| Empery Asset Management, LP | 8.95M | $35.8M | — | Held |
| Fidelity | 8.5M | $34M | — | Held |
| MORGAN STANLEY | 8.21M | $32.8M | $2.16K | Added$32.8M |
| Bain Capital Life Sciences Investors, LLC | 7.97M | $31.9M | — | Held |
| PERCEPTIVE ADVISORS LLC | 6.31M | $25.3M | — | Held |
| Saturn V Capital Management LP | 5.8M | $23.2M | — | Held |
| Deep Track Capital, LP | 5.01M | $20.1M | — | Held |
| Kalehua Capital Management LLC | 3.72M | $14.9M | — | Held |
| Vanguard | 3.42M | $13.7M | — | Held |
| BRAIDWELL LP | 3.37M | $13.5M | — | Held |
| NEA Management Company, LLC | 3.23M | $12.9M | — | Held |
| Blackstone Inc. | 2.68M | $10.7M | — | New |
| Rosalind Advisors, Inc. | 2.61M | $10.4M | — | Held |
| Trails Edge Capital Partners, LP | 2.57M | $10.3M | — | Held |
| Nantahala Capital Management, LLC | 2.45M | $9.8M | — | Held |
| BVF INC/IL | 2.23M | $8.93M | — | Held |
| SAMSARA BIOCAPITAL, LLC | 1.96M | $7.84M | — | Held |
| Siren, L.L.C. | 1.5M | $6M | — | Held |
| BlackRock, Inc. | 1.23M | $4.91M | — | Held |
| Woodline Partners LP | 1M | $4M | — | Held |
| GEODE CAPITAL MANAGEMENT, LLC | 940.4K | $3.76M | — | Held |
| STEMPOINT CAPITAL LP | 898.5K | $3.59M | — | Held |
| GOLDMAN SACHS GROUP INC | 831.9K | $3.33M | — | Held |
| Point72 Asset Management, L.P. | 808.2K | $3.23M | — | Held |
| Stonepine Capital Management, LLC | 593.6K | $2.37M | — | Held |
| SILVERARC CAPITAL MANAGEMENT, LLC | 357.4K | $1.43M | — | Held |
| ACORN CAPITAL ADVISORS, LLC | 273.3K | $1.09M | — | Held |
| State Street | 198.2K | $792.9K | — | Held |
| NORTHERN TRUST CORP | 178.2K | $712.9K | — | Held |
| Pale Fire Capital SE | 167.6K | $670.4K | — | Held |
| Affinity Asset Advisors, LLC | 145K | $580K | — | Held |
| Citadel | 128.7K | $514.7K | — | Held |
| Palumbo Wealth Management LLC | 113.4K | $453.4K | — | Held |
| OMERS ADMINISTRATION Corp | 109.2K | $436.8K | — | Held |
| JANE STREET GROUP, LLC | 91.4K | $365.7K | — | Held |
| MARSHALL WACE, LLP | 80.5K | $321.8K | — | Held |
| ExodusPoint Capital Management, LP | 79.1K | $316.3K | — | Held |
| Qube Research & Technologies Ltd | 67.7K | $271K | — | Held |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 66.8K | $267.2K | — | Held |
| Balyasny Asset Management L.P. | 64.5K | $258K | — | Held |
| BARCLAYS PLC | 57.5K | $230K | — | New |
| MILLENNIUM MANAGEMENT LLC | 56K | $223.9K | — | Held |
| Susquehanna Portfolio Strategies, LLC | 43.3K | $173K | — | Held |
| BANK OF AMERICA CORP /DE/ | 35.8K | $143K | $11.2K | Added$77K |
| CITIGROUP INC | 32.3K | $129.3K | — | Held |
| Hudson Bay Capital Management LP | 32.2K | $129K | — | New |
| Jefferies Financial Group Inc. | 26.1K | $104.5K | — | Held |
| Man Group plc | 24.2K | $96.7K | — | Held |
| Lighthouse Investment Partners, LLC | 22.2K | $88.8K | — | Held |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 22.1K | $88.5K | — | Held |
| STIFEL FINANCIAL CORP | 20.5K | $82K | — | Held |
| TWO SIGMA INVESTMENTS, LP | 17.2K | $69K | — | Held |
| Creative Planning | 16.4K | $65.7K | — | Held |
| CAXTON CORP | 15.6K | $62.2K | — | Held |
| Squarepoint Ops LLC | 12.5K | $50.1K | — | Held |
| Tower Research Capital LLC (TRC) | 10.4K | $41.8K | — | Held |
| Indivisible Partners | 10K | $40K | — | Held |
| JPMORGAN CHASE & CO | 4.58K | $18.3K | — | Held |
| UBS Group AG | 4.13K | $16.5K | — | Held |
| GROUP ONE TRADING LLC | 4K | $16K | — | Held |
| SIGNATUREFD, LLC | 2.75K | $11K | — | Held |
| CIBC Private Wealth Group LLC | 2.17K | $8.66K | — | Held |
| PNC Financial Services Group, Inc. | 1.76K | $7.04K | — | Held |
| Russell Investments Group, Ltd. | 729 | $2.92K | — | Held |
| Allworth Financial LP | 715 | $2.86K | — | New |
| Bleichroeder LP | 595 | $2.38K | — | Held |
| BNP PARIBAS FINANCIAL MARKETS | 511 | $2.04K | — | Held |
| Farther Finance Advisors, LLC | 331 | $1.32K | — | Held |
| Blue Trust, Inc. | 284 | $1.14K | — | Held |
| Fortitude Family Office, LLC | 137 | $548 | — | Held |
| SBI Securities Co., Ltd. | 50 | $200 | — | Held |
| JONES FINANCIAL COMPANIES LLLP | 38 | $152 | — | Held |
| NewEdge Advisors, LLC | 33 | $132 | — | Held |
| Rockefeller Capital Management L.P. | 33 | $132 | — | Held |
| Virtu Financial LLC | 22.5K | $90 | — | Held |
| RMG Wealth Management LLC | 28 | $64 | — | Held |
| HighMark Wealth Management LLC | 6 | $24 | — | Held |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 5 | $20 | — | Held |
| ROYAL BANK OF CANADA | 104 | $0 | — | Held |