| EcoR1 Capital, LLC | 23M | $604.8M | — | Held |
| Rubric Capital Management LP | 5.75M | $151.4M | — | Held |
| BlackRock, Inc. | 4.6M | $121M | — | Held |
| BVF INC/IL | 3.94M | $103.7M | — | Held |
| PERCEPTIVE ADVISORS LLC | 3.26M | $85.9M | — | Held |
| MORGAN STANLEY | 2.59M | $68.3M | $24M | Added$219.1K |
| Vanguard | 2.33M | $61.3M | — | Held |
| Siren, L.L.C. | 1.68M | $44.2M | — | Held |
| DEUTSCHE BANK AG\ | 1.6M | $42M | — | Held |
| DIMENSIONAL FUND ADVISORS LP | 1.16M | $30.5M | — | Held |
| Nextech Invest, Ltd. | 1.11M | $29.3M | — | Held |
| State Street | 1.04M | $27.3M | — | Held |
| Capricorn Fund Managers Ltd | 1.02M | $26.9M | — | Held |
| Vestal Point Capital, LP | 865K | $22.8M | — | Held |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 700K | $18.4M | — | Held |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 663.5K | $17.5M | — | Held |
| Nuveen, LLC | 648.3K | $17.1M | — | Held |
| GEODE CAPITAL MANAGEMENT, LLC | 648K | $17.1M | — | Held |
| Assenagon Asset Management S.A. | 647.4K | $17M | — | Held |
| Fidelity | 560.1K | $14.7M | — | Held |
| Prosight Management, LP | 530.4K | $14M | — | Held |
| Redmile Group, LLC | 491.7K | $12.9M | — | Held |
| Qube Research & Technologies Ltd | 474.3K | $12.5M | — | Held |
| GOLDMAN SACHS GROUP INC | 420.2K | $11.1M | — | Held |
| MILLENNIUM MANAGEMENT LLC | 381.6K | $10M | — | Held |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 320.3K | $8.43M | — | Held |
| NORTHERN TRUST CORP | 308K | $8.11M | — | Held |
| Schonfeld Strategic Advisors LLC | 288.6K | $7.6M | — | Held |
| UBS Group AG | 278.9K | $7.34M | — | Held |
| Invesco Ltd. | 257.6K | $6.78M | — | Held |
| Citadel | 255.4K | $6.72M | — | Held |
| PICTON MAHONEY ASSET MANAGEMENT | 244.8K | $6.45M | — | Held |
| Hillsdale Investment Management Inc. | 237.9K | $6.26M | — | Held |
| Granahan Investment Management, LLC | 224.4K | $5.91M | — | Held |
| SummitTX Capital, L.P. | 224.3K | $5.9M | — | Held |
| D. E. Shaw & Co., Inc. | 223.8K | $5.89M | — | Held |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 220.9K | $5.82M | — | Held |
| Renaissance Technologies | 220.9K | $5.82M | — | Held |
| WELLS FARGO & COMPANY/MN | 208.3K | $5.48M | — | Held |
| RAYMOND JAMES FINANCIAL INC | 187.7K | $4.94M | — | Held |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 181.8K | $4.79M | — | Held |
| WELLINGTON MANAGEMENT GROUP LLP | 181.7K | $4.78M | — | Held |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 176.1K | $4.64M | — | Held |
| FEDERATED HERMES, INC. | 152.7K | $4.02M | — | Held |
| KENNEDY CAPITAL MANAGEMENT LLC | 145.5K | $3.83M | — | Held |
| Bank of New York Mellon Corp | 128.1K | $3.37M | — | Held |
| JUPITER ASSET MANAGEMENT LTD | 125.5K | $3.3M | — | Held |
| AMERIPRISE FINANCIAL INC | 113.1K | $2.98M | — | Held |
| CITIGROUP INC | 111.2K | $2.93M | — | Held |
| Opaleye Management Inc. | 108.9K | $2.87M | — | Held |
| PLATINUM INVESTMENT MANAGEMENT LTD | 105.2K | $2.77M | — | Held |
| Trexquant Investment LP | 101.3K | $2.67M | — | Held |
| Soleus Capital Management, L.P. | 100K | $2.63M | — | Held |
| Susquehanna Portfolio Strategies, LLC | 99.8K | $2.63M | — | Held |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 97.9K | $2.6M | — | Held |
| XTX Topco Ltd | 93.5K | $2.46M | — | Held |
| Icahn Capital | 91.1K | $2.4M | — | Held |
| BANK OF AMERICA CORP /DE/ | 89.5K | $2.36M | $696.8K | Added$1.07M |
| KORNITZER CAPITAL MANAGEMENT INC /KS | 88.8K | $2.34M | — | Held |
| ACUTA CAPITAL PARTNERS, LLC | 80.1K | $2.11M | — | Held |
| BARCLAYS PLC | 80K | $2.11M | $739.7K | Cut−$1.29M |
| PANAGORA ASSET MANAGEMENT INC | 78.3K | $2.06M | — | Held |
| NEOS Investment Management LLC | 77.1K | $2.03M | — | Held |
| TEMA ETFS LLC | 76K | $2M | — | Held |
| STIFEL FINANCIAL CORP | 75.8K | $2M | — | Held |
| STATE OF WISCONSIN INVESTMENT BOARD | 75.6K | $1.99M | — | Held |
| RHUMBLINE ADVISERS | 75.5K | $1.99M | — | Held |
| Man Group plc | 75.3K | $1.98M | — | Held |
| CREDIT AGRICOLE S A | 75K | $1.97M | — | Held |
| Pictet Asset Management Holding SA | 73.6K | $1.97M | — | Held |
| Swiss National Bank | 74.2K | $1.95M | — | Held |
| JANE STREET GROUP, LLC | 70.4K | $1.85M | — | Held |
| Fisher Asset Management, LLC | 68.2K | $1.8M | — | Held |
| FRANKLIN RESOURCES INC | 59K | $1.55M | — | Held |
| AMERICAN CENTURY COMPANIES INC | 58.8K | $1.55M | — | Held |
| Russell Investments Group, Ltd. | 58.4K | $1.54M | — | Held |
| ROYAL BANK OF CANADA | 55.1K | $1.45M | — | Held |
| ALLIANCEBERNSTEIN L.P. | 50K | $1.32M | — | Held |
| Dana Investment Advisors, Inc. | 48.3K | $1.27M | — | Held |
| SIMPLEX TRADING, LLC | 48K | $1.26M | — | Held |
| MACKENZIE FINANCIAL CORP | 45.5K | $1.2M | — | Held |
| O'SHAUGHNESSY ASSET MANAGEMENT, LLC | 43.1K | $1.13M | — | Held |
| VICTORY CAPITAL MANAGEMENT INC | 42.9K | $1.13M | — | Held |
| ENVESTNET ASSET MANAGEMENT INC | 40.8K | $1.07M | — | Held |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 37.8K | $994.2K | — | Held |
| JPMORGAN CHASE & CO | 35K | $921.8K | — | Held |
| TANG CAPITAL MANAGEMENT LLC | 34.6K | $911.8K | — | Held |
| Campbell & CO Investment Adviser LLC | 33.6K | $884.4K | — | Held |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 32.8K | $864K | — | Held |
| SBI Okasan Asset Management Co.Ltd. | 32K | $855.7K | — | Held |
| Legal & General Group Plc | 32.1K | $846.5K | — | Held |
| TWO SIGMA ADVISERS, LP | 31.4K | $827.2K | — | Held |
| TUDOR INVESTMENT CORP ET AL | 30.3K | $798.4K | $280.5K | Added$156.5K |
| JOURNEY STRATEGIC WEALTH LLC | 29.1K | $764.9K | — | Held |
| Quantinno Capital Management LP | 28.9K | $760.5K | — | Held |
| MetLife Investment Management, LLC | 28.6K | $753.8K | — | Held |
| Creative Planning | 28.3K | $745K | — | Held |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 28.1K | $739.4K | — | Held |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 27.9K | $735.5K | — | Held |
| STRS OHIO | 26.6K | $700.4K | — | Held |
| COMMONWEALTH EQUITY SERVICES, LLC | 26.1K | $687.1K | — | Held |
| RITHOLTZ WEALTH MANAGEMENT | 24.3K | $640.8K | — | Held |
| Aquatic Capital Management LLC | 24.1K | $634.6K | — | Held |
| Brevan Howard Capital Management LP | 23.3K | $614.4K | — | Held |
| BNP PARIBAS FINANCIAL MARKETS | 23.3K | $613.4K | — | Held |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 23.1K | $608.5K | — | Held |
| Quadrature Capital Ltd | 23K | $606K | — | Held |
| Y-Intercept (Hong Kong) Ltd | 22.6K | $596.2K | — | Held |
| Seven Fleet Capital Management LP | 20.6K | $542.4K | — | Held |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 20.4K | $537.7K | — | Held |
| INTECH INVESTMENT MANAGEMENT LLC | 20.3K | $535.3K | — | Held |
| PSP Research LLC | 20.3K | $534.8K | — | Held |
| Duncan Williams Asset Management, LLC | 22.1K | $510.6K | — | Held |
| Vinva Investment Management Ltd | 12.2K | $483.9K | — | Held |
| CreativeOne Wealth, LLC | 18.3K | $480.9K | — | Held |
| JANUS HENDERSON GROUP PLC | 18.2K | $479.1K | — | Held |
| HSBC HOLDINGS PLC | 17.9K | $476.2K | — | Held |
| BANK OF MONTREAL /CAN/ | 17.5K | $459.9K | — | Held |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 17.4K | $459K | — | Held |
| NEW YORK STATE COMMON RETIREMENT FUND | 17.4K | $457.4K | — | Held |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 15.3K | $403.9K | — | Held |
| AGF MANAGEMENT LTD | 15K | $394.9K | — | Held |
| LAZARD ASSET MANAGEMENT LLC | 13.8K | $362.7K | — | Held |
| Police & Firemen's Retirement System of New Jersey | 13.7K | $360.8K | — | Held |
| Walleye Capital LLC | 13.7K | $359.9K | — | Held |
| Walleye Trading LLC | 13.3K | $348.9K | — | Held |
| PRUDENTIAL FINANCIAL INC | 12.8K | $335.8K | — | Held |
| ProShare Advisors LLC | 12.4K | $326.2K | — | Held |
| China Universal Asset Management Co., Ltd. | 12.2K | $321.1K | — | Held |
| Northwest & Ethical Investments L.P. | 12K | $319.6K | — | Held |
| WINTON GROUP Ltd | 11.2K | $294.4K | — | Held |
| Ewing Morris & Co. Investment Partners Ltd. | 10.8K | $289.2K | — | Held |
| JAMES INVESTMENT RESEARCH, INC. | 10.9K | $287.7K | — | Held |
| State of Wyoming | 10.9K | $286.3K | — | Held |
| Virtus Investment Advisers, LLC | 10.4K | $274.9K | — | Held |
| ARIZONA STATE RETIREMENT SYSTEM | 10.4K | $273.7K | — | Held |
| Abacus Wealth Partners, LLC | 10.2K | $269.1K | — | Held |
| Baader Bank Aktiengesellschaft | 10K | $263.5K | — | Held |
| VARCOV Co. | 9.82K | $258.5K | — | Held |
| VOYA INVESTMENT MANAGEMENT LLC | 9.23K | $243.1K | — | Held |
| GROUP ONE TRADING LLC | 8.84K | $232.8K | — | Held |
| AlphaQuest LLC | 8.31K | $218.9K | — | Held |
| Brooklyn Investment Group | 8.02K | $214.5K | — | Held |
| Cresset Asset Management, LLC | 8.12K | $213.8K | — | New |
| KLP KAPITALFORVALTNING AS | 8K | $210.6K | — | Held |
| Apollon Wealth Management, LLC | 7.88K | $207.3K | — | Held |
| Allspring Global Investments Holdings, LLC | 7.71K | $205.2K | — | Held |
| Persistent Asset Partners Ltd | 7.35K | $193.4K | — | New |
| Ameritas Investment Partners, Inc. | 4.16K | $109.6K | — | Held |
| Mirae Asset Global Investments Co., Ltd. | 3.64K | $95.8K | — | Held |
| CFG Wealth Management Services, Inc. | 3.08K | $81.1K | — | Held |
| OSAIC HOLDINGS, INC. | 2.51K | $66.1K | — | Held |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 1.82M | $48K | — | Held |
| GF FUND MANAGEMENT CO. LTD. | 1.47K | $38.7K | — | Held |
| Caitong International Asset Management Co., Ltd | 1.4K | $36.8K | — | Held |
| Tower Research Capital LLC (TRC) | 1.35K | $35.6K | — | Held |
| Optiver Holding B.V. | 1.15K | $30.3K | — | Held |
| GAMMA Investing LLC | 985 | $25.9K | — | Held |
| NISA INVESTMENT ADVISORS, LLC | 968 | $25.5K | — | Held |
| PNC Financial Services Group, Inc. | 781 | $20.6K | — | Held |
| NBC SECURITIES, INC. | 623 | $16.4K | — | Held |
| THURSTON, SPRINGER, MILLER, HERD & TITAK, INC. | 610 | $16.1K | — | Held |
| Federation des caisses Desjardins du Quebec | 570 | $15K | — | Held |
| NATIONAL BANK OF CANADA /FI/ | 545 | $14.3K | — | Held |
| UMB Bank, n.a. | 466 | $12.3K | — | Held |
| ALGERT GLOBAL LLC | 423.6K | $11.2K | — | Held |
| HUNTINGTON NATIONAL BANK | 364 | $9.58K | — | Held |
| Sterling Capital Management LLC | 331 | $8.71K | — | Held |
| Parallel Advisors, LLC | 329 | $8.66K | — | Held |
| TD Waterhouse Canada Inc. | 311 | $8.19K | — | Held |
| US BANCORP \DE\ | 287 | $7.56K | — | Held |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 387 | $7.4K | — | Held |
| Farther Finance Advisors, LLC | 279 | $7.35K | — | Held |
| Truvestments Capital LLC | 231 | $6.08K | — | Held |
| HighMark Wealth Management LLC | 230 | $6.05K | — | Held |
| COMERICA BANK | 211 | $5.56K | — | Held |
| EverSource Wealth Advisors, LLC | 182 | $4.79K | — | Held |
| Arax Advisory Partners | 169 | $4.45K | — | Held |
| Allworth Financial LP | 146 | $3.85K | $1.29K | Added$1.45K |
| HRT FINANCIAL LP | 121.1K | $3.19K | — | Held |
| IFP Advisors, Inc | 96 | $2.53K | $888 | Added$888 |
| Quarry LP | 90 | $2.37K | — | Held |
| Kilter Group LLC | 66 | $1.74K | $610 | Added$610 |
| Bare Financial Services, Inc | 64 | $1.69K | — | Held |
| Penserra Capital Management LLC | 60.1K | $1.58K | — | Held |
| True Wealth Design, LLC | 58 | $1.53K | — | Held |
| ROTHSCHILD INVESTMENT LLC | 56 | $1.47K | — | Held |
| Steward Partners Investment Advisory, LLC | 53 | $1.4K | — | Held |
| Physician Wealth Advisors, Inc. | 51 | $1.34K | — | Held |
| North Growth Management Ltd. | 45K | $1.18K | — | Held |
| SIGNATUREFD, LLC | 42 | $1.11K | — | Held |
| PRICE T ROWE ASSOCIATES INC /MD/ | 28.8K | $758 | — | Held |
| Sunbelt Securities, Inc. | 27 | $711 | — | Held |
| INTERNATIONAL ASSETS INVESTMENT MANAGEMENT, LLC | 25 | $658 | — | Held |
| JONES FINANCIAL COMPANIES LLLP | 20 | $527 | — | Held |
| CoreCap Advisors, LLC | 18 | $474 | — | Held |
| SG Americas Securities, LLC | 17.6K | $462 | — | Held |
| Smartleaf Asset Management LLC | 12 | $318 | — | Held |
| Essential Partners LLC | 12 | $316 | $111 | Added$111 |
| Janney Montgomery Scott LLC | 11.1K | $291 | — | Held |
| SBI Securities Co., Ltd. | 11 | $290 | — | Held |
| CWM, LLC | 6.97K | $184 | — | Held |
| Larson Financial Group LLC | 6 | $158 | — | Held |
| Cygnus Capital Advisors, LLC | 6K | $158 | — | Held |
| MAI Capital Management | 5 | $132 | — | Held |
| AMALGAMATED BANK | 1.57K | $41 | — | Held |
| DekaBank Deutsche Girozentrale | 3.84K | $35 | — | Held |
| Daiwa Securities Group Inc. | 186 | $5 | — | Held |
| Covestor Ltd | 54 | $1 | — | Held |