Logos Global Management LP | 500K | $1.88M | $370K | Added$69K |
| Monashee Investment Management LLC | 500K | $1.88M | — | New |
| JPMORGAN CHASE & CO | 486.6K | $1.7M | $233.6K | Cut−$185.8K |
| Aisling Capital Management LP | 434.5K | $1.63M | $321.5K | Added$321.5K |
| TWO SIGMA INVESTMENTS, LP | 395.6K | $1.48M | $292.8K | Cut−$244.7K |
| MPM BIOIMPACT LLC | 391.9K | $1.47M | — | New |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 379.9K | $1.42M | $281.1K | Cut−$1.33M |
| SUPERSTRING CAPITAL MANAGEMENT LP | 366.5K | $1.37M | — | New |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 330K | $1.24M | $244.2K | Added$244.2K |
| Russell Investments Group, Ltd. | 308.2K | $1.16M | $7.24K | Added$1.13M |
| HighTower Advisors, LLC | 305.8K | $1.15M | $226.3K | Added$226K |
| RAYMOND JAMES FINANCIAL INC | 266.4K | $999.2K | $197.2K | Added$187.4K |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 261K | $978.7K | $193.1K | Added$122.1K |
| WELLINGTON MANAGEMENT GROUP LLP | 257.2K | $964.3K | $190.3K | Added$168.6K |
| SEI INVESTMENTS CO | 217.2K | $814.3K | — | New |
| Invesco Ltd. | 214.9K | $806K | $155.3K | Added$174.2K |
| MACKENZIE FINANCIAL CORP | 213.4K | $800.3K | — | New |
| Bank of New York Mellon Corp | 207K | $776.3K | $150.6K | Added$163.8K |
| UBS Group AG | 206.8K | $775.6K | $153K | Cut−$315.7K |
| Verdad Advisers, LP | 197K | $738.9K | — | New |
| Qube Research & Technologies Ltd | 194.5K | $729.4K | $143.9K | Cut−$616.6K |
| Informed Momentum Co LLC | 178.4K | $668.9K | — | New |
| Assenagon Asset Management S.A. | 177.3K | $664.8K | $114.4K | Added$199.6K |
| Fidelity | 176.4K | $661.3K | $33.9K | Added$523.4K |
| Creative Planning | 152.1K | $570.3K | $37.9K | Added$416.3K |
| ADAR1 Capital Management, LLC | 132.4K | $496.6K | $98K | Cut−$1.35M |
| AMERICAN CENTURY COMPANIES INC | 118.7K | $445.1K | $57.4K | Added$211.7K |
| Nuveen, LLC | 118K | $442.6K | $87.3K | Cut−$273.3K |
| ALPS ADVISORS INC | 98.2K | $368.2K | $65.8K | Added$100.4K |
| XTX Topco Ltd | 97.8K | $366.7K | $72.4K | Added$26.8K |
| BANK OF AMERICA CORP /DE/ | 79.5K | $298.3K | $47.7K | Added$104.1K |
| RHUMBLINE ADVISERS | 75.4K | $282.7K | $53.1K | Added$66.6K |
| Quadrature Capital Ltd | 72.5K | $272K | $42.7K | Added$98.4K |
| Icahn Capital | 72.4K | $271.5K | $53.6K | Cut−$40.9K |
| Vanguard Global Advisers, LLC | 68.8K | $258K | — | Held |
| CenterBook Partners LP | 66.6K | $249.7K | — | New |
| MetLife Investment Management, LLC | 43.9K | $164.5K | $18.9K | Added$87.5K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 43.6K | $163.5K | $31.5K | Added$35.3K |
| Susquehanna Portfolio Strategies, LLC | 39.7K | $148.9K | $29.4K | Added$29.4K |
| WELLS FARGO & COMPANY/MN | 36.3K | $136K | $26.8K | Cut−$178.5K |
| EntryPoint Capital, LLC | 33K | $123.8K | — | New |
| DIVERSIFIED TRUST CO | 29.5K | $110.5K | — | New |
| NEW YORK STATE COMMON RETIREMENT FUND | 27.3K | $102.4K | $20.2K | Added$20.2K |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 25.4K | $95.2K | $18.8K | Added$7.96K |
| Vontobel Holding Ltd. | 25K | $93.8K | $18.5K | Added$15.5K |
| TWO SIGMA SECURITIES, LLC | 22.5K | $84.3K | $8.54K | Added$49.5K |
| NEUBERGER BERMAN GROUP LLC | 22.1K | $82.7K | $14K | Added$25.7K |
| BARCLAYS PLC | 21.5K | $80.7K | $15.9K | Cut−$351K |
| BNP PARIBAS FINANCIAL MARKETS | 21.4K | $80.4K | $15.9K | Added$15.7K |
| China Universal Asset Management Co., Ltd. | 21.4K | $80.3K | $13.1K | Added$27.1K |
| Police & Firemen's Retirement System of New Jersey | 19.7K | $73.9K | $14.6K | Added$14.6K |
| INTECH INVESTMENT MANAGEMENT LLC | 19.2K | $72K | $14.2K | Cut−$68.4K |
| ProShare Advisors LLC | 18.7K | $70.1K | $13.8K | Added$5.24K |
| Engineers Gate Manager LP | 18.3K | $68.6K | — | New |
| CRA Financial Services, LLC | 17.8K | $66.7K | $13.2K | Added$13.2K |
| Vanguard Personalized Indexing Management, LLC | 17.6K | $65.8K | — | New |
| CIBC Asset Management Inc | 17.4K | $65.4K | $12.9K | Added$12.9K |
| ExodusPoint Capital Management, LP | 16.9K | $63.4K | — | New |
| Hudson Bay Capital Management LP | 16.8K | $63.1K | — | New |
| VOYA INVESTMENT MANAGEMENT LLC | 16.3K | $61.2K | $12.1K | Added$9.25K |
| STRS OHIO | 16K | $60K | — | New |
| PRUDENTIAL FINANCIAL INC | 13.4K | $50.2K | — | New |
| ALLIANCEBERNSTEIN L.P. | 15.2K | $45.8K | $0 | Held |
| VICTORY CAPITAL MANAGEMENT INC | 11.7K | $44.1K | $7.88K | Added$12K |
| SIMPLEX TRADING, LLC | 11.2K | $42.1K | $8.3K | Cut−$8.11K |
| Jefferies Financial Group Inc. | 11K | $41.3K | $8.14K | Added$8.13K |
| MERCER GLOBAL ADVISORS INC /ADV | 10.6K | $39.7K | $7.52K | Added$9.13K |
| M&T Bank Corp | 10.1K | $37.8K | — | New |
| Ameritas Investment Partners, Inc. | 9.27K | $34.8K | $6.86K | Added$6.86K |
| Legal & General Group Plc | 8.24K | $30.9K | $6.1K | Added$6.1K |
| CITIGROUP INC | 7.83K | $29.3K | $5.79K | Cut−$96K |
| Mirae Asset Global Investments Co., Ltd. | 6.29K | $23.6K | $3.9K | Added$7.74K |
| Rockefeller Capital Management L.P. | 6.11K | $22.9K | $908 | Added$19.2K |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 5.01K | $18.8K | — | New |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 4.96K | $18.6K | $3.67K | Added$1.62K |
| Tower Research Capital LLC (TRC) | 3.87K | $14.5K | $2.77K | Added$3.21K |
| MBM WEALTH CONSULTANTS, LLC | 3.2K | $12K | — | New |
| Sterling Capital Management LLC | 3.04K | $11.4K | $2.25K | Cut−$4.53K |
| GF FUND MANAGEMENT CO. LTD. | 2.42K | $9.07K | $1.57K | Added$2.67K |
| PNC Financial Services Group, Inc. | 2.07K | $7.76K | $1.53K | Added$1.53K |
| ACADIAN ASSET MANAGEMENT LLC | 1.54M | $5.77K | $1.14K | Cut−$615 |
| CWM, LLC | 1.36K | $5.09K | $1.42K | Added$5.09K |
| GAMMA Investing LLC | 1.02K | $3.83K | $170 | Added$3.14K |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 500 | $1.88K | $370 | Added$370 |
| EverSource Wealth Advisors, LLC | 477 | $1.79K | $339 | Added$410 |
| Bollard Group LLC | 431.6K | $1.62K | $320 | Cut−$802 |
| Farther Finance Advisors, LLC | 347 | $1.44K | $393 | Added$239 |
| Parallel Advisors, LLC | 357 | $1.34K | — | New |
| Smartleaf Asset Management LLC | 376 | $1.31K | $222 | Added$222 |
| NISA INVESTMENT ADVISORS, LLC | 318 | $1.19K | $236 | Added$236 |
| Cornerstone Financial Management LLC | 270 | $1.01K | $200 | Added$200 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 156.7K | $588 | $104 | Added$166 |
| Truvestments Capital LLC | 150 | $563 | $111 | Added$111 |
| SBI Securities Co., Ltd. | 67 | $251 | $49 | Added$13 |
| Allworth Financial LP | 49 | $184 | — | New |
| Cambridge Investment Research Advisors, Inc. | 41.9K | $157 | $31 | Added$31 |
| Root Financial Partners, LLC | 27 | $101 | — | New |
| SG Americas Securities, LLC | 26.8K | $100 | $12 | Added$54 |
| ROTHSCHILD INVESTMENT LLC | 9 | $34 | $6 | Added$10 |
| Essential Partners LLC | 5 | $19 | $4 | Added$4 |
| MAI Capital Management | 1 | $4 | — | New |
| Capital Advisors, Ltd. LLC | 454 | $2 | $1 | Added$1 |
| ROYAL BANK OF CANADA | 88 | $0 | −$269 | Cut−$8K |